基本信息科学研究教育教学论文专著
基本信息




吴彦超，男，汉族，1975年生，教授，博士生导师，天然产物与药物合成化学带头人。 现主持威海市科技攻关重点项目，山东省自然科学基金和国家自然科学基金等课题。

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新闻标题课题组现状

发表时间2015-02-12

课题组成立于2012年，现有实验室面积150平方米，拥有15个先进的通风柜系统，HPLC 分离分析/提纯系统，零下120度超低温合成反应浴系统，无污染合成反应铁浴加热系统，溶剂蒸馏提纯系统等现代化实验室设备设施，目前拥有2000 个不同的化学试剂，为科研项目实施提供了有力保障。

2013 年秋，课题组所在学院的核磁共振波谱仪、高分辨质谱仪、红外光谱仪、高精度旋光仪等设备陆续到位，课题组各类科研项目得以顺利开展。课题组对进入课题组做科研的研究生和本科生进行生活补贴。生活补贴 = 基础补贴 + 勤奋补贴 + 成果补贴等部分。

初进实验室的本科生需和研究生联合组成合作共赢的科研小组，待能力提高后根据意愿可以从科研小组中独立出来做课题。学生可以根据科研能力、科研经验和科研意愿等从事天然产物（药物）合成、绿色化学和有机合成等领域的研究。应用化学系、生物工程系和环境工程系本科生均可进入课题组，在传帮带形式下短期内可以上手课题研究。

欢迎本科生来课题组从事科研锻炼或进行本科毕业设计！欢迎同学报考或免试推荐到我们课题组做硕士生和博士生！让我们携手为理想而奋斗！


新闻标题李惠静教授博导的个人主页

发表时间2014-12-08

http://homepage.hit.edu.cn/pages/lihuijing


新闻标题本科生科研成果

发表时间2015-07-02

本科生邓凯, 本科生崔同旭, 本科生朱帅, 本科生蒋官赞, 本科生王晓彤. 《基于绿色化学理念合成三苯基苯、苯并吡喃和喹啉类化合物》. 2015年, 第十四届“挑战杯”·鲁信山东省大学生课外学术科技作品竞赛一等奖。本科生邓凯, 本科生朱帅, 本科生崔同旭, 本科生蒋官赞, 本科生王晓彤, 本科生刘晨. “功能化合物的绿色合成”. 2015年, 第十四届“挑战杯”大学生课外学术科技作品竞赛校内竞赛特等奖。Kai Deng (本科生邓凯), Qi-Yong Huai, Zhi-Lun Shen, Hui-Jing Li*, Chen Liu (本科生刘晨) and Yan-Chao Wu*. "Rearrangement of dypnones to 1,3,5-triarylbenzenes." Org. Lett. 2015, 17(6), 1473-1476. (SCI, IF = 6.364)Hui-Jing Li*, Chen-Chao Wang, Shuai Zhu (本科生朱帅), Chun-Yang Dai and Yan-Chao Wu*. "Ru(II)-catalyzed hydrogen transfer/annulation cascade processes between alcohols and 2-nitrobenzaldehydes." Adv. Synth. Catal. 2015, 357(2-3), 583-588. (SCI, IF = 5.663)Hui-Jing Li, Rui Wang, Jing Gao (本科生高晶), Yuan-Yuan Wang, Dong-Hui Luo and Yan-Chao Wu*. "Bismuth(III) bromide-catalyzed substitution of benzyl alcohols with arylsulfonylmethyl isocyanides: an unexpected access to sulfinates." Adv. Synth. Catal. 2015, 357(7), 1393-1397. (SCI, IF = 5.663)Hui-Jing Li*, Kai Deng (本科生邓凯), Dong-Hui Luo, De-Hui Liu(本科生刘德辉), Jun-Li Wang, Chun-Hua Lin (本科生林春华) and Yan-Chao Wu*. "Synthesis of functional 4H-chromenes from phenols and acetophenones under solvent- and metal-free conditions." RSC Adv. 2014, 4 (50), 26316-26324. (SCI, IF = 3.840)Hui-Jing Li,* Ying-Ying Wu (本科生吴莹莹), Qin-Xi Wu, Rui Wang, Chun-Yang Dai, Zhi-Lun Shen, Cheng-Long Xie (本科生谢成龙) and Yan-Chao Wu*. "Water-promoted ortho-selective monohydroxymethylation of phenols in NaBO2 system." Org. Biomol. Chem. 2014, 12 (19), 3100-3107. (SCI, IF = 3.567)本科生邓凯等，"一种以β-甲基查尔酮为原料制备1,3,5-三苯基苯的方法. " 2015, 中国发明专利，申请号为**6.5本科生朱帅等，"一种喹啉类化合物的制备方法." 2015, 中国发明专利，申请号为**9.2本科生高晶等，"一种以苯磺酰甲基异腈为原料制备亚磺酸酯的方法." 2015, 中国发明专利，申请号为**1.1本科生朱帅等，Iron-catalysed triple hydrogen transfer processes among 2-nitrobenzyl alcohols, alcohols, and formic acid: a new access to quinolines, in preparation.本科生邓凯，本科生刘晨等，Cyclotrimerization of acetophenones in the KOH/18-crown-6 system: Synthesis of 1,3,5-triarylbenzenes under acid-free conditions, in preparation.



荣誉称号
2015年 优秀硕士研究生指导老师

2012年 哈尔滨工业大学威海校区科研先进个人奖

2004年 中国科学院化学研究所青年科学特别奖

2003年 中国科学院化学研究所青年科学优秀奖

2002年 南开大学杨石先奖

2001年、2000年 南开大学一等奖学金

工作经历
时间工作经历
2011年-至今

哈尔滨工业大学威海校区海洋科学与技术学院，天然产物化学，教授
2009年-2011年

法国国家研究中心天然产物研究所，天然产物全合成，CDD chercheur
2006年-2009年

法国国家研究中心天然产物研究所，天然产物全合成，博士后



教育经历
2005年，中国科学院化学研究所，分子识别与功能重点实验室，有机化学，理学博士

主要任职


ACS, RSC, Wiley, Springer等数据库部分期刊的审稿人

研究领域
天然产物合成精细化学品合成有机合成方法学 研究方向：挑战合成化学极限造福人类生活是我们的目标。课题组从事天然产物合成，精细化学品合成，有机合成方法学，以及药物研发及其工艺改进等。

团队成员
吴彦超教授博导、李惠静博士、刘颖博士、王军利博士(在读）、王洪双博士(在读）、黄登明博士（在读）、武芹席硕士(在读）、罗东辉硕士(在读）、王陈超硕士(在读）、王琦硕士(在读）、吉元昭硕士(在读）、张振国硕士(在读）、戴春阳硕士（在读）、沈志仑硕士（在读）、邓凯学士（在读）、朱帅学士（在读）等。

科研项目
国家自然科学基金面上项目**，基于有机SOMO活化串联环化反应的几种多环萜类天然产物的不对称全合成研究，负责，201301?201612山东省自然科学基金面上项目ZR2012BM002，Puupehenone类海洋天然产物的全合成，负责，201207?201507威海市科技攻关重点项目2011DXGJ13，若干具有高生物活性海洋天然产物全合成，负责，201201?201412天然药物及仿生药物国家重点实验室开放基金K**，嘌酮菌素天然产物全合成研究，负责，201206?201306哈尔滨工业大学创新基金HIT.NSRIF.**，四环酮（醇）类海洋天然产物全合成，负责，201201?201312哈尔滨工业大学威海校区科研启动基金HIT (WH) 201105，稠环酮和稠环醇类海洋天然产物全合成，负责，201101?201312国家自然科学基金青年科学基金**，具有重要生物活性的啤酒花多酚类天然产物的全合成与结构修饰研究，参与，201301?201512山东省科技攻关2013GGA10075，活性构象导向的海洋天然抗癌药物apratoxin的研制，参与，201308?201508威海市科技攻关重点项目2012DXGJ02，海洋船舶防污导向的天然产物全合成与结构修饰，参与，201301?201412威海市科技攻关重点项目2011DXGJ15，环境友好海洋防污工程的研究，参与，201201?201312国家自然科学基金面上项目**, 具有芳香性的alpha-和beta-氨基酸的不对称合成，参与，200501?200712国家自然科学基金重点项目**，金属促进的非活性化学键的选择性切断与应用，参与，200301?200612国家自然科学基金面上项目**，基于药效团模型的新型除草剂的设计、合成及生物活性研究，参与，200201?200412


讲授课程
《有机波谱分析》、《药物合成反应》 简介：本科生课程

《有机结构波谱分析》、《有机合成化学》 简介：硕士生课程

招生信息
硕士招生: 海洋科学/应用化学 2～4名/年，天然产物合成，精细化学品合成，有机合成方法学

博士招生: 化学工程与技术/应用化学 1～2名/年，天然产物合成，精细化学品合成，有机合成方法学

论文期刊
[43] "Rearrangement of dypnones to 1,3,5-triarylbenzenes." Kai Deng, Qi-Yong Huai, Zhi-Lun Shen, Hui-Jing Li, Chen Liu and Yan-Chao Wu*. Org. Lett. 2015, 17(6), 1473-1476.

[42] "Catalyst-free synthesis of spiropyrazolines from chalcones and cyclic-ketone N-tosylhydrazones." Qin-Xi Wu, Hui-Jing Li,* Hong-Shuang Wang, Zhen-Guo Zhang, Chen-Chao Wang and Yan-Chao Wu*. Synlett 2015, 26(2), 243-249.

[41] "Bismuth(III) bromide-catalyzed substitution of benzyl alcohols with arylsulfonylmethyl isocyanides: an unexpected access to sulfinates." Hui-Jing Li, Rui Wang, Jing Gao, Yuan-Yuan Wang, Dong-Hui Luo and Yan-Chao Wu*. Adv. Synth. Catal. 2015, 357(7), 1393-1397.

[40] "Ru(II)-catalyzed hydrogen transfer/annulation cascade processes between alcohols and 2-nitrobenzaldehydes." Hui-Jing Li, Chen-Chao Wang, Shuai Zhu, Chun-Yang Dai and Yan-Chao Wu*. Adv. Synth. Catal. 2015, 357(2-3), 583-588.

[39] "Synthesis of functional 4H-chromenes from phenols and acetophenones under solvent- and metal-free conditions." Hui-Jing Li, Kai Deng, Dong-Hui Luo, De-Hui Liu, Jun-Li Wang, Chun-Hua Lin and Yan-Chao Wu*. RSC Adv. 2014, 4 (50), 26316-26324.

[38] "Water-promoted ortho-selective monohydroxymethylation of phenols in NaBO₂ system." Hui-Jing Li,* Ying-Ying Wu, Qin-Xi Wu, Rui Wang, Chun-Yang Dai, Zhi-Lun Shen, Cheng-Long Xie and Yan-Chao Wu*. Org. Biomol. Chem. 2014, 12 (19), 3100-3107.

[37] "An "ortho effect" in electrophilic aromatic nitrations: Theoretical analysis and experimental validation." Hui-Jing Li, Yan-Chao Wu,* Jian-Hong Dai, Yan Song,* Runjiao Cheng and Yuanyuan Qiao. J. Chin. Chem. Soc. 2014, 61 (12), 1307-1312.

[36] "Bi(OTf)₃-catalyzed tandem reaction of naphthols with β,γ-unsaturated α-ketoesters. Efficient synthesis of functionalized 4H-chromenes." Hui-Jing Li,* Dong-Hui Luo, Qin-Xi Wu, Chun-Yang Dai, Zhi-Lun Shen and Yan-Chao Wu*. Chin. Chem. Lett. 2014, 25 (9), 1235-1239.

[35] "Regioselective electrophilic aromatic bromination: theoretical analysis and experimental verification." Hui-Jing Li, Yan-Chao Wu,* Jian-Hong Dai, Yan Song,* Runjiao Cheng and Yuanyuan Qiao. Molecules 2014, 19 (3), 3401-3416.

[34] "Synthetic studies on potent marine drugs: Synthesis and the crystal structure of 6-tert- butyl-4-phenyl-4H-chromene-2-carboxylic acid." Hui-Jing Li,* Jun-Li Wang, Rui Wang, Dong-Hui Luo and Yan-Chao Wu*. J. Chem. 2013, 2013, Article ID: 106908.

[33] "Mild and efficient allylation of indoles and amides using amberlyst-15 as a recyclable heterogeneous catalyst." Zhe Liu, Dong Wang, Yanchao Wu, Yongjun Chen. Synthetic Commun. 2012, 42 (12), 1813-1823.

[32] "Hafnium triflate as an efficient catalyst for direct Friedel-Crafts reaction of chromene hemiacetals." Yan-Chao Wu,* Hui-Jing Li, Li Liu, Zhe Liu, Dong Wang, Yong-Jun Chen.* Adv. Synth. Catal. 2011, 353 (6), 907-912.

[31] "Cascade reaction of β,γ-unsaturated α-ketoesters with phenols in trityl chloride/TFA system. Highly selective synthesis of 4-aryl-2H-chromenes and their applications." Yan-Chao Wu,* Hui-Jing Li, Li Liu, Zhe Liu, Dong Wang and Yong-Jun Chen.* Org. Biomol. Chem. 2011, 9 (8), 2868-2877.

[30] "Facile Synthesis of Spiropyrans from Chromene Hemiacetal Esters and Bifunctional Nucleophiles." Yan-Chao Wu,* Hui-Jing Li, Li Liu, Zhe Liu, Dong Wang and Yong-Jun Chen.* Synlett 2011, (11), 1573-1578.

[29] "A sensitive and highly selective fluorescent sensor for In³⁺." Yan-Chao Wu,* Hui-Jing Li and Hua-Zheng Yang. Org. Biomol. Chem. 2010, 8 (15), 3394-3397.

[28] "Efficient and Metal-Free Friedel-Crafts Alkylation of Indoles with Allyl Acetate Mediated by TFE." Zhe Liu, Li Liu, Yan-Chao Wu, Dong Wang and Yong-Jun Chen. Lett. Org. Chem. 2010, 7 (8), 666-670.

[27] Yan-Chao Wu and Jieping Zhu. Synfacts, 2010, 4, 0836?0836.

[26] "Asymmetric Total Syntheses of (–)-Renieramycin M and G and (–)-Jorumycin Using Aziridine as a Lynchpin." Yan-Chao Wu and Jieping Zhu. Org. Lett. 2009, 11 (23), 5558-5561.

[25] "Synthetic Studies on (–)-Lemonomycin: An Efficient Asymmetric Synthesis of Lemonomycinone Amide." Yan-Chao Wu, Guillaume Bernadat, Cédric Couturier, Thierry Schlama and Jieping Zhu. J. Org. Chem. 2009, 74 (5), 2046-2052.

[24] Yan-Chao Wu, Guillaume Bernadat, Cédric Couturier, Thierry Schlama and Jieping Zhu. Synfacts, 2009, 10, 1070?1070.

[23] "Asymmetric Total Synthesis of (–)-Quinocarcin." Yan-Chao Wu, Mélanie Liron and Jieping Zhu. J. Am. Chem. Soc. 2008, 130 (22), 7148-7152.

[22] Yan-Chao Wu, Mélanie Liron and Jieping Zhu. Synform, 2008, 09, A97?A98.

[21] Yan-Chao Wu, Mélanie Liron and Jieping Zhu. Synfacts, 2008, 12, 1253?1253.

[20] "Hafnium Trifluoromethanesulfonate (Hafnium Triflate) as a Highly Efficient Catalyst for Chemoselective Thioacetalization and Transthioacetalization of Carbonyl Compounds." Yan-Chao Wu and Jieping Zhu. J. Org. Chem. 2008, 73 (23), 9522-9524.

[19] Yan-Chao Wu and Jieping Zhu. Synfacts, 2008, 3, 0314?0314.

[18] "Efficient Construction of Pyrazolo[1,5-a]pyrimidine Scaffold and its Exploration as a New Heterocyclic Fluorescent Platform." Yan-Chao Wu, Hui-Jing Li,Li Liu,Dong Wang,Hua-Zheng Yang,Yong-Jun Chen. J. Fluoresc. 2008, 18 (2), 357-363.

[17] "TFA-Mediated Tandem Friedel?Crafts Alkylation/Cyclization/Hydrogen Transfer Process for the Synthesis of Flavylium Compounds." Yan-Chao Wu, Li Liu, Yu-Liang Liu, Dong Wang and Yong-Jun Chen. J. Org. Chem. 2007, 72 (24), 9383-9386.

[16] "InCl₃-catalyzed propargylation of indoles and phenols with propargylic acetates: Application to the syntheses of benzofurans and naphthofurans." Zhe Liu, Li Liu, Zahid Shafiq, Yan-Chao Wu, Dong Wang and Yong-Jun Chen. Synthesis 2007, (13), 1961-1969.

[15] "Iodine-catalyzed allylation and propargylation of indoles with allylic and propargylic acetates." Zhe Liu, Li Liu, Zahid Shafiq, Yan-Chao Wu, Dong Wang and Yong-Jun Chen. Tetrahedron Lett. 2007, 48 (23), 3963-3967.

[14] "Efficient synthesis of 3-arylaminopyrroline-2-ones by the tandem reaction of anilines and β,γ-unsaturated α-ketoesters." Yan-Chao Wu, Li Liu, Dong Wang and Yong-Jun Chen. J. Heterocyclic Chem. 2006, 43(4), 949-955.

[13] "Synthesis of trifluoromethyl-promoted functional pyrazolo[1,5-a]pyrimidine and pyrazolo[5,1-d][1,2,3,5]tetrazine-4(3H)-ones." Yan-Chao Wu, Yong-Jun Chen, Hui-Jing Li, Xiao-Mao Zou, Fang-Zhong Hu and Hua-Zheng Yang. J. Fluorine Chem. 2006, 127 (3), 409-416.

[12] "Skraup?Doebner?Von Miller Quinoline Synthesis Revisited: Reversal of the Regiochemistry for γ-aryl-β,γ-unsaturated α-Ketoesters." Yan-Chao Wu, Li Liu, Hui-Jing Li, Dong Wang and Yong-Jun Chen. J. Org. Chem. 2006, 71 (17), 6592-6595.

[11] "Three-component Friedel-Crafts reaction of indoles, glyoxylate, and amine under solvent-free and catalyst-free conditions - Synthesis of (3-indolyl)glycine derivatives." Jun-Ling Zhao, Li Liu, Hai-Bo Zhang, Yan-Chao Wu, Dong Wang, Yong-Jun Chen. Synlett 2006, (1), 96-100.

[10] "Rapid and convenient synthesis of aryl- and heteroaryl-α-hydroxy-α- trifluoromethyl acetate via Friedel–Crafts alkylation under solvent- and catalyst- free conditions." Jun-Ling Zhao, Li Liu, Hai-Bo Zhang, Yan-Chao Wu, Dong Wang, Yong-Jun Chen. Tetrahedron Lett. 2006, 47 (15), 2511-2514.

[9] "Process for preparation of quinoline derivatives." Yongjun Chen, Yanchao Wu, Li Liu and Wang Dong. Chinese Patent (Faming Zhuanli Shenqing Gongkai Shuomingsu), 2006, 6pp. CN ** A ** CAN 145:489137 AN 2006:**.

[8] "Process for preparation of 2H-chromene derivatives." Yongjun Chen, Yanchao Wu, Li Liu and Wang Dong. Chinese Patent (Faming Zhuanli Shenqing Gongkai Shuomingsu), 2006, 7pp. CN ** A ** CAN 145:292871 AN 2006:900954.

[7] "Design and synthesis of novel fluorine-containing acrylates." Yan-Chao Wu, Chao Wu, Xiao-Mao Zou, Fang-Zhong Hu and Hua-Zheng Yang. Chin. Chem. Lett. 2005, 16 (10), 1293-1296.

[6] "Design and synthesis of novel 5-sulfoxide-substituted pyrazolo[5,1-d][1,2,3,5]tetrazin-4(3H)ones." Yan-Chao Wu, Xiao-Mao Zou, Fang-Zhong Hu and Hua-Zheng Yang. Chin. Chem. Lett. 2005, 16 (9), 1143-1146.

[5] "Design and synthesis of novel sulfone-containing pyrazolo[1,5-a]-pyrimidines and pyrazolo[5,1-d][1,2,3,5]tetrazine-4(3H)-ones." Yan-Chao Wu, Xiao-Mao Zou, Fang-Zhong Hu and Hua-Zheng Yang. J. Heterocyclic Chem. 2005, 42 (4), 609-613.

[4] "3-(4-Methoxystyryl)-2H-1,4-benzoxazin-2-one." Yan-Chao Wu, Hai-Bin Song, Li Liu, Dong Wang and Yong-Jun Chen.* Acta. Cryst. 2005, E61, o1590-o1591.

[3] "Aqueous asymmetric mukaiyama aldol reaction catalyzed by chiral gallium lewis acid with trost-type semi-crown ligands." Hui-Jing Li, Hong-Yu Tian, Yan-Chao Wu, Yong-Jun Chen, Li Liu, Dong Wang and Chao-Jun Li. Adv. Synth. Catal. 2005, 347 (9), 1247-1256.

[2] "Temperature effect in the selective oxidation of pyrazole sulfide derivatives." Yan-Chao Wu, Fang-Zhong Hu and Hua-Zheng Yang. Chemical Reagents 2003, 25 (6), 329-331.

[1] "Research development on inhibitors of 4-hydroxyphenylpyruvate dioxygenase." Yanchao Wu, Fangzhong Hu and Huazheng Yang. Chin. J. Pestic. Sci. 2001, 3 (3), 1-10