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付琴

付琴，博士，华中科技大学同济医学院药理学系副教授。2003~2005年德国柏林Max-Delbrueck分子医学中心访问学者；2011~2013年美国伊利诺伊大学香槟分校和加州大学戴维斯分校博士后。主要研究方向为肾上腺素受体信号通路在心脑血管疾病和糖尿病发病机制中的调控作用，并探寻新的治疗策略和药物治疗靶点。主持及参与国家自然科学基金、国家科技部科技攻关项目、省厅项目等部委课题研究多项。




E-mail: fu_qin@aliyun.com




代表性论文：




Fu Q, Xu B, Liu Y, Parikh D, Li J, Li Y, Zhang Y, Riehle C, Zhu Y, Rawlings T, Shi Q, Clark RB, Chen X, Abel ED, Xiang YK. Insulin inhibits cardiac contractility by inducing a Gi-biased β2 adrenergic signaling in hearts. Diabetes. 2014 Aug;63(8):2676-89.




Fu Q*#, Kim S#, Soto D, De Arcangelis V, Dipilato L, Liu S, Xu B, Zhang J, Shi Q, Xiang YK*. A long-lasting β1 adrenergic receptor stimulation of cAMP/PKA signals in cardiac myocytes. J Biol Chem. 2014 May 23;289(21):14771-14781 (*co-corresponding author, #co-first author)




Fu Q, Chen X, Xiang YK. Compartmentalization of β-adrenergic signals in cardiomyocytes. Trends Cardiovasc Med. 2013 Oct;23(7):250-6




Zhang Q, Xiang J, Wang X, Liu H, Hu B, Feng M, Fu Q*. Beta(2)-adrenoceptor agonist clenbuterol reduces infarct size and myocardial apoptosis after myocardial ischaemia/reperfusion in anaesthetized rats. Br J Pharmacol. 2010 160(6):1561-72. (*corresponding authour)




Liu P, Xiang JZ, Zhao L, Yang L, Hu BR, Fu Q*. Effect of beta2-adrenergic agonist clenbuterol on ischemia/reperfusion injury in isolated rat hearts and cardiomyocyte apoptosis induced by hydrogen peroxide. Acta Pharmacol Sin. 2008 29(6):661-9. (*corresponding author)




Fu Q, Hu BR, Han ZM, Xiang JZ. Effects of Clenbuterol on Phosphorylation of Phospholamban in Neonatal Rat Cardiomyocytes J Huazhong Univ Sci Technolog Med Sci. 2007, 36( 4): 441-443




Li JJ, Tang Q, Li Y, Hu BR, Ming ZY, Fu Q*, Qian JQ, Xiang JZ*. Role of oxidative stress in the apoptosis of hepatocellular carcinoma induced by combination of arsenic trioxide and ascorbic acid. Acta Pharmacol Sin. 2006 27(8):1078-84. (*corresponding author)




Wang D, Fu Q, Zhou Y, Xu B, Shi Q, Igwe B, Matt L, Hell JW, Wisely EV, Oddo S,Xiang YK. β2 adrenergic receptor, protein kinase A (PKA) and c-Jun N-terminal kinase (JNK) signaling pathways mediate tau pathology in Alzheimer disease models. J Biol Chem. 2013 Apr 12;288(15):10298-307.




Zhang X, Szeto C, Gao E, Tang M, Jin J, Fu Q, Makarewich C, Ai X, Li Y, Tang A, Wang J, Gao H, Wang F, Ge XJ, Kunapuli SP, Zhou L, Zeng C, Xiang KY, Chen X. Cardiotoxic and cardioprotective features of chronic β-adrenergic signaling. Circ Res. 2013 Feb 1;112(3):498-509.




Liu R, Wang D, Shi Q, Fu Q, Hizon S, Xiang YK. Palmitoylation Regulates Intracellular Trafficking of β(2) Adrenergic Receptor/Arrestin/Phosphodiesterase 4D Complexes in Cardiomyocytes. PLos One. 2012; 7(8): e42658




Liu S, Li Y, Kim S, Fu Q, Parikh D, Sridhar B, Shi Q, Zhang X, Guan Y, Chen X, Xiang YK. Phosphodiesterases coordinate cAMP propagation induced by two stimulatory G protein-coupled receptors in hearts. Proc Natl Acad Sci U S A. 2012 Apr 24;109(17):6578-83




Feng M, Xiang JZ, Ming ZY, Fu Q, Ma R, Zhang QF, Dun YY, Yang L, Liu H. Activation of epidermal growth factor receptor mediates reperfusion arrhythmias in anaesthetized rats. Cardiovasc Res. 2012 Jan 1;93(1):60-8.




Wang Y, Xu H, Fu Q, Ma R, Xiang J. Protective effect of resveratrol derived from Polygonum cuspidatum and its liposomal form on nigral cells in Parkinsonian rats. J Neurol Sci. 2011 May 15;304(1-2):29-34




Li G, Ma R, Huang C, Tang Q, Fu Q, Liu H, Hu B, Xiang J. Protective effect of erythropoietin on beta-amyloid-induced PC12 cell death through antioxidant mechanisms. Neurosci Lett. 2008 Sep 12;442(2):143-7.




Xu LM, Fu Q, Hu BR, Tang Q, Xiang JZ. Effects of Anandamide on the Cardiac Function, Nitric Oxide Content and Nitric Oxide Synthase Activity in the Myocardium of the Rat. Herald of Medicine. 2006, 25(12):1241-1246




Tang Q, Hu BR, Tan Y, Ma R, Fu Q, Chen JG, Xiang JZ. Effects of Pre-incubation with hβ-CGRP on Elevation of Intracellular Free Calcium Concentration Activated by H2O2 in Myocardial Cells. J Huazhong Univ Sci Technolog Med Sci. 2006 35(5):570-572,579




Ruan CJ, Hu BR, Tang Q, Fu Q, Hu F, Li YW, Xiang JZ. Protective Effect of WIN55212-2 on Ischemia-Reperfusion Injury in Isolated Rat Hearts . J Huazhong Univ Sci Technolog Med Sci. 2006 35(5), 573-575




Pan LR, Tang Q, Fu Q, Hu BR, Xiang JZ, Qian JQ. Roles of nitric oxide in protective effect of berberine in ethanol-induced gastric ulcer mice. Acta Pharmacol Sin. 2005 26(11):1334-8




Fu Y, Hu BR, Tang Q, Fu Q, Zhang QY, Xiang JZ. Effect of jatrorrhizine, berberine, Huanglian Decoction and compound-mimic prescription on blood glucose in mice. Chinese traditional and herbal Drugs. 2005 36(4):548-551.




Han ZM, Yang YH, Fu Q, Xiang JZ, Hu BR. Effects of cyclosporine A on angiotensin II-induced c-fos protein expression and Ca2+ influx in cultured neonatal cardiomyocytes. Chinese pharmacological bulletin. 2004 20(7):838-839.




Wang GB, Fu Q, Lin XM, Hu BR, Liu AH, Xiang JZ. Experimental study on antiarrythmic effects of Xinlu tai capsule. Traditional Chinese Drug Research & Clinical Pharmacology. 2003 14(2):34-36










论著：




Fu Q, Wang JL. Prostaglandins receptor agonists and antagonists and leukotrienes agonist and antagonists. Practical Cardiovascular Receptor Biology, Scientific Press of China, 2001, 259-278




Fu Q, Wang JL. Peripheral dopamine receptors and agonists. Practical Cardiovascular Receptor Biology, Scientific Press of China, 2001, 309-315










主持在研课题：




1. β2肾上腺素受体依赖性的胰岛素诱导的PDE4在糖尿病心功能不全中的作用。国家自然科学基金，2015.1-2018.12




2. 神经激素对 β肾上腺素受体阻断剂抗心力衰竭疗效的影响。国家自然科学基金海外合作项目,




2015.1-2016.12




3. ERK1/2-CX43信号通路在β2肾上腺素受体激动剂抗心肌缺血再灌注损伤中的作用。国家自然科学基金，2012.1-2014.12




4. 胰岛素对心脏肾上腺素受体信号通路的影响。华中科技大学自主创新基金， 2014.4-2015.12