首页 > 导师简介 > 病原生物学系
杨红枚

杨红枚，华中科技大学同济医学院基础医学院人才引进特聘教授、博士生导师。毕业于武汉大学病毒学专业；留学美国十年，先后在哈佛医学院和美国生物医药公司从事病毒免疫、蛋白质代谢和肿瘤生物学的研究及肿瘤治疗药物的研发。现任湖北省微生物学学会常务理事，微生物及免疫学会理事，国家自然科学基金委和教育部通讯评审专家等社会职务。共计发表科研论文30余篇，其中已被SCI收录近二十篇。










研究方向：




1.感染与肿瘤




2.丙型肝炎病毒致病机制及抗病毒药物研发




3.蛋白质代谢与肿瘤恶病质










主要论文：










1. Chen X, Han W, Ruan A, Zhao Y, Xu Z, Lu X, Yang H*, Zhang X*. miR-141 is A Key Regulator of Renal Cell Carcinoma Proliferation and Metastasis by Controlling EphA2 Expression. Clinical Cancer Research. 2014 ( IF：7.8，共同通讯作者)

2. Yang H, Chen X, Wang X, Li Y, Chen S, Qian X, Wang R, Chen L, Han W, Ruan A, Du Q, Olumi AF, Zhang X*. Inhibition of PP2A Activity Confers a TRAIL-sensitive Phenotype During Malignant Transformation. Mol Cancer Res, Feb;12(2):217-27, 2014 ( IF：4.6，第一作者)

3. Wang X. Chen X, Wang R, Xiao P, Xu Z, Chen L, Han W, Ruan A, Yang H*, Zhang X*. microRNA-200c modulates the epithelial-to-mesenchymal transition in human renal cell carcinoma metastasis. Oncol Rep,30(2): p. 643-50. 2013 ( IF：2.2，共同通讯作者)

4. Hongmei Yang, Charles H. Lin, Gang Ma, Michael Baffi and Marc G. Wathelet Transcriptional activity of interferon regulatory factor (IRF)-3 depends on multiple protein-protein interactions. FEBS J. (Eur. J. Biochem.); 269(24): 6142-51, 2002 Dec.

5. Hongmei Yang, Charles H. Lin, Gang Ma, Michael Baffi and Marc G. Wathelet Interferon regulatory factor-7 synergizes with other transcription factors through multiple interactions with p300/CBP coactivators. J Biol Chem.; 278(18): 15495-504, 2003 May 2.

6. Hongmei Yang, Gang Ma, Michael Baffi and Marc G. Wathelet. Mechanism for transcriptional synergy between interferon regulatory factor (IRF)-3 and IRF-7 in activation of the interferon-beta gene promoter. FEBS J. (Eur. J. Biochem.); 271(18): 3693-703, 2004 Sep.

7. Hongmei Yang, Wei Wei , Michael Menconi, and Per-Olof Hasselgren. Dexamethasone-induced Protein Degradation in Cultured Myotubes is p300/HAT-dependent. Am I Physiol Regul Integr Comp Physiol.; 292(1):R337-4, 2007 Jan.




8. Hongmei Yang, Joshua Mammen, Micahel Menconi, Per-Olof Hasselgren. Expression and Activity of C/EBPbeta and delta are Upregulated by Dexamethasone in Skeletal Muscle. J Cell Physiol.; 204(1): 219-26, 2005 July.




9. Hongmei Yang, Mike Menconin, Per-Olof Hasselgren. Dexamethasone Upregulates the Expression of the Nuclear Cofactor p300 and its Interaction with C/EBP BETA in Cultured Myotubes. J Cell Biochem.; 94(5): 1058-67, 2005 Apr 1.




10. Xiaoping Zhang, Liang Zhang, Hongmei Yang, Xu Huang, Hasan Otu, Towia A. Libermann,, William C. DeWolf, Roya Khosravi-Far, Aria F. Olumi. c-Fos as a Proapoptotic Agent in TRAIL-Induced Apoptosis in Prostate Cancer Cells. Cancer Res; 67(19): 9425-34,2007 Oct 1.




11. Wei Wei , Hongmei Yang , Peirang Cao , Michael Menconi, and Per-Olof Hasselgren. Treatment of Cultured Myotubes with the Proteasome Inhibitor β-lactone Increase the expression of the Transcription Factor C/EBP β. Am J Physiol Cell Physiol.; 292(1):C216-26, 2007 Jan.




12. Wei Wei , Hongmei Yang, Peirang Cao , Michael Menconi, Petkova V, Hasselgren PO. Degradation of C/EBP β in cultured Myotubes is Calpain-dependent. J Cell Physiol.; 208(2): 386-98,2006 Aug.




13. Hasselgren PO, Menconi MJ, Fareed MU, Yang H, Wei W, Evenson A. Novel aspects on the regulation of muscle wasting in sepsis. Int J Biochem Cell Biol. 2005 Oct;37(10):2156-68. Epub 2005 Mar 13




14. Wei Wei, Fareed MU, Evenson A, Menconi MJ, Hongmei Yang , Petkova V, Hasselgren PO. Sepsis Stimulates Calpain Activity in Skeletal Muscle by Decreasing Calpastatin Activity but Does not Activate Caspase-3. Am J Physiol Regul Integr Comp Physiol. 2005 Mar; 288(3):R580-90.




15. Xiaoping Zhang, Tai-Guang Jin, Hongmei Yang, William C. DeWolf, Roya Khosravi-Far and Aria F. Olumi. Persistent c-FLIP(L) Expression is Necessary and Sufficient to Maintain Resistance to Tumor Necrosis Factor-related Apoptosis-inducing Ligand-mediated Apoptosis in Prostate Cancer. Cancer Res. 2004 Oct 1; 64(19): 7086-91.




16. Menconi MJ, Wei W, Hongmei Yang, Wray CJ, Hasselgren PO. Treatment of Cultured Myotubes with the Calcium Ionophore A23187 Increases Proteasome Activity via a CaMK II-caspase-calpain-dependent Mechanism. Surgery. 136(2): 135-42, 2004 Aug.










主要著作：




杨红枚参编，《病毒转基因技术原理》。科学出版社，2014年。




科研项目：




1.MicroRNA-141调控HCV复制的机制研究，病毒学国家重点实验室开放课题，2014-2016年；




2.恶病质肌肉萎缩中Myostatin表达调控的机制研究，国家自然科学基金面上项目，2012-2015年；




3.病毒激活因子（VAF）调控丙型肝炎病毒诱导的干扰素表达机制的研究，国家自然科学基金面上项目，2011-2013年。




4.恶病质肌肉萎缩中Myostatin表达调控的机制研究，湖北省科技厅面上项目，2011-2012年；




5.丙型肝炎病毒感染的肝细胞对TRAIL敏感的机制研究，湖北省卫生厅科研一般项目，2011-2012年。




6.HCV感染的肝细胞对TRAIL敏感的机制研究，华中科技大学自主创新研究基金资助项目，2010-2012年。