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黄波

黄波，湖北京山人。湖北京山人。




教育背景




1985-1988 湖北荆州中学， 高中




1988-1993 湖北医科大学， 医学学士




1996-1999 同济医科大学，生物化学与分子生物学硕士




1999-2002.5华中科技大学同济医学院，生物化学与分子生物学博士




工作经历




1993-1996 武汉科技大学医学院，助教




2002.5-2002. 12 瑞典卡罗琳斯卡医学院，博士后研究




2003.1-2002. 7加拿大卡尔加里大学医学院，博士后研究




2003.8-2006. 2纽约西奈山医学院，博士后研究




2006.3-2008.10华中科技大学同济医学院，副教授




2008.11-华中科技大学同济医学院， 教授




研究兴趣




1.肿瘤研究：采用多种手段和模型研究抗肿瘤免疫、肿瘤免疫逃逸的细胞和分子机制；肿瘤炎症微环境塑造的相关机制；以及肿瘤侵袭转移的细胞和分子机制。通过以上研究，希望发展新的抗肿瘤药物。




2.免疫相关疾病的研究：联合临床皮肤科，进行皮肤免疫相关机制和治疗研究；采用多种动物模型研究哮喘、食物过敏等变态反应性疾病的免疫学相关机制；自身免疫性疾病如风湿性关节炎炎性机制；与临床合作进行临床基础研究。研究目标为将上述研究转化为临床应用。




3.microRNA与肿瘤以及免疫：联合分子生物学和其它手段，研究microRNA对肿瘤以及免疫的作用机制，以及microRNA在肿瘤和免疫细胞间的转移。




4.从氧化还原反应以及氧自由基和能量代谢角度出发，研究免疫反应和炎症。










主要发表的论文（*为通信作者）：




1.Jing Liu, Jie Zhao, Yuchun Cao, Bo Huang*. Low Dosages: new chemotherapeutic weapons on the battlefield of immune-related diseases. Cell Mol Immunol. 2011; in press




2.Jing Liu, Yi Zhang, Jie Zhao, Zhuoshun Yang, Dapeng Li, Foad Katirai, Bo Huang*. Mast cell: insight into remodeling a tumor microenvironment. Cancer Metastasis Rev. 2011; [Epub ahead of print]




3.Biao Zhang, Haibo Jia, Jing Liu, Zhuoshun Yang, Tao Jiang, Ke Tang, Dapeng Li, Chunmei Huang, Jingwei Ma, Guan-Xin Shen, Duyun Ye, Bo Huang*. Depletion of T regulatory cells facilitates growth of established tumors: a mechanism involving the regulation of myeloid-derived suppressor cells by lipoxin A4. J Immunol. 2010;185:7199-206.




4.Jie Zhao, Yuchun Cao, Zhang Lei, Zhuoshun yang, Biao Zhang, Bo Huang*. Selective Depletion of CD4+CD25+Foxp3+ Regulatory T Cells by Low-Dose Cyclophosphamide Is Explained by Reduced Intracellular ATP Levels. Cancer Res. 2010;70:4850-8.




5.Yu Zhou, Shuo Wang, Jing-Wei Ma, Zhang Lei, Hui-Fen Zhu, Ping Lei, Zhuo-Shun Yang, Biao Zhang, Xin-Xin Yao, Chuan Shi, Li-Fang Sun, Xiong-Wen Wu, Qin Ning, Guan-Xin Shen*, Bo Huang*. HBx-induced expression of the CXC chemokine IP-10 is mediated through activation of NF-kappaB and increases migration of leukocytes. J Biol Chem, 2010;285:12159-68.




6.Zhuoshun Yang, Biao Zhang, Dapeng Li, Meng Lv, Chunmei Huang, Guan-Xin Shen, Bo Huang*. Mast cells mobilize myeloid-derived suppressor cells and Treg cells in tumor microenvironment via IL-17 pathway in murine hepatocarcinoma model. PLoS One. 2010;5:e8922.




7.Lei Z, Li B, Yang Z, Fang H, Zhang GM, Feng ZH, Huang B *. Regulation of HIF-1alpha and VEGF by miR-20b tunes tumor cells to adapt to the alteration of oxygen concentration. PLoS One. 2009;4:e7629.




8.Jie Zhao, Zhang Lei Yanyan Liu, Bo Li, Liang Zhang, Haoshu Fang, Chuanwang Song, Xiaomei Wang, Gui-Mei Zhang, Zuo-Hua Feng, Bo Huang*. Human Pregnancy Upregulates Tim-3 in Innate Immune Cells for Systemic Immunity. J Immunol. 2009;182:6618-24.




9.Bo Huang *, Jie Zhao, Zhang Lei, Shiqian Shen, Dong Li, Guan-Xin Shen, Gui-Mei Zhang, Zuo-Hua Feng*. miR-142-3p Regulates cAMP Production in T cells by Targeting Adenylyl Cyclase 9 mRNA. EMBO Rep. 2009;10:180-5.




10.Chuanwang Song, Liqiong Luo, Zhang Lei, Bo Li, Zhihui Liang, Guanghui Liu, Dong Li, Guimei Zhang, Bo Huang *, Zuo-Hua Feng*. IL-17-producing alveolar macrophages mediate allergic lung inflammation related to asthma. J Immunol. 2008;181:6117-24.




11.Yuchun Cao, Jie Zhao, Bo Huang*. Response to Comment on "Local Accumulation of FOXP3+ Regulatory T Cells: Evidence for an Immune Evasion Mechanism in Patients with Large Condylomata Acuminata". J Immunol, 2008 181: 4433-4.




12.Bo Huang*，Zhang Lei, Gui-Mei Zhang, Dong Li, Chuanwang Song, Bo Li, Yanyan Liu, Ye Yuan, Jay Unkeless, Huabao Xiong, Zuo-Hua Feng*. SCF-mediated mast cell infiltration and activation exacerbate the inflammation and immunosuppression in tumor microenvironment. Blood, 2008;112:1269-79.




13.Yuchun Cao, Jie Zhao, Zhang Lei, Shiqian Shen, Cong Liu, Dong Li, Jihong Liu, Guan-Xin Shen, Gui-Mei Zhang, Zuo-Hua Feng, Bo Huang*. Local Accumulation of FOXP3+ Regulatory T Cells: Evidence for an Immune Evasion Mechanism in Patients with Large Condylomata Acuminata. J Immunol, 2008;180:7681-6.

14.Bo Huang*，Jie Zhao, Jay Unkeless, Zuo-Hua Feng, Huabao Xiong. TLR signaling by tumor and immune cells: a double-edged sword. Oncogene, 2008;27:218-24.




15.Bo Huang, Jie Zhao, Shiqian Shen, Hongxing Li, Kai-Li He, Guan-Xin Shen, Lloyd Mayer, Jay Unkeless, Dong Li, Ye Yuan, Gui-Mei Zhang, Huabao Xiong, Zuo-Hua Feng. Listeria monocytogenes promotes tumor growth via tumor cell Toll-like receptor 2 signaling. Cancer Res, 2007;67:4346-52.




16.Bo Huang, Ping-Ying Pan, Qingsheng Li, Alice I. Sato, David E Levy, Jonathan Bromberg, Celia M Divino, Shu-Hsia Chen. Gr-1+CD115+ immature myeloid suppressor cells mediate the development of tumor specific T regulatory cell and T cell anergy. Cancer Res, 2006; 66:1123-31.




17.Bo Huang, Jie Zhao, Hongxing Li, Kaili He, Yibang Chen, Lloyd Mayer, Jay C.Unkeless, Huabao Xiong. Toll like receptor(TLR) on tumor cells facilitate evasion of immune surveillance. Cancer Res, 2005; 65:5009-14.