1. 基本情况：
鲍娇琳 女 博士 副教授 硕士生导师
联系方式：海南省海口市人民大道58号热带生物资源教育部重点实验室309室
邮箱：baojiaolin@hainanu.edu.cn
2. 教育背景及工作经历
2019.11-至今 海南大学，药学院，副教授
2017.8-2019.11 澳门大学，健康科学学院，博士后研究员
2012.8-2017.7 澳门大学，中药质量研究国家重点实验室，生物医药博士
2010.8-2012.7 澳门大学，中药质量研究国家重点实验室，中药学硕士
2006.9-2010.6 暨南大学，药学院，药学学士
3. 教学情况
本科生专业课程：药物动力学、中医药与养生健康
本科生通识课程：科研美图之AI从入门到精通
研究生专业课程：药物代谢（英文）、海洋药物学、药学研究实验、专业前沿研讨
硕士生招生专业：药学学术硕士（100700）、生物与医药专业硕士（086000）
4. 科研情况
主要从事肿瘤个体化治疗和抗肿瘤药物研发方向研究，已发表SCI论文50余篇，H-index=24，总被引次数>2400次。
欢迎大一、大二学生进入本实验室开展科研训练、从事科学研究和撰写科研论文。
5. 研究领域
1）精准医学：肿瘤个体化治疗、肿瘤早筛和耐药标志物发现。
2）新药研发：抗肿瘤药物研发、神经保护药物研发。
6. 社会兼职
Technology in Cancer Research & Treatment (IF: 3.399)副主编
7. 代表性项目
1）国家自然科学基金青年项目（**），2022-1至2024-12，主持
2）海南省自然科学基金青年项目（820QN248），2020-1至2022-12，主持
3）海南大学药学省级特色重点学科开放课题（KLTBR2020yx02），2020年度，主持
4）海南大学科研启动基金（KYQD(ZR)-21030），2019-11至2024-11，主持
8. 代表性成果
2021年度
1. LC Li, JL Bao (Co-first author), HT Wang, JH Lei, C Peng, JM Zeng, WH Hao, X Zhang, XL Xu, CD Yu, CX Deng*, Q Chen*. Upregulation of amplified in breast cancer 1 contributes to pancreatic ductal adenocarcinoma progression and vulnerability to blockage of hedgehog activation. Theranostics 2021, 4, 1672-1689. (IF=11.556, 中科院大类一区)
2. RB Ding, P Chen, BK Rajendran, XY Lyu, HT Wang, JL Bao, JM Zeng, WH Hao, H Sun, AH Wong, M Valecha, EJ Yang, SM Su, TK Choi, SM Liu, KI Chan, LL Yang, JB Wu, K Miao, Q Chen, JS Shim, XL Xu, CX Deng*. Molecular landscape and subtype-specific therapeutic response of nasopharyngeal carcinoma revealed by integrative pharmacogenomics, Nature Communications, 2021, 12, 3046.
3.P Chen, X Zhang, RB Ding, LL Yang, XY Lyu, JM Zeng, HP Lei, LJ Wang, J Bi, N Shao, DT Shu, B Wu, JB Wu, ZH Yang, HY Wang, BQ Wang, K Xiong, Y Lu, SZ Fu, TK Choi, NW Lon, YY Quan, Y Meng, K Miao, H Sun, M Zhao, JB Bao, L Zhang, XL Xu, YX Shi, Y Lin, CX Deng*. Patient-derived organoids can guide personalized-therapies for patients with advanced breast cancer. Advanced Science. 2021, DOI: 10.1002/advs..

2020年度
1. Q Chen, JH Lei, JL Bao, HT Wang, WH Hao, LC Li, C Peng, T Masuda, K Miao, J Xu, XL Xu, CX Deng*. BRCA1 Deficiency Impairs Mitophagy and Promotes Inflammasome Activation and Mammary Tumor Metastasis. Advanced Science. 2020, 6, **.
2. ZH Sun, JL Bao, MQ Zhangsun, S Dong, DT Zhangsun, SL Luo*. αO-Conotoxin GeXIVA Inhibits the Growth of Breast Cancer Cells via Interaction with α9 Nicotine Acetylcholine Receptors. Marine Drugs. 2020, 4, 195.
3. K Miao, HP Lei, MV Valecha, AP Zhang, J Xu, S Chen, ZQ Miao, X Zhang, SM Su, FY Shao, BK Rajendran, JL Bao, JM Zeng, H Sun, P Chen, KL Tan, Q Chen, KH Wong, XL Xu, CX Deng*. Blocking Non-canonical NOTCH1 Signalling Revives Mitotic Catastrophe Associate with BRCA1 Deficiency to Inhibit Triple Negative Breast Cancer. Nature Communications. 2020, 11, 3256.
4. XJ Jia, C Zhang, JL Bao, K Wang, YB Tu, JB Wan, CW He*. Flavonoids from Rhynchosia minima root exerts anti-inflammatory activity in lipopolysaccharide-stimulated RAW 264.7 cells via MAPK/NF-κB signaling pathway. Inflammopharmacology. 2020, 1, 289-297.

2019年度及之前
1. JL Bao, RB Ding, XJ Jia, YE Liang, F Liu, K Wang, C Zhang, MW Chen, P Li, HX Su, JB Wan, YT Wang, CW He*. Fast identification of anticancer constituents in Forsythiae Fructus based on the metabolomics approaches. Journal of Pharmaceutical and Biomedical Analysis. 2018, 5, 312-320.
2. JL Bao, RB Ding, YE Liang, F Liu, K Wang, XJ Jia, C Zhang, MW Chen, P Li, HX Su, JB Wan, YT Wang, CW He*. Differences in chemical component and anticancer activity of green and ripe Forsythiae Fructus. The American Journal of Chinese Medicine. 2017, 7, 1513-1536.
3. JL Bao, F Liu, C Zhang, K Wang, XJ Jia, XT Wang, MW Chen, P Li, HX Su, YT Wang, JB Wan*, CW He*. Anti-melanoma activity of Forsythiae Fructus aqueous extract in mice involves regulation of glycerophospholipid metabolisms by UPLC/Q-TOF MS-based metabolomics study. Scientific Reports. 2016, 6, 39415.
4. JL Bao, RB Ding, LD Zou, C Zhang, K Wang, F Liu, P Li, MW Chen, JB Wan, HX Su, YT Wang, CW He*. Forsythiae Fructus aqueous extract inhibits B16 melanoma growth involving MAPKs/Nrf2/HO-1 mediated anti-oxidation and anti-inflammation. The American Journal of Chinese Medicine. 2016, 5, 1043-1061.
5. JL Bao, BR Huang, LD Zou, SH Chen, C Zhang, YL Zhang, MW Chen, JB Wan, HX Su, YT Wang, CW He*. Hormetic effect of berberine attenuates the anticancer activity of chemotherapeutic agents. PLos One. 2015, 9, e**.
6. JJ Lu, JL Bao (Co-first author), GS Wu, MQ Huang, XP Chen*, YT Wang*. Quinones derived from plant secondary metabolites as anti-cancer agents. Anti-Cancer Agents in Medicinal Chemistry. 2013, 3, 456-463.
7. CH Wu, JL Bao (Co-first author), CW He, JJ Lu, XP Chen*. Cucurbitacin B inhibited proliferation, induced G2/M cell cycle arrest and autophagy without affecting apoptosis but enhanced MTT reduction in PC12 cells. Bangladesh Journal of Pharmacology. 2016, 1, 110-118.
8. W Lin, JL Bao (Co-first author), QW Zhang, XP Chen*. Anti-proliferative effect of MAM, a natural product on human breast cancer cell MCF-7 by inducing apoptosis through the mitochondria- dependent pathway. Acta Pharmacologica Sinica. 2013, 8, 129.
9. JL Bao, RB Ding, LD Zou, C Zhang, K Wang, F Liu, P Li, MW Chen, JB Wan, HX Su, YT Wang, CW He*. Liaoqiao aqueous extract inhibits B16 melanoma growth involving MAPKs/Nrf2/HO-1 mediated anti-oxidation and anti-inflammation. Chinese Pharmacological Bulletin. 2015, B11, 112.
10. 鲍娇琳, 陆金健, 陈修平*, 王一涛*. 苦参碱与氧化苦参碱抗肿瘤作用及其机制的研究进展. 中药新药与临床药理. 2012, 3, 369-373.
11. 鲍娇琳, 郭佳杰, 陈修平*, 王一涛*. 葫芦素B对PC12细胞增殖的影响:MTT假阳性陷阱. 中国药理学与毒理学杂志. 2011, S1, 100.
12. JJ Lu*, JL Bao, XP Chen, M Huang, YT Wang*. Alkaloids isolated from natural herbs as the anti-cancer agents. Evidence-Based Complementary and Alternative Medicine. 2012, 485042.
13. XP Chen*, JL Bao, JJ Guo, Q Ding, JJ Lu, M Huang, YT Wang*. Biological activities and potential molecular targets of cucurbitacins: a focus on cancer. Anti-Cancer Drugs. 2012, 9, 777-787.
14. W Sun, JL Bao, W Lin, HW Gao, WW Zhao, QW Zhang, CH Leung, DL Ma, JJ Lu, XP Chen*. 2-Methoxy-6-acetyl-7-methyljuglone (MAM), a natural naphthoquinone, induces NO-dependent apoptosis and necroptosis by H2O2-dependent JNK activation in cancer cells. Free Radical Biology and Medicine, 2016, 3, 61-77.
15. RB Ding, JL Bao, CX Deng*. Emerging roles of SIRT1 in fatty liver diseases. International Journal of Biological Sciences. 2017, 7, 852-867.
16. Q Ding, JL Bao, WW Zhao, JJ Lu, H Zhu, XP Chen*. Ethanol enhances cucurbitacin B-induced apoptosis by inhibiting cucurbitacin B-induced autophagy in LO2 hepatocytes. Molecular & Cellular Toxicology, 2016, 1, 29-36.
17. Q Ding, JL Bao, WW Zhao, YY Hu, JJ Lu, XP Chen*. Natural autophagy regulators in cancer therapy: a review. Phytochemistry Reviews. 2015, 1, 137-154.
18. YL Zhang, JL Bao, K Wang, XJ Jia, C Zhang, BR Huang, MW Chen, JB Wan, HX Su, YT Wang, CW He*. Pulsatilla saponin D inhibits autophagic flux and synergistically enhances the anticancer activity of chemotherapeutic agents against HeLa cells. The American Journal of Chinese Medicine. 2015, 8, 1657-1670.
19. RB Ding, JL Bao, YW Cao, CW He, YT Wang, JB Wan*. Panax notoginseng saponins protect against chronic ethanol-induced hepatic steatosis. Journal of Chinese Pharmaceutical Sciences. 2014, 6, 361-368.
20. W Sun, JL Bao, W Lin, WW Zhao, JJ Lu, QW Zhang, XP Chen*. 2-Methoxystypandrone induces iNOS expression by H2O2-dependent JNK activation for multiple cancer cell death. 中国药理学与毒理学杂志. 2015, S1, 22.
21. 徐俊, 鲍娇琳, 沈伟哉, 蔡绍晖*. 穿心莲内酯衍生物炎琥宁对α-葡萄糖苷酶抑制活性及机制研究. 时珍国医国药. 2012, 7, 1637-1640.
22. XP Chen, JJ Guo, JL Bao, JJ Lu, YT Wang*. The anticancer properties of salvia miltiorrhiza bunge (Danshen): a systematic review. Medicinal Research Reviews. 2014, 4, 768-794.
23. XP Chen*, JJ Lu, JL Bao, JJ Guo, JS Shi, YT Wang*. Adiponectin: A biomarker for rheumatoid arthritis? Cytokine & Growth Factor Reviews. 2013, 1, 83-89.
24. JJ Guo, GS Wu, JL Bao, JJ Lu, XP Chen*. Cucurbitacin B induced ATM-mediated DNA damage causes G2/M cell cycle arrest in a ROS-dependent manner. PLos One. 2014, 2, e88140.
25. K Wang, C Zhang, JL Bao, XJ Jia, YE Liang, XT Wang, MW Chen, HX Su, P Li, JB Wan CW He*. Synergistic chemopreventive effects of curcumin and berberine on human breast cancer cells through induction of apoptosis and autophagic cell death. Scientific Reports. 2016, 6:26064.
26. C Zhang, XJ Jia, JL Bao, SH Chen, K Wang, YL Zhang, P Li, JB Wan, HX Su, YT Wang, ZN Mei, CW He*. Polyphyllin VII induces apoptosis in HepG2 cells through ROS-mediated mitochondrial dysfunction and MAPK pathways. BMC Complementary and Alternative Medicine. 2016, 2, 16:58.
27. C Zhang, SH Chen, JL Bao, YL Zhang, BR Huang, XJ Jia, MW Chen, JB Wan, HX Su, YT Wang, CW He*. Low doses of Camptothecin induced hormetic and neuroprotective effects in PC12 cells. Dose Response. 2015, 2, 1-7.
28. LD Zou, FQ Chen, JL Bao, SP Wang, L Wang, MW Chen*, CW He*. Preparation, characterization, and anticancer efficacy of evodiamine-loaded PLGA nanoparticles. Drug Delivery, 2014, 6, 1-9.
29. GS Wu, JJ Guo, JL Bao, XW Li, XP Chen, JJ Lu, YT Wang*. Anti-cancer properties of triterpenoids isolated from Ganoderma lucidum-a review. Expert Opinion on Investigational Drugs. 2013, 8, 981-992.
30. XP Chen*, JJ Guo, JL Bao, WS Xu, YY Huang, YT Wang*. Screening neuroprotective agents through 4-hydroxynonenal, ethanol, high glucose, homocysteine, okadaic acid, rotenone, and oxygen-glucose deprivation induced PC12 injury models: a review. Current Psychopharmacology. 2012, 1, 103-110.
31. JJ Guo, GS Wu, JL Bao, JJ Lu, XP Chen*. Cucurbitacin B induced ATM-mediated DNA damage causes G2/M cell cycle arrest in a ROS-dependent manner. Acta Pharmacologica Sinica. 2013, S1, 50.
32. 吴国胜, 郭佳杰, 鲍娇琳, 徐文珊, 陆金健*.灵芝提取物介导乳腺癌细胞的DNA损伤、G1期的周期阻滞和凋亡. 中国药理学与毒理学杂志. 2011, S1, 106.
33. C Zhang, XJ Jia, K Wang, JL Bao, P Li, MW Chen, JB Wan, HX Su, ZN Mei, CW He*. Polyphyllin VII Induces an Autophagic Cell Death by Activation of the JNK Pathway and Inhibition of PI3K/AKT/mTOR Pathway in HepG2 Cells. PLos One. 2016,1, e**.
34. RB Ding, K Tian, YW Cao, JL Bao, M Wang, CW He, YJ Hu, HX Su, JB Wan*. Protective effect of panax notoginseng saponins on acute ethanol-induced liver injury is associated with ameliorating hepatic lipid accumulation and reducing ethanol-mediated oxidative stress. Journal of Agricultural and Food Chemistry. 2015, 9, 2413-2422.
35. YB Li, ZF Zhong, MW Chen, JL Bao, GS Wu, QW Zhang, S MY Lee, PM Hoi, YT Wang*. Bisdemethoxycurcumin Increases Sirt1 to Antagonize t-BHP-Induced Premature Senescence in WI38 Fibroblast Cells. Evidence-Based Complementary and Alternative Medicine. 2013, 7, 851714.
36. M Huang, JJ Lu, MQ Huang, JL Bao, XP Chen, YT Wang*. Terpenoids: natural products for cancer therapy. Expert Opinion on Investigational Drugs. 2012, 12, 1801-1818.
37. ZT Xu, XP Chen, S Fu, JL Bao, YY Dang, MQ Huang, LD Chen, YT Wang*. Dehydrocorydaline inhibits breast cancer cells proliferation by inducing apoptosis in MCF-7 cells. The American Journal of Chinese medicine. 2012, 1, 177-185.
38. 陈修平, 陆金建, 郭佳杰, 鲍娇琳, 徐文珊, 丁倩, 王一涛*.基于天然产物的药物研发对创新中药研究的启示—TTD 收录天然药物分析. 药学学报. 2012, 11, 1423-1427.
39. XJ Jia, C Zhang, JF Qiu, LL Wang, JL Bao, K Wang, MW Chen, JB Wan, HX Su, JP Han, CW He*. Purification, structural characterization and anticancer activity of the novel polysaccharides from Rhynchosia minima root. Carbohydrate Polymers. 2015, 11, 67-71.
40. XJ Jia, C Zhang, J Hu, MX He, JL Bao, K Wang, P Li, MW Chen, JB Wan, HX SU, QW Zhang, CW He*. Ultrasound-Assisted Extraction, Antioxidant and Anticancer Activities of the Polysaccharides from Rhynchosia minima Root. Molecules. 2015, 11, 20901-20911.
41. YB Li, ZQ Wang, X Yan, MW Chen, JL Bao, GS Wu, ZM Ge, DM Zhou, YT Wang*, RT Li*. IC-4, a new irreversible EGFR inhibitor, exhibits prominent anti-tumor and anti-angiogenesis activities. Cancer Letters. 2013, 1, 88-96.
42. J Xu, SC Huang, HB Luo, GJ Li, JL Bao, SH Cai*, YQ Wang*. QSAR studies on andrographolide derivatives as α-Glucosidase inhibitors. International Journal of Molecular Sciences. 2010, 3, 880-895.
43. GS Wu, ZM Qian, JJ Guo, DJ Hu, JL Bao, J Xie, WS Xu, JJ Lu, XP Chen, YT Wang*. Ganoderma lucidum extract induces G1 cell cycle arrest, and apoptosis in human breast cancer cells. The American Journal of Chinese Medicine. 2012, 3, 631-642.
44. J Xu, YJ Lu, WZ Shen, HB Luo, SC Huang, JL Bao, SH Cai*, YQ Wang*. Homology modeling of α-Glucosidase and its interactions with andrograpolide derivatives. Letters in Drug Design & Discovery. 2011, 5, 440-451.
45. C Zhang, CW Li, SH Chen, ZP Li, XJ Jia, K Wang, JL Bao, YE Liang, XT Wang, MW Chen, P Li, HX Su, JB Wan, S MY Lee, KC Liu, CW He*. Berberine protects against 6-OHDA-induced neurotoxicity in PC12 cells and zebrafish through hormetic mechanisms involving PI3K/AKT/Bcl-2 and Nrf2/HO-1 pathways. Redox Biology. 2017, 4, 1-11.
46. C Zhang, CW Li, SH Chen, ZP Li, LJ Ma, XJ Jia, K Wang, JL Bao, YE Liang, MW Chen, P Li, HX Su, S MY Lee, KC Liu, JB Wan, CW He*. Hormetic effect of panaxatriol saponins confers neuroprotection in PC12 cells and zebrafish through PI3K/AKT/mTOR and AMPK/SIRT1/FOXO3 pathways. Scientific Reports. 2017, 7, 41082.