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学习经历■1994.9-1998.7，北京大学医学部，获理学学士学位；
■ 1998.9-2003.7，清华大学生物科学与技术系，获理学博士学位。
工作经历■ 2003.9至今，兰州大学生命科学学院，教学科研。
社会工作
研究方向■重要蛋白质参与慢性炎症疾病调控的分子机制；
■蛋白质的结构/功能、膜脂-蛋白相互作用。
项目成果■ 国家自然科学基金重点项目1项，面上项目13项；
■ 国家自然科学基金优秀青年基金1项；
■ 国家自然科学基金国际合作项目2项；
■ 教育部新世纪优秀人才支持计划2项；
■ 教育部博士点基金3项；
■ 教育部科技研究重点项目1项；
■ FEI合作研究基金1项；
■ 兰州大学人才引进专项2项。
荣誉、获奖■ 清华大学优秀博士学位论文二等奖，2003；
■ 国家自然科学二等奖（5/5），2005；
■ 教育部新世纪优秀人才支持计划，2007。
教学及指导研究生情况 研究团队：教授2人、副教授2人，研究生14人。

发表论文及专著[1]Zhang S.-C., Wang M.-Y., Feng J.-R., Chang Y., Ji S.-R. *,Wu Y.*(2020) Reversible promoter methylation determines fluctuating expression of acute phase proteins. eLife, 9: e51317. (IF 7.551)
[2]Zhang L., Shen Z.-Y., Wang K., Li W., Shi J.-M., Osoro E.K., Ullah N., Zhou Y., Ji S.-R. * (2019) C-reactive protein exacerbates epithelial-mesenchymal transition through Wnt/b-catenin and ERK signaling in streptozocin-induced diabetic nephropathy. FASEB Journal, 33(5): 6551-6563. (IF 5.391)
[3]Li H.-Y., Liu X.-L., Liu Y.-T., Jia Z.-K., Filep J.G., Potempa L.A., Ji S.-R. *,Wu Y.*(2019) Matrix sieving-enforced retrograde transcytosis regulates tissue accumulation of C-reactive protein. Cardiovascular Research, 115(2): 440-452. (IF 7.014)
[4]Zhang L., Li H.-Y., Li W., Shen Z.-Y., Wang Y.-D., Ji S.-R. *,Wu Y.*(2018) An ELISA assay for quantifying monomeric C-reactive protein in plasma.Frontiers in Immunology, 9: 511. (IF5.511)
[5]Jia Z.-K., Li H.-Y., Liang Y.-L., Potempa L.A., Ji S.-R.*,Wu Y.*(2018) Monomeric C-reactive protein binds and neutralizes RANKL-induced osteoclast differentiation.Frontiers in Immunology, 9: 234.(IF5.51)
[6]Lv J.-M., Lv S.-Q., Liu Z.-P., Zhang J., Gao B.-X., Yao Z.-Y., Wu Y.-X., Potempa L.A., Ji S.-R.*,Long M.*,Wu Y.*(2018) Conformational folding and disulfide bonding drive distinct stages of protein structure formation.Scientific Reports,8: 1494.(IF4.122)
[7]Li H.-Y., Wang J., Meng F., Jia Z.-K., Su Y., Bai Q.-F., Lv L.-L., Ma F.-R., Potempa L.A., Ji S.-R.*,Wu Y.*(2016) An intrinsically disordered motif mediates diverse actions of monomeric C-reactive protein.Journal of Biological Chemistry, 291 (16): 8795-8804. (IF4.01)
[8]Zhang L., Liu S.-H., Wright T.T., Shen Z.-Y., Li H.-Y., Zhu W., Potempa L.A., Ji S.-R.*, Szalai A.J.*,Wu Y.*(2015) C-reactive protein directly suppresses T helper 1 cell differentiation and alleviates experimental autoimmune encephalomyelitis.Journal of Immunology,194 (11): 5243-5252. (IF4.539)
[9]Su H.-X., Zhou H.-H., Wang M.-Y., Cheng J., Zhang S.-C., Hui F., Chen X-Z, Liu S.-H., Liu Q.-J., Zhu Z.-J., Hu Q.-R.,Wu Y.*, Ji S.-R.* (2014) Mutations of C-reactive protein (CRP) -286 SNP, APC and p53 in colorectal cancer: implication for a CRP-Wnt crosstalk.Plos One, 9 (7): e102418. (IF2.766)
[10]Li H.-Y., Wang J., Wu Y.-X., Zhang L., Liu Z.-P., Filep J.G., Potempa L.A.,Wu Y.*, Ji S.-R.* (2014) Topological localization of monomeric C-reactive protein determines pro-inflammatory endothelial cell responses.Journal of Biological Chemistry, 289 (20): 14283-14290. (IF4.01)
[11]Wang M.-Y., Zhou H.-H., Zhang S.-C., Hui F., Zhu W., Su H.-X., Guo H.-Y., Li X.-W., Ji S.-R.*,Wu Y.*(2014) Recurrent mutations at C-reactive protein promoter SNP position -286 in human cancers.Cell Research, 24(4): 505-508. (IF15.393)
[12]Zhang Y.-J., Shi J.-M., Bai C.-J., Wang H., Li H.-Y.,Wu Y.*, Ji S.-R.* (2012) Intra-membrane oligomerization and extra-membrane oligomerization of amyloid-β peptide are competing processes as a result of distinct patterns of motif interplay.Journal of Biological Chemistry, 287(1): 748-756. (IF4.01)
[13]Wang M.-Y., Ji S.-R., Bai C.-J., El Kebir D., Li H.-Y., Shi J.-M., Zhu W., Costantino S., Zhou H.-H., Potempa L.A., Zhao J., Filep J.G.*,Wu Y.*(2011) A redox switch in C-reactive protein modulates activation of endothelial cells.FASEB Journal, 25(9): 3186-3196. (IF5.595)
[14]Zhu L., Chen L., Zhou X.-M., Zhang Y.-Y., Zhang Y.-J., Zhao J., Ji S.-R., Wu J.-W.*,Wu Y.*(2011) Structural insights into the architecture and allostery of full-length AMP-activated protein kinase.Structure, 19(4): 515-522. (IF4.907)
[15]Liu R.-Q., Zhou Q.-H., Ji S.-R., Zhou Q., Feng D.,Wu Y., Sui S.-F.* (2010) Membrane localization of β-Amyloid 1–42 in lysosomes: a possible mechanism for lysosome labilization.Journal of Biological Chemistry, 285(26): 19986-19996. (IF4.01)
[16]Ji S.-R., Ma L., Bai C.-J., Shi J.-M., Li H.-Y., Filep J.G., Potempa L.A., Zhao J.,Wu Y.*(2009) Monomeric C-reactive protein activates endothelial cells via interaction with lipid raft micro-domains.FASEB Journal, 23(6): 1806-1816. (IF5.595)
[17]Ji S.-R.,Wu Y.*, Zhu L., Potempa L.A., Sheng F.-L., Lu W., Zhao J. (2007) Cell membranes and liposomes dissociate C-reactive protein (CRP) to form a new, biologically active structural intermediate: mCRPm.FASEB Journal, 21(1): 284-294. (IF5.595)
[18]Ji S.-R.,Wu Y.*, Potempa L.A., Liang Y.-H., Zhao J. (2006) Effect of modified C-reactive protein on complement activation: A possible complement regulatory role of mCRP in atherosclerotic lesions.Arteriosclerosis, Thrombosis, and Vascular Biology, 26(4): 935-941. (IF6.086)
[19]Ji S.-R.,Wu Y.*, Potempa L.A., Qiu Q., Zhao J. (2006) Interactions of C-reactive protein with low density lipoproteins: implications of an active role of modified C-reactive protein in atherosclerosis.International Journal of Biochemistry & Cell Biology, 384(4): 648-661. (IF3.247)
[20]Wu Y., He Y., Bai J., Ji S.-R., Tucker W.C., Chapman E.R.*, Sui S.-F.* (2003) Visualization of synaptotagmin I oligomers assembled on lipid monolayers.Proceedings of the National Academy of Sciences of the United States of America, 100(4): 2082-2087. (IF9.504)
[21]Ji S.-R.,Wu Y., Sui S.-F.* (2002) Cholesterol is an important factor affecting the membrane insertion of beta-amyloid peptide (ABeta 1-40), which may potentially inhibit the fibril formation.Journal of Biological Chemistry, 277(8): 6273-6279. (IF4.01)
[22]Wu Y., Wang H.-W., Ji S.-R., Sui S.-F.* (2003) Two-dimensional crystallization of rabbit C-reactive protein monomeric subunits.Acta Crystallographica Section D-Biological Crystallography,59(5): 922-926. (IF3.099)



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