姓 名:
　孙永华 性 别:
　男
职 称:
　研究员 学 历:
　研究生
电 话:
　86-** 电子邮件:
　yhsun@ihb.ac.cn

简历：
　　孙永华，1976年生，博士、中国科学院水生生物研究所研究员、博士生导师、国家斑马鱼资源中心主任（http://zfish.cn）、首届国家优秀青年科学基金获得者、中国科学院卢嘉锡青年人才奖获得者、中国科学院青年创新促进会会员。1997 年毕业于武汉大学生命科学学院，获理学学士学位；2002 年毕业于中国科学院水生生物研究所，获理学博士学位；2006 年9 月-2008 年3 月获法中科学及应用基金会（FFCSA）奖励在法国国家科研中心从事博士后研究，2009 年10 -12 月以Visiting Associate Professor身份在美国弗吉尼亚大学进行合作研究。

　　主要从事鱼类早期发育的分子调控和基于基因组操作的鱼类分子育种研究(Cell Research, 2000; 中国科学，2014)。阐明Smad蛋白在早期胚胎中介导BMP信号通路的网络调控机制（Journal of Biological Chemistry, 2014），发现经典Wnt信号通路的新调控因子——homeobox基因Lbx2，阐明了其通过解除Groucho的转录抑制上调Wnt信号活性的分子机制(Nature Communications, 2014)；首次获得转基因鱼的属间克隆鱼，揭示母源因子对克隆鱼发育图式形成的重要作用和克隆鱼败育的分子机制（Biology of Reproduction, 2005; Theriogenology, 2007, 2008; BMC Developmental Biology, 2008；Journal of Physiology, 2014）；建立不依赖于生长激素水平且快速生长的激活型生长激素受体转基因鱼模型（Transgenic Research, 2011, 中国发明专利授权，2013）；利用合成生物学途径研制首例具有从头合成omega-6和omega-3不饱和脂肪酸能力的转基因鱼（Marine Biotechnology, 2014）；创制特异高效的鱼类原始生殖细胞操作技术（Marine Biotechnology, 2013）并将之应用于稳定高效的基因组操作。

先后主持科技部973 课题、863子课题、国家优秀青年科学基金、国家自然科学基金重大研究计划课题、国家自然科学基金面上项目、中科院重点部署项目等课题。在 Nature Communications、Journal of Biological Chemistry、Biology of Reproduction、Journal of Physiology、PLoS Genetics、Cell Research、Marine Biotechnology、Transgenic Research、Science China等SCI刊物上发表研究论文30 余篇。多次作为会议主席或秘书长主持国际性或全国性学术会议，应邀10多次在美、英、法等举行的国际学术会议上作口头报告。

研究方向：
早期发育的分子调控；鱼类基因组操作和定向育种


专家类别：


职务：


社会任职：


获奖及荣誉：

代表论著：
1. Lu FI^*, Sun YH^*, Wei CY, Thisse C, Thisse B (2014) Tissue Specific Derepression of TCF/LEF Controls the Activity of the Wnt/β-Catenin Pathway. Nature Communications (in press, ^* co-first-author)

2. Sun YH*, Zhu ZY (2014) Cross-species cloning: influence of cytoplasmic factors on development. The Journal of Physiology 592:2375-2379.

3. Pang SC, Wang HP, Li KY, Zhu ZY, Kang JX, Sun YH* (2014) Double Transgenesis of Humanized fat1 and fat2 Genes Promotes Omega-3 Polyunsaturated Fatty Acids Synthesis in a Zebrafish Model. Mar Biotechnol (NY) 16 (5):580-593.

4. Wei CY, Wang HP, Zhu ZY, Sun YH* (2014) Transcriptional factors Smad1 and Smad9 act redundantly to mediate zebrafish ventral specification downstream of Smad5. The Journal of Biological Chemistry 289:6604-6618.

5. Xiong F, Wei ZQ, Zhu ZY, Sun YH* (2013) Targeted Expression in Zebrafish Primordial Germ Cells by Cre/loxP and Gal4/UAS Systems. Mar Biotechnol (NY) 15 (5):526-539.

6. Wang YW, Wei CY, Dai HP, Zhu ZY, Sun YH* (2013) Subtractive phage display technology identifies zebrafish marcksb that is required for gastrulation. Gene 521 (1):69-77.

7. Liu CW, Xiong F, Jia HZ, Wang XL, Cheng H, Sun YH*, Zhang XZ, Zhuo RX, Feng J (2013) Graphene-based anticancer nanosystem and its biosafety evaluation using a zebrafish model. Biomacromolecules 14 (2):358-366.

8. Ishtiaq Ahmed AS, Xiong F, Pang SC, He MD, Waters MJ, Zhu ZY, Sun YH* (2011) Activation of GH signaling and GH-independent stimulation of growth in zebrafish by introduction of a constitutively activated GHR construct. Transgenic Res 20 (3):557-567.

9. Liu Y, Bourgeois CF, Pang S, Kudla M, Dreumont N, Kister L, Sun YH, Stevenin J, Elliott DJ (2009) The germ cell nuclear proteins hnRNP G-T and RBMY activate a testis-specific exon. PLoS Genetics 5 (11):e**.

10. Chen CH, Sun YH*, Pei DS, Zhu ZY (2009) Comparative expression of zebrafish lats1 and lats2 and their implication in gastrulation movements. Dev Dyn 238 (11):2850-2859.

11. Liu J, Sun YH*, Wang YW, Wang N, Pei DS, Wang YP, Hu W, Zhu ZY (2008) Identification of differential transcript profiles between mutual crossbred embryos of zebrafish (Danio rerio) and Chinese rare minnow (Gobiocypris rarus) by cDNA-AFLP. Theriogenology 70 (9):1525-1535.

12. Pei DS, Sun YH*, Chen CH, Chen SP, Wang YP, Hu W, Zhu ZY (2008) Identification and characterization of a novel gene differentially expressed in zebrafish cross-subfamily cloned embryos. BMC Dev Biol 8:29.

13. Pei DS, Sun YH*, Chen SP, Wang YP, Hu W, Zhu ZY (2007) Identification of differentially expressed genes from the cross-subfamily cloned embryos derived from zebrafish nuclei and rare minnow enucleated eggs. Theriogenology 68 (9):1282-1291.

14. Liu J, Sun YH*, Wang N, Wang YP, Zhu ZY (2006) Upstream regulatory region of zebrafish lunatic fringe: isolation and promoter analysis. Mar Biotechnol (NY) 8 (4):357-365.

15. Sun YH*, Chen SP, Wang YP, Hu W, Zhu ZY (2005) Cytoplasmic impact on cross-genus cloned fish derived from transgenic common carp (Cyprinus carpio) nuclei and goldfish (Carassius auratus) enucleated eggs. Biology of Reproduction 72 (3):510-515.

16. Wu B, Sun YH*, Wang YW, Wang YP, Zhu ZY (2005) Characterization of transgene integration pattern in F4 hGH-transgenic common carp (Cyprinus carpio L.). Cell Res 15 (6):447-454.

17. Liu WY, Wang Y, Sun YH*, Wang YP, Chen SP, Zhu ZY (2005) Efficient RNA interference in zebrafish embryos using siRNA synthesized with SP6 RNA polymerase. Development, Growth & Differentiation 47 (5):323-331.

18. Wu G*, Sun Y*, Zhu Z (2003) Growth hormone gene transfer in common carp. Aquat Living Resour 16:416-420 (^* co-first-author)

19. Sun Y, Chen S, Wang Y, Zhu Z (2000) The onset of foreign gene transcription in nuclear-transferred embryos of fish. Science in China (Series C) 43:597-605

20. Zhu ZY, Sun YH (2000) Embryonic and genetic manipulation in fish. Cell Res 10 (1):17-27.