姓 名： 杨钧棠

职 称： 讲师

办公电话：

电子邮箱： **@htu.edu.cn









个人简介：
博士毕业于第三军医大学，博士期间主要从事肺癌和乳腺癌发病机制研究工作，发现了Wnt/β-catenin通路在肺癌中的新的调控机制，该通路在胚胎发育，肿瘤发生以及肺纤维化中发挥关键功能。
博士毕业后于美国希望城国家医学中心从事DNA损伤修复与肺癌发生关系的研究。
2018年7月进入河南师范大学生命科学学院工作，从事肺纤维化发病机理的研究。目前总计发表SCI论文7篇，其中5分以上5篇，第一作者3篇（＞5分1篇），共同第一作者1篇（＞5分）。

研究领域：
肺纤维化发病机制研究。

主要学术及社会兼职：
无

主持或参加科研项目情况：
1.河南省高等学校重点科研项目（20A310006）2019-2021
2.河南师范大学博士科研启动基金（82）2019-2022
学术成果：
1.Tang CZ#,YangJT#（共同第一）, Liu QH, Wang YR, Wang WS: Up-regulated miR-192-5pexpression rescues cognitive impairment and restores neural function in micewith depression via the Fbln2-mediated TGF-beta1 signaling pathway. FASEBjournal(IF=5.595) : officialpublication of the Federation of American Societies for Experimental Biology 2019, 33(1):606-618.
2. Tang CZ, Zhang DF, Yang JT,Liu QH, Wang YR, Wang WS. Overexpression of microRNA-301b accelerateshippocampal microglia activation and cognitive impairment in mice withdepressive-like behavior through the NF-κB signaling pathway. Cell Death Dis (IF=5.638). 2019 Apr 8;10(4):316. doi: 10.1038/s41419-019-1522-4.
3.Han F,Liu WB, Li JJ, Zhang MQ, Yang JT, Zhang X, Hao XL, YinL, Mao CY, Jiang X et al: SOX30 is a prognostic biomarker and chemotherapeuticindicator for advanced-stage ovarian cancer. Endocrine-related cancer(IF=5.331) 2019.
4.Han F,Liu WB, Shi XY, Yang JT, Zhang X, Li ZM, Jiang X, Yin L, Li JJ, Huang CSet al: SOX30 Inhibits Tumor Metastasis through Attenuating Wnt-Signaling viaTranscriptional and Posttranslational Regulation of beta-Catenin in LungCancer. EBioMedicine (IF=6.138) 2018,31:253-266.
5.YangJ, Han F, Liu W, Chen H, Hao X, Jiang X, Yin L, Huang Y, Cao J,Zhang H et al: ALX4, an epigenetically down regulated tumor suppressor,inhibits breast cancer progression by interfering Wnt/beta-catenin pathway.Journal of experimental & clinical cancer research : CR(IF=6.217) 2017, 36(1):170.
6.YangJ, Han F, Liu W, Zhang M, Huang Y, Hao X, Jiang X, Yin L, Chen H,Cao J et al: LHX6, An Independent Prognostic Factor, Inhibits LungAdenocarcinoma Progression through Transcriptional Silencing of beta-catenin.Journal of Cancer 2017(IF=3.2), 8(13):2561-2574.
7.YangJ, Wang R, Liu B, Xue Q, Zhong M, Zeng H, Zhang H: Kinetic analysisof bypass of abasic site by the catalytic core of yeast DNA polymerase eta.Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis (IF=2.5) 2015, 779:134-143.
8.Yu GY, Yang JT, Zhao WM, Guo XS. Role of HMSG2 MediatedFAO Deficiency in IPF Pathogenesis. AJRCCM-conference. 2019.199.A5232
9. Yu GY, YangJT, Zhao WM, Iberra G, Chen X, Guo XS, Kaminski.N. Role of Terra on Telomericand Mitochondrial Functions in IPF Pathogenesis. AJRCCM-conference. 2019.199. A1045