李岩，华中科技大学基础医学院病原生物学系教授，博士生导师。2007年于中国科学技术大学获得学士学位。2012年于新加坡南洋理工大学获得博士学位。2014-2018年在新加坡科技研究局试验治疗中心从事新药研究工作。主要利用多维核磁共振技术从事重要靶标蛋白的结构解析及小分子抑制剂的相关研究。在Science、Nature Communications、Angewandte Chemie International Edition、Nucleic Acids Research等期刊发表SCI论文40余篇。目前担任Frontiers in Microbiology等期刊编委会成员以及The BMJ等期刊审稿人
联系方式: yanli@hust.edu.cn


发表文章：
1. Li, Y.#, Zhong, W.#, Koay, A., Ng, H., Koh-Senta, X., Nah, Q., Lim, S., Larsson, A., Lescar, J., Hill, J., Dedon, P., & Kang, C. (2018). Backbone resonance assignment for the N-terminal region of bacterial tRNA-(N¹G37) methyltransferase. Biomolecular NMR Assignments, in press.
2. Zhong, W., Koay, A., Ngo, A., Li, Y., Nah, Q., Wong, Y., Chionh, Y., Ng, H., Koh-Stenta, X., Poulsen, A., Foo, K., McBee, M., Choong, M., Sahili, A., Kang, C., Matter, A., Lescar, J., Keller, T., Hill, J., & Dedon, P. (2018). Targeting the bacterial epitranscriptome for antibiotic development: discovery of novel tRNA-(N¹G37) methyltransferase (TrmD) inhibitors. ACS infectious disease, 2019(5), 326-335. (Highlighted as Featured Article)
3. Ng, E., Loh, Y., Li, Y., Li, Q., & Kang, C. (2019). Expression, purification of Zika virus membrane protein-NS2B in detergent micelles for NMR studies. Protein Expression and Purification, 154, 1-6.
4. Li, Y., Loh, Y., Hung, A., &Kang, C. (2018). Characterization of molecular interactions between Zika virus protease and peptides derived from the C-terminus of NS2B. Biochemical and Biophysical Research Communications, 503(2), 691-696.
5. Li, Y.#, Liu, S.#, Ng, E.#, Li, R., Poulsen, A., Hill, J., Pobbati, A., Hung, A., Hong, W., Keller, T., & Kang, C. (2018). Structural and ligand binding analysis of the YAP-binding domain of transcription factor TEAD4. Biochemical Journal, 475(12), 2043-2055.
6. Lau, Q.#, Li, J.#, Sani, M.#, Sinha, S.#, Li, Y.#, Ng, F., Kang, C., Bhattacharjya, S., Separovic, F., Verma, C., & Chia, C. (2018). Elucidating the bactericidal mechanism of action of the linear antimicrobial tetrapeptide BRBR-NH₂. Biochimica et Biophysica Acta (BBA) - Biomembranes, 1860(8), 1517-1527.
7. Surya, W., Li, Y., & Torres, J. (2018). Structural model of the SARS coronavirus E channel in LMPG micelles. Biochimica et Biophysica Acta (BBA) - Biomembranes, 1860(6), 1309-1317.
8. Li, Y.#, Zhang, Z.#, Phoo, W.#, Loh, Y., Li, R., Yang, H., Jansson, A., Hill, J., Keller, T., Nacro, K., Luo, D., & Kang, C. (2018). Structural insight into the inhibition of Zika virus NS2B-NS3 protease by a small-molecule inhibitor. Structure, 26(4), 555-564.e3.
9. Li, Y., Lee, M., Loh, Y., & Kang, C. (2018). Secondary structure and membrane topology of Dengue Virus NS4A protein in micelles. Biochimica et Biophysica Acta (BBA) - Biomembranes, 1860(2), 442-450.
10. Li, Y., Ng, H., Ngo, A., Liu, S., Tan, Y., Kwek, P., Hung, A., Joy, J., Hill, J., Keller, T., & Kang, C. (2017). Backbone resonance assignments for the SET domain of human methyltransferase NSD3 in complex with its cofactor. Biomolecular NMR Assignments, 11(2), 225-229.
11. Li, Y., & Kang, C. (2017). Solution NMR spectroscopy in target-based drug discovery. Molecules, 22(9), 1399.
12. Li, Y., Phoo, W., Loh, Y., Zhang, Z., Ng, E., Wang, W., Keller, T., Luo, D., & Kang, C. (2017). Structural characterization of the linked NS2B-NS3 protease of Zika virus. FEBS Letters, 591(15), 2338-2347.
13. Li, Y.#, Zhang, Z.#, Phoo, W., Loh, Y., Wang, W., Liu, S., Chen, M., Hung, A., Keller, T., Luo, D., & Kang, C. (2017). Structural dynamics of Zika virus NS2B-NS3 protease binding to dipeptide inhibitors. Structure, 25(8), 1242-1250.e3.
14. To, J., Surya, W., Fung, T., Li, Y., Verdia-Baguena, C., Queralt-Martin, M., Aguilella, V., Liu, D., & Torres, J. (2017). Channel-inactivating mutations and their revertant mutants in the envelope protein of the Infectious Bronchitis Virus. Journal of Virology, 91(5), e02158-16.
15. Zhang, Z.#, Li, Y.#, Loh, Y., Phoo, W., Hung, A., Kang, C., & Luo, D. (2016). Crystal structures of unlinked NS2B-NS3 protease from Zika Virus. Science, 354(6319), 1597-1600.
16. Phoo, W.#, Li, Y.#, Zhang, Z., Lee, M., Loh, Y., Tan, Y., Ng, E., Lescar, J., Kang, C., & Luo, D. (2016). Structure of the NS2B-NS3 protease from Zika virus after self-cleavage. Nature Communications, 7, 13410.
17. Li, Y., Wong, Y., Lee, M., Li, Q., Wang, Q., Lescar, J., Shi, P., & Kang, C. (2016). Secondary structure and membrane topology of the full-length Dengue Virus NS4B in micelles. Angewandte Chemie International Edition, 55(39), 12068-12072.
18. Guan, S., Tan, S., Li, Y., Torres, J., & Law, S. (2016). Function and conformation analyses of an aspartate substitution of the invariant glycine in the integrin βI domain α1-α1’ helix. Biochemistry and Biophysics Reports, 7, 214-217.
19. Li, Y., Wong, Y., Ng, F., Liu, B., Wong, Y., Poh, Z., Liu, S., Then, S., Lee, M., Ng, H., Huang, Q., Hung, A., Cherian, J., Hill, J., Keller, T., & Kang, C. (2016). Escherichia coli topoisomerase IV E subunit and an inhibitor binding mode revealed by NMR spectroscopy. Journal of Biological Chemistry, 291(34), 17743-17753.
20. Li, Y., Wong, Y., Lee, M., Ng, H., & Kang, C. (2016). Backbone assignment of the N-terminal 24-kDa fragment of Escherichia coli topoisomerase IV ParE subunit. Biomolecular NMR Assignments, 10(1), 135-138.
21. Li, Y., Ng, H., Li, Q., & Kang, C. (2016). Structure of the cyclic nucleotide-binding homology domain of the hERG channel and its insights into type 2 long QT syndrome. Scientific Reports, 6, 23712.
22. Li, Y., Liew, L., Li, Q., & Kang, C. (2016). Structure of the transmembrane domain of human nicastrin-a component of γ-secretase. Scientific Reports, 6, 19522.
23. Pillay, S., Li, Y., Wong, L., & Pervushin, K. (2016). Structural characterization of eRF1 mutants indicate a complex mechanism of stop codon recognition. Scientific Reports, 6, 18644.
24. Li, Y., Kim, Y., Zou, J., Wang, Q., Gayen, S., Wong, Y., Lee, L., Xie, X., Huang, Q., Lescar, J., Shi, P., & Kang, C. (2015). Secondary structure and membrane topology of dengue virus NS4B N-terminal 125 amino acids. Biochimica et Biophysica Acta (BBA) - Biomembranes, 1848(12), 3150-3157.
25. Li, Y., Wong, Y., Ng, F., Liu, B., Wong, Y., Poh, Z., Then, S., Lee, M., Ng, H., Hung, A., Cherian, J., Hill, J., Keller, T., & Kang, C. (2015). Characterization of the interaction between Escherichia coli topoisomerase IV E subunit and an ATP competitive inhibitor. Biochemical and Biophysical Research Communications, 467(4), 961-966.
26. Kang, C., Li, Y., Cherian, J., Liu, B., Ng, H., Lee, M., Binte Ahmad, N., Poh, Z., Wong, Y., Huang, Q., Wong, Y., Hung, A., Hill, J., & Keller, T. (2015). Biophysical studies of bacterial topoisomerases substantiate their binding modes to an inhibitor. Biophysical Journal, 109(9), 1969–1977.
27. Li, Y.#, Li, Q.#, Wong, Y., Liew, L., & Kang, C. (2015). Membrane topology of NS2B of dengue virus revealed by NMR spectroscopy. Biochimica et Biophysica Acta (BBA) - Biomembranes, 1848(10 Pt A), 2244-2252.
28. Li, Y., Wong, Y., Poh, Z., Wong, Y., Lee, M., Ng, H., Liu, B., Hung, A., Cherian, J., Hill, J., Keller, T., & Kang, C. (2015). NMR structural characterization of the N-terminal active domain of the gyrase B subunit from Pseudomonas aeruginosa and its complex with an inhibitor. FEBS Letters, 589(19 Pt B), 2683-2689.
29. Li, Y., Jain, N., Limpanawat, S., To, J., Quistgaard, E., Nordlund, P., Thanabalu, T., & Torres, J. (2015). Interaction between human BAP31 and Respiratory Syncytial Virus Small Hydrophobic (SH) protein. Virology, 482, 105-110.
30. Li, Q., Wong, Y., Lee, M., Li, Y., & Kang, C. (2015). Solution structure of the transmembrane domain of the mouse erythropoietin receptor in detergent micelles. Scientific Reports, 5, 13586.
31. Torres, J., Surya, W., Li, Y., & Liu, D. (2015). Protein-protein interactions of viroporins in coronaviruses and paramyxoviruses: new targets for antivirals? Viruses, 7(6), 2858-2883.
32. Surya, W., Li, Y., Verdia-Baguena, C., Aguilella, V., & Torres, J. (2015). MERS coronavirus envelope protein has a single transmembrane domain that forms pentameric ion channels. Virus Research, 201, 61-66.
33. Guan, S., Tan, S., Li, Y., Torres, J., Uzel, G., Xiang, L., & Law, S. (2015). Characterization of single amino acid substitutions in the β2 integrin subunit of patients with Leuskocyte Adhesion Deficiency (LAD)-1. Blood Cells, Molecules, and Diseases, 54(2), 177-182.
34. Surya, W., Li, Y., & Torres, J. (2014). Pentameric viral ion channels: from structure to function. Journal of Receptor, Ligand and Channel Research, 2015(8), 9-18.
35. Li, Y.#, To, J.#, Verdia-Baguena, C.#, Dossena, S., Surya, W., Huang, M., Paulmichl, M., Liu, D., Aguilella, V., & Torres, J. (2014). Inhibition of the human respiratory syncytial virus small hydrophobic protein and structural variations in a bicelle environment. Journal of Virology, 88(20), 11899-11914.
36. Li, Y.#, Surya, W.#, Claudine, S., & Torres, J. (2014) Structure of a conserved Golgi complex-targeting signal in coronavirus envelope proteins. Journal of Biological Chemistry, 289(18), 12535-12549.
37. Surya, W.#, Li, Y.#, Millet, O., Diercks, T., & Torres, J. (2013). Transmembrane and juxtamembrane structure of αL integrin in bicelles. PLOS ONE, 8(9), e74281.
38. Wong, L.#, Li, Y.#, Pillay, S., Frolova, L., & Pervushin, K. (2012). Selectivity of stop codon recognition in translation termination is modulated by multiple conformations of GTS loop in eRF1. Nucleic Acids Research, 40(12), 5751-5765.
39. Narasimhan, K., Pillay, S., Bin Ahmad, N., Bikadi, Z., Hazai, E., Li, Y., Kolatkar, P., Pervushin, K., & Jauch, R. (2011). Identification of a polyoxometalate inhibitor of the DNA binding activity of Sox2. ACS Chemical Biology, 6(6), 573-581.
40. Rong, H., Li, Y., Shi, X., Zhang, X., Gao, Y., Dai, H., Teng, M., Niu, L., Liu, Q., & Hao, Q. (2007). Structure of human upstream binding factor HMG box 5 and site for binding of the cell-cycle regulatory factor TAF1. Acta Crystallographica Section D: Biological Crystallography, 63(Pt 6), 730-737.
41. Rong, H., Li, Y., Lou, X., Zhang, X., Gao, Y., Teng, M., & Niu, L. (2007). Purification, partial characterization, crystallization and preliminary X-ray diffraction of a novel cardiotoxin-like basic protein from Naja naja atra (South Anhui) venom. Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 63(Pt 2), 130-134.