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刘丹

刘丹，讲师，硕士生导师，湖北省优秀博士论文获得者。研究方向：表观遗传学在神经精神疾病中的作用。承担国家自然科学基金青年项目一项。目前发表SCI论文16篇，其中包括Neuron, J Neurosci, Mol Neurobiol等国际知名杂志。










联系方式

基础医学院二号教学楼12楼1221办公室




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Email: liudan_echo@mail.hust.edu.cn

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工作简介

主要从事阿尔茨海默病（Alzheimer’s disease, AD）发病的分子机制及防治措施的研究。该病是最常见的一类老年痴呆症，以进行性认识功能障碍为特征，严重影响老年人群的生活质量，同时对整个社会也带来极大的负担。然而，目前对于该病的发病机制、预防及治疗措施尚不清楚。微小RNA是一类高度保守的非编码RNA，其主要在转录/转录后水平对基因的表达进行调控。近年来的研究表明microRNA的失调对AD的发病进程起重要作用，所以本课题组的主要研究方向为microRNA在AD发病中的作用与机制研究。










发表论文

(1) Wang X, Wang LP, Tang H, Shan WY, Wang X, Liu D*, Wu YY, Tian Q, Wang JZ*, Zhu LQ*. Acetyl-l-carnitine rescues scopolamine-induced memory deficits by restoring insulin-like growth factor II via decreasing p53 oxidation. Neuropharmacology. 2014 Jan;76 Pt A:80-7. (IF=4.114，*通讯作者)




(2) Tang H, Shen N, Jin H, Liu D*, Miao X*, Zhu LQ*. GSK-3β Polymorphism Discriminates Bipolar Disorder and Schizophrenia: A Systematic Meta-Analysis. Mol Neurobiol. 2013 Dec;48(3):404-11. (IF=5.471，*通讯作者)




(3) Wang X, Wang ZH, Wu YY, Tang H, Tan L, Wang X, Gao XY, Xiong YS, Liu D*, Wang JZ, Zhu LQ*. Melatonin attenuates scopolamine-induced memory/synaptic disorder by rescuing EPACs/miR-124/Egr1 pathway. Mol Neurobiol. 2013 Feb;47(1):373-81. (IF=5.471，*通讯作者)




(4) Tan L, Wang X, Ni ZF, Zhu X, Wu W, Zhu LQ, Liu D. A Systematic Analysis of Genomic Changes in Tg2576 Mice. Mol Neurobiol. 2013 Jun;47(3):883-91. (IF=5.471，通讯作者)




(5) Peng CX, Hu J, Liu D, Hong XP, Wu YY, Zhu LQ, Wang JZ. Disease-modified glycogen synthase kinase-3β intervention by melatonin arrests the pathology and memory deficits in an Alzheimer's animal model. Neurobiol Aging. 2013 Jun;34(6):1555-63. (IF=6.166)




(6) Qu M, Jiang J, Liu XP, Tian Q, Chen LM, Yin G, Liu D, Wang JZ, Zhu LQ. Reduction and the intracellular translocation of EphB2 in Tg2576 mice and the effects of β-amyloid. Neuropathol Appl Neurobiol. 2013 Oct;39(6):612-22. (IF=4.837)




(7) Wu YY, Wang X, Tan L, Liu D, Liu XH, Wang Q, Wang JZ, Zhu LQ. Lithium attenuates scopolamine-induced memory deficits with inhibition of GSK-3β and preservation of postsynaptic components. J Alzheimers Dis. 2013;37(3):515-27. (IF=4.174)




(8) Wang SH, Liao XM, Liu D, Hu J, Yin YY, Wang JZ, Zhu LQ. NGF promotes long-term memory formation by activating poly(ADP-ribose)polymerase-1. Neuropharmacology. 2012 Nov;63(6):1085-92. (IF=4.114)




(9) Yang Y*, Shu X*, Liu D*, Shang Y, Wu Y, Pei L, Xu X, Tian Q, Zhang J, Qian K, Wang YX, Petralia RS, Tu WH, Zhu LQ*, Wang JZ*, Lu Y*. EPAC Null Mutation Impairs Learning and Social Interactions via Aberrant Regulation of miR-124 and Zif268 Translation. Neuron. 2012 Feb 23;73(4):774-88. (IF=15.766，*第一作者)




(10) Liao K, Liu D, Zhu LQ. Enriched odor exposure decrease tau phosphorylation in the rat hippocampus and cortex. Neurosci Lett. 2012 Jan 17;507(1):22-6. (IF=2.026)




(11) Hu J, Wang X, Liu D, Wang Q, Zhu LQ. Olfactory deficits induce neurofilament hyperphosphorylation. Neurosci Lett. 2012 Jan 11;506(2):180-3. (IF=2.026)




(12) Zhou P, Chen Z, Zhao N, Liu D, Hu J, Guo ZY, Wang Q, Wang JZ, Zhu LQ. Acetyl-L-Carnitine attenuates homocysteine-induced Alzheimer-like histopathological and behavioral abnormalities. Rejuv Res. 2011 Dec;14(6):669-79. (IF=2.919)




(13) Liu D, Zheng HY, Luo ZZ, Wang Q, Zhu LQ. Effect of PP-2A on neurite outgrowth in neuronal cells. In Vitro Cell Dev-AN. 2010 Sep;46(8):702-7. (IF=1.289，第一作者)




(14) Zhu LQ*, Liu D*, Hu J, Cheng J, Wang SH, Wang Q, Wang F, Chen JG, Wang JZ. GSK-3b inhibits presynaptic vesicle exocytosis by phosphorylating P/Q-type calcium channel and interrupting SNARE complex formation. J Neurosci. 2010 Mar 10;30(10):3624-33. (IF=6.908，*第一作者，当期亮点文章)




(15) Zhu LQ, Zheng HY, Peng CX, Liu D, Li HL, Wang Q, Wang JZ. Protein phosphatase 2A facilitates functional axonogenesis by dephosphorylating CRMP2. J Neurosci. 2010 Mar 10;30(10):3839-48. (IF=6.908)




(16) Zhu LQ, Wang SH, Liu D, Yin YY, Tian Q, Wang XC, Wang Q, Chen JG, Wang JZ. Activation of glycogen synthase kinase-3 inhibits long term potentiation with synapse-associated impairments. J Neurosci. 2007 Nov 7;27(45):12211-20. (IF=6.908)










承担项目

（1）国家自然科学基金，编号**，糖原合酶激酶3 对树突棘可塑性的调控作用和机制及其应用，2013.01-2015.12，金额23万，负责人。（在研）




（2）华中科技大学自主创新基金，编号2012QN134，糖原合酶激酶3 在阿尔茨海默病突触病变中的作用和机制，2012.05-2013.12，金额5万，负责人。（在研）