职称副教授
学位博士
邮箱 liuhan@mail.hzau.edu.cn
研究方向鱼类基因组学及功能基因组学



教育经历
2013.9~2016.7 华中农业大学，水产养殖，农学博士
2009.9~2012.7 广东海洋大学，动物遗传育种与繁殖，农学硕士
2005.9~2009.7 西北农林科技大学，生物科学（动物方向），理学学士
主要职历
2018.11~至今华中农业大学，水产学院，副教授
2019.3~2020.5 瑞典乌普萨拉大学，生物医学中心，博士后
2016.7~2018.10 华中农业大学，水产学院，师资博士后
科研成果
本人长期开展鱼类基因组学及基因功能研究，结合基因组学、鱼类行为学及分子生物学技术手段探究鱼类食性调控的内源性遗传机制和外源性调控机制，尤其是鱼类感觉系统进化及其（包括嗅觉和味觉受体基因家族）在食性调控中的作用及分子机制。近五年来主持科研项目8项，发表研究论文35篇，其中SCI论文27篇，第1或通讯作者在GigaScience和Free Radical Biology and Medicines等杂志发表SCI论文14篇。
（1）近五年主持的科研项目：
1.国家自然科学青年基金项目，2018.1-2020.12，主持，在研；
2.国家重点研发计划“蓝色粮仓科技创新”子课题任务，2018.10-2022.12，主持，在研；
3.中央高校基本科研业务费专项基金-科研启动经费，2021.01-2023.12，主持，在研；
4.广西水产遗传育种与健康养殖重点实验室开放研究基金，2020.9-2022.9，主持，在研；
5.湖北省自然基金项目，2018.1-2019.12，主持，已结题；
6.中国博士后面上一等资助，2017.1-2018.12，主持，已结题；
7.浙江省淡水研究中心开放课题，2018.1-2020.12，主持，已结题；
8.农业部淡水渔业与种质资源开放课题，2017.1-2017.12，主持，已结题。
（2）近五年发表文章（*corresponding author，IF为发表当年）
1.Wang, Z., Jia, X., Huang, X., Zhu, D., Liu, H* & Wang, W*.Transcriptome profiling towards understanding of the morphogenesis in the scale development of blunt snout bream (Megalobrama amblycephala), Genomics, 113(3): 983-991(2021).(IF: 6.2)
2.Chen, J., Huang, X., Geng, R., Zhu, D., Wang, W.*& Liu, H*. Ribonuclease1 contributes to the antibacterial response and immune defense in blunt snout bream (Megalobrama amblycephala).International Journal of Biological Macromolecules, 172, 309–320(2021).(IF: 5.1)
3.Chen, J., Chen, X., Huang, X., Huang, G., Gao, Z., Wang, W., & Liu, H*. Genome-wide analysis of intermuscular bone development reveals changes of key genes expression and signaling pathways in blunt snout bream (Megalobrama amblycephala). Genomics, 113(1), 654-663(2021).(IF: 6.2)
4.刘宁, 黄欣, 刘寒*, 王卫民. 团头鲂Hox基因家族的鉴定、进化与表达分析[J]. 水产学报,45(2): 161?169(2021).
5.Liu, H.,Li, J., Guo, X., Liang, Y., & Wang, W*. Yeast culture dietary supplementation modulates gut microbiota, growth and biochemical parameters of grass carp. Microbial biotechnology, 11(3), 551-565 (2018). (IF:4.8)
6.Liu, H^#.,Chen, C. H^#., Gao, Z. X^#., Min, J. M^#., Gu, Y. M^#., Jian, J. B^#., et al.The draft genome of blunt snout bream (Megalobrama amblycephala) reveals the development of intermuscular bone and adaption to herbivorous diet. GigaScience, 6, 1–13 (2017). (IF:7.2)
7.Liu, H.,Guo, X. W., Gooneratne, R., Lai, R. F., Zeng, C. & Wang, W. M*. The gut microbiome and degradation enzyme activity of wild freshwater fishes influenced by their trophic levels. Scientific Reports,6, 24340 (2016). (IF: 5.2)
8.Liu, H.& Wang, W. M*. Expression patterns and functional novelty of ribonuclease 1 in herbivorous Megalobrama amblycephala. International Journal of Molecular Sciences, 17(5), 786 (2016). (IF: 3.2)
9.Liu, H.,Gooneratne, R., Huang, X., Lai, R. F., Wei, J. & Wang, W. M.*. A rapid in vivozebrafish model to elucidate oxidative stress-mediated PCB126-induced apoptosis and developmental toxicity. Free Radical Biology and Medicine, 84, 91–102 (2015). (IF: 5.7)
10.Geng, R., Jia, Y., Chi, M., Wang, Z., Liu, H.,*& Wang, W.*. RNase1 alleviates the Aeromonas hydrophila-induced oxidative stress in blunt snout bream. Developmental & Comparative Immunology, 91, 8-16 (2019). (IF: 2.9)
11.Geng, R., Liu, H.,*& Wang, W*. Differential expression of six Rnase2 and three Rnase3 paralogs identified in blunt snout bream in response to Aeromonas hydrophila infection. Genes, 9(2), 95 (2018). (IF: 3.2)
12.Tan, K., Geng, R., Wang, Z., Liu, H.,*& Wang, W*. Anatomical structure and expression of CCL4 and CCL13-like during the development of maxillary barbel in Paramisgurnus dabryanus. Organogenesis, 15(1), 1-11(2019).(IF: 2.3)
13.耿瑞静, 谢明辉, 王卫民, 刘寒*. 团头鲂微卫星亲子鉴定[J]. 淡水渔业, 48(4): 9-15(2018).
14.王志强, 刘寒*，耿瑞静, 王卫民. 团头鲂和斑马鱼鳞片发生发育比较研究[J]. 淡水渔业, 49(1): 20-26(2019).
15.刘寒, 吴云倩, 李会峰, 王卫民*. 日粮中高糖高脂对团头鲂肝脏及肠道微生物菌群组成的影响[J]. 华中农业大学学报, 37(4): 85-92(2018).
16.Liu, H^#.,Nie, F. H^#., Lin, H. Y., Ma, Y., Ju, X. H., Chen, J. J.* & Gooneratne, R.*. Developmental toxicity, EROD, and CYP1A mRNA expression in zebrafish embryos exposed to dioxin-like PCB126.Environmental Toxicology, 31, 201–210 (2016). (IF: 2.8)
17.Liu, H^#.,Nie, F. H^#., Lin, H. Y., Ma, Y., Ju. X. H., Chen, J. J.* & Gooneratne, R.*. Developmental Toxicity, Oxidative Stress, and Related Gene Expression Induced by Dioxin –Like PCB 126 in Zebrafish (Danio rerio). Environmental Toxicology, 31, 295–303 (2016). (IF: 2.8)
18.Tran, N. T., Liu, H., Jakovli?, I. & Wang, W. M*. Blunt Snout Bream (Megalobrama amblycephala) MyD88 and TRAF6: Characterisation, Comparative Homology Modelling and Expression. International Journal of Molecular Sciences,16(4), 7077–7097 (2015). (IF: 2.8)
19.Lai, R. F.,Liu, H., Jakovli?, I., Zhan, F. B., Wei, J., Yang, P. H. & Wang, W. M*. Molecular cloning and expression of toll-like receptor 4 (tlr4) in the blunt snout bream (Megalobrama amblycephala).Developmental & Comparative Immunology, 59, 63–76 (2016). (IF: 3.6)
20.Zhan, F. B., Liu, H., Lai, R. F., Jakovli?, I., & Wang, W. M*. Expression and functional characterization of interferon regulatory factors (irf2, irf7 and irf9) in the blunt snout bream (Megalobrama amblycephala). Developmental & Comparative Immunology. 67, 239–248 (2016). (IF: 3.6)
21.Jakovli?, I., Liu, H.& Wang, W. M*. Identification, origin and evidence for retained functionality of two IκBα paralogs in Megalobrama amblycephala.Developmental & Comparative Immunology, 62, 89-96 (2016). (IF: 3.6)
22.Lai, R. F., Jakovli?, I., Liu, H., Zhan, F. B., Wei, J., & Wang, W. M*. Molecular characterization and immunological response analysis of toll-like receptors from the blunt snout bream (Megalobrama amblycephala). Developmental & Comparative Immunology, 67, 471–475 (2016). (IF: 3.6)
23.Prisingkorn, W., Prathomya, P., Jakovli?, I., Liu, H.,Zhao, Y. H., Wang, W. M*. Transcriptomics, metabolomics and histology indicate that high-carbohydrate diet negatively affects the liver health of blunt snout bream (Megalobrama amblycephala). BMC Genomics, 18, 856 (2017).
24.Wei, J., Guo, X. W., Liu, H.,Chen, Y., Wang, W. M*. The variation profile of intestinal microbiota in blunt snout bream (Megalobrama amblycephala) during feeding habit transition.BMC Microbiology, 18, 99(2018).
（3）参加的国内外学术会议：
2018.8 World Aquaculture Montpelier 2018, APA（法国蒙彼利埃）；
2018.1 Charoen Pokphand Bangkok 2018（泰国曼谷）；
2017.10 第十二届国际基因组学大会，深圳;
2017.6 World Aquaculture Cape Town 2017（南非开普敦）；
2017.3 Short-term teaching（克罗地亚萨格勒布大学）
2016.10水产生物技术专业第八届学术研讨会，海口
2016.9中国动物学会23届学术年会，武汉
2016.6 Asian Pacific Aquaculture 2016, APA（印度尼西亚泗水）
2015.6 International Symposium on Genetics in Aquaculture 2015（西班牙圣地亚哥-德孔波斯特拉）
2014.6 World Aquaculture Adelaide 2014）（澳大利亚阿德莱德）
备注
现致力于鱼类基因组学及基因功能研究，欢迎感兴趣的研究生报考。