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胡壮丽

胡壮丽




个人简介：华中科技大学同济医学院药理系副教授，硕士生导师。1999年毕业于原同济医科大学临床医疗专业，获学士学位。2004-2005在美国俄亥俄州立大学心肺实验室学术交流一年，2008年获得华中科技大学博士学位。




主要方向：1. 离子通道与情感障碍性疾病；




2. 神经胶质细胞与情感障碍性疾病。




作为负责人主持课题：

①国家自然科学基金青年基金 心肌酸敏感离子通道（ASICs）：治疗心肌缺血的新靶点（No. **）；




②国家自然科学基金面上基金酸敏感离子通道(ASICs):小胶质细胞炎症免疫反应的重要调节蛋白（No. **）；




③湖北省科技研究与开发计划项目作用于多靶点神经保护药物的合作研发（2011BFA006）；




④华中科技大学自主创新基金重点专项项目酸敏感离子通道在抑郁症中的作用机制探讨：小胶质细胞功能失调（**）




代表性论文：

①.Rui-Li Liu, Qiu-Ju Xiong, Qing Shu, Wen-Ning Wu, Jin Cheng, Hui Fu, Fang Wang, Jian-Guo Chen, Zhuang-Li Hu (通讯作者). Hyperoside protects cortical neurons from oxygen-glucose deprivation-reperfusion induced injury via nitric oxide signal pathway. Brain Res. 2012 Aug 21; 1469:164-73.




②.Zhuang-Li Hu, Chao Huang, Hui Fu, You Jin, Wen-Ning Wu, Qiu-Ju Xiong, Na Xie, Li-Hong Long, Jian-Guo Chen and Fang Wang. PICK1 disruption attenuates both functions of ASICs and regulations of PKC on ASICs. Am J Physiol Cell Physiol. 2010 Dec; 299(6):C1355-62. (SCI, IF＝4.013)




③.Qiu-Ju Xiong, Zhuang-Li Hu(并列第一作者), Peng-Fei Wu, Lan Ni, Zhi-Fang Deng, Wen-Ning Wu, Jian-Guo Chen, Fang Wang. Acid-sensing ion channels contribute to the increase in vesicular release from SH-SY5Y cells stimulated by extracellular protons. Am J Physiol Cell Physiol. 2012 Aug; 303(4):C376-84.




④.Chao Huang, Zhuang-Li Hu(并列第一作者), Wen-ning Wu, Dan-Fang Yu, Qiu-Ju Xiong, Jian-Ren Song, Qing Shu, Hui Fu, Fang Wang and Jian-Guo Chen. Existence and distinction of acid-evoked currents in rat astrocytes. Glia. 2010 Sep;58(12):1415-24. (SCI, IF＝4.932)




⑤.Zhuangli Hu, Juan Chen, Qin Wei, and Yong Xia. Bidirectional Actions of Hydrogen Peroxide on Endothelial Nitric Oxide Synthase Phosphorylation and Function: co-commitment and interplay of Akt and AMPK. J. Biol. Chem. 2008 Sep 12; 283(37): 25256-25263. (SCI, IF＝5.328)




⑥.Bo Jiang, Wei Wang, Fang Wang, Zhuang-Li Hu, Jun-Li Xiao, Si Yang, Jing Zhang, Xiao-Zhong Peng, Jin-Hui Wang, Jian-Guo Chen. The Stability of NR2B in the Nucleus Accumbens Controls Behavioral and Synaptic Adaptations to Chronic Stress. Biol Psychiatry. 2013 Jul 15; 74(2):145-155.




⑦.Jun-Qi Zhang, Peng-Fei Wu, Li-Hong Long, Yu Chen, Zhuang-Li Hu, Lan Ni, Fang Wang, Jian-Guo Chen. Resveratrol promotes cellular glucose utilization in primary cultured cortical neurons via calcium-dependent signaling pathway. J Nutr Biochem. 2012 Jul 20. [Epub ahead of print]




⑧.Yu Chen, Jun Zhou, Na Xie, Chao Huang, Jun-qi Zhang, Zhuang-Li Hu, Lan Ni, You Jin, Fang Wang, Jian-guo Chen and Li-hong Long. Lowering glucose level elevates [Ca2+]i in hypothalamic arcuate nucleus NPY neurons through P/Q-type Ca2+ channel activation and GSK3β inhibition. Acta Pharmacol Sin. 2012 May;33(5):594-605.




⑨.Yan-Kun Li, Fang Wang, Wei Wang, Yi Luo, Peng-Fei Wu, Jun-Li Xiao, Zhuang-Li Hu, You Jin, Gang Hu and Jian-Guo Chen. Aquaporin-4 Deficiency Impairs Synaptic Plasticity and Associative Fear Memory in the Lateral Amygdala: Involvement of Downregulation of Glutamate Transporter-1 Expression. Neuropsychopharmacology. 2012 Jul; 37(8):1867-78.




⑩.Bo Jiang, Zhe Xiong, Jun Yang, Wei Wang, Yue Wang, Zhuang-Li Hu, Fang Wang, Jian-Guo Chen. Antidepressant-like effects of ginsenoside Rg1 are due to activation of the BDNF signalling pathway and neurogenesis in the hippocampus. Br J Pharmacol. 2012 Jul;166(6):1872-87.




?.Xiong Z, Jiang B, Wu PF, Tian J, Shi LL, Gu J, Hu ZL, Fu H, Wang F, Chen JG. Antidepressant effects of a plant-derived flavonoid baicalein involving extracellular signal-regulated kinases cascade. Biol Pharm Bull. 2011; 34(2):253-9.




?.Yang J, Hu ZL, Jiang B, Ni L, Jin Y, Chen JG, Wang F. Effect of chloramine-T on long-term potentiation at synapses between perforant path and dentate gyrus in hippocampus of rats in vivo. Neurotoxicology. 2011 Mar; 32(2):199-205.




?.Wang W, Zheng LL, Wang F, Hu ZL, Wu WN, Gu J, Chen JG. Tanshinone IIA attenuates neuronal damage and the impairment of long-term potentiation induced by hydrogen peroxide. J Ethnopharmacol. 2011 Mar 8; 134(1):147-55.




?.Wang W, Wang F, Yang YJ, Hu ZL, Long LH, Fu H, Xie N, Chen JG. The flavonoid baicalein promotes NMDA receptor-dependent long-term potentiation and enhances memory. Br J Pharmacol. 2011 Mar; 162(6):1364-79.




?.Wang T, Yang YJ, Wu PF, Wang W, Hu ZL, Long LH, Xie N, Fu H, Wang F, Chen JG. Tetrahydroxystilbene glucoside, a plant-derived cognitive enhancer, promotes hippocampal synaptic plasticity. Eur J Pharmacol. 2011 Jan 10;650(1):206-14.




?.Yang YJ, Wu PF, Long LH, Yu DF, Wu WN, Hu ZL, Fu H, Xie N, Jin Y, Ni L, Wang JZ, Wang F, Chen JG. Reversal of Aging-Associated Hippocampal Synaptic Plasticity Deficits by Reductants via Regulation of Thiol Redox and NMDA Receptor Function. Aging Cell. 2010 Oct; 9(5):709-21.




?.Yang MJ, Wang F, Wang JH, Wu WN, Hu ZL, Cheng J, Yu DF, Long LH, Fu H, Xie N, Chen JG. PI3-k integrates the effects of insulin and leptin on large-conductance Ca2+-activated K+ channels in neuropeptide Y neurons of the hypothalamic arcuate nucleus. Am J Physiol Endocrinol Metab. 2010 Feb; 298(2):E193-201.




?.Li-Hong Long, Jue Liu, Rui-Li Liu, Fang Wang, Zhuang-Li Hu, Na Xie, Hui Fu, Jian-Guo Chen. Differential Effects of Methionine and Cysteine Oxidation on [Ca2+]i in Cultured Hippocampal Neurons. Cell Mol Neurobiol. 2009, 29(1):7-15.




?.Long LH, Liu RL, Wang F, Liu J, Hu ZL, Xie N, Jin Y, Fu H, Chen JG. Age-related alterations at hippocampal synapses and deficits in spatial memory in rats. Clin Exp Pharmacol Physiol. 2009 Jul; 36(7):675-81.




?.Liu J, Wang W, Wang F, Cai F, Hu ZL, Yang YJ, Chen J, Chen JG. Phosphatidylinositol-linked novel D(1) dopamine receptor facilitates long-term depression in rat hippocampal CA1 synapses. Neuropharmacology. 2009 Aug; 57(2):164-71.