华北理工大学生命科学学院教授王希胤 (Dr. Xiyin Wang)
学习经历
1. 2000/9–2005/7， 北京大学， 生物学（生物信息学）， 博士
2. 1991/9–1995/6， 吉林大学， 数学， 学士
工作经历
1. 2010-至今，华北理工大学，生命科学学院，教授，院长，硕导
2. 2008-至今，华北理工大学，基因组学与计算生物学研究中心，主任
3. 2006/2-2009/12，美国乔治亚大学，博士后
教学及指导研究生情况
硕士生导师，指导在读硕士研究生4人，毕业硕士研究生6人。
发表论文及著作
1.Wang X, Guo H, Wang J, Lei T, Liu T, Wang Z, Li Y, Lee TH, Li J, Tang H, Jin D, Paterson AH. Comparative genomic de-convolution of the cotton genome revealed a decaploid ancestor and widespread chromosomal fractionation. New phytologist 2016, 209(3):1252-1263.
2.Xiyin Wang, Jingpeng Wang, Dianchuan Jin , Hui Guo , Tae-Ho Lee, Tao Liu and Andrew H. Paterson. Genome Alignment Spanning Major Poaceae Lineages Reveals Heterogeneous Evolutionary Rates and Alters Inferred Dates for Key Evolutionary Events.Molecular Plant2015, 8(6):885-898.
3.Wang X,Wang Z, Guo H, Zhang L, Wang L, Li J, Jin D, Paterson AH. Telomere-centric genome repatterning determines recurring chromosome number reductions during the evolution of eukaryotes.New Phytologist2015, 205(1):378-389.
4.Ding M, Ye W, Lin L, He S, Du X, Chen A, Cao Y, Qin Y, Yang F, Jiang Y, Zhang H, Wang X, Paterson AH, Rong J. The Hairless Stem Phenotype of Cotton (Gossypium barbadense) Is Linked to a copia-Like Retrotransposon Insertion in homeodomain leucine zipper Gene (HD1).Genetics2015, 201(1):143-154.
5.Li C, Zhang Y, Zhang K, Guo D, Cui B, Wang X, and Huang X. Promoting Flowering, Lateral Shoot Outgrowth, Leaf Development, and Flower Abscission in Tobacco Plants Overexpressing Cotton FLOWERING LOCUS T (FT)-Like Gene GhFT1. Frontiers in Plant Sciences2015, 6:454-454.
6.Ratnaparkhe MB, Lee TH, Tan X, Wang X,Li J, Kim C, Rainville LK, Lemke C, Compton RO, Robertson J, Gallo M, Bertioli DJ, Paterson AH. Comparative and evolutionary analysis of major peanut allergen gene families.Genome Biol Evol2014, 6(9):2468-2488.
7.Boulos Chalhoub, France Denoeud, Shengyi, Liu, Yongming Zhou, Isobel A. P. Parkin, Haibao Tang, Xiyin Wang*, Julien Chiquet, Harry Belcram, Chaobo Tong, Birgits Samans, Corinne Da Silva, Margot Corréa, Jérémy Just,…, Dave Edwards, Wei Hua†, Andrew G. Sharpe§, Andrew H. Paterson, Chunyun Guan, Patrick Wincker. Early allopolyploid evolution in the post-neolithic Brassica napus oilseed genome.Science2014, 345(6199): 950-953(*Xiyin Wang is the group leader of comparative genomics research) (citation # 39)
8.Kim C*, Wang X*, Lee TH, Jakob K, Lee GJ, Paterson AH: Comparative Analysis of Miscanthus and Saccharum Reveals a Shared Whole-Genome Duplication but Different Evolutionary Fates.Plant Cell 2014, 26(6):2420-2429(co-first-author) (citation # 5)
9.Parkin IA, Koh C, Tang H, Robinson SJ, Kagale S, Clarke WE, Town CD, Nixon J, Krishnakumar V, Bidwell SL, et al: Transcriptome and methylome profiling reveals relics of genome dominance in the mesopolyploid Brassica oleracea.Genome Biol 2014, 15(6):R77-R77. (citation 12)
10.Guo H, Wang X, Gundlach H, Mayer KF, Peterson DG, Scheffler BE, Chee PW, Paterson AH: Extensive and Biased Intergenomic Nonreciprocal DNA Exchanges Shaped a Nascent Polyploid Genome, Gossypium (Cotton).Genetics 2014, 197(4):1153-1163. (citation # 2)
11.Liu S, Liu Y, Yang X, Tong C, Edwards D, Parkin IA, Zhao M, Ma J, Yu J, Huang S, et al: The Brassica oleracea genome reveals the asymmetrical evolution of polyploid genomes.Nat Commun 2014, 5:3930. (Xiyin Wang is the PI of comparative genomics research) (citation # 40)
12.Lee TH, Guo H, Wang X, Kim C, Paterson AH: SNPhylo: a pipeline to construct a phylogenetic tree from huge SNP data.BMC Genomics 2014, 15:162. (citation # 4)
13.Renny-Byfield S, Gallagher JP, Grover CE, Szadkowski E, Page JT, Udall JA, Wang X, Paterson AH, Wendel JF: Ancient gene duplicates in Gossypium (cotton) exhibit near-complete expression divergence.Genome Biol Evol 2014, 6(3):559-571. (citation # 5)
14.He N, Zhang C, Qi X, Zhao S, Tao Y, Yang G, Lee TH, Wang X, Cai Q, Li D, et al: Draft genome sequence of the mulberry tree Morus notabilis.Nat Commun 2013, 4:2445. (Xiyin Wang is the PI of comparative genomics research) (citation # 30)
15.Wang Z, Zhang D, Wang X, Tan X, Guo H, Paterson AH: A whole-genome DNA marker map for cotton based on the D-genome sequence of Gossypium raimondii L.G3 (Bethesda) 2013, 3:1759-1767. (citation # 14)
16.Guo H, Lee TH, Wang X, Paterson AH: Function relaxation followed by diversifying selection after whole-genome duplication in flowering plants.Plant Physiol 2013, 162(2):769-778. (citation # 18)
17.Zhang D, Guo H, Kim C, Lee TH, Li J, Robertson J, Wang X, Wang Z, Paterson AH: CSGRqtl, a comparative quantitative trait locus database for Saccharinae grasses.Plant Physiol 2013, 161(2):594-599. (citation # 6)
18.Wang Y, Wang X, Lee TH, Mansoor S, Paterson AH: Gene body methylation shows distinct patterns associated with different gene origins and duplication modes and has a heterogeneous relationship with gene expression in Oryza sativa (rice).New Phytol 2013, 198(1):274-283. (citation # 11)
19.Lee TH, Tang H, Wang X, Paterson AH: PGDD: a database of gene and genome duplication in plants.Nucleic Acids Res 2013, 41(D1):D1152-1158. (citation # 58)
20.Paterson AH, Wendel JF, Gundlach H, Guo H, Jenkins J, Jin D, Llewellyn D, Showmaker KC, Shu S, Udall J, et al: Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.Nature 2012, 492(7429):423-427. (Xiyin Wang is the PI of comparative genomics research) (citation # 194)
21.The Tomato Genome Sequencing Project Consortium. The genomes genome sequence provides insights into fleshy fruitevolution. Nature2012, 485(7400)：635-641. (Wang. X. is a PI and group leader of comparative genomics research) (citation # 633)
22.Wang Y, Wang X, Paterson AH: Genome and gene duplications and gene expression divergence: a view from plants.Ann N Y Acad Sci 2012, 1256:1-14. (citation # 45)
23.Wang Y, Tang H, Debarry JD, Tan X, Li J, Wang X, Lee TH, Jin H, Marler B, Guo H, et al: MCScanX: a toolkit for detection and evolutionary analysis of gene synteny and collinearity.Nucleic Acids Res 2012, 40(7):e49. (citation # 78)
24.J Rong, X Wang, SR Schulze, RO Compton, TD Williams-Coplin, V Goff , PW Chee, AH Paterson: Types, levels and patterns of low-copy DNA sequencedivergence, and phylogenetic implications, for Gossypium genome types.Heredity2012, 108(5):500-506.
25.Wang Y, Wang X, Tang H, Tan X, Ficklin SP, Feltus FA, Paterson AH: Modes of gene duplication contribute differently to genetic novelty and redundancy, but show parallels across divergent angiosperms.PLoS One 2011, 6(12):e28150. (citation # 38)
26.Wang X, Torres MJ, Pierce G, Lemke C, Nelson LK, Yuksel B, Bowers JE, Marler B, Xiao Y, Lin L, et al: A physical map of Brassica oleracea shows complexity of chromosomal changes following recursive paleopolyploidizations.BMC Genomics 2011, 12:470. (citation # 10)
27.Wang X, Wang H, Wang J, Sun R, Wu J, Liu S, Bai Y, Mun JH, Bancroft I, Cheng F, et al: The genome of the mesopolyploid crop species Brassica rapa.Nat Genet 2011, 43(10):1035-1039. (Xiyin Wang is the PI of comparative genomics research) (citation #557)
28.Ratnaparkhe MB*, Wang X*, Li J, Compton RO, Rainville LK, Lemke C, Kim C, Tang H, Paterson AH: Comparative analysis of peanut NBS-LRR gene clusters suggests evolutionary innovation among duplicated domains and erosion of gene microsynteny.New Phytol 2011, 192(1):164-178. (co-first-authorship) (citation # 17)
29.Lin L, Tang H, Compton RO, Lemke C, Rainville LK, Wang X, Rong J, Rana MK, Paterson AH: Comparative analysis of Gossypium and Vitis genomes indicates genome duplication specific to the Gossypium lineage.Genomics 2011, 97(5):313-320. (citation # 10)
30.Wang X, Tang H, Paterson AH: Seventy million years of concerted evolution of a homoeologous chromosome pair, in parallel, in major Poaceae lineages.Plant Cell 2011, 23(1):27-37. (citation # 38)
31.Lin L, Pierce GJ, Bowers JE, Estill JC, Compton RO, Rainville LK, Kim C, Lemke C, Rong J, Tang H, et al: A draft physical map of a D-genome cotton species (Gossypium raimondii).BMC Genomics 2010, 11:395. (citation # 35)
32.Wang, X., and Paterson, A.H. Gene conversion in angiosperm genome with an Emphasis on genes duplicated by polyploidization.Genes2011, 2(1):1-20(citation # 12)
33.Paterson AH, Freeling M, Tang H, Wang X: Insights from the comparison of plant genome sequences.Annu Rev Plant Biol 2010, 61(1):349-372. (citation #112)
34.Tang H, Bowers JE, Wang X, Paterson AH: Angiosperm genome comparisons reveal early polyploidy in the monocot lineage.Proc Natl Acad Sci U S A 2010, 107(1):472-477. (citation # 112)
35.Wang X, Gowik U, Tang H, Bowers JE, Westhoff P, Paterson AH: Comparative genomic analysis of C4 photosynthetic pathway evolution in grasses.Genome Biol 2009, 10(6):R68. (citation # 69)
36.Wang X, Tang H, Bowers JE, Paterson AH: Comparative inference of illegitimate recombination between rice and sorghum duplicated genes produced by polyploidization.Genome Res 2009, 19(6):1026-1032. (citation # 43)
37.Paterson AH, Bowers JE, Bruggmann R, Dubchak I, Grimwood J, Gundlach H, Haberer G, Hellsten U, Mitros T, Poliakov A, Wang. X.et al: The Sorghum bicolor genome and the diversification of grasses.Nature 2009, 457(7229):551-556. (citation # 1267)
38.Paterson AH, Bowers JE, Feltus FA, Tang H, Lin L, Wang X: Comparative genomics of grasses promises a bountiful harvest.Plant Physiol 2009, 149(1):125-131. (citation # 38)
39.Lyons E, Pedersen B, Kane J, Alam M, Ming R, Tang H, Wang X, Bowers J, Paterson A, Lisch D, Freeling M: Finding and comparing syntenic regions among Arabidopsis and the outgroups papaya, poplar, and grape: CoGe with rosids.Plant Physiol 2008, 148(4):1772-1781. (citation # 125)
40.Tang H, Wang X, Bowers JE, Ming R, Alam M, Paterson AH: Unraveling ancient hexaploidy through multiply-aligned angiosperm gene maps.Genome Res 2008, 18(12):1944-1954. (citation # 218)
41.Tang H, Bowers JE, Wang X, Ming R, Alam M, Paterson AH: Synteny and collinearity in plant genomes.Science 2008, 320(5875):486-488 (citation #326)
42.Ming R, Hou S, Feng Y, Yu Q, Dionne-Laporte A, Saw JH, Senin P, Wang W, Ly BV, Lewis KL, et al: The draft genome of the transgenic tropical fruit tree papaya (Carica papaya Linnaeus).Nature 2008, 452(7190):991-996. (citation # 571)
43.Wang X, Tang H, Bowers JE, Feltus FA, Paterson AH: Extensive concerted evolution of rice paralogs and the road to regaining independence.Genetics 2007, 177(3):1753-1763. (citation # 64)
44.Wang X, Shi X, Li Z, Zhu Q, Kong L, Tang W, Ge S, Luo J: Statistical inference of chromosomal homology based on gene colinearity and applications to Arabidopsis and rice.BMC Bioinformatics 2006, 7:447. (citation # 55)
45.Shi X*, Wang X*, Li Z, Zhu Q, Tang W, Ge S, Luo J: Nucleotide substitution pattern in rice paralogues: implication for negative correlation between the synonymous substitution rate and codon usage bias.Gene 2006, 376(2):199-206. (co-first-authorship) (citation # 10)
46.Wang X, Shi X, Hao B, Ge S, Luo J: Duplication and DNA segmental loss in the rice genome: implications for diploidization.New Phytol 2005, 165(3):937-946. (citation # 224)
47.Yu J, Wang J, Lin W, Li S, Li H, Zhou J, Ni P, Dong W, Hu S, Zeng C, et al: The Genomes of Oryza sativa: a history of duplications.PLoS Biol 2005, 3(2):e38. (citation # 671)
48.Wang X, Shi X, Hao B: The transfer RNA genes in Oryza sativa L. ssp. indica.Sci China C Life Sci 2002, 45(5):504-511. (citation # 14)
49.Shi X, Wang X, Li Z, Zhu Q, Yang J, Ge S, Luo J: Evidence that natural selection is the primary cause of the Guanine-cytosinecontent variation in rice genes.Journal of Integrative Plant Biology 2007, 49(9):1393-1399. (co-first-authorship) (citation # 8)
50.Wang X, Shi XL, Hao B: The tRNA and rRNA genes in the Oryza sativa genome.Acta Genetics Sinica 2004, 31(9):871-877. (citation # 3)

研究方向
申请人主要从事生物信息学和基因组学的研究，在多个植物基因组测序的国际合作项目中任生物信息学/比较基因组学分析的首席科学家或研究组组长；作为植物基因组信息学领域著名专家之一，取得了多项突出的独创性成果：生物信息学软件和数据库开发，染色体进化理论创新，基因组多倍化与稳定性研究，重要经济作物全基因组比对算法和应用研究，基因家族和调控网络研究。共发表论文50 余篇，其中20 篇发表在《Science》（2）、《Nature》（4）、《Nature Genetics》（1）《Nature Communications》（2）、《Genome Research》（2）、《Plant Cell》（2）、《PNAS》（1）、《Genome Biology》（1）、《New Phytologist》（4）、《Molecular Plant》（1）等一流学术杂志上，第一作者论文17 篇，作为首席科学家之一发表的论文6 篇，这些文章已被他引3136多次（止于2016 年3 月）。发表的学术论文仅2014年单年就有9篇ESI全球前1%文章被收录。被引频次最高的是发表在Nature期刊上题名为《The Sorghum bicolor genome and the diversification of grasses》的文章，共被引用943次，该篇文章在全球分子生物学与遗传学影响力已经位列全球学术领域中最优秀的1‰之列，具有极高的学术价值和国际影响力。
项目成果
1.国家自然科学基金面上项目：水稻和高粱基因进化的比较基因组分析（**/C060602，2010-2012，32 万），主持，已结题。
2.国家自然科学基金面上项目：稻属一对部分同源染色体间的非正常遗传重组研究（**/C020303，2012-2015，60 万），主持，已结题。
3.国家自然科学基金面上项目：棉花基因组结构与功能的比较基因组学研究（**/C060501，2014-2017，70 万），主持，在研。
4.主持河北省自然科学基金****项目：粳稻和籼稻同源染色体间的遗传重组研究（C，2013-2015，30 万)，主持，已结题。
荣誉、获奖
2010 年入选河北省教育厅百名新世纪创新人才支持计划
2010年入选河北省“三三三人才工程”****
2014 年入选河北省百名创新人才项目
2015 年入选河北省特贴津贴专家
社会工作
1. 国际计算生物学学会会员（ISCB)；
2. 国际分子进化学会会员（SMBE)；
3. 美国遗传学会会员（GSA）；
4. 知名国际学术刊物审稿人《Plant Cell》、《Molecular Biology and Evolution》、《Genetics》、《New Phytologist》、《Data in Brief》、《Journal of Bioinformatics and Computational Biology》、《Molecular Plant》、《BMC Genomics》、《BMC research notes》、《BMC plant biology》、《Frontiers in Plant Genomics》、《Frontiers in Bioinformatics》、《PLOS one》等十余个国际知名学术杂志审稿人；
5. 学术杂志《American Journal of Molecular Biology》主编(2012, 2013);
6. 学术杂志《Acta Horiculturae Sinica》编委（2015)。
其他信息