宗成利 课题组：www.carbo-zone.com/Zong-Group/
1.基本情况
宗成利 男 博士 教授 博士生导师
联系方式：海南省海口市人民大道58号海南大学生命科学与药学院药学系，570228
邮箱：hanghai01@163.com
2.教育背景
2010.09-2016.05乔治亚大学-复杂碳水化合物研究中心化学（博士）
2007.09-2010.07中国海洋大学-药物所 药物化学（硕士）
2003.09-2007.07中国海洋大学-药物所 药学（本科）
3.教学情况
暂无
4.科研情况
糖类化合物的化学生物学研究以及其药物和疫苗应用。针对糖类药物的构效关系，生物学功能，开展糖类化合物的化学合成以及改造，生物活性评价，哺乳动物细胞的工程化修饰研究等。重点开展了多糖结合型疫苗的偶联化学/分析方法的研究以及分析标准的制定。
5.研究领域
药物化学，多糖疫苗。
6.社会兼职
暂无
7.代表性项目
（1）多糖疫苗研究
作为肺炎球菌多糖领域的行业专家，参与了默沙东下一代肺炎球菌疫苗的开发：例如细菌的发酵，荚膜多糖的分离，纯化，活化，与CRM197偶联等。参与研究的默沙东多价肺炎球菌结合型疫苗研发V114和V116项目已经进入临床实验。
（2）糖胺聚糖的化学生物学研究
建立了一种可以快速合成糖胺聚糖类化合物的保护基以及纯化策略，为此类化合物的构效关系研究奠定了基础。领导并完成了以下项目：建立了一个硫酸肝素四糖化合物库，通过微阵列筛选，发现了一系列硫酸肝素结合蛋白的底物特点；发现了一个在神经导向过程中起重要作用的硫酸肝素八糖结构；发现了一种可以修饰哺乳动物细胞表面的新方法；确定了肿瘤细胞表面一种特殊的硫酸软骨素A。
8.代表性成果
Zong, C.; Fang, L.; Song, F.; Wang, A.; Wan, Y., “Fluorescent Fingerprint Bacteria by Multi-channel Magnetic Fluorescent Nanosensor.” Sensors and Actuators B: Chemical.2019, 289, 234-241.
Zong, C.; Venot, A., Li, X.; Lu, W; Xiao, W.; Wilkes, J-W; Salanga, C-L.; Handel, T-M.; Wang, L.; Wolfert, M-A.; Boons, G-J., “A Heparan Sulfate Microarray Reveals that Heparan Sulfate-Protein Binding Exhibit Different Ligand Requirements.” Journal of the American Chemical Society, 2017, 139, 9534-9543
Zong, C.; Huang, R.; Condac, E.; Chiu, Y.; Xiao, W.; Li, X.; Lu, W.; Ishihara, M.; Wang, S.; Ramiah, A.; Stickney, M.; Azadi, P.; Amster, I-J.;Moremen, K-W.; Wang,L.; Sharp,J-S.; Boons, G-J., “Integrated Approach to Identify Heparan Sulfate Ligand Requirements of Robo1.” Journal of the American Chemical Society, 2016, 138, 13059-13067
Zong, C.;Venot, A.; Dhamale, O-P.; Boons, G-J., “Fluorous supported modular synthesis of heparan sulfate oligosaccharides” Org. Lett., 2013, 15, 342–345.
Zong, C.; Li, Z.; Sun, T.; Wang, P.; Li, Y., “Convenient Synthesis of Sulfated Oligofucosides” Carbohydr. Res.2010. 11, 1522-1532.
Lu, W.; Zong, C.; Liu, J.; Boons, G-J., “Controlled chemoenzymatic synthesis of heparan sulfate oligosaccharide.” Angewandte Chemie, 2018, 57, 5340-5344.
Yi, F.; Hong, X.; Kumar, A.B.; Zong, C.; Boons, G-J.; Scott, C.R.; Turecek, F.; Robinson, B.H.; Gelb, M.H., “Detection of mucopolysaccharidosis III-A (Sanfilippo Syndrome-A) in dried blood spots (DBS) by tandem mass spectrometry.” Molecular Genetics and Metabolism, 2018, 125, 59-63.
Moure, M.J.; Eletsky, A.; Gao, Q.; Morris, L.C.; Yang, J.Y.; Chapla, D.; Zhao, Y.; Zong, C.; Amster, I.J.; Moremen, K.W.; Boons, G-J., “Paramagnetic Tag for Glycosylation Sites in Glycoproteins: Structural Constraints on Heparan Sulfate Binding to Robo1.” ACS chemical biology, 2018, 13, 2560-2567.
Capicciotti, C. J., Zong, C., Sheikh, M. O., Sun, T., Wells, L., & Boons, G-J. "Cell-Surface Glyco-Engineering by Exogenous Enzymatic Transfer using a Bi-Functional CMP-Neu5Ac Derivative."Journal of the American Chemical Society, 2017, 139, 13342-13348.
Agyekum, I.; Zong, C.; Boons, G-J.; Amster, I-J, “Single Stage Tandem Mass Spectrometry Assignment of the C-5 Uronic Acid Stereochemistry in Heparan Sulfate Tetrasaccharide using Electron Detachment Dissociation” Journal of the American Society for Mass Spectrometry, 2017, 29, 1-10.
Zhao, Y.; Singh, A.; Xu, Y.; Zong, C.; Zhang, F.; Boons, G.J.; Liu, J.; Linhardt, R.J.; Woods, R.J.; Amster, I.J., “A Traveling Wave Ion Mobility Spectrometry (TWIMS) Study of the Robo1-Heparan Sulfate Interaction” Journal of the American Society for Mass Spectrometry,2017, 28, 96-109.
Huang, R.; Zong, C.; Venot A.; Chiu, Y.; Zhou, D.; Boons G-J.; Sharp, J., "The de novo Sequencing of Complex Mixtures of Heparan Sulfate Oligosaccharides” Analytical Chemistry, 2016, 88, 5299-5307
Gao, Q.; Chen, C.Y.; Zong, C.; Wang, S.; Ramiah, A.; Prabhakar, P.; Morris, L.C.; Boons, G.J.; Moremen, K.W.; Prestegard, J.H., “Structural Aspects of Heparan Sulfate Binding to Robo1–Ig1–2” ACS Chemical Biology, 2016, 11, 3106-3113.
Agyekum, I.; Patel, A-B.; Zong, C.; Boons, G-J.; Amster, J., “Assignment of Hexuronic Acid Stereochemistry in Synthetic Heparan Sulfate Tetrasaccharides with 2-O-sulfo Uronic Acids Using Electron Detachment Dissociation” International Journal of Mass Spectrometry, 2015, 390, 163-169.
Huang, Y.; Mao, Y.; Zong, C.; Lin, C.; Boons, G-J.; Zaia, J., “Discovery of a Heparan Sulfate 3-O-Sulfation Specific Peeling Reaction” Analytical Chemistry, 2015, 87, 592-600.
Hu, H.; Huang, Y.; Mao, Y.; Yu, X.; Xu, Y.; Liu, J.; Zong, C.; Boons, G-J.; Zaia, J., “A Computational Framework for Heparan Sulfate Sequencing Using High-resolution Tandem Mass Spectra”Molecular & Cellular Proteomics, 2014,13, 2490-2502.
Dhamale, O-P.; Zong, C.; Al-Mafraji, K.; Boons, G-J., “New Glucuronic Acid Donors for the Modular Synthesis of Heparan Sulfate Oligosaccharides” Organic & Biomolecular Chemistry, 2014, 12, 2087-2098.