姓名:雷东升
教授
所在教研室:计算物理基础
电子邮箱:leids@lzu.edu.cn
招生专业: 凝聚态物理
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个人简历
雷东升，男，博士，兰州大学物理科学与技术学院教授，兼聘兰州大学电镜中心学术与管理决策委员会主席，并任西北四省电子显微学会常务理事。于2006年、2009年和2014年分别获西安交通大学理学学士、硕士和博士学位。2014年至2019年间在美国劳伦斯伯克利国家实验室工作，主要发展和使用冷冻电子断层扫描实验方法，并将其与分子动力学理论模拟相结合，解析脂蛋白、框架核酸、胆固醇酯转运蛋白和抗体等多种生物大分子的动态三维结构，探究功能实现的分子机理。在Nature Communications、Nature Chemical Biology和Journal of Biological Chemistry等SCI刊物上发表论文18篇，研究成果被美国能源部等二十余家机构报道。
研究方向
1、冷冻电子断层扫描技术(cryo-electron tomography)及其应用；2、分子动力学模拟方法及其应用；3、生物大分子（如脂蛋白和框架核酸等）的动态结构与功能机理。
教学及学生指导情况
讲授课程：2021年春，电子显微镜及其在前沿研究中的应用（电子显微学II）2021年春，电子显微学实验方法2020年秋，计算物理基础实验Ⅱ（实践课）
发表论文及专著
[1] Dongsheng Lei, Alex Marras, Jianfang Liu, Chaomin Huang, Lifeng Zhou, Shawn Zheng, Michael Braunfeld, David Agard, Carlos Castro, Hai-Jun Su*, Gang Ren*. Three-dimensional structural dynamics of DNA origami Bennett linkages using individual-particle electron tomography. Nature Communications, 2018, 9:592[2] Xiaobo Zhai#, Dongsheng Lei#, Meng Zhang, Jianfang Liu, Hao Wu, Yadong Yu, Lei Zhang, Gang Ren*. LoTToR: An Algorithm for Missing-Wedge Correction of the Low-Tilt Tomographic 3D Reconstruction of a Single-Molecule Structure. Scientific Reports, 2020, 10:10489[3] Xia Deng#, Hong Zhang#, Junwei Zhang, Dongsheng Lei, Yong Peng*. Synergistic effect of hierarchical nanopores in Co-doped cobalt oxide 3D flowers for electrochemical energy storage. RSC Advances, 2020, 10:43825[4] Dongsheng Lei#, Yadong Yu#, Yu-Lin Kuang, Jianfang Liu, Ronald M. Krauss, Gang Ren*. Single-Molecule 3D Imaging of Human Plasma Intermediate-Density Lipoproteins Reveals a Polyhedral Structure. Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids, 2019, 1864(3):260-270[5] Dongsheng Lei, Jianfang Liu, Hongbin Liu, Thomas E. Cleveland IV, John P. Marino, Ming Lei*, Gang Ren*. Single-Molecule 3D Images of "Hole-Hole" IgG1 Homodimers by Individual-Particle Electron Tomography. Scientific Reports, 2019, 9:8864[6] Valentina Masciotti*, Luca Piantanida, Denys Naumenko, Heinz Amenitsch, Mattia Fanetti, Matja? Valant, Dongsheng Lei, Gang Ren, Marco Lazzarino*. A DNA origami plasmonic sensor with environment-independent read-out. Nano Research, 2019, 12(11): 2900–2907[7] Hao Wu*, Xiaobo Zhai, Dongsheng Lei, Jianfang Liu, Yadong Yu, Rongfang Bie*, Gang Ren*. An Algorithm for Enhancing the Image Contrast of Electron Tomography. Scientific Reports, 2018, 8:16711[8] Meng Zhang, Dongsheng Lei, Bo Peng, Mickey Yang, M Art Charles, Kerry-Anne Rye, Ronald M Krauss, Douglas G Johns, Gang Ren*. Assessing the mechanisms of cholesteryl ester transfer protein inhibitors. Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids, 2017, 1862(12): 1606-1617[9] Hui-Min Zhang*, Charlene Li, Ming Lei, Victor Lundin, Ho Young Lee, Milady Ninonuevo, Kevin Lin, Guanghui Han, Wendy Sandoval, Dongsheng Lei, Gang Ren, Jennifer Zhang, Hongbin Liu*. Structural and Functional Characterization of a Hole-Hole Homodimer Variant in a “Knob-Into-Hole” Bispecific Antibody. Analytical Chemistry, 2017, 89(24): 13494-13501[10] Dongsheng Lei, Matthew Rames, Xing Zhang, Lei Zhang, Shengli Zhang*, Gang Ren*. Insights into the tunnel mechanism of cholesteryl ester transfer protein using all-atom molecular dynamics simulations. The Journal of Biological Chemistry, 2016, 291(27):14034-14044[11] Lei Zhang, Dongsheng Lei, Jessica Smith, Meng Zhang, Huimin Tong, Xing Zhang, Zhuoyang Lu, Jiankang Liu, Paul Alivisatos, Gang Ren*. Three-dimensional structural dynamics and fluctuations of DNA-nanogold conjugates by individual-particle electron tomography. Nature Communications, 2016, 7: 11083[12] Yadong Yu, Yu-Lin Kuang, Dongsheng Lei, Xiaobo Zhai, Meng Zhang, Ronald M. Krauss, Gang Ren*. Polyhedral 3D Structure of Human Plasma Very-Low-Density Lipoproteins by Individual Particle Cryo-Electron Tomography. Journal of Lipid Research, 2016, 57(10):1879-1888[13] Xiangyu Deng, Xiangjing Qin, Lei Chen, Qian Jia, Yonghui Zhang, Zhiyong Zhang, Dongsheng Lei, Gang Ren, Zhihong Zhou, Zhong Wang, Qing Li, Wei Xie*. Large Conformational Changes of Insertion 3 in Human Glycyl-tRNA synthetase (hGlyRS) during Catalysis. The Journal of Biological Chemistry, 2016, 291(11):5740-5752[14] Xing Zhang, Dongsheng Lei, Lei Zhang, Matthew Rames, Shengli Zhang*. A Model of Lipid-Free Apolipoprotein AI Revealed by Iterative Molecular Dynamics Simulation. PloS one, 2015, 10(3):e**[15] Dongsheng Lei, Huimin Tong, Lei Zhang, Xing Zhang, Shengli Zhang*, Gang Ren*. Structure and Function of Cholesteryl Ester Transfer Protein in Transferring Cholesteryl Ester. Progress in Chemistry, 2014, 26(5):879-888[16] Dongsheng Lei, Xing Zhang, Shengbo Jiang, Zhaodi Cai, Matthew J Rames, Lei Zhang, Gang Ren*, Shengli Zhang*. Structural features of cholesteryl ester transfer protein: A molecular dynamics simulation study. Proteins-Structure Function and Bioinformatics, 2013, 81(3): 415-425[17] Lei Zhang#, Feng Yan#, Shengli Zhang, Dongsheng Lei, Arthur M. Charles, Giorgio Cavigiolio, Michael Oda, Ronald M. Krauss, Karl H. Weisgraber, Kerry-Anne Rye, Henry J Pownall, Xiayang Qiu, Gang Ren*. Structural basis of transfer between lipoproteins by cholesteryl ester transfer protein. Nature Chemical Biology, 2012, 8(4):342-349[18] Lei Zhang, Shengli Zhang*, Huimin Tong, Dongsheng Lei, Bambi Hu. Spontaneously periodic wave generation in coupled excitable media. Physical Review E, 2009, 79(5):056213
社会工作
西北四省电子显微镜学会常务理事
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