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牟阳灵

牟阳灵，博士，教授










研究方向：




调控成年动物大脑中神经干细胞发育和新生神经元整合的神经环路




新生神经元在处理学习和记忆信息过程中的编码机制与功能




情绪影响海马学习记忆的神经基础










1996年于华中理工大学获生物医学工程专业学士学位。1999年获清华大学生物物理学硕士学位。2006年在美国加州大学伯克利分校（University of California，Berkeley）分子与细胞生物学系（Department of Molecular & Cell Biology）取得博士学位，主要研究中枢神经系统发育早期神经环路建立过程中突触连接精细修整的机制。2007-2012年在美国Salk Institute从事博士后研究，重点探索成年期海马神经发生与学习记忆的相互作用。2012年底回国工作，在中国科学院深圳先进技术研究院担任研究员，同年入选中组部“青年千人”计划。2014年1月受聘为华中科技大学基础医学院教授。










联系方式：




基础医学院2号楼16楼1604办公室




电话：**




Email：ymu@hust.edu.cn










主要论文：




Wang X, Zhao Y, Zhang X, Badie H, Zhou Y, Mu Y, Loo LS, Cai L, Thompson RC, Yang B, Chen Y, Johnson PF, Wu C, Bu G, Mobley WC, Zhang D, Gage FH, Ranscht B, Zhang YW, Lipton SA, Hong W and Xu H (2013). Loss of sorting nexin 27 contributes to excitatory synaptic dysfunction by modulating glutamate receptor recycling in Down's syndrome. Nat Med. 19, 473-80.




Boyer LF, Campbell B, Larkin S, Mu Y and Gage FH (2012). Dopaminergic differentiation of human pluripotent cells.Curr Protoc Stem Cell Biol. Chapter 1:Unit1H.6.




Giorgetti A, Marchetto MC, Li M, Yu D, Fazzina R, Mu Y, Adamo A, Paramonov I, Cardoso JC, Monasterio MB, Bardy C, Cassiani-Ingoni R, Liu GH, Gage FH and Izpisua Belmonte JC (2012). Cord blood-derived neuronal cells by ectopic expression of Sox2 and c-Myc. Proc Natl Acad Sci U S A. 109, 12556-61.




Yao J*, Mu Y* and Gage FH (2012). Neural stem cells: mechanisms and modeling. Protein Cell 3, 251-61 (*equally contributed).




Israel MA, Yuan SH, Bardy C, Reyna SM, Mu Y, Herrera C, Hefferan MP, Van Gorp S, Nazor KL, Boscolo FS, Carson CT, Laurent LC, Marsala M, Gage FH, Remes AM, Koo EH and Goldstein LS (2012). Probing sporadic and familial Alzheimer's disease using induced pluripotent stem cells. Nature 482, 216-20.




Mu Y* and Gage FH (2011). Adult hippocampal neurogenesis and its role in Alzheimer's disease. Mol Neurodegener 6, 85 (*corresponding author).




Coufal NG, Garcia-Perez JL, Peng GE, Marchetto MC, Muotri AR, Mu Y, Carson CT, Moran JV and Gage FH (2011). Ataxia telangiectasia mutated (ATM) modulates long interspersed element-1 (L1) retrotransposition in human neural stem cells. Proc Natl Acad Sci U S A. 108, 20382-7.




Brennand KJ, Simone A, Jou J, Gelboin-Burkhart C, Tran N, Sangar S, Li Y, Mu Y, Chen G, Yu D, McCarthy S, Sebat Jand Gage FH (2011). Modelling schizophrenia using human induced pluripotent stem cells. Nature 473, 221-5.




Mu Y, Zhao C and Gage FH (2011). Dopaminergic modulation of cortical inputs during maturation of adult-born dentate granule cells. J Neurosci 31, 4113-23.




Yuan SH, Martin J, Elia J, Flippin J, Paramban RI, Hefferan MP, Vidal JG, Mu Y, Killian RL, Israel MA, Emre N, Marsala S, Marsala M, Gage FH, Goldstein LS and Carson CT (2011). Cell-surface marker signatures for the isolation of neural stem cells, glia and neurons derived from human pluripotent stem cells. PLoS ONE 6, e17540.




Marchetto MC, Carromeu C, Acab A, Yu D, Yeo GW, Mu Y, Chen G, Gage FH and Muotri AR (2010). A model for neural development and treatment of Rett syndrome using human induced pluripotent stem cells. Cell 143, 527-39.




Mu Y*, Lee SW* and Gage FH (2010). Signaling in adult neurogenesis. Curr Opin Neurobiol 20, 416-23 (*equally contributed).




Coufal NG, Garcia-Perez JL, Peng GE, Yeo GW, Mu Y, Lovci MT, Morell M, O′Shea KS, Moran JV and Gage FH (2009). L1 Retrotransposition in Human Neural Progenitor Cells. Nature 460, 1127-31.




Li Y*, Mu Y* and Gage FH (2009). Development of neural circuits in the adult hippocampus. Curr Top Dev Biol 87, 149-74 (*equally contributed).




Marchetto MC, Muotri AR, Mu Y, Smith AM, Ceza GG and Gage FH (2008). Non-cell-autonomous effect of human SOD1 G37R astrocytes on motor neurons derived from human embryonic stem cells. Cell Stem Cell 3, 649-57.




Mu Y and Poo M (2006). Spike timing-dependent LTP/LTD mediates visual experience-dependent plasticity in a developing retinotectal system. Neuron 50, 115-25.




Lien CC*, Mu Y*, Vargas-Caballero M and Poo M (2006). Visual stimuli-induced LTD of GABAergic synapses mediated by presynaptic NMDA receptors. Nat Neurosci 9, 372-80 (*equally contributed).