职称副教授
学位博士
电话**
邮箱tujiagang@mail.hzau.edu.cn
研究方向鱼类病毒致病机理及免疫防治

教育经历
2002.9-2003.6华中农业大学水产学院；
2003.9-2006.6华中农业大学生命科学技术学院，获学士学位；
2006年9月至2011年12月华中农业大学动物科学技术学院动物医学院，获博士学位，导师：陈焕春 教授、金梅林 教授。
主要职历
2012.9-2015.5，University of Texas Medical Schoolat Houston,博士后；
2015.10-2017.9，华中农业大学水产学院，师资博后；
2017.10-至今，华中农业大学水产学院，副教授。
科研成果
主持的科研项目：
1. Leader RNA与N蛋白互作调节乌鳢水泡病毒增殖的分子机制研究，国家自然科学基金面上项目，**，2020.1-2023.12,58万
2. 鱼类病毒病疫苗和药物研发，华中农业大学水产学院-广东海大集团股份有限公司合作项目，2020.1-2022.12,60万
3. 乌鳢水泡病毒P蛋白异构体P3的功能研究，华中农业大学自主科技创新基金，**QD017，2018.1-2020.12，20万
4. MiR-214在乌鳢水泡病毒感染SSN-1细胞中的调控机制研究，国家自然科学基金青年项目，**，2017.1-2019.12,20万
5.乌鳢水泡病毒减毒疫苗的研制，华中农业大学水产学院-广东海大集团股份有限公司合作项目，2019.1-2019.12,10万
6.乌鳢水泡病毒调控宿主microRNA的机制研究，中国博士后科学基金，2016M600604，2017.1-2018.12, 8万
7.乌鳢水泡病毒先导RNA与宿主蛋白的互作研究，湖北省自然科学基金，2016CFB233，2017.1-2018.12, 3万
8.乌鳢水泡病毒先导RNA作为核酸疫苗添加剂的研究，农业部渔用药物创制重点实验室开放课题，201501，2016.1-2017.12，4万

发表的科研论文：
1.Xiangmou Qin#, Shuangshuang Feng#, Yanwei Zhang, Jianguo Su, Li Lin, Yong-An Zhang*, Jiagang Tu*. Leader RNA regulates snakehead vesiculovirus replication via interacting with viral nucleoprotein. RNA Biology, 2020, doi:10.1080/**.2020.**. (IF=5.35)
2.Chunyan Wang#, Jiagang Tu#,Jun Liu*, Ian J. Molineux*.Structural dynamics of bacteriophage P22 infection initiation revealed by Cryo-electron tomography. Nature Microbiology, 2019, 4(6): 1049-56.(IF=14.3)
3.Shuangshuang Feng, Jianguo Su, Li Lin*, Jiagang Tu*. Development of a reverse genetics system for snakehead vesiculovirus (SHVV),Virology, 2019, 526: 32-37. (IF=3.3)
4.Chi Zhang, Ningqiu Li, Xiaozhe Fu, Qiang Lin, Li Lin*, Jiagang Tu*. MiR-214 inhibits snakehead vesiculovirus (SHVV) replication by targeting host GS. Fish & Shellfish Immunol 2019, 84:299-303. (IF=3.1)
5.Zhuan Qin, Jiagang Tu,Tao Lin,Steven J. Norris,Chunhao Li,Md A. Motaleb*, Jun Liu*.Cryo-electron tomography of periplasmic flagella in Borrelia burgdorferi reveals a distinct cytoplasmic ATPase complex. PLos Biology, 2018,16(11): e**.(IF=9.1)
6.Chi Zhang, Shuangshuang Feng, Wenting Zhang, Nan Chen, Abeer M. Hegazy, Wenjie Chen, Xueqin Liu, Lijuan Zhao, Jun Li, Li Lin*, Jiagang Tu*. MicroRNA miR-214 inhibits snakehead vesiculovirus replication by promoting IFN-a expression via targeting host adenosine 5’-monophosphate-activated protein. Frontiers in immunology, 2017, 8:1775. (IF=5.5)
7.Chi Zhang, Lizhu Yi, Shuangshuang Feng. Xueqin Liu, Jianguo Su, Li Lin, Jiagang Tu*. MicroRNA miR-214 inhibits snakehead vesiculovirus (SHVV) replication by targeting the coding regions of viral N and P. Journal of General Virology, 2017, 98(7): 1611-1619. (IF=3.2)
8.Jiagang Tu, Taehyun Park, Dusustin R. Morado, Kelly T.Hughes, Ian J. Molineux*, Jun Liu*. Dual host specificity of phage SP6 is facilitated by tailspike rotation. Virology, 2017, 507:206-215. (IF=3.3)
9.Jiagang Tu, ChangxuTian, Peiqi Zhao, Junxiao Sun,Min Wang, Qixue Fan,Yongchao Yuan*. Identification and profiling of growth-related microRNAs in Chinese perch (Siniperca chuatsi). BMC Genomics, 2017, 18(1): 489. (IF=3.7)
10.Lindan Sun#, Jiagang Tu#, Lizhu Yi, Wenjie Chen, Lijuan Zhao, Yunmao Huang, Rishen Liang, Jun Li, Meng Zhou*, Li Lin*. Pathogenicity of snakehead vesiculovirus in rice field eels (Monopterus albus). Microbial Pathogenesis, 2017, 110:578-585. (IF=2.0)
11.Madeline M. Farley#, Jiagang Tu#, Daniel B. Kearns, Ian J. Molineux*, Jun Liu*. Ultrastructural analysis of bacteriophage Φ29 during infection of Bacillus subtilis. Journal of Structural Biology, 2017, 197 (2): 163-171. (IF=2.7)
12.Farman Ullah Dawar#, Jiagang Tu#, Muhammad Nasir Khan Khattak, Jie Mei*, Li Lin*. Cyclophilin A: A Key Factor in Virus Replication and Potential Target for Anti-viral Therapy. Current Issues in Molecular Biology, 2017,21:1-20. (IF=5.2)
13.Wenjie Chen, Lizhu Yi, Shuangshuang Feng, Lijuan Zhao, Jun Li, Meng Zhou, Rishen Liang, Na Gu, Zaohe Wu, Jiagang Tu*, Li Lin*. Characterization of microRNAs in orange-spotted grouper (Epinephelus coioides) fin cells upon red-spotted grouper nervous necrosis virus infection. Fish and shellfish immunology, 2017, 63:228-236. (IF=3.1)
14.Wenjie Chen, Lizhu Yi, Shuangshuang Feng, Xiaodan Liu, Muhammad Asim, Yongcan Zhou, Jiangfeng Lan, Sanjie Jiang, Jiagang Tu*, Li Lin*. Transcriptomic profiles of striped snakehead fish cells (SSN-1) infected with red-spotted grouper nervous necrosis virus (RGNNV) with an emphasis on apoptosis pathway. Fish and shellfish immunology, 2017, 60:346-354 (IF=3.1)
15.Muhammad Asim, Sanjie Jiang, Lizhu Yi, Wenjie Chen, Lindan Sun, Lijuan Zhao, Muhammad Nasir Khan Khattak, Jiagang Tu*, Li Lin*. Glutamine is required for red-spotted grouper nervous necrosis virus replication via replenishing the tricarboxylic acid cycle. Virus Research, 2017, 227:245-248. (IF=2.6)
16.Wenting Zhang, WenjieZheng,Yukimatsu Toh, Miguel A. Betancourt-Solos,Jiagang Tu, Yanlin Fan, Vikram N. Vakharia, Jun Liu,James A. McNew,Meilin Jin*,Yizhi J. Tao*. Crystal structure of an orthomyxovirus matrix protein reveals mechanisms for self-polymerization and membrane association. Proc. Natl. Acad. Sci. USA, 2017, 114(32): 8550-8555(IF=9.8)
17.Xiaozhe Fu#, Xianqin Hu#, Ningqiu Li*, Feifei Zheng, Xingxing Dong, Jing Duan, Qiang Lin, Jiagang Tu, Lijuan Zhao, Zhibin Huang, Jianguo Su, Li Lin*. Glutamine and glutaminolysis are required for efficient replication of infectious spleen and kidney necrosis virus in Chinese perch brain cells. Oncotarget, 2017, 8(2):2400-2412(IF=5.1)
18.Jiagang Tu#, Wenjie Chen#, Xiaozhe Fu, Qiang Lin, Ouqin Chang, Lijuan Zhao. Jiangfeng Lan*, Ningqiu Li*, Li Lin*. Susceptibility of Chinese Perch Brain (CPB) Cell and Mandarin Fish to Red-Spotted Grouper Nervous Necrosis Virus (RGNNV) Infection. Int. J. Mol. Sci., 2016, 17(5):e740.(IF=3.2)
19.Xiaodan Liu#, Jiagang Tu#*, Junfa Yuan, Xueqin Liu, Lijuan Zhao, Farman Dawar. Muhammad Khattak, Abeer Hegazy, Nan Chen, Vikram Vakharia, Li Lin*. Identification and Characterization of MicroRNAs in Snakehead Fish Cell Line upon Snakehead Fish Vesiculovirus Infection. Int. J. Mol. Sci., 2016, 17(2): e154. (IF=3.2)
20.Lijuan Zhao#, Jiagang Tu#, Yulei Zhang, Jinfu Wang, Ling Yang, Weimin Wang, Zaohe Wu, Qinglei Meng*, Li Lin*. Transcriptomic analysis of the head kidney of Topmouth culter (Culter alburnus) infected with Flavobacterium columnare with an emphasis on phagosome pathway. Fish and Shellfish Immunology, 2016, 57:413-418. (IF=3.1)
21.Lindan Sun, Lizhu Yi, Chi Zhang, Xiaodan Liu, Shuangshuang Feng, Wenjie Chen, Jiangfeng Lan, Lijuan Zhao, Jiagang Tu*, Li Lin*. Glutamine was required for snakehead fish vesiculovirus (SHVV) propagation via replenishing the tricarboxylic acid cycle. Journal of General Virology, 2016, 97(11): 2849-2855. (IF=3.2)
22.Farman Ullah Dawar, Jiagang Tu, Xingxing Dong, Muhammad Nasir Khan Khattak, Jiangfeng Lan, Jie Mei*,Li Lin*. Chemotactic activity of cyclophilin A in the skin mucus of yellow catfish (Pelteobagrus fulvidraco) and its active site for chemotaxis. Int. J. Mol. Sci., 2016, 17(9): e1422. (IF=3.2)
23.Jiangfeng Lan, Shun Wei, Yuqing Wang, Yunjia Dai, Jiagang Tu, Lijuan Zhao, Xincang Li, Qiwei Qin, Nan Chen, Li Lin*. PcToll3 was involved in anti-Vibrio response by regulating the expression of antimicrobial peptides in red swamp crayfish, Procambarus clarkii. Fish and shellfish immunology, 2016, 57:17-24 (IF=3.1)
24.Linxu Chen, Qilong Xu, Jiagang Tu, Yihe Ge, Jun Liu, Fangting Liang*. Increasing RpoS expression causes cell death in Borrelia burgdorferi. PLos One. 2013, 8(12): e83276. (IF=3.5)
25.Wenting Zhang, Jiagang Tu, Zongzheng Zhao, Hongbo Zhou, Xiaojuan Xu, Huanchun Chen, Meilin Jin*. The new temperature-sensitive mutation PA-F35S for developing recombinant avian live attenuated H5N1 influenza vaccine. Virology Journal, 2012, 9:97. (IF=2.1)
26.Jiagang Tu#, Jing Guo#, Anding Zhang#, Wenting Zhang, Zongzheng Zhao, Hongbo Zhou, Cheng Liu, Huanchun Chen, Meilin Jin*. Effects of the C-terminal truncation in NS1 protein of the 2009 pandemic H1N1 influenza virus on host gene expression. PLos One, 2011, 6(10): e26175 (IF=4.1)
27.Hongbo zhou#, Jiping zhu#, Jiagang Tu, Wei Zou, Yong Hu, Zhengjun Yu, Wensi Yin, Yongtao Li, Anding Zhang, Ziniu Yu, Huanchun Chen, Meilin Jin*. Effects on virulence and pathogenicity of H5N1 influenza A virus through truncations of NS1 eIF4GI binding domain. J. Infect. Dis., 2010, 202(9): 1338-1346. (IF=6.3)
28.Wei Zou, Jianjiang Ke, Anding Zhang, Mingguang Zhou, Yonghong Liao, Jiping Zhu, Hongbo Zhou, Jiagang Tu, Huanchun Chen, Meilin Jin*. Proteomics analysis of differential expression of chicken brain tissue proteins in response to the neurovirulent H5N1 avian influenza virus infection.J Proteome Res, 2010, 9(8): 3789-3798. (IF=5.4)
29.Jiagang Tu#, Hongbo Zhou#, Chun Li, Anding Zhang, Xuebo Guo, Wei Zou, Huanchun Chen, Meilin Jin*. Isolation and molecular characterization of equine H3N8 influenza viruses from pigs in China. Arch Virol, 2009, 154(5): 887-890. (IF=1.9)
30.Hongbo Zhou, Zhengjun Yu, Yong Hu, Jiagang Tu, Wei Zou, Yaping Peng, Jiping Zhu, Yongtao Li, Anding Zhang, Ziniu Yu, Huanchun Cheng, Meilin Jin*. The special neuraminidase stalk-motif responsible for increased virμlence and pathogenesis of H5N1 influenza A virus. PLoS One, 2009, 4(7): e6277. (IF=4.3)
31.Wei Zou, Zhengjun Yu, Hongbo Zhou, Jiagang Tu, Meilin Jin*. Genetic characterization of an H5N1 avian influenza virus with neurovirμlence in ducks. Virus Genes, 2009, 38(2): 263-268. (IF=1.7)
32.伊丽竹，徐镇，林蠡，涂加钢*. miRNAs在乌鳢水泡病毒感染SSN-1细胞中的调节作用. 水产学报. 2019 43(5):1288-1297.

授权和申请专利：
1. 金梅林*; 涂加钢; 周红波; 徐晓娟; 陈焕春。一种重组H5N1禽流感病毒细胞苗及应用。CNA. 华中农业大学。2012-07-04
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