乔艳，女，副教授

研究方向：肿瘤化学预防与计算生物学

地址：郑州市科学大道100号 基础医学院楼A1-6层

电话：0371-**（办）

邮箱：yanqiao@zzu.edu.cn

教育和工作经历：

2015至今郑州大学基础医学院病理生理学教研室副教授

2014郑州大学化学与分子工程学院讲师

2011-2013 美国肯塔基大学药学院，联合培养博士

2008-2013 中科院大连化学物理研究所，物理化学专业，博士

2004-2008 郑州大学化学与分子工程学院，学士

教学承担：

《生物信息学》课程；

研究方向：

1.创新药物发现和药物设计

2.生物化学反应机理研究

代表性文章：

1.Y Qiao, J Zhao, J Chang, D Wei. Insights into the OxidativePalladium-Catalyzed Regioselective Synthesis of 3-Arylindoles fromN-Ts-Anilines and Styrenes: A Computational Study. ChemCatChem, 2019, 11: 780-789. (第一作者)

2.Y Xiao, XZhang, J Zhao*, Y Qiao*. Mechanisms and regioselectivities ofDABCO/DMAP-catalyzed [2+4] annulation reactions of allenoate withalpha,beta-unsaturated cyclic ketimine: A DFT study. J. Phys. Org. Chem. 2019, 32, e3914. （共同通讯）

3. QShi, Y Wang, Y Wang, L Qu, Y Qiao*,D Wei*. Insights into N-heterocyclic carbene-catalyzed [3 + 4] annulationreactions of 2-bromoenals with N-Ts hydrazones. Org. Chem. Front., 2018, 5:2739-2748. （共同通讯）

4. R Wang, Z Han, B Liu, B Zhou, N Wang, Y Qiao, C Song, J Chai*, J Chang*. Identificationof Natural Compound Radicicol as a Potent FTO Inhibitor. Mol. Pharmaceutics. 2018, 15: 4092-4098.

5.J Gao,P Zhao, Y Qiao*, H Li*. Mechanisticinsights into N-heterocyclic carbene (NHC)-catalyzed N-acylation ofN-sulfonylcarboxamides with aldehydes. J. Phys. Org. Chem. 2018, 31, e3811. （共同通讯）

6. DWei, X Huang, Y Qiao, J Rao,L Wang, F Liao, C Zhan*. Catalytic Mechanisms forCofactor-Free Oxidase-Catalyzed Reactions: Reaction Pathways ofUricase-Catalyzed Oxidation and Hydration of Uric Acid. ACSCatal. 2017, 7: 4623-4636.

7. Y Qiao*, QYang, CSong, J Chang. Computational insights into theorigin of decrease/increase in potency of N-CDPCB analogues toward FTO. J.Biomol. Struct. Dyn. 2017, 35: 1758-1765. (第一作者)

8. JBai, R Bai, Y Qiao, A Wang, CFang*, Schiff base derived from thiosemicarbazone and anthracene showed highpotential in overcoming multidrug resistance in vitro with low drug resistanceindex. Drug Des. Dev. Ther. 2017, 11: 2227-2237.

9. Y Qiao, X Chen, D Wei*,J Chang*. Insights into the CompetingMechanisms and Origin of Enantioselectivity for N-HeterocyclicCarbene-Catalyzed Reaction of Aldehyde with Enamide.Sci. Rep., 2016, 6:38200. (第一作者)

10. LZheng, D Wei*, Y Wang, Y Qiao*.Insights into N-Heterocyclic Carbene-Catalyzed[4+2] Annulation Reaction of Enals with Nitroalkenes: Mechanisms, Origin ofChemo- and Stereoselectivity, and Role of Catalyst. Chem Asian J.2016, 11, 3046-3054. （共同通讯）

11. F Li^#,Y Tao^#, Y Qiao^#,K Li, Y Jiang, C Cao, S Ren, X Chang, X Wang, Y Wang, Y Xie, Z Dong, J Zhao*and K Liu*. Int. J. Oncol. 2016, 49: 1148-1154. (并列第一作者)

12. Y Qiao, W Yang, D Wei*and J Chang*. Theoretical investigations towardTMEDA-catalyzed [2+4] annulation of allenoate with 1-aza-1,3-diene: mechanism,regioselectivity, and role of the catalyst. RSC Adv.,2016, 6(75), 70723-70731. (第一作者)

13. LZheng, M Tang, Y Wang, X Guo, D Wei* and YQiao*. A DFT studyon PBu3-catalyzed intramolecular cyclizations of N-allylic substitutedalpha-amino nitriles for the formation of functionalized pyrrolidines:mechanisms, selectivities, and the role of catalysts. Org.Biomol. Chem., 2016, 14, 3130–3141. （共同通讯）

14. Y Qiao, B Zhou, MZhang, W Liu, Z Han, C Song, W Yu, Q Yang, R Wang, S Wang, S Shi, R Zhao, JChai* and J Chang*. A Novel Inhibitor of theObesity-Related Protein FTO. Biochemistry, 2016, 55, 1516−1522. (第一作者)

15. Y Qiao, B Chen, YYang, X Wang, Y Xu*, H Li*. Rationaldesign of a highly selective fluorescent sensor for L-histidine detection inaqueous solution. Dalton Trans. 2016, 45, 1310-1314. (第一作者)

16. Y Qiao, DWei*, and J Chang*. Insights into theUnexpected Chemoselectivity for the N-Heterocyclic Carbene-Catalyzed AnnulationReaction of Allenals with Chalcones. J.Org. Chem. 2015, 80, 8619-8630. (第一作者)

17. WZhang, X Zhao, Y Qiao*, XGuo, Y Wang, D Wei*, M Tang, J Niu. A DFT study on the reactionmechanisms of phosphonation of heteroaryl N-oxides with H-phosphonates.Comput. Theor. Chem. 2015, 1071, 33-38. （共同通讯）

18. LZheng, Y Qiao*, M Lu, and JChang*. Theoretical investigations of thereaction between 1,4-dithiane-2,5-diol and azomethine imines: mechanisms anddiastereoselectivity. Org. Biomol. Chem., 2015, 13,7558-7569. （共同通讯）

19. Y Qiao and K Han*. Theoretical investigations toward the tandem reactions ofN-aziridinyl imine compounds forming triquinanes via trimethylenemethane diyls:mechanisms and stereoselectivity.Org. Biomol. Chem. 2014, 12(8), 1220-1231. (第一作者)

20. Y Qiao, K Han*, and CZhan*. Reaction pathways and free energyprofiles for cholinesterase-catalyzed hydrolysis of 6-monoacetylmorphine. Org. Biomol. Chem., 2014, 12(14),2214-2227. (第一作者)

21. Y Qiao, K Han*, and CZhan*. Fundamental Reaction Pathway and FreeEnergy Profile for Butyrylcholinesterase-Catalyzed Hydrolysis of Heroin.Biochemistry, 2014, 52(37), 6467-6479. (第一作者)

22. Y Qiao, T Chu*. Reaction Mechanism andChemoselectivity of Intermolecular Cycloaddition Reactions betweenPhenyl-Substituted Cyclopropenone Ketal and Methyl Vinyl Ketone. J.Org. Chem. 2011, 76, 3086-3095. (第一作者)

承担科研项目：

1. 河南省高等学校重点科研项目，19A350013，肥胖相关蛋白FTO抑制剂的筛选与设计，2019/01 –2020/12. 3万元、在研、主持。

2. 河南省联合基金重点项目，U**,新型抗HIV嘌呤核苷的设计、合成、生物活性及作用机制研究。2019/01-2022/12，210万，在研、参与。

3. 国家自然科学基金面上项目，**，不含金属和辅因子的氧化酶和加氧酶催化反应机理的理论研究，2018、01-2021/12. 65万，在研、参与。

4. 国家自然科学基金面上项目，**冬凌草甲素和乙素抑制食管上皮细胞转化的分子机制研究，2018/01-2021/12. 65万，在研、参与。

5. 国家自然科学基金青年项目，**、尿苷二磷酸葡糖醛酸转移酶催化尼古丁及其主要代谢物的葡糖醛酸化反应的理论研究、2015/01-2017/12、25万元、结题、主持。

6. 第55批中国博士后科学基金面上资助项目，编号：2014M552010、UGT2B10催化的尼古丁的葡糖醛酸化反应的理论研究、2014/01-2016/01、5万元、结题、主持。

7. 上海市新药设计重点实验室开放课题，编号：14DZ**、基于反应机理的肥胖相关蛋白（FTO）抑制剂的虚拟筛选，2015.5.1-2017.4.30. 5万元、结题、主持。

获得奖励：

1.