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朱峰

朱峰，男，1968年7月出生， M.D., Ph.D. “楚天学者”特聘教授。1993年，毕业于第四军医大学，获学士学位，1996年，获第四军医大学生物化学专业硕士学位，1999年获第四军医大学生物化学专业博士学位，1999-2000，第四军医大学 生物化学教研室任教，2000-2001年，Institute of Molecular and Cellular Biology, Singapor e 访问学者，2001-2002，超英生物，2002-2013，Hor mel Institute, University of Minnesota，Postdoctor al Fellow，Resear ch Assistant Pr ofessor， Resear ch Associate Pr ofessor。共发表文章90余篇










研究领域：肿瘤相关的新激酶的功能研究；肿瘤标志物；肿瘤细胞的信号转导。










主要发表文章：










1. The TOPK/PRPK/Survivin Signaling Axis Promotes Colorectal Cancer Metastasis. Zykova TA*, Zhu F*, Wang L*, Li HT*, Ma WY, Bode AM, Dong Z. (Submitted to Gut. Under Review).




2. TRAF4 is a critical molecule for Akt activation in lung cancer W Li, C Peng, MH Lee, F Zhu, Y Fu, G Yang, Y Sheng… - Cancer research, 2013 – AACR




3. Select Dietary Phytochemicals Function as Inhibitors of COX-1 but Not COX-2




H Li, F Zhu, Y Sun, B Li, N Oi, H Chen, RA Lubet… - PloS one, 2013




4. Aspirin tale: Inhibiting EGFR on transcription level through AP-1 by Targeting Cox-2. Li HT*, Zhu F*, Ma WY, Bode AM, Dong Z. (Submitted to Nature. Under Review).




5. Ceftriaxone, an FDA-approved cephalosporin antibiotic, suppresses lung cancer growth by targeting Aurora B. Li X*, Li H*, Li S*, Zhu F*, Kim DJ, Xie H, Li Y, Nadas J, Oi N, Zykova TA, Yu DH, Lee MH, Kim MO, Wang L, Ma W, Lubet RA, Bode AM, Dong Z, Dong Z. Carcinogenesis. 2012 Dec;33(12):2548-57.




6. Identification of an aurora kinase inhibitor specific for the aurora B isoform. Xie H*, Lee MH*, Zhu F*, Reddy K, Peng C, Li Y, Lim do Y, Joon Kim D, Li X, Kang S, Li H, Ma W, Lubet RA, Ding J, Bode AM, Dong Z. Cancer Res. 2013 Jan 15;73(2):716-24.




7. Identification of mammalian target of rapamycin (mTOR) as a direct target of fenretinib both in vitro and in vivo. Xie H*, Zhu F*, Huang ZN, Lee MH, Li X, Lim DY, Jung SK, Kang S, Li HT, Reddy T, Ma W, Lubet RA, Bode AM, Dong Z. Carcinogenesis. 2012 Sep;33(9):1814-21..




8. Zhu F, Zykova TA, Kang BS, Wang Z, Bode AM, Dong Z. (2007). “Bidirectional Signals Transduced by TOPK–ERK Interaction Promote Transformation in HCT116 Colorectal Cancer Cells” Gastroenterology, 2007 133(1):219-31. (Co-first authors)




9. Zhu F*, Zykova TA*, Peng C, Cho YY, Zhang JS, Zheng D, Yao K, Law A, Ma WY, Bode AM, Dong Z. “Phosphorylation of H2AX at Ser 16 and Ser 139 by RSK2 promotes the ability of




H2AX to inhibit cell transformation via decreased H2AX ubiquitination.”.Cancer Res. 2011 Jan 15;71(2):393-403




10. Li S*, Zhu F*, Zykova TA*, Zhang JS, Ma WY, Bode AM, Dong Z. “TOPK can inhibit inflammation induced by solar UV through phosphorylating MKP1” 2011J Biol Chem. 2011 Aug 26;286(34):29601-9. (* Co- fir st author s)




11. Zhang JS*, Zhu F*, Zykova TA, Ma WY, Bode AM, Dong Z. “Inhibition of cell transformation by Rack1 by regulating c-Jun stability.” Oncogene. 2012 Apr 5;31(14):1835-44. (* Co- fir st author s)




12. Li X*, Wen WH*, Liu KD*, Zhu F*, Malakhova M, Peng C, Kim HG, Ma WY, Cho YY, Bode A, Dong ZM, and Dong Z “Phosphorylation of caspase-7 by P21-Activated Protein Kinase (PAK)-2 inhibit staurosporine induced apoptosis of MCF-7 cells” J Biol Chem. 2011 May 9. [Epub ahead of print] (* Co-fir st authors)




13. Li S*, Bode AM*, Zhu F*, Zhang JS, Ma WY, Dong Z. TRPV1 antagonist AMG9810 promotes mouse skin tumorigenesis through EGFR/Akt signaling. Carcinogenesis. 2011May;32(5):779-85. (* Co- fir st author s)




14. Zykova TA*, Zhu F*, Peng C, Cho YY, Zhang JS, Ma WY, Bode AM, Dong Z. “Phosphorylation of Prx-1 by TOPK prevent apoptosis induced by UVB.” J Biol Chem. 2010Sep 17;285(38):29138-46 (* Co-fir st author s)




15. Li TT*, Zhang JS*, Zhu F*, Wen WH, Zykova TA, Liu KD, Li X, Bode A, Dong Z. “Phosphorylation of c-Jun by Pak2 at Threonine sites promotes JB6 Cl41 cell transformation induced by EGF. Carcinogenesis. 2011 May;32(5):659-66. (* Co-fir st author s).




16. Zhu F, Choi BY, Ma WY, Zhao ZL, Zhang YG, AM, Dong Z. (2006). “CSK-Mediated C-Jun Phosphorylation Promotes Its Degradation and Inhibits Cell Transformation Caused by C-Jun.” Cancer Res. 2006 66(11):5729-36. E dit or’ highlight




17. Zhu F, Zhang Y, Bode AM, Dong Z.(2004). “Involvement of ERKs and Mitogen- and Stress- activated Protein Kinase in UVC-induced Phosphorylation of ATF-2.” Carcinogenesis, 200425(10):1847-52.




18. Zykova TA, Zhu F, Bode AM, Dong Z. (2006). “Phosphorylation of Histone H2AX by TOPK Inhibits As3+ Induced Apoptosis In RPMI7951 Melanoma Cell Lines.” Clin Cancer Res. 2006 12(23):6884-93. E d itor ’ h igh ligh t (Co-first authors)




19. Lu C, Zhu F, Cho YY, Tang F, Zykova T, Ma WY, Bode AM, Dong Z. (2006). “Cell Apoptosis: Requirement of H2AX in DNA Ladder Formation, But Not for the Activation of Caspase-3.” Mol Cell. 2006 23(1):121-32.




20. Choi BY, Choi HS, Ko K, Cho YY, Zhu F, Kang BK, Svetlana E, Ma WY, AM, Dong Z. (2005) “The Tumor Suppressor, p16INK4a Prevents Cell Transformation Through Inhibition Of C-Jun Phosphorylation And AP-1 Activity.” Nat Struct Mol Biol. 2005 12(8):699-707.




21. Knockdown of RNF2 induces apoptosis by regulating MDM2 and p53 stability.Wen W, Peng C, Kim MO, Ho Jeong C, Zhu F, Yao K, Zykova T, Ma W, Carper A, Langfald A, Bode AM, Dong Z Oncogene. 2013 Jan 14. doi: 10.1038/onc.2012.605. [Epub ahead of print]




22. TRAF2 is a key mediator of the EGF-induced RSK2/CREB/Fos signaling pathway. Peng C, Zhu F, Wen W, Yao K, Li S, Zykova T, Liu KD, Li X, Ma WY, Bode AM, Dong Z. J Biol Chem. 2012 Jun 8. [Epub ahead of print]




23. Li J, Zhu F, Lubet RA, De Luca A, Grubbs C, Ericson ME, D'Alessio A, Normano N, Dong Z, Bode AM. “Quercetin-3-methyl ether inhibits lapatinib-sensitive and -resistant breast cancer cell growth by inducing G(2) /M arrest and apoptosis.” Mol Carcinog. 2011 Nov 15. doi: 10.1002/mc.21839.




24. Li J, Malakhova M, Mottamal M, Reddy K, Kurinov I, Carper A, Langfald A, Oi N, Kim MO, Zhu F, Sosa CP, Zhou K, Bode AM, Dong Z.” Norathyriol suppresses skin cancers induced by solar ultraviolet radiation by targeting ERK kinases.” Cancer Res. 2012 Jan 1;72(1):260-70. Epub 2011 Nov 14.




25. Li J, Mottamal M, Li H, Liu K, Zhu F, Cho YY, Sosa CP, Zhou K, Bowden GT, Bode AM, Dong Z.” Quercetin-3-methyl ether suppresses proliferation of mouse epidermal JB6 P+ cells by targeting ERKs.” Carcinogenesis. 2012 Feb;33(2):459-65.




26. Xu YM, Zhu F, Zykova TA, Zhang JS, Ma WY, Bode AM, Dong Z. “Extracellular signal- regulated kinase 8-mediated c-Jun phosphorylation increases tumorigenesis of human colon cancer” Cancer Res. 2010 70(8):3218-27.




27. Peng C, Cho YY, Zhu F, Zykova TA, Zhang JS, Ma WY, Bode AM, Dong Z. “Phosphorylation of Caspase 8 by RSK2 promotes its degradation.” J Biol Chem. 2011 Mar 4;286(9):6946-54.




28. Law A, Zheng D, Zhu F, Zykova TA, Zhang JS, Ma WY, Bode AM, Dong Z. “Regulation of




Histone H2B by Mst1.” J Biol Chem. 2011 Jul 29;286(30):26628-37




29. Wen WH, Zhu F, Zykova TA, Zhang JS, Ma WY, Bode AM, Dong Z. “Phosphorylation of




Histone H2AX by Mst1 regulates cell apoptosis.” J Biol Chem. 2010 Dec 10;285(50):39108-16.




30. Zykova TA, Zhu F, Zhai X, Ermakova SP, Lee KW, Bode AM, Dong Z. Resveratrol directly targets COX-2 to inhibit carcinogenesis. Mol Carcinog. 2008 47(10):797-805.




31. Zykova TA, Zhu F, Zhang Y, Bode AM, Dong Z. (2007). “ERK2 and RSK2 Mediate Phosphorylation of PKR (Thr451) and PKR Directly Catalyzes the Phosphorylation of eIF2??at Ser51.” Carcinogenesis. 2007 28(7):1543-51.




32. Sang-Muk Oh, Zhu F, Yong-Yeon Cho, Ki Won Lee, Bong Seok Kang, Hong-Gyum Kim, Tatyana Zykova, Ann M. Bode, and Zigang Dong. (2007). “T-LAK Cell-Originated Protein Kinase (TOPK) Functions as a Positive Regulator of JNK1 Signaling and H-Ras-Induced Cell Transformation.” Cancer Res. 2007 67(11):5186-94.




33. Ewing SJ, Zhu S, Zhu F, House JS, Smart RC. (2008) “C/EBPbeta represses p53 to promote cell survival downstream of DNA damage independent of oncogenic Ras and p19(Arf).” Cell Death Differ. 2008 Nov;15(11):1734-44.




34. Deterding LJ, Williams JG, Humble MM, Petrovich RM, Wei SJ, Trempus CS, Gates MB, Zhu F, Smart RC, Tennant RW, Tomer KB.” CD34 Antigen: Determination of Specific Sites of Phosphorylation In Vitro and In Vivo.” Int J Mass Spectrom. 2011 Mar 30;301(1-3):12-21.




35. Bode AM, Cho YY, Zheng D, Zhu F, Ericson ME, Ma WY, Yao K, Dong Z. (2009) “Transient receptor potential type vanilloid 1 suppresses skin carcinogenesis.” Cancer Res. 2009 69(3):905-13.




36. Zheng D, Bode AM, Zhao Q, Cho YY, Zhu F, Ma WY, Dong Z.(2008) “The cannabinoid receptors are required for ultraviolet-induced inflammation and skin cancer development.” Cancer Res. 2008 68(10):3992-8.




37. Cho YY, Tang F, Yao K, Lu C, Zhu F, Zheng D, Pugliese A, Bode AM, Dong Z.(2009) “Cyclin- dependent kinase-3-mediated c-Jun phosphorylation at Ser63 and Ser73 enhances cell transformation.” Cancer Res. 2009 69(1):272-81.




38. Li M, He Z, Ermakova S, Zheng D, Tang F, Cho YY, Zhu F, Ma WY, Sham Y, Rogozin EA, Bode AM, Cao Y, Dong Z. (2007). “Direct Inhibition of Insulin-Like Growth Factor-I Receptor Kinase Activity by (-)-Epigallocatechin-3-Gallate Regulates Cell Transformation.” Cancer Epidemiol Biomarkers Prev. 2007 16(3):598-605.




39.Mizuno H, Cho YY, Zhu F, Ma WY, Bode AM, Yang CS, Ho CT, Dong Z. (2006). “Theaflavin-3,




3’-DigallateInducesEpidermalGrowthFactorReceptorDownregulation.Mizuno.”Mol Carcinog. 2006 45(3):204-12.




40. Zhao Q, He Z, Chen N, Cho YY, Zhu F, Lu C, Ma WY, Bode AM, Dong Z. (2005). “2- Arachidonoylglycerol Stimulates AP-1-Dependent Transcriptional Activity And Enhances EGF- Induced Cell Transformation In JB6 P+ Cells.” J Biol Chem. 2005 280(29):26735-42.




41. Cho YY, He Z, Zhang Y, Choi HS, Zhu F, Choi BY, Kang BS, Ma WY, Bode AM, Dong Z. (2005). “The p53 Protein Is A Novel Substrate Of Ribosomal S6 Kinase 2 and a Critical Intermediary for Ribosomal S6 Kinase 2 and Histone H3 Interaction.” Cancer Res. 2005 65(9):3596-603.




42.Choi HS, Choi BY, Cho YY, Zhu F, Bode AM, Dong Z. (2005). “Phosphorylation of Ser28 In Histone H3 Mediated By Mixed Lineage Kinase-Like Mitogen-Activated Protein Triple Kinase Alpha.” J Biol Chem. 2005 280(14):13545-53.




43. Zykova TA, Zhang Y, Zhu F, Dong Z.(2005). “The Signal Transduction Networks Required for Phosphorylation of STAT1 At Ser727 In Mouse Epidermal JB6 Cells in the UVB Response and Inhibitory Mechanisms of Tea Polyphenols.” Carcinogenesis. 2005 26(2):331-42.




44. Yan W, Wang WL, Zhu F, Cheng SQ, Li QL, Wang L, Wang CJ. (2005). “Cloning and




Subcellular Localization of Apr-1--A New Gene of Tumor Specific Antigen Family.” Cancer.




2005 24(2):129-34. In Chinese.




45. Zhang Y, Cho YY, Petersen BL, Zhu F, Dong Z. (2004). “Evidence of STAT1 Phosphorylation




Modulated by MAPKs, MEK1 and MSK1.” Carcinogenesis. 2004 25(7):1165-75.




46. Xu YM, Wang LF, Jia LT, Qiu XC, Zhao J, Yu CJ, Zhang R, Zhu F, Wang CJ, Jin BQ, Chen SY Yang AG. (2004). “A Caspase-6 and Anti-Human Epidermal Growth Factor Receptor-2 (HER2) Antibody Chimeric Molecule Suppresses The Growth Of HER2-Overexpressing Tumors.” J Immunol. 2004 173(1):61-67.




47. Zhang Y, Cho YY, Petersen BL, Bode AM, Zhu F, Dong Z. (2003). “Ataxia Telangiectasia Mutated Proteins, MAPKs, and RSK2 are Involved in the Phosphorylation of STAT3.” J Biol Chem. 2003 278(15):12650-12659.




48. Yan W, Wang WL, Zhu F, Chen SQ, Li QL, Wang L. (2003). “Isolation of a Novel Member of




Small G Protein Superfamily and its Expression in Colon Cancer.” World J Gastroenterol. 2003 9(8):1719-1724.




49. Zhao ZL, Lu F, Zhu F (2002). “Cloning and Biological Comparison of Restin, A Novel Member of Mage Superfamily.” Science in China (Series C). 2002 45(4):413420.




50.Yan W, Zhu F and Li Q. (2001). “Apoptosis-related Genes Cloned by Improved Subtractive Hybridization.”Cancer in CHINA (Zhonghua Zhong Liu Za Zhi). 2001 23(3):193 195.




51. Yan W, Zhu F, and Li Q (2001). “Molecular Cloning and Characterization of Apr-1, A New




Member Of The Melanoma-Associated Antigen Family.” Journal of tumor marker oncology.2001 16(4) winter: 289.




52.Yan W, Zhu F and Li. Q (2001). “Improved PCR-based Subtractve Hybridization, A New Strategy On Clonging Differential Expression Genes In Apoptotic MCF-7 Cells.” Chin J Cell Mol Immunol.2001 17(1):243-247.




53. Zhu F, Yan W, Zhao ZL (2000). “Improved PCR-based Subtractive Hybridization Strategy for loning Differentially Expressed Genes.” Biotechniques. 2000 29(2):310-313.










专利：




1. “Ceftriaxone as a therapeutic treatment of human lung cancer”: Case Number: **

2. “Identification of compound HOI-07 as a novel Aurora B inhibitor in vitro and in vivo”: Case Number: ROI**







综述与书的章节




1. Zhu F and CJ Wang (1998). Defects of Differential Display Technique and Strategies to Deal with. Chinese Bulletin of Life Science. 10(1):37-39.










2.YT Zhao, Zhu F and CJ Wang. (1996). Ribozyme and cancer. F oreign Medicine-sectionof Oncology.










3. Zhao YT, Zhu F and CJ Wang.(1996). The Molecular Machenism of Apoptosis. Chinese Bulletin of Life Science. 8(2):19-23.










4. Chinese Edition of Cecil Textbook of Medcine (19th edition by Wyngaarden, Smith & Bennett, Copyright 1992 by W. B. Saunders Company).1996; World Book Publication Company, Xi’an, P. R. CHINA (ISBN 7-5062-1945-X/R.39). Co-translator










5. Chinese Edition of Cecil Essentials of Medicine (3rd edition by Andreoli, Bennett, Carpenter et al. Copyright 1994 by W. B.Saunders Company). 1996; World Book Publication Company, Xi’an, P. R. CHINA (ISBN 7-5062-2184-5/R.63). pp340-368; Translator










会议交流










1.#278: ERKs and mitogen- and stress-activated protein kinase are required in UVC-induced phosphorylation of ATF-2. 95th AACR Annual Meeting, March 27-31, 2004, Orange County Convention Center, Orlando, Florida.




2.#5484: CSK phosphorylates c-Jun and promotes its ubiquitin-dependent degradation. 96th AACR Annual Meeting, April 16-20, 2005, Anaheim Convention Center, Anaheim. Orange County, CA.




3.#15: ERK2 and RSK2 mediate phosphorylation of PKR (Thr451) and PKR directly catalyzes the phosphorylation of eIF2??at Ser51. Targeting Carcinogenesis, A jointly-sponsored program of Hormel Institute/University of Minnesota and Mayo School of Continuing Medical Education. Oct. 6-7, 2005, Rochester, MN.




4.#1265: TOPK functions as an oncogene. 98th AACR Annual Meeting, April 14-19, 2007, Los




Angeles, CA.




5.#2707: TOPK phosphorylation of histone H2AX prevents arsenite-induced apoptosis in RPMI7951 melanoma cells99th Annual Meeting of the American Association for Cancer Research; 2008 Apr 12-16; San Diego, CA.




6.#4093: Resveratrol directly targets COX-2 to inhibit carcinogenesis. 100th Annual Meeting of the American Association for Cancer Research; 2009 Apr 18-22; Denver, CO.










奖励










2002军队科技进步二等奖：骨形成蛋白在颌骨肿瘤和多形性腺瘤生物学作用的研究。2002




2001陕西省优秀博士论文：改良消减杂交克隆差异表达基因方法的建立。2001




1999第四军医大学优秀博士研究生 (http://graduate.fmmu.sn.cn/degree/graduater.asp)。