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陈汇

陈汇，华中科技大学同济医学院基础医学院药理学系教授，博士生导师，系副主任。日本金泽医科大学访问学者。曾任华中科技大学同济医学院国家药品临床研究基地委员会副主任委员，临床药理教研室及研究室副主任，现任华中科技大学药物临床试验伦理委员会主任委员。




学术兼职：中国药理学会临床药理专业委员会副主任委员，中国药理学会药物代谢专业委员会委员，国际药物代谢学会（ISSX）会员，中国女医师协会心血管专业委员会委员，中华医学会医学伦理委员会委员，湖北省药理学会副理事长，武汉市药学会常务理事。《中国临床药理学杂志》、《中国药理学与毒理学杂志》、《中国药师》、《中国抗生素杂志》及《华中科技大学学报（医学版）》等杂志编委及审稿专家。




研究方向：临床药理学，药物代谢与动力学，肿瘤耐药及逆转机制，新药研究与评价




科研项目：




1.国家自然科学基金“随机环境下的药动学-药效学建模及其在白藜芦醇抗肿瘤多靶点效应中的研究”（**）




2.国家高技术研究发展计划“一类抗高血压新药盐酸非洛普的研究”（02AA 2Z3118）子课题“盐酸非洛普缓释制剂一期临床试验”




3.湖北省自然科学基金课题“中药对实验性动脉再狭窄保护作用机制研究”（03ABA133）




4.湖北省重点科技发展计划“蝙蝠葛碱类药代动力学与药效动力学相关性研究”（9911P1609）




5.华中科技大学科研基金“基于rhCYP3A4抑制作用的黄酮类化合物体外药代筛选3D-QSAR模型的建立”




6.新药研究：抗高血压一类新药盐酸非洛普缓释制剂临床耐受性及药代动力学研究；抗肺纤维化一类新药吡非尼酮临床前及临床药代动力学研究；比索洛尔氢氯噻嗪片临床药代动力学（桥接试验）研究等




成果及获奖：




获湖北省及武汉市科技成果各一项，获华中科技大学教学成果二等奖，指导七年制研究论文获湖北省大学生科研成果二等奖，指导研究生论文获湖北省自然科学优秀论文二等奖，研究论文获ISSX第二届亚太地区学术会议优秀论文奖等奖项。




教材及专著：




1. “十二五”国家规划教材《临床药理学》编委人民卫生出版社




2. “十二五”国家规划教材《临床药理学学习指导及习题集》编委人民卫生出版社




3. 《新编实用药物学》 编委科学出版社




发明专利：




咖伦宾在制备用于治疗2型糖尿病药物中的应用，专利号：ZL 2009 1 **.4.







主要论文：




1．Aimei Gao, Zunping Ke, Jianing Wang，Jianye Yang, Shiyou chen, Hui Chen*. Apigenin sensitizes doxorubicin-resistant hepatocellular carcinoma BEL-7402/ADM cells to doxorubicin via inhibiting PI3K/Akt/Nrf2 pathway. Carcinogenesis. 2013;34:1806-1814




2．Aimei Gao, Zunping Ke, Fang Shi, Hui Chen*. Chrysin enhances sensitivity of BEL-7402/ADM cell to doxorubicin by suppressing PI3K/Akt/Nrf2 and ERK/Nrf2 pathway. Chemico-Biological Interactions. 2013;206:100-108




3．Guanghui Huang, Jianping Wan, Hui Chen*. Density-based Monte Carlo filter and its applications in nonlinear stochastic differential equation models. Computers in Biology and Medicine. 2013;43:135-143




4．Xinxia Liu, Heng Zheng, Wei Tang, Zhenyu Qian, Yinsong Zhu,Jing Wang,Shiying Yuan, Xin Wen,Cuiing Cao, Hui Chen*. Development of a novel LC–MS/MS method for the determination of letosteine in human plasma and its application on pharmacokinetic studies. J Chromatogr B. 2011;879(25):2554-2560




5．Wei Tang, Xinxia Liu, Xiangjun Qiu, Shiying Yuan, Jing Wan, Hui Chen*. A simple and sensitive liquid chromatography method for the determination of low dihydrocodeine concentrations in human plasma: its application in Chinese healthy volunteers. Arzneimittelforschung. 2011;61(7):411-416




6．Wan Jianping, Zhang Kongsheng, Chen Hui. The bootstrap and Bayesian bootstrap method in assessing bioequivalence. Chaos,Solitons and Fractals. 2009;41:2246-2249




7．Libo Zhao, Shifen Gu, Rong Xu, Xiaoyu Cui, Fangliang Gan, Hui Chen*. Comparison of liquid chromatography-ultraviolet and chromatography-tandem mass spectrometry for the determination of indapamide in human whole blood and their applications in bioequivalence studies. Arzneimittelforschung. 2010;60(7):432-439




8．Libo Zhao, Xiaoyan Yang, Rong Xu, Jianhong Wu, Shifen Gu, Li Zhang, Peili Gong, Hui Chen*, Fandian Zeng. Safety, tolerability and pharmacokinetics of phenoprolamine hydrochloride floating sustained-release tablets in healthy Chinese subjects. International Journal of Pharmaceutics. 2009:377: 99–104




9．Zhao Li-bo, Hu Jiong, Chang Qing, Ke Qiu-lin, Xu Rong, Gu Shi-fen, Chen Hui* and Zeng Fan-dian. A simple and sensitive HPLC method for quantitation of low phenoprolamine hydrochloride concentrations in human plasma and its pharmacokinetic application. Biomed Chromatogr. 2008; 22(3):333




10． Xu Ke, Hui Chen*, Rong Xu, Fan-dian Zeng. Pharmacokinetics of the combination hydrochlorothiazide and bisoprolol tablet in Chinese healthy young male and female volunteers. Asian J pharmacodynamics and pharmacokinetics 2008;8(2):131




11． Shi Shao-jun, Wu Jian-hong, Chen Hua-ting, Chen Hui, Wu Jun, Zeng Fan-dian. Single- and multiple-dose pharmacokinetics of pirfenidone, an antifibrotic agent, in healthy Chinese volunteers. J Clin Pharmacol. 2007;47(10):1268-76




12． Shi Shao-jun, Chen Hui, Zeng Fan-dian. Pharmacokinetic- pharmacodynamic modeling of daurisoline and dauricine in beagle dogs. Acta Pharmacol Sin 2003;24(10):1011










会议论文：




1.Kang sisi, Liu Xinxia, Ma Chang,Chen Hui*. Effect of resveratrol on RUNX3 gene in B16F10 murine melanoma cell. The 12th Meeting of the Asia Pacific Federation of Pharmacologists. July 9-13,2013




2.Gao Xiujuan, Wan Jianping, Chen Hui*. A stochastic differential equations based PK-PD model applied in the clinical medication of cyclosporin A. 4th ISSX/CSSX Joint Workshop May 17-19,2013




3.Ai-Mei GAO, Zun-Ping KE, Xuan-Bin WANG, Jia-Ning WANG, Hui CHEN*. Apigenin enhances sensitization of BEL-7402/ADM cells to therapeutic drugs via inhibiting PI3K-AKT/Nrf2/ARE pathway. Chin J Pharmacol Toxicol. 26(5):731,2012, The Second World Conference on the Pharmacology of Natural and Traditional Medicines, Macau, China, Nov.06-08,2012




4.ZHU Yin-Song, LIU Xin-Xia, KANG Si-Si, MA Chang, CHEN Hui*. Identification of the metabolites of trans-resveratrol in melanoma mice. 3th ISSX/CSSX Meeting. Sep.21-24,2012




5.Guan Chang-rong, Ren Ping, Hu Jiong, Gu Shi-fen Chen Hui*. Effects of Dauricine on Hepatic Drug Metabolizing Enzymes in Rats. Drug Metabolism Reviews. 40 (Suppl 2), 2nd Asian Pacific Regional ISSX Meeting, May.11-13 2008