Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 庄立信教授 (肿瘤学系) |
| 金永强教授 (外科学系) |
| 彭智培教授 (眼科及视觉科学学系) |
| 邓亮生教授 (化学病理学系) |
| 王昭春教授 (病理解剖及细胞学系) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1016/S0165-4608(00)00328-9 |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/16WOS source URL
其它资讯
摘要While much information has been reported on the genetic alterations in breast cancers of Caucasians, little is known about the Oriental populations where breast cancers currently rank the second most common neoplasm. As a first step toward understanding the underlying genetics changes in this population, we used comparative genomic hybridization (CGH) to the genome-wide analysis of forty pT2 tumors from patients of a racially homogenous population in southern China. A complex pattern of genetic alterations emerged with the commonest chromosomal gains identified on 1q(58%), 8q (55%), 11q13 (25%), http://aims.cuhk.edu.hk/converis/portal/Publication/16p (2856): 17q (53%) and 20q (35%), and frequent Losses on gp (38%), 11q (28%), 13q (30%) and 18q (25%). When breast cancers with and without lymph-node metastasis were compared, a higher copy gain of Inp was identified in the node-positive group (P=.036). An overall increase in the average number of genetic aberrations was also identified in the late onset group (>45 years)(P=.042) with a higher incidence of genetic losses noted (P=.035). In particular, losses on http://aims.cuhk.edu.hk/converis/portal/Publication/16q were detected in 30%,:, of the late onset patients but none in the early onsets (P=0.049). In this study, we have illustrated the pattern of genetic changes in breast tumors of southern Chinese females. While frequent 1q, 8q, 17q and 20q gains, and common 8p and 13q deletions detected were consistent to those aberrations reported from the Caucasian populations, the difference in genetic changes associated in lymph-node metastasis and age of onset identified should provide the basis for additional investigations into the underlying tumorigenesis in the Oriental population. (C) 2001 Elsevier Science Inc. All rights reserved.
着者Fung LF, Wong N, Tang N, Lau A, Wong V, Pang CP, Suen M, King W, Johnson PJ
期刊名称CANCER GENETICS AND CYTOGENETICS
出版年份2001
月份1
日期1
卷号124
期次1
出版社ELSEVIER SCIENCE INC
页次56 - 61
国际标準期刊号0http://aims.cuhk.edu.hk/converis/portal/Publication/165-4608
语言英式英语
Web of Science 学科类别Genetics & Heredity; GENETICS & HEREDITY; Oncology; ONCOLOGY
