刘超红，华中科技大学基础医学院微生物系教授，副主任，负责科研和研究生教学，2017年国家自然科学基金优秀青年基金获得者。2003年于武汉大学获理学学士学位，2006年于中科院武汉病毒所获硕士学位。2013于美国马里兰大学帕克分校获博士学位。2013以研究助理加入到圣裘德儿童研究医院迟洪波实验室，主要研究T细胞中的mTOR信号。现在主要研究领域是血液系统免疫相关疾病，包括免疫缺陷病和自身免疫疾病和白血病。研究方向包括血液系统免疫相关疾病和白血病中B细胞、iNKT细胞和调节性T细胞功能紊乱的分子机制。另外病毒主要包括新冠和乙肝病毒和寄生虫感染所导致的宿主的免疫系统紊乱也是正在拓展的研究领域。以第一作者或通讯作者发表20篇SCI文章，共同作者累积31篇文章。其工作在Immunity、 Blood、Journal of Allergy and Clinical Immunology、Science Advances、PLos Biology、 Leukemia、 Journal of Experimental Medicine、 Cell report 和Journal of Immunology等杂志发表。任中国生理学会血液分会委员，亚太医学生物免疫学会基础免疫学分会副秘书长，湖北省生物免疫学会转化医学专委会副主委，Journal of Clinical and Translational Hepatology 杂志Associate editor和Journal of Leukocyte Biology编辑。担任Signal Transduction and Targeted Therapy、Experimental Hematology、European Journal of Immunology 和Clinical Immunology等杂志审稿人。
联系方式：chaohongliu80@126.com发表文章
Yang L, Jing Y, Kang D, Jiang P, Li N, Zhou X, Chen Y, Westerberg L, Liu C*. Ubiquitin-Specific Peptidase 18 Regulatesthe Differentiation and Function of Treg cells. Genes and diseases.2020.in Press.


Yang L, Jing Y, Wang W, Ying W, Lin L, Jiang C, Luo L, Kang D, Jiang P, Liu J, Chen Q, Miller H, Herrada A, Kubo M, Sun J*, Liu C* DOCK2 couples with LEF-1 to regulate B cell metabolism and memory response. Biochemical and Biophysical Research Communications.2020. in Press. *Co-corresponding author


Chen Y^#,Chen Y^#,Yin W^#, Han H, Miller H, Li J, Herrada A, Kubo M, Sui Z*, Gong Q*, Liu C*.The regulation of DOCK family proteins on T and Bcells. J Leukoc Biol
. 2020 Jun 15. *Co-corresponding author. IF=3.69


Raynor JL, Liu C, Dhungana Y, Guy C, Chapman NM, Shi H, Neale G, Sesaki H, Chi H*. Hippo/Mst Signaling Coordinates Cellular Quiescence with Terminal Maturation in iNKT Cell Development and Fate Decisions. J Exp Med. 2020 Jun 1;217(6): e**.IF=11.9


Record J^#, Sendel A^#, Kritikou J, Kuznetsov N, Brauner H, He M, Nagy N, Oliveira M, Griseti E, Haase C, Dahlstr?m J, Boddul S, Wermeling F, Thrasher A, Liu C, Andersson J, Claesson H, Winqvist O, Burns S, Bj?rkholm M, Westerberg L*. An intronic deletion in megakaryoblastic leukemia 1 is associated with hyperproliferation of B cells in triplets with Hodgkin lymphoma. Haematologica. 2020 May;105(5):1339-1350. IF=7.57


Jing Y^#, Dai X^#, Yang L^#, Kang D, Jiang P, Li N, Cheng J, Li J, Miller H, Ren B, Gong Q, Yin W, Liu Z, Mattila P, Ning Q, Sun J, Yu B* and Liu C *.STING couples with PI3K to regulate actin reorganization during BCR activation. Science Advances. 2020 Apr 22; 6(17): eaax9455. *Co-corresponding author. IF=12.804

Du Z^#, Yang D^#, Zhang Y, Xuan X, Li H, Hu L, Ruan C, Li L, Chen A, Deng L, Chen Y, Xie J, Westerberg L, Huang L* and Liu C*. AKT2 deficiency impairs formation of the BCR signalosome. Cell Communication and Signaling. 2020 Apr 6;18(1):56. *Co-corresponding author. IF=5.1

Lai Y^#, Zhao A^#, Tan M^#, Yang M, Lin Y, Li S, Song J, Zheng H, Zhu Z, Liu D, Liu C, Li L* and Yang G*. DOCK5 regulates energy balance and hepatic insulin sensitivity by targeting mTORC1 signaling. EMBO Reports. 2020 Feb 5; 21 (2), e49473. IF=8.383


Li N^#, Jiang P^#, Chen A, Luo X, Jing Y, Yang L, Kang D, Chen Q, Liu J, Chang J, Jellusova J, Miller H, Westerberg L, Wang CY, Gong Q*, Liu C*. CX3CR1 positively regulates BCR signaling coupled with cell metabolism via negatively controlling actin remodeling. Cellular and Molecular Life Sciences .2020 Feb 4; *Co-corresponding author. IF=7.014


Zheng B, Zhang J, Chen H, Nie H, Miller H, Gong Q*, Liu C*. T Lymphocyte-Mediated Liver Immunopathology of Schistosomiasis. Frontiers in Immunology. 2020 Feb 18; 11:61. *Co-corresponding author. IF=4.7

Huang L, Sun X, Yang D, Dai X, Jiang P, Bai X, Zhang Y, Wang J, Li W, Miller H, Song W, Treanor B, Zhao X*, Liu C*. WASP and Mst1 coregulate B-cell development and B-cell receptor signaling. Blood Advances. 2020 Feb 11; 4 (3):573-585. *Co-corresponding author.


Jing Y^#, Kang D^#, Liu L, Huang H, Chen A, Yang L, Jiang P, Li N, Miller H, Liu Z, Zhu X, Yang J, Wang X, Sun J*, Liu Z*, Liu W*, Zhou X*, Liu C*.Dock2 couples with LEF-1 to regulate the expression of CD21 and B cell differentiation. Journal of Allergy and Clinical Immunology. 2019 Nov; 144(5): p. 1377-1390 e4. *Co-corresponding author. IF=14.11

Xu C, Fang Y, Yang Z, Jing Y, Zhang Y, Liu C*, Liu W*. MARCKS Regulates Tonic and Chronic Active B Cell Receptor Signaling.Leukemia.2019 Mar; 33(3):710-729. *Co-corresponding author. IF=9.944

Wang C, Ming B, Wu X, Wu T, Cai S, Hu P, Tang J, Tan Z, Liu C, Zhong J, Zheng F*, Dong L*. Sphingomyelin synthase 1 enhances BCR signaling to promote lupus-like autoimmune response. EBioMedicine. 2019 Jul; 45:578-587.IF=6.68


Zhang J, Chen Q, Zhong J, Liu C, Zheng B*, Gong Q*.DPP-4 Inhibitors as Potential Candidates for Antihypertensive Therapy: Improving Vascular Inflammation and Assisting the Action of Traditional Antihypertensive Drugs. Frontiers in Immunology.2019 May 9;10:1050. IF=5.511


Li J^#, Yin W^#, Jing Y, Kang D, Yang L, Cheng J, Yu Z, Peng Z, Li X, Wen Y, Sun X, Ren B*, Liu C*. The Coordination Between B Cell Receptor Signaling and the Actin Cytoskeleton During B Cell Activation. Frontiers in Immunology. 2019 Jan 9; 9:3096. *Co-corresponding author. IF=5.511

Cheng J^#, Zhao L^#, Zhang Y, Qin Y, Guan Y, Zhang T, Liu C, Zhou J*. Understanding the Mechanisms of Resistance to CAR T-Cell Therapy in Malignancies.Frontiers in Oncology.2019 Nov 21; 9, 1237.IF=4.1


Sun X^#, Wei Y^#, Lee PP, Ren B*, Liu C*. The role of WASp in T cells and B cells. Cellular immunology. 2019 Jul; 341:103919. *Co-corresponding author. IF=3.291


Chen A, Yang D, Xuan X, Miller H, Luo X, Yu J, Yang G, Wang H*, Liu C*. Dock5 controls the peripheral B cell differentiation via regulating BCR signaling and actin reorganization.Cellular immunology.2019 Mar;337:15-21.*Co-corresponding author. IF=3.291


Shi H, Liu C, Tan H, Li Y, Nguyen TM, Dhungana Y, Guy C, Vogel P, Neale G, Rankin S, Feng Y, Peng J, Tao W*, Chi H*. Hippo Kinases Mst1 and Mst2 Sense and Amplify IL-2R–STAT5 Signaling in Regulatory T Cells to Establish Stable Regulatory Activity. Immunity. 2018 Nov 20; 49 (5): 899-914.e6. IF=21.5


Niu L, Xuan X, Wang J, Li L, Yang D, Jing Y, Westerberg LS, Liu C*. Akt2 Regulates the Differentiation and Function of NKT17 Cells via FoxO-1-ICOS Axis. Frontiers in Immunology.2018 Sep 12; 9:1940. IF=5.511


Zheng B, Xi Z, Liu R, Yin W, Sui Z, Ren B, Miller H, Gong Q*, Liu C*. The function of microRNAs in B cell development, lymphoma, and their potential in clinical practice. Frontiers in Immunology.2018. 2018 Apr 30; 9:936. *Co-corresponding author. IF=5.511


Sun X^#, Wang J^#, Qin T, Zhang Y, Huang L, Niu L, Bai X, Jing Y, Xuan X, Miller H, Zhao Y, Song W, Tang X, Zhang Z, Zhao X, Liu C*. Dock8 regulates BCR signaling and activation of memory B cells via WASP and CD19. Blood Advances. 2018 Feb 27; 2(4):401-413.


Cheng J, Jing Y, Kang D, Yang L, Li J, Yu Z, Peng Z, Li X, Wei Y, Gong Q, Miron RJ, Zhang Y, Liu C*. The Role of Mst1 in Lymphocyte homeostasis and function. Frontiers in Immunology. 2018 Feb 5; 9:149. IF=5.511

Huang L, Zhang Y, Xu C, Gu X, Niu L, Wang J, Sun X, Bai X, Xuan X, Li Q, Shi C, Yu B, Miller H, Yang G, Westerberg LS, Liu W, Song W, Zhao X*, Liu C*. Rictor positively regulates B cell receptor signaling by modulating actin reorganization via ezrin. PLos Biology. 2017 Aug 18; 15(8): e**. *Co-corresponding author. IF=9.797

Yang M^#, Wang J^#, Wu S^#, Yuan L, Zhao X, Liu C, Xie J, Jia Y, Lai Y, Zhao A, Boden G, Li L* and Yang G*. Duodenal GLP-1 signaling regulates hepatic glucose production through a PKC-δ-dependent neurocircuitry. Cell Death and Disease. 2017 Feb 9; 8 (2): e2609.IF=5.965.
Li W^#, Sun X^#, Wang J^#, Zhao Q, Dai R, Wang Y, Zhou L, Westerberg L, Ding Y*, Zhao X*, Liu C*. Defective thymic output in WAS patients is associated with abnormal actin organization. Scientific Reports. 2017 Sep 20; 7(1):11978. *Co-corresponding author. IF=4.259



Bai X, Huang L, Niu L, Zhang Y, Wang J, Sun X, Jiang H, Zhang Z, Miller H, Tao W, Zhou X*, Zhao X*, Liu C*. Mst1 positively regulates B cell receptor signaling via CD19 transcriptional levels. Blood Advances. 2016 Dec 14;1(3):219-230.*Co-corresponding author.


Bai X, Zhang Y, Huang L, Wang J, Li W, Niu L, Jiang H, Dai R, Zhou L, Zhang Z, Miller H, Song W*, Zhao X*, Liu C*. The early activation of memory B cells from Wiskott-Aldrich syndrome patients is suppressed by CD19 down regulation. Blood. 2016 Sep 29; 128(13):1723-34. *Co-corresponding author. IF=13.164


Zhang X^#, Dai R^#, Li W, Zhao H, Zhang Y, Zhou L, Du H, Luo G, Wu J, Niu L, An Y, Zhang Z, Ding Y, Song W, Liu C*, Zhao X*. Abnormalities of follicular helper T-cell number and function in Wiskott-Aldrich syndrome. Blood. 2016 Jun 23; 127(25):3180-91. *Co-corresponding author. IF=13.164


Liu C*, Richard K, Wiggins M, Zhu X, Conrad DH, Song W*.CD23 can negatively regulate B-cell receptor signaling. Sci Rep. 2016 May 16; 6:25629. *Co-corresponding author. IF=4.259



Bai X, Liu J, Zhang Z, Liu C, Zhang Y, Tang W, Dai R, Wu J, Tang X, Zhang Y, Ding Y, Jiang L, Zhao X*. Clinical, immunologic, and genetic characteristics of RAG mutations in 15 Chinese patients with SCID and Omenn syndrome. Immunol Res. 2016 Apr; 64(2):497-507. IF=3.02


Zhang Y, Cheng J, Liu C*. The unique role of the hepatitis virus B X protein on HEK 293 cell morphology and cellular change. Arch Virol. 2016 May;161 (5), 1347-52. IF=2.39


Qin T, An Y, Liu C, Wu J, Dai R, Liu D, Li X, Jiang L, Wu D, Tang X, Song W, Wang T*, Zhao X*. Novel DOCK8 gene mutations lead to absence of protein expression in patients with hyper-IgE syndrome. Immunol Res. 2016 Feb; 64(1):260-71. IF=3.02


Liu C, Chapman NM, Karmaus PW, Zeng H, Chi H*. mTOR and metabolic regulation of conventional and regulatory T cells. J Leukoc Biol. 2015 May; 97 (5), 837-847.IF=4.304


Miao H^#, Ou J^#, Ma Y, Guo F, Yang Z, Wiggins M, Liu C, Song W, Han X, Wang M, Cao Q, Liang H, Xue B, Shi H, Gan L*, and Yu L*. Macrophage CGI-58 deficiency activates ROS-Inflammasome pathway to promote insulin resistance in mice. Cell Report. 2014 Apr 10; 7(1):223-35. IF=7.215


Song W*, Liu C, Upadhyaya A. The pivotal position of the actin cytoskeleton in the initiation and regulation of B cell receptor activation. Biochim Biophys Acta. 2014 Feb; 1838(2):569-78. IF=4.495



Liu C *, Chen X*. Potential cellular host factor homologous to ZNF-136 can interact with truncated NS2 of HCV. Archive of Virology. 2014 Apr; 159(4):785-9. *Corresponding author. IF=2.282



Song W*, Liu C, Seeley-Fallen MK, Miller H, Ketchum C, Upadhyaya A. Actin-mediated feedback loops in B-cell receptor signaling. Immunological Reviews. 2013 Nov; 256(1):177-89. IF=12.909



Liu C, Bai X, Wu J, Sharma S, Upadhyaya A, Dahlberg C, Westerberg L, Snapper S, Zhao X, Song W*. N-WASP is Essential for the Negative Regulation of B cell Receptor Signaling. Plos Biology. 2013 Nov; 11(11): e**. IF=11.77



Liu C, Fallen M, Miller H, Upadhyaya A, Song W*. The actin cytoskeleton coordinates the signal transduction andantigen processing functions of the B cell antigen receptor. Front. Biol. 2013 Oct; 8(5):475-485.


Arunkumar N^#, Liu C^#, Hang H, and Song W*. Toll-like receptor agonist induces apoptosis in mouse lymphoma B cells by altering NF-kB activation. Cell Mol Immunol. 2013 Jul;10(4):360-72. IF=4.185


Liu C*, Wang Y, Wu C, Pei R, Song J, Chen S, Chen X*. Dioscin's antiviral effect in vitro. Virus Research. 2013 Mar; 172(1-2):9-14. * Corresponding author. IF=2.827


Liu C, Miller H, Orlowski G, Hang H, Upadhyaya A, Song W*. Actin reorganization is required for the formation of polarized BCR signalosomes in response to both soluble and membrane-associated antigens. J Immunol. 2012 Apr 1; 188(7):3237-46. IF=5.52


Liu C*, Miller H, Sharma S, Beaven A, Upadhyaya A, Song W. Analyzing actin dynamics during the activation of the B cell receptor in live B cells. Biochem Biophys Res Commun. 2012 Oct 12; 427(1): 202-6. IF=2.281


Becker-Herman S^#, Meyer-Bahlburg A^#, Schwartz M^#, Jackson S, Hudkins K, Liu C, Sather B, Khim S, Liggitt D, Song W, Silverman G, Alpers C, Rawlings D*. WASp-deficient B cells play a critical, cell-intrinsic role in triggering autoimmunity. J Exp Med. 2011 Sep 26; 208(10):2033-42. IF=13.214
Liu C, Miller H, Hui KL, Grooman B, Bolland S, Upadhyaya A, Song W*. A balance of Bruton's tyrosine kinase and SHIP activation regulates B cell receptor cluster formation by controlling actin remodeling. J Immunol. 2011 Jul 1; 187(1):230-239. IF=5.52
Cao J, Yu J, Liu C, Chen X, Liu S, Luo H, Yu H. Effects of hFRNK on E-cadherin/beta-catenin in colon cancer cells in vitro. Zhonghua Zhong Liu Za Zhi. 2007 May; 29(5):346-50. Chinese.
Cao J,Yu J, Liu C, Chen X, Luo H, Yu H. Effects of adenovirus vector expression hFRNK on phosphorylated 190RhoGAP and RhoA Activity in colo320WT colorectal cells. Chinese Journal of Practical Internal Medicine; 2007.8:581-584.
Cao J, Sun T, Ding M, Chen Y, Liu C, Yu J, Yu H. Construction of inhibiting tumor cell motility and invasion murine FRNK recombinant adenovirus vector. Chinese Journal of Experimental Surgery; 2006.12:1502-1504.
Cao J^#, Yu J^#, Liu C^#, Zhou L^#, Yu H*. Effects of gastrin 17 on beta-catenin/Tcf-4 pathway in Colo320WT colon cancer cells. World J Gastroenterol. 2006 Dec 14; 12(46):7482-7. IF=2.433
Liu C, Jiao C, Chen X. Cloning of HCV ns2 gene and its expression in prokaryotic and mammalian cells. Virologica Sinica 2006; 21(3):217-220.




承担课题
1、以WASp蛋白为靶向的慢性病和免疫缺陷的治疗NSFC 中瑞国合项目 300万 课题负责人;刘超红
2、创新提升基因修饰T细胞治疗恶性实体瘤安全和有效性研究及临床转化 科技部慢病重点研发项目 50万 课题骨干;刘超红
3、血液系统的免疫疾病NSFC ** 国家自然科学基金优秀青年基金 130万 课题负责人;刘超红
4、WASH通过促进STAT1磷酸化调控B细胞功能的机制研究NSFC ** 国家自然科学基金面上项目 58万 课题负责人;刘超红
5、CD23调控BCR信号和肌动蛋白重组机制的研究NSFC ** 国家自然科学基金青年基金 22万 课题负责人;刘超红



主要著作
“B cell receptor signaling”, Methods in Molecular Biology, Springer， 2017

“T cell receptor signaling”, Methods in Molecular Biology, Springer， 2019