张西锋
博士(后) 副教授 硕士生导师
武汉轻工大学生物与制药工程学院
湖北道地药材分子生物学实验室
武汉轻工大学药物研究开发研究中心
武汉市食药兼用资源研究与开发工程技术中心
青岛农业大学生殖科学研究院
山东省高校动物生殖与种质创新重点实验室
西北农林科技大学博士，意大利罗马Tor Vergata大学访问学者(2014.12-至今，国家留学基金委全额资助)，韩国Konkuk大学博士后(2013.6-2014.7)，中国科学技术大学国内访问学者(2011.9-2012.6)，中国动物学会细胞与分子显微技术分会会员，世界中医药学会联合会会员。主要从事纳米生物技术，细胞生物学和生药学的研究。近年来主持国家自然科学基金青年基金项目1项，国家自然科学基金面上项目子课题1项，湖北省自然科学基金1项，湖北省教育厅科学技术研究计划重点项目1项，山东大学微生物技术国家重点实验室开放课题1项，参与国家自然科学基金青年项目1项，山东省农业良种工程项目1项，基因生物新品种培育重大专项1项。近年来在＂Environ Mol Mutagen＂，＂Int J Nanomed＂，＂Reprod Fert Develop＂，＂Mol Biol Rep＂，＂Cell Cycle＂，＂Plos One＂，＂Appl Environ Microbiol＂等期刊上共发表SCI收录论文20篇，其中第一作者或通讯作者11篇；授权国家发明专利1项；获省、市自然科学奖4项。
联系电话： ** **（武汉）
** **（青岛）
Email：zhangxf9465@163.com
近年来发表与完成的主要研究论文：
1. Xi-Feng Zhang, Eun-Su Kim, Min-Hee Kang, Sangiliyandi Gurunathan, Jin-Hoi Kim Silver nanoparticles cause complication in pregnant mice. Int J Nanomed, 2015.(submitted)
2. Xi-Feng Zhang, Jin-Hoi Kim. Effects of silver nanoparticles on testis development of neonatal mice. J Nanobiotechnol , 2015.( submitted)
3. Xi-Feng Zhang, Yun-Jung Choi, Jae Woong Han, Eun-Su Kim, Jung-Hyun Park, Sangiliyandi Gurunathan, and Jin-Hoi Kim. Differential nanoreprotoxicity of silver nanoparticles in male somatic cells and spermatogonial stem cells. Int J Nanomed, 2015,10: 1335-1357.
4. Gui-Jin Liang, Xi-Feng Zhang(co-first authors), Yan-Min Feng, Lin-Qing Wang, Yuan-Chao Sun, Lan Li, Shun-Feng Cheng, Ping Chen, Qing-Hua Shi, Massimo De Felicid, Wei Shen. ActivinA promote the meiotic initiation of female germ cells in mouse. Stem cell Dev, 2015(recepted)
5. Xiao-Feng Sun, Xing-Hong Sun, Shun-Feng Cheng, Jun-Jie Wang, Gui-Jin Liang, Yan-Ni Feng, Zhu-Mei Hou, Yong Zhao, Shen Yin, Lan Li, Wei Shen, Xi-Feng Zhang*. Cross-talk between the TGF-β and Notch signaling pathways in regulating granulosa cell proliferation. Reprod Fert Develop, 2015(accepted)
6. Lin-Qing Wang, Jing-Cai Liu, Chun-Lei Chen, Shun-Feng Cheng, Xiao-Feng Sun, Yong Zhao, Shen Yin, Zhu-Mei Hou, Lan Li, Bo Pan, Cheng Ding, Wei Shen, Xi-Feng Zhang*. Regulation of primordial follicle recruitment by cross-talk between the Notch and phosphatase and tensin homologue (PTEN)/AKT pathways. Reprod Fert Develop, 2014, http://dx.doi.org/10.1071/RD14212
7. Xi-Feng Zhang, Teng Zhang, Zhe Han, Jing-Cai Liu,Yu-Ping Liu,Lan Li, Wei Shen. Transgenerational inheritance of ovarian development deficiency induced by maternal diethylhexyl phthalate exposure. Reprod Fert Develop, 2014 Jun 12. doi: 10.1071/RD14113. [Epub ahead of print]
8. Lan Li, Teng Zhang, Hua-Gang Ma, Hong Chen, Ping Chen, Guo-Qing Qin, Wei Shen, Xi-Feng Zhang*. Exposure to Diethylhexyl phthalate (DEHP) results in a heritable modification of imprint genes DNA methylation in mouse oocytes. Mol Biol Rep, 2014， 41(3):1227-1235.
9. Xi-Feng Zhang, Lian-Jun Zhang, Lan Li, Yan-Ni Feng, Bo Chen, Jin-Mei Ma, Gui-Jin Liang, Yan-Min Feng, Lin-Qing Wang, Qing-Hua Shi, Wei Shen. Diethylhexyl Phthalate Exposure Impairs Follicular Developmentand and Affects Oocyte Maturation in the Mouse. Environ Mol Mutagen, 2013, 54(5):354-361.
10. Xi-Feng Zhang, Teng Zhang, Liu Wang, Hong-Ying Zhang，Yong-De Chen, Xun-Si Qin, Yan-Min Feng, Yan-Ni Feng, Wei Shen, Lan Li. Effects of diethylhexyl phthalate (DEHP) given neonatally on spermatogenesis of mice. Mol Biol Rep, 2013,40(11):6509-6517.
11. Guo-Liang Zhang, Xi-Feng Zhang (co-first authors),Yan-Min Feng, Zhong-Yi Sun, Lan Li,
Xiao-Feng Sun, Wei Shen. Exposure to bisphenol A results in a decline of spermatogenesis. Reprod Fert Develop, 2013, 25(6):847-59.
12. Xi-Feng Zhang, Lian-Jun Zhang, Yan-Ni Feng, Bo Chen, Yan-Min Feng, Gui-Jin Liang, Lan Li, Wei Shen. Bisphenol A exposure modifies DNA methylation of imprint genes in mouse fetal germ cells. Mol Biol Rep, 2012,39 (9): 8621-8628.
13. Han-Qiong Zhang, Xi-Feng Zhang(co-first authors), Lian-Jun Zhang, Hu-He Chao, Bo Pan, Yan-Min Feng, Lan Li, Xiao-Feng Sun, Wei Shen. Fetal exposure to bisphenol A affects the primordial follicle formation by inhibiting the meiotic progression of oocytes, Mol Bio Rep，2012, 39(5):5651-5657.
14. Sangiliyandi Gurunathan, Jae-Kyo Jeong, Jae Woong Han, Xi-Feng Zhang, Jung Hyun Park, Jin-Hoi Kim. Multidimensional effects of biologically synthesized silver nanoparticles in Helicobacter pylori, Helicobacter felis, and human lung (L132) and lung carcinoma A549 cells. Nanoscale Res Lett. 2015, 10:35. DOI 10.1186/s11671-015-0747-0.
15. Yan-Min Feng, Gui-Jin Liang, Bo Pan, Xun-si Qin，Xi-Feng Zhang, Chun-Lei Chen, Lan Li, Shun-Feng Cheng, Massimo De Felicid, Wei Shen. Notch pathway regulates meiotic prophase I, apoptosis and growth of oocytes and perinatal follicle assembly in the mouse ovary. Cell Cycle, 2014, 13(5):782-791.
16. Teng Zhang, Lan Li, Xun-si Qin，Yang Zhou，Xi-Feng Zhang, Lin-Qing Wang, Hong Chen, Guo-Qing Qin, Wei Shen. Exposure to Di-(2-ethylhexyl) Phthalate and Bisphenol A Impairs Newborn Mouse Primordial Follicle Assembly in Vitro. Environ Mol Mutagen, 2014, 55:343-353.
17. Zhi-Peng Zhang, Gui-Jin Liang, Xi-Feng Zhang, Guo-Liang Zhang, Hu-He Chao, Lan Li, Xiao-Feng Sun, Ling-Jiang Min, Qing-Jie Pan, Qing-Hua Shi, Qing-Yuan Sun, Massimo De Felici,Wei Shen. Growth of Mouse Oocytes to Maturity from Premeiotic Germ Cells In Vitro, Plos One, 2012,7(7):e41771.
18. Hu-He Chao, Xi-Feng Zhang, Bo Chen, Bo Pan, Lian-Jun Zhang, Lan Li, Xiao– Feng Sun, Qing-Hua Shi, Wei Shen. Bisphenol A exposure modifies methylation of imprinted genes in mouse oocytes via the estrogen receptor signaling pathway. Histoch Cell Bio, 2012,137:249-259.
19. Lian-Jun Zhang, Bo Pan, Bo Chen, Xi-Feng Zhang, Gui-Jin Liang, Yan-Ni Feng, Lin-Qing Wang, Jin-Mei Ma, Lan Li, Wei Shen. Expression and epigenetic dynamics of transcription regulator Lhx8 during mouse oogenesis. Gene, 2012,506:1-9.
20. Xiaoyun Wang, Wenjun Chen, Xiaoli Lv,Yanli Tian, Jingtao Men, Xifeng Zhang, Huali Lei, Chenhui Zhou, Fangli Lu, Chi Liang, Xuchu Hu, Jin Xu, Zhong dao Wu, Xuerong Li, Xinbing Yu.Identification and Characterization of Paramyosin from Cyst Wall of Metacercariae Implicated Protective Efficacy against Clonorchis sinensis Infection. Plos One, 2012,7(3),e33703.
21. Xiaoman Xu, Chao Gao, Xifeng Zhang, Bin Che, Cuiqing Ma,Jianhua Qiu, Fei Tao, and Ping Xu1.Production of N-Acetyl-D-Neuraminic Acid by Use of an Efficient Spore Surface Display System. Appl Environ Microbiol, 2011, 77(10): 3197-3201.
22. Chao Gao, Xiaomam Xu, Xifeng Zhang, Bin Che, cuiqing ma, Jianhua Qiu, Fei Tao, and Ping Xu. Chemoenzymatic synthesis of N-acetyl-D-neuraminic acid from N-acetyl- D-glucosamine using the spore surface displayed N-acetyl-D-neuraminic acid aldolase. Appl Environ Microbiol, 2011, 77(19):7080-7083.
授权的国家发明专利：
1 ActA促进减数分裂前雌性生殖细胞体外发育的技术方法，国家发明专利，专利号：**2.0
获奖：
1 沈伟，李兰，孙晓风，张西锋，闵令江. 动物卵母细胞体外发生及其表观遗传调节机制的研究，2012年山东省高等学校优秀科研成果奖（贰等奖），山东省教育厅，2012年12月；
2 沈伟，李兰，孙晓风，张西锋，闵令江. 哺乳动物卵母细胞发生的分子调节机制，自然科学类（贰等奖），青岛市人民政府，2013年1月；
3 张腾，张西锋，李兰，朝呼和，张国梁. 2014年山东省研究生优秀科技创新成果三等奖, 山东省教育厅，2014年7月；
4 沈伟，张西锋，李兰，孙晓风. 2014年山东高等学校优秀科研成果奖（贰等奖），山东省教育厅，2014年9月.