杨在清 【教授】 姓名杨在清性别男
职称教授学位博士
电话 **邮箱yangzq@mail.hzau.edu.cn
工作单位华中农业大学生命科学技术学院
研究方向动物功能基因组
教育经历1975.9-1978.8年武汉大学生物化学专业学习(学士)；
1978.9-1994.3在西北农业大学动物生物化学教研室工作；
1982.5-1982.11赴德国Gie?en大学访问学者；
1987.9-1990.7在西北农业大学硕士学位研究；
1991.8-1994.6在西北农业大学做博士学位研究；
1995.4-1997.4在华中农业大学分子生物学专业做博士后研究；

主要职历1978.9-1994.3西北农业大学动物生物化学教研室工作，讲师，副教授，硕士生导师；
1995.4-1996.11在华中农业大学生命科学技术学院，副教授，硕士生导师
1996.12-2014华中农业大学生命科学技术学院，教授，博士生导师。
科研成果1. Zhou L, Yu X, Meng Q, Li H, NiuC, Jiang Y, Cai Y, Li M, Li Q, An C, Shu L, Chen A, Su H, Tang Y, Yin S,Raschke S, Eckardt K, Eckel J, Yang Z. Resistin reduces mitochondria andinduces hepatic steatosis in mice by the protein kinase C/protein kinaseG/p65/PPAR gamma coactivator 1 alpha pathway. Hepatology. 2013 Apr;57(4):1384-93. 2. LeiP, Baysa A, Nebb HI, Valen G, Skomedal T, Osnes JB, Yang Z, Haugen F. Activation of Liver X receptors inthe heart leads to accumulation of intracellular lipids and attenuation ofischemia-reperfusion injury.Basic Res Cardiol. 2013 Jan;108(1):323.

3. Yu A, Zheng Y, Zhang R, Huang J, Zhu Z, Zhou R, Jin D, YangZ. Resistin impairs SIRT1 function andinduces senescence-associated phenotype in hepatocytes.Mol CellEndocrinol. 2013 Sep 5;377(1-2):23-32.

4. Wang SB, Lei T, Zhou LL,Zheng HL, Zeng CP, Liu N, Yang ZQ, Chen XD. Functional analysis andtranscriptional regulation of porcine six transmembrane epithelial antigen ofprostate 4 (STEAP4) gene and its novel variant in hepatocytes.Int J BiochemCell Biol. 2013 Mar;45(3):612-20.

5. Feng B, Jiao P, Yang Z, Xu H. MEK/ERK pathway mediatesinsulin-promoted degradation of MKP-3 protein in liver cells. Mol Cell Endocrinol. 2012;361(1-2):116-23.

6. Wu Y, Long Q, Feng B, Zhu X,Zheng Z, Gao S, Gao M, Gan L, Zhou L, Yang Z.Molecular cloning andcharacterization of the anti-obesity gene adipose in pig.Gene. 2012;509(1):110-9

7. ZhouL, Zhang L, Meng Q, Niu C, Jin D, Yu A, Gan L, Yang Z.C/EBPα promotes transcription of theporcine perilipin5 gene.Mol Cell Endocrinol. 2012；364(1-2):28-35.

8. ChengM, Yang H, Long H, Zhang Y, Chen X, Yang Z, Lei T.Molecular characterization andtranscriptional analysis of fad24 in pigs.Gene. 2012;503(2):208-14.

9. Chen Z, Gao X, Lei T,Chen X, Zhou L, Yu A, Lei P, Zhang R, Long H, Yang Z.＊.Molecularcharacterization, expression and chromosome localization of porcine PNPLA3 andPNPLA4. Biotechnol Lett. 2011 Jul;33(7):1327-37

10. ZhouL, Meng Q, Qian T, Yang Z＊.Ginkgo biloba extract enhances glucose tolerance in hyperinsulinism-inducedhepatic cells.J Nat Med. 2011,65(1):50-6

11. Huan Long1, 2, Hans HBock2, 3, Ting Lei1, Xuejun Chai2, Jihong Yuan1, Joachim Herz2, 4, Zaiqing Yang1 * Identification ofalternatively spliced Dab1 and Fyn isoforms in pig. BMC Neurosci 2011 Feb5;12:17.

12. Long Q, Zhu X, Wu Y,Feng B, Jin D, Huang J, Lei T, Gan L, YangZ.Molecularcloning and characterization of the porcine Ero1 and ERp44 genes: Potentialroles in controlling energy metabolism.GenComp Endocrinol. 2011;173(2):259-69.

13. Zhang Y, Lei T, HuangJF, Wang SB, Zhou LL, Yang ZQ, ChenXD.The linkbetween fibroblast growth factor 21 and sterol regulatory element bindingprotein 1c during lipogenesis in hepatocytes.MolCell Endocrinol. 2011;342(1-2):41-7.

14. Feng B., Jiao P., Nie Y., Kim T., Jun D., Rooijen N., YangZ., and Xu H. (2011). Clodronate liposomes improve metabolic profile and reducevisceral adipose macrophage levels in diet-induced obese mice. PLoS ONE 6(9): e24358.

15. Zhang J, Lei T, ChenX, Peng Y, Long H, Zhou L, Huang J, Chen Z, Long Q, Yang Z＊.. ResistinUp-Regulates COX-2 Expression via TAK1-IKK-NF-kappaB Signaling Pathway. Inflammation. 2010 ;33(1):25-33.

16. ChenZ,Lei T, Zhang J,Chen X, Long Q,Yang Z＊.PorcineKLF gene family: structure, mapping, and phylogenetic analysis.Genomics, 2010,95(2):111-119

17. X.D.Chen,Y.L.Chen,S.B.Wang, T. Lei,L.Gan,Z.Q.Yang＊.MolecularCharacterization and functional analysis of porcine macrophage migrationinhibitory factor (MIF) gene. Cytokine.2010,50(1):84-90

18. RongrongZhang,Ting Lei, ZaiqingYang＊.Molecularcloning, chromosomal localization, and expression pattern of porcine Arf genefamily. Animal Science Journal,2010, 81(4):425-31

19. Qinqiang Long, TingLei, Bin Feng, Changjun Yin, Dan Jin, Yanling Wu, Xiaoyue Zhu, XiaodongChen, LiGan, Zaiqing Yang＊.Peroxisomeproliferator-activa 1 ted receptor γ increases adiponectin secretion via2transcriptional repression of endoplasmic reticulum chaperone protein ERp44. Endocrinology. 2010,151(7):3195-203

20. .Huang J, Zhang J,Lei T, Chen X, Zhang Y, Zhou L, Yu A, Chen Z, Zhou R, Yang Z＊. Cloning of porcinechemerin, ChemR23 and GPR1 and their involvement in regulation of lipogenesis. BMBRep. 2010,43(7):491-8

21. Y.H.Li,T.Lei,X.D.Chen,T.Xia,Q.Q.Long,J.Zhang,S.Q.Feng,Y.Peng,L.Zhou,Z.Q.Yang＊. Molecularcloning,chromosomeal location and expression pattern of porcine CIDEa andCIDEc. Mol Biol Rep. 36(3):575-82(2009)

22. Qi YM, Lei T, Zhou L,Chen XD, Long QQ, Long H, Jin D, Gan L, YangZQ＊. Genomic organization,alternative splicing and tissues expression of porcine CREB3L4 gene. MolBiol Rep. 36(7):1881-1888(2009)

23. Yanmei Qi? Ting lei?Lei Zhou? Xiaodong Chen? Huan Long? Qinqiang Long? , Rongrong Zhang?Zaiqing Yang＊.cDNA cloning, genomic structure, chromosomal mapping and expression analysis ofporcine CREB2 and CREB3. Folia Biol (Praha).55(4):137-44(2009).

24. Dan Jin Lei Ting Gan Li Chen Xiaodong ZaiqingYang＊. . Molecular cloningand characterization of Porcine Sirtuins . Comparative Biochemistry and Physiology,PartB. 153 : 348-358(2009)

25. Huan Long,Ting Lei,Tao Xia,Xiaodong Chen,Zaiqing Yang＊.Cloning,expression and chromosomal localization of porcine Fyn and Cdk5 genes. AnimalBiotechnology, 20(3):133(2009).

26. Changjun Yin,Qinqiang Long, Ting Lei, Xiaodong Chen, Huan Long, Bin Feng, Yin Peng, YanlingWu, Zaiqing Yang＊.Lipid Accumulation Mediated by Adiponectin in C2C12 Myogenesis. Biochemistryand Molecular Biology Reports.42(10): 667-672(2009)

27. Peng Y, Lei T, YuanJ, Chen X, Long Q, Zhang J, Lei P, Feng B, YangZ＊. Arachidonic acid induces acetyl-CoAcarboxylase 1 expression via activation of CREB1.Endocrine. 2009,36(3):491-497

2009(12.003)

28. XiaTao, Yuan Jihong, Gan Li, Feng Bin, Zhu Yi, Chen Xiaodong, Zhang Peichao, Yang Zaiqing＊.Cloning, chromosome mapping and expression pattern of porcine PLIN and M6PRBP1genes. Genetics Selection Evolution. 40(2):215-226(2008)

29. XiaofengLi, Ting Lei, Tao Xia, Xiaodong Chen, Shengqiu Feng, Huaping Chen, ZhilongChen, Yin Peng and Zaiqing Yang＊Molecularcharacterization,chromosomal localization and expression patterns of threeaquaglyceroporins (AQP3, 7, 9) from pig. Comparative Biochemistry and Physiology,PartB. 149(3)：468-476(2008)

30. Chen H, Yao W, Jin D,Xia T, Chen X, Lei T, Zhou L, Yang Z＊.Cloning,expression pattern, chromosomal localization, and evolution analysis of Porcinegnaq, gna11, and gna14.Biochem Genet.46(7-8):398-405(2008).

31. LeiZhou, Tao Nie, Shengqiu Feng, Huaping Chen, Xin Gao, Yanmei Qi, Zaiqing Yang^＊.Clenbuterolinhibited SREBP-1c expression by activating CREB1. Journal of Biochemistry andMolecular Biology. 40(4):525-31(2007) .

32. H.W.Yang, T. Xia, Z.L. Chen, S.Q. Feng, Y. Peng, L. Zhou, L. Gan, Z.Q. Yang＊.Cloning, chromosomallocalization and expression patterns of porcine Kruppel-like factors 4, -5, -7and the early growth response factor 2. Biotechnol Lett. 29(1):157-63(2007)

33. LeiZhou, Henrike Sell, Kristin Eckardt, ZaiqingYang,Jürgen Ecke.Adipocyte-conditioned medium and resistin induce insulinresistance in human hepatocytes. FEBS Leters. 581(22):4303-8(2007).

34. DaiMH, Zhang GD, Xia.T, Chen.XD, Gan.L, Feng.SQ, Qiu.H, Peng.Y, Yang. ZQ＊. Cloning,Expression, Chromosome localization of pig adiponectin and its receptors gene. Domestic Animal Endocrinology. 30(2):117-25 (2006).

35. DaiM, Xia T，Chen XD,Lei T,Gan L，Yang ZQ＊.Cloningand characterization of porcine resistin gene. Domestic Animal Endocrinology. 30(2): 88-97 (2006).

36. LeiZhou, Yixing Li, Xia Tao, Li Gan,Chen Xiaodong, Zaiqing Yang＊. TranscriptionalRegulation of Resistin Gene. Domest Anim Endocrinol. 30(2):98-107(2006).

37. FengSQ, Chen XD,Xia T, Gan L, Qiu H, Dai MH, Zhou L,Peng Y, Yang ZQ＊. Cloning, chromosomemapping and expression pattern of pig angptl3 and angptl4. Cytogenetic and Genome Research. 114(1):44-49(2006).

38. ZhouL; Li YX; Xia T; Feng SQ; Chen XD; YangZQ＊. Resistinoverexpression impaired glucose tolerance in hepatocytes. European Cytokine Network. 17(3): 189-195(2006).

39. HuapingChen, Tao Xia, Huan Qiu, Lei zhou, Xiaodong Chen, Li Gan,Wenshu Yao, Yin Peng, Zaiqing Yang＊.Gene organization, alternate splicing and expression pattern of porcinevisfatin gene. Domestic Animal Endocrinology.32:235-245 (2007)

40. QiuH, Xia T，Chen XD,Lei T ,and Z.Q. Yang＊.Cloning, comparativecharacterization of porcine SCAP gene, and identification of its two splicevariants. Molecular Genetics and Genomics. 276(2):187-96( 2006)

41. YueGP, Du LR, Xia T, He XH, Qiu H, Xu LH, Chen XD, Feng SQ, Yang ZQ＊. One in vitro modelfor visceral adipose-derived fibroblasts in chronic inflammation. BiochemBiophys Res Commun. 333: 850-7 (2005).

42. TingLei，ZaiqingYang＊，Tao xia，LiGan，Xiaodong Chen，jihongYuan and Yi Zhu. Stage- specific expression of leukemia inhibitory factor andits receptor in rabbit preimplantation embryos and uterine epithelium during early pregnancy. Reproduction in Domestic Animals.39:1-6 (2004).

43. X.D. Chen, T. Lei, T. Xia, L. Gan and Z.Q. Yang＊. Increasedexpression of resistin and tumor necrosis factor-α in pig adipose tissue aswell as the relationship between resistin and lipolysis pathway. Diabetes,Obesity & Metabolism. 6 (4):271-9 (2004).

44. QiuH,Xia T,Chen XD,Feng SQ,Gan L,lei T,Peng Y,Zhang GD,Nie T,Yue GP, ZhaoXL, Yang ZQ＊. Sequencing andchromosome mapping of pig INSIG 2 and a related pseudogene. AnimGenet. 36(2): 188 (2005).

45. QiuH, Xia T, Chen XD, Gan L, Feng SQ, Lei T, Dai MH, Yang ZQ＊. Characterization ofpig INSIG1 and assignment to SSC18. Animal Genet. 36(3): 284-6 (2005).

46. NieT, X.L. Zhao, H. Qiu, T. Xia, X.D. Chen, L. Gan, S.Q. Feng, T. Lei , M.H. Daiand Z.Q. Yang＊.Sequence analysis and map assignment of pig SREBF2 and ADFP genes. AnimalGenet. 36(5): 455-7 (2005).


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