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金肆

金肆 男，1974年出生，教授，博士生导师。1998年毕业于同济医科大学(现华中科技大学同济医学院)临床医学系后留校病理生理学系任教，同时攻读研究生并获病理与病理生理学博士学位。历任助教、讲师，2005年任副教授、硕士生导师。2006-2008，赴美国弗吉尼亚联邦大学(Virginia Commonwealth University)药理学系作博士后。回国后调入同济医学院药理学系任教；2009年, 被遴选为药理学博士生导师；2010年，任药理学教授。主要研究血管内皮细胞功能障碍在心血管疾病（动脉粥样硬化、缺血性心脏病、高血压、心律失常、代谢性疾病等）中的作用机制与新药发现及药效学评价。现主持多项国家自然科学基金及教育部留学回国人员基金的研究，在国际著名期刊Arterioscler Thromb Vasc Biol.，Antioxidants Redox Signaling等发表SCI 收录论文18篇，其中第1作者或通讯作者11篇，SCI引用约200次。以第1发明人获得国家发明专利授权1项。多次参加国际国内学术会议。担任国家自然科学基金及教育部博士点基金等评审专家，Antioxidants Redox Signaling，Acta Pharmacologica Sinica等SCI收录期刊特邀审稿人。兼任中国药理学会心血管药理专业委员会委员；曾获“湖北省自然科学三等奖”、“湖北省高等学校优秀教学成果二等奖”、华中科技大学“十佳青年教工”、“优秀共产党员”、美国弗吉尼亚联邦大学“Excellent Postdoctoral Research Award”等奖励与称号。入选教育部2010年新世纪优秀人才支持计划。热忱欢迎有志青年加入我们的队伍，一起探究医学和药学交叉的奥妙，为促进人类健康作贡献！（联系方式：bsjinsi@yahoo.com）










近年发表的论文及获得专利情况如下：

1. Jin S*, Zhou F, Katirai F, Li PL. Lipid raft redox signaling: molecular mechanisms in health and disease. Antioxid Redox Signal. 2011 Aug 15;15(4):1043-83. (*, Corresponding author)2.Wang L, Zhen H, Yao W, Bian F, Zhou F, Mao X, Yao P, Jin S*. Lipid raft-dependent activation of dual oxidase 1/H2O2/NF-{kappa}B pathway in bronchial epithelial cells. Am J Physiol Cell Physiol. 2011 Jul;301(1):C171-80. (*, Corresponding author)3. Chen L, He T, Han Y, Sheng JZ, Jin S, Jin MW. Pentamethylquercetin Improves Adiponectin Expression in Differentiated 3T3-L1 Cells via a Mechanism that Implicates PPARγ together with TNF-α and IL-6. Molecules. 2011 Jul 6;16(7):5754-68.4. Bao JX*, Jin S*, Zhang F, Wang ZC, Li N, Li PL. Activation of Membrane NADPH Oxidase Associated with Lysosome-Targeted Acid Sphingomyelinase in Coronary Endothelial Cells. Antioxid Redox Signal. 2010 Mar 15;12(6):703-12. (*, equal contribution);5. Jin S*, Zhou F. Lipid raft redox signaling platforms in vascular dysfunction: features and mechanisms. Curr Atheroscler Rep. 2009 May;11(3):220-6. (*, Corresponding author)

6. Jin S, Yi F, Zhang F, Poklis JL, Li PL. Lysosomal targeting and trafficking of acid sphingomyelinase to lipid raft platforms in coronary endothelial cells. Arterioscler Thromb Vasc Biol. 2008 Nov;28(11):2056-62. Epub 2008 Sep 4.7. Jin S, Zhang Y, Yi F, Li PL. Critical role of lipid raft redox signaling platforms in endostatin-induced coronary endothelial dysfunction. Arterioscler Thromb Vasc Biol. 2008 Mar;28(3):485-90. Epub 2007 Dec 27.8. Jia SJ*, Jin S*, Zhang F, Yi F, Dewey WL, Li PL. Formation and function of ceramide-enriched membrane platforms with CD38 during M1-receptor stimulation in bovine coronary arterial myocytes. Am J Physiol Heart Circ Physiol. 2008 Oct;295(4):H1743-52. Epub 2008 Aug 22. (*, equal contribution)9. Jin S, Yi F, Li PL. Contribution of lysosomal vesicles to the formation of lipid raft redox signaling platforms in endothelial cells. Antioxid Redox Signal. 2007 Sep;9(9):1417-26.10. Jin S, Tian D, Chen JG, Zhu LP, Liu SY, Wang DX. Passive sensitization increases histamine-stimulated calcium signaling and NF-kappaB transcription activity in bronchial epithelial cells. Acta Pharmacol Sin. 2006 Jun;27(6):708-14.11. Jin S, Lu D, Ye S, Ye H, Zhu L, Feng Z, Liu S, Wang D, Hu Q. A simplified probe preparation for ELISA-based NF-kappaB activity assay. J Biochem Biophys Methods. 2005 Oct 31;65(1):20-9. Epub 2005 Sep 15.12 .Jin S, Chen JG, Zhu LP, Liu SY, Wang DX, Hu QH, Subacute mild hypoxia increases histamine-stimulated calcium oscillation frequency in pulmonary artery endothelial cells. Progress in Biochemistry and Biophysics, 2005, 32 ( 6) : 551-556. 13. Zhang F, Jin S, Yi F, Li PL. TRP-ML1 Functions as a Lysosomal NAADP-Sensitive Ca(2+) Release Channel in Coronary Arterial Myocytes. J Cell Mol Med. 2009 Sep,13(9b), 3174-3185 ; 14. Yi F, Jin S, Zhang F, Xia M, Bao JX, Hu J, Poklis JL, Li PL. Formation of lipid raft redox signalling platforms in glomerular endothelial cells: an early event of homocysteine-induced glomerular injury. J Cell Mol Med. 2009 Sep;13(9B):3303-14.15. Yi F, Jin S, Li PL. Lipid raft-redox signaling platforms in plasma membrane. Methods Mol Biol. 2009;580:93-107.16. Zhang F, Jin S, Yi F, Xia M, Dewey WL, Li PL. Local production of O2- by NAD(P)H oxidase in the sarcoplasmic reticulum of coronary arterial myocytes: cADPR-mediated Ca2+ regulation. Cell Signal. 2008 Apr;20(4):637-44. 17. Yi F, Chen QZ, Jin S, Li PL. Mechanism of homocysteine-induced Rac1/NADPH oxidase activation in mesangial cells: role of guanine nucleotide exchange factor Vav2. Cell Physiol Biochem. 2007;20(6):909-18.18. Zhang AY, Yi F, Jin S, Xia M, Chen QZ, Gulbins E, Li PL. Acid sphingomyelinase and its redox amplification in formation of lipid raft redox signaling platforms in endothelial cells. Antioxid Redox Signal. 2007 Jul;9(7):817-28.授权国家发明专利1．一种转录因子活性测定方法及试剂盒，专利号：ZL**8.7.承担科研项目1. 脂筏来源的神经酰胺在Ox-LDL穿胞于血管内皮细胞中的作用及药物干预， 2011.1-2013.12, 36万元，2009.1-2011.12，负责，国家基金委；2. 脂筏-双氧化酶信号平台在气道上皮细胞防御反应及介导上皮损伤中的作用和机制， 32万元，2009.1-2011.12，负责，国家基金委；

3. 教育部留学回国人员基金，脂筏及其标志蛋白在动脉粥样硬化发生发展中的作用及调血脂药的影响，3万元，2011.1-2013.12；

4. 教育部新世纪优秀人才支持基金，50万元， 2011.1-2013.12。