Pathology of fatal human infection associated with avian influenza A H5N1 virus
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香港中文大学研究人员 ( 现职)


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摘要Eighteen cases of human influenza A H5N1 infection were identified In Hong Kong from May to December 1997. Two of the six fatal cases had undergone a fu II post-mortem which showed reactive hemophagocytic syndrome as the most prominent feature. Other findings included organizing diffuse alveolar damage with interstitial fibrosis, extensive hepatic central lobular necrosis, acute renal tubular necrosis and lymphoid depletion. Elevation of soluble interleukin-2 receptor, interleukin-6 and interferon-gamma was demonstrated in both patients, whereas secondary bacterial pneumonia was not observed. Virus detection using isolation, reverse transcription-polymerase chain reaction and immunostaining were all negative. It is postulated that in fatal human infections with this avian subtype, initial virus replication in the respiratory tract triggers hypercytokinemia complicated by the reactive hemophagocytic syndrome. These findings suggest that the pathogenesis of influenza A H5N1 infection might be different from that of the usual human subtypes H1-H3. J. Med. Virol. 63:242-246, 2001. (C) 2001 Wiley-Liss, Inc.

着者To KF, Chan PKS, Chan KF, Lee WK, Lam WY, Wong KF, Tang NLS, Tsang DNC, Sung RYT, Buckley TA, Tam JS, Cheng AF
期刊名称Journal of Medical Virology
出版年份2001
月份3
日期1
卷号63
期次3
出版社WILEY-LISS
页次242 - 246
国际标準期刊号0146-6615
电子国际标準期刊号1096-9071
语言英式英语

关键词emerging infection; hemophagocytic syndrome; hypercytokinemia
Web of Science 学科类别Virology; VIROLOGY