职称 副教授
学位 博士
邮箱 xujiezhang@mail.hzau.edu.cn
研究方向 鱼类病害免疫防治的应用基础研究




教育经历
2012.09-2015.06 中国科学院水生生物研究所理学博士（专业：遗传学）
2009.09-2012.06 中国科学院水生生物研究所理学硕士（专业：水生生物学）
2005.09-2009.06 华中农业大学农学学士（专业：水产养殖）

主要职历
2018.07-至今 华中农业大学水产学院，副教授
2017.08-2018.06 上海海洋大学水产与生命学院，讲师
2015.09-2017.07 上海海洋大学水产与生命学院，师资博士后

科研成果
主要研究内容
[1] 鱼类B细胞和免疫球蛋白的组成、功能及分化机制
[2] 鱼类抗菌多肽的结构、功能、演化及分子设计
[3] 鱼用免疫佐剂及免疫增强剂的研发



主持和参与的主要科研项目
[1] 国家自然科学基金面上项目（**），2020/01-2023/12，58万元，主持
[2] 国家重点研发计划蓝色粮仓科技创新专项课题（2018YFD**），2018/12-2022/12，45.4万元，课题骨干
[3] 中央高校基本科研业务费专项基金-科研启动经费（**QD053），2018/09-2021/09，20万元，主持
[4] 国家自然科学基金青年科学基金项目（**），2017/01-2019/12，20万元，主持
[5] 国家自然科学基金面上项目（**），2015/01-2018/12，88万元，参与
[6] 国家自然科学基金青年科学基金项目（**），2012/01-2014/12，23万元，参与
[7] 国家自然科学基金面上项目（**），2011/01-2013/12，32万元，参与

学术论文
1.Cui, Z. W., Zhang, X. Y., Wu, C. S., Zhang, Y. A., Zhou, Y.* & Zhang, X. J.* (2020). Membrane IgM⁺ plasma cells in grass carp (Ctenopharyngodon idella): Insights into the conserved evolution of IgM⁺ plasma cells in vertebrates. Developmental & Comparative Immunology, 106:1-10. (通讯作者)
2.Cui, Z. W., Zhang, X. Y., Chen, X. H.* Zhang, X. J.* & Zhang, Y. A. (2020). Splicing variants of grass carp (Ctenopharyngodon idellus) IL-21: Functions in IgM⁺ B cell proliferation and IgM secretion. Developmental & Comparative Immunology, 110:1-9. (通讯作者)
3.Zhang, X. J.* Zhang, X. Y.* Wang, P. & Zhang, Y. A. (2018). Identification of another primordial CD80/86 molecule in rainbow trout: Insights into the origin and evolution of CD80 and CD86 in vertebrates. Developmental & Comparative Immunology, 89:73-82. (第一作者)
4.Zhang, X. J., Wang, P., Zhang, N., Chen, D. D., Nie, P., Li, J. L. & Zhang, Y. A. (2017). B Cell Functions Can Be Modulated by Antimicrobial Peptides in Rainbow Trout Oncorhynchus mykiss: Novel Insights into the Innate Nature of B cells in Fish. Frontiers in Immunology, 8:1-14. (第一作者)
5.Zhang, X. J., Zhang, X. Y., Zhang, N., Guo, X., Peng, K. S., Wu, H., Lu, L. F., Wu, N., Chen, D. D., Li, S., Nie, P. & Zhang, Y. A. (2015). Distinctive Structural Hallmarks and Biological Activities of the Multiple Cathelicidin Antimicrobial Peptides in a Primitive Teleost Fish. Journal of Immunology, 194: 4974-4987. (第一作者)
6.Zhang, X. J., Yang, W. M., Zhang, D. F., Li, T. T., Gong, X. N. & Li, A. H. (2015). Does the gastrointestinal tract serve as the infectious route of Aeromonas hydrophila in crucian carp (Carassius carassius)? Aquaculture Research, 46: 141-154. (第一作者)
7.Zhang, X. J., Yang, W. M., Wu, Han., Gong, X. N. & Li, A. H. (2014). Multilocus sequence typing revealed a clonal lineage of Aeromonas hydrophila caused motile Aeromonas septicemia outbreaks in pond-cultured cyprinid fish in an epidemic area in central China. Aquaculture, 432: 1-6. (第一作者)
8.Zhang, N., Zhang, X. J., Chen, D. D., Sunyer, J. O., & Zhang, Y. A., (2017). Molecular characterization and expression analysis of three subclasses of IgT in rainbow trout (Oncorhynchus mykiss). Developmental & Comparative Immunology, 70, 94-105.
9.Li, T. T., Long, M., Li, A. H., Gatesoupe, F.J., Zhang, X. J., Zhang, Q. Q., Feng, D. Y. & Li, A. H. (2017). Multi-Omics Analysis Reveals a Correlation between the Host Phylogeny, Gut Microbiota and Metabolite Profiles in Cyprinid Fishes. Frontiers in Microbiology, 8:1-11.
10.Zhang, N., Zhang, X. J., Song, Y. L., Lu, X. B., Chen, D. D., Xia, X. Q., Sunyer, J.O. & Zhang, Y. A. (2016). Preferential combination between the light and heavy chain isotypes of fish immunoglobulins. Developmental & Comparative Immunology, 61:169-179.
11.Lu, L. F., Li, S., Lu, X. B., LaPatra, S. E., Zhang, N., Zhang, X. J., Chen, D. D., Nie, P. & Zhang, Y. A. (2016). Spring Viremia of Carp Virus N Protein Suppresses Fish IFN1 Production by Targeting the Mitochondrial Antiviral Signaling Protein. Journal of Immunology, 196:3744-3753.
12.Li, T. T., Long, M., Ji, C., Shen, Z. X., Gatesoupe, F. J., Zhang, X. J., Zhang, Q. Q., Zhang, L. L., Zhao, Y. L., Liu, X. H. & Li, A. H. (2016). Alterations of the gut microbiome of largemouth bronze gudgeon (Coreius guichenoti) suffering from furunculosis. Scientific Reports, 6:30606.
13.Guo, X., Chen, D. D., Peng, K. S., Cui, Z. W., Zhang, X. J., Li, S. & Zhang, Y. A. (2016). Identification and characterization of Bacillus subtilis from grass carp (Ctenopharynodon idellus) for use as probiotic additives in aquatic feed. Fish Shellfish Immunology, 52:74-84.
14.Wu, N., Song, Y. L., Wang, B., Zhang, X. Y., Zhang, X. J., Wang, Y. L., Cheng, Y. Y., Chen, D. D., Xia, X. Q., Lu, Y. S. & Zhang, Y.A. (2016). Fish gut-liver immunity during homeostasis or inflammation revealed by integrative transcriptome and proteome studies. Scientific Reports, 6:36048.
15.Wu, N., Zhang, X. Y., Huang, B., Zhang, N., Zhang, X. J., Guo, X., Chen, X. L., Zhang, Y., Wu, H., Li, S., Li, A. H. & Zhang, Y. A. (2015). Investigating the potential immune role of fish NCAMs: Molecular cloning and expression analysis in mandarin fish. Fish Shellfish Immunology, 46:765-777.
16.Zhang, D. F*., Ji, C*., Zhang, X. J., Li, T. T., Li, A. H. & Gong, X. N. (2013). Mixed mycobacterial infections in farmed sturgeons. Aquaculture Research, 46:1914-1923.