Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 崔耀隆教授 (化学病理学系) |
| 陈颂立博士 (中医中药研究所) |
| 李碧珊小姐 (生物医学学院) |
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Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/14WOS source URL
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摘要BRE, a putative stress-modulating gene, found able to down-regulate TNF-alpha -induced NF-kappaB activation upon overexpression, is now shown in human cells expressed as multiple m-RNA isoforms. A total of six isoforms are produced by alternative splicing predominantly at either end of the gene. Predicted from the cDNA sequences of these isoforms, three of them (alphaa, alphab, and alphac) code for BRE of different C-terminus, and the other three (betaa, betab, and betac) may possibly be the nonfunctional counterparts. All human cells examined coexpress all the predominant splice variants, albeit at different ratios. Comparing with normal cells, immortalized human cell lines uniformly express higher levels of BRE. Interestingly, peripheral blood monocytes responded to LPS by down-regulating the expression of all the BRE isoforms, which was however less obvious in the cell fine counterpart, THP-1. Isoform aa, which codes for the canonical BRE with a C-terminal peroxisomal targeting sequence, is the most abundant transcript. We propose that the function of BRE and its isoforms is to regulate peroxisomal activities. (C) 2001 Academic Press.
着者Ching AKK, Li PS, Li Q, Ben Chung LC, Chan JYH, Lim PL, Pang JCS, Chui YL
期刊名称Biochemical and Biophysical Research Communications
出版年份2001
月份11
日期2
卷号288
期次3
出版社ACADEMIC PRESS INC
页次535 - 545
国际标準期刊号0006-291X
电子国际标準期刊号1090-2104
语言英式英语
Web of Science 学科类别Biochemistry & Molecular Biology; BIOCHEMISTRY & MOLECULAR BIOLOGY; Biophysics; BIOPHYSICS
