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叶笃筠

叶笃筠 病理生理学教授，博士生导师，1982年毕业于武汉医学院（学士），1987年毕业于暨南大学医学院（硕士）。1989-1991年西德自由大学访问学者。主持多项国家自然科学基金、卫生部和省市科研课题。主要从事炎症、子痫前期和肿瘤发病机制研究。所带博士研究生的毕业论文已分别在《自然—通讯》（Nature Communications）、Oncogene等杂志发表。多位毕业后分别赴美国哈佛大学、尤他州大学、英国帝国理工大学、德国马普（Max Planck Institute， MPI）等世界一流实验室从事博士后科学研究工作，其成果已在《免疫》（immunity）等杂志发表。部分毕业生已作为高端人才被国内其它高校引进，有的已担任行政领导。大多数毕业生均在国内高校从事教学或临床工作，多位老师已主持两项以上国家自然科学基金课题。




1.Ruihua Ma, Wanguang Zhang, Ke Tang, Huafeng Zhang, Yi Zhang, Dapeng Li, Yong Li, Pingwei Xu, Shunqun Luo, Wenqian Cai, Tiantian Ji, Foad Katirai, Duyun Ye, Bo Huang Switch of glycolysis to gluconeogenesis by dexamethasone for treatment of hepatocarcinoma Nature Commun. 2013Oct 22. DOI:




doi:10.1038/ncomms3508




2.KeTang,Yi Zhang,Huafeng Zhang,PingweiXu,Jing Liu,Jingwei Ma,Meng LvDapeng Li,Foad Katirai,Guan-Xin Shen,Guimei Zhang,Zuo-Hua Feng,Duyun Ye& Bo Huang Delivery of chemotherapeutic drugs in tumour cell-derived microparticles Nature Commun. 2012 Dec 18;3:1282. .




3. Li Y, Ye D Molecular biology for formyl peptide receptors in human diseases．J Mol Med (Berl). 2013 Feb 13. [Epub ahead of print] PMID: **




4. Jing Xiong , Pan Zeng, Xue Cheng, Sen Miao, Le Wu, Sheng Zhou,Ping Wu and Duyun YeLipoxin A4 blocks embryo implantation by controlling estrogen receptor α activity .the Journal of Society for Reproduction and Fertility 2013 ;145(4):411-20.




5. Zhangye Xu,Jie Zhao,Huafeng Zhang, Tang Ke,Pingwei Xu,Wenqian Cai,Foad Katirai, Duyun Ye,Yingping Huang and Bo Huang Spontaneous Miscarriages Are Explained by the Stress/ Glucocorticoid/Lipoxin A4 Axis The Journal of Immunology 2013 vol. 190 no. 12 6051




6. F. Lin,X. Yu,X. Zhang,Y. Guo, Y. Huang,J. Zhou, P. Zeng,D. Ye,Y. Huang A synthetic analog of lipoxin A4 partially alleviates dexamethasone-induced fetal growth restriction in rats placenta,vol.34, October 2013, Pages 941–948




7.Feng Lin, Pan Zeng,Zhangye Xu, Duyun Ye, Xiaofang Yu, Ni Wang, Jie Tang, Ye Zhou, Yinping Huang, Treatment of Lipoxin A4 and its analogue on low-dose endotoxin induced preeclampsia in rat and possible mechanisms Reproductive Toxicology 2012 PMID:**




8. Wu L, Miao S, Zou LB, Wu P, Hao H, Tang K, Zeng P, Xiong J, Li HH, Wu Q, Cai L, Ye DY. Lipoxin A(4) Inhibits 5-Lipoxygenase Translocation and Leukotrienes Biosynthesis to Exert a Neuroprotective Effect in Cerebral Ischemia/Reperfusion Injury. J Mol Neurosci. (2012) 48:185–200 PMID:**




9.Shengxing Zheng, Qian Wang, Qian He, Duyun Ye, Fang Gao, Shengwei Jin and Qing Quan Li An novel biphasic role of lipoxin A4 on expression of cyclooxygenase-2 in Lipopolysaccharide -stimulated lung fibroblasts Mediators Inflamm. 2011;:745340. Epub 2011 Jul 2. PMID: **




10.Hao H,Liu M,Wu P,Cai L,Tang K,Yi P,Li Y,Chen Y,Ye D Lipoxin A4 and its analog suppress hepatocellular carcinoma via remodeling tumor microenvironment Cancer lett.2011 85-94 Jun 14 PMID:**




11.Pang H, Yi P, , Wu P, Liu Z, Liu Z, Gong J, Hao H, Cai L, Ye D, Huang Y Effect of lipoxin a4 on lipopolysaccharide-induced endothelial hyperpermeability ScientificWorldJournal. 2011 May 5;11:1056-67. PMID:**

12.Y Li ,L Cai ,H Wang , P Wu ,W Gu ,Y Chen , H Hao ,K Tang ,P Yi ,M Liu ,S Miao and D Ye Pleiotropic regulation of macrophage polarization and tumorigenesis by formyl peptide receptor-2 Oncogene 2011 Mar 28. PMID: **(IF 6.373)




13.Xiong, J., Zeng, P., and Ye, D. Lipoxins: a novel regulator in embryo implantation. ScientificWorldJournal. 2011 Jan 18;11:235-41. PMID: **




14.Zhang B, Jia H, Liu J, Yang Z, Jiang T, Tang K, Li D, Huang C, Ma J, Shen GX Ye D, Huang B. Depletion of Regulatory T Cells Facilitates Growth of Established Tumors: A Mechanism Involving the Regulation of Myeloid-Derived Suppressor Cells by Lipoxin A4 J Immunol. 2010 Dec 15;185(12):7199-206.




15.Tang K, Liu J, Yang Z, Zhang B, Zhang H, Huang C, Ma J, Shen GX, Ye D, Huang B Microparticles mediate enzyme transfer from platelets to mast cells: A new pathway for lipoxin A4 biosynthesis. Biochem Biophys Res Commun. 2010 Sep 24;400(3):432-6.




16.Li Y, Ye D. Cancer Therapy By Targeting Hypoxia-Inducible Factor-1. Curr Cancer Drug Targets. 2010 Jun 25. 10(4)782-6




17.Chen Y, Hao H, He S, Cai L, Li Y, Hu S, Ye D, Hoidal J, Wu P, Chen X. Lipoxin A4 and its analogue suppress the tumor growth of transplanted H22 in mice: the role of antiangiogenesis. Mol Cancer Ther. 2010 Aug;9(8):2164-74.




18.Zhou XY, Li YS, Wu P, Wang HM, Cai ZY, Xu FY, Ye DY. Lipoxin A inhibited hepatocyte growth factor-induced invasion of human hepatoma cells. Hepatol Res. 2009 Apr 23




19.Xu LM, Jin SW, Zhou XY, Wu P, Li YS, Zhang L, Lin YY, Chen Y, Ye DY Effects of exogenous annexin-1 on lipopolysaccharide -induced proliferation and reactive oxygen species production partially through modulation of CRAC channels but independent of NF-kappaB pathway. Inflamm Res. 2009 Dec;58(12):921-30. Epub 2009 Aug 15.




18.Songjun Liu Ping Wu Duyun Ye Yinping Huang Xiaoyan Zhou Yongsheng Li Lei Cai. Effects of Lipoxin A(4) on CoCl(2)-Induced Angiogenesis and Its Possible Mechanisms in Human Umbilical Vein Endothelial Cells. Pharmacology. 2009 May 28;84(1):17-23.




19.Li YS, Wu P, Zhou XY, Chen JG, Cai L, Wang F, Xu LM, Zhang XL, Chen Y, Liu SJ, Huang YP, Ye DY. Formyl-peptide receptor like 1: a potent mediator of the Ca2+ release-activated Ca2+ current ICRAC.Arch Biochem Biophys. 2008 Oct 1;478(1):110-8




20.Zhang L, Zhang X, Wu P, Li H, Jin S, Zhou X, Li Y, Ye D, Chen B, Wan J. BML-111, a lipoxin receptor agonist, modulates the immune response and reduces the severity of collagen-induced arthritis.Inflamm Res. 2008 Apr;57(4):157-62..




21.Li Y, Zhou X, Ye D. Molecular beacons: an optimal multifunctional biological probe.Biochem Biophys Res Commun. 2008 Sep 5;373(4):457-61. Epub 2008 May 19. Review.




22.Wu LH, Xu SJ, Teng JY, Wu W, Ye DY, Wu XZ. Differential response of human fetal smooth muscle cells from arterial duct to retinoid acid.Acta Pharmacol Sin. 2008 Apr;29(4):413-20.




23.Li G, Wu P, Xu Y,Yu Y,Sun L,Zhu L,Ye D The effect of Lipoxin A4 on the interaction between macrophage and osteoblast: possible role in the treatment of aseptic loosening BMC Musculoskelet Disord. 2009 Jun 2;10:57.




24.Zhou XY, Wu P, Zhang L, Xiong W, Li YS, Feng YM, Ye DY. Effects of lipoxin A(4) on lipopolysaccharide induced proliferation and reactive oxygen species production in RAW264.7 macrophages through modulation of G-CSF secretion. Inflamm Res. 2007 Aug;56(8):324-33.




25.Zhang L, Wu P, Jin SW, Yuan P, Wan JY, Zhou XY, Xiong W, Fang F, Ye DY.Lipoxin A4 negatively regulates lipopolysaccharide-induced differentiation of RAW264.7 murine macrophages into dendritic-like cells.Chin Med J (Engl). 2007, 120(11):981-7.




26.Jin SW, Zhang L, Lian QQ, Liu D, Wu P, Yao SL, Ye DY. Posttreatment with aspirin-triggered lipoxin A4 analog attenuates lipopolysaccharide-induced acute lung injury in mice: the role of heme oxygenase-1. Anesth Analg. 2007 Feb;104(2):369-77.




27.Wu P, Zhang L, Zhou X, Li Y, Zhang D, Wan J, Ye D. Inflammation pro-resolving potential of 3,4-dihydroxyacetophenone through 15-deoxy-delta12,14 –prosta－ glandin J2 in murine macrophages. Int Immunopharmacol. 2007 Nov; 7(11):1450-9.




28.Zhang L, Wan J, Li H, Wu P, Jin S, Zhou X, Yuan P, Xiong W, Li Y, Ye D . Protective effects of BML-111, a lipoxin A(4) receptor agonist, on carbon tetrachloride-induce d liver injury in mice. Hepatol Res. 2007 Nov;37 (11):948-56.




29.Jin SW, Zhang L, Lian QQ, Yao SL, Wu P, Zhou XY, Xiong W, Ye DY. Close functional coupling between Ca2+ release-activated Ca2+ channels and reactive oxygen species production in murine macrophages. Mediators Inflamm. 2006;2006(6):36192.




30.Zhen H, Fang F, Ye DY, Shu SN, Zhou YF, Dong YS, Nie XC, Li G . Experimental study on the action of allitridin against human cytomegalovirus in vitro: Inhibitory effects on immediate-early genes. Antiviral Res. 2006 Oct;72(1):68-74. Epub 2006 Apr 27




31.Wu P, Ye D, Zhang D, Zhang L, Wan J, Pan Q. Dual effect of 3,4-dihydroxyacetophenone on LPS-induced apoptosis in RAW264.7 cells by modulating the production of TNF-alpha. J Huazhong Univ Sci Technolog Med Sci. 2005;25(2):131-4.




32.Huang Y, Ye DY, Wu P, Huang Y, Zhang L, Zhou X, Huang Y, Yuan P, Zhang D, Wan J. Expression of cyclooxygenase-2 mRNA and identification of its splice variant in human myometrium obtained from women in labor. J Huazhong Univ Sci Technolog Med Sci. 2005;25(1):5-7.




33.Zhou YF, Fang F, Fu JR, Dong YS, Ye DY, Shu SN, Zhen H, Li G. An experimental study on astrocytes promoting production of neural stem cells derived from mouse embryonic stem cells.Chin Med J (Engl). 2005 Dec 5;118(23):1994-9.




主要承担科研课题




国家自然科学基金




炎症“刹车”因子：脂氧素在子痫前期发病中的作用及其机制研究

2011－2013

负责人（合作项目）

正在进行




脂氧素与粒细胞集落刺激因子介导T细胞耐受作用及其机制异同性和关联性研究

2008－2010

负责人

已结题




脂氧素功能新现：缘自其负性免疫调节？

2006－2008

负责人

已结题




COX-2及其剪接异构体的表达对大鼠移植心脏存活的影响

2004－2006

主要参与者

已结题




抗炎中药对巨噬细胞TOLL基因表达调控机制研究

2003－2005

主要参与者

已结题




几种抗炎中西药对巨噬细胞NO/CO调控机制的异同性研究

2002－2004

主要参与者

已结题




几种消炎中药对炎症过程中PGs生成的影响及其机制

2001－2003

负责人

已结题







卫生部科研课题和湖北省自然科学基金




用炎症缓解新说诠释几种清热解毒中药的“清解”机制

2006－2007

负责人

已结题




参麦注射液对肺缩容术后膈肌功能影响，卫生部基金，，

1999—2001

负责人