基本情况
姓名：杨立群
性别：女
籍贯：云南昆明
理学博士，副教授，硕士生导师
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联系方式
邮箱：yanglq@mail.sysu.edu.cn
通讯地址：广东省广州市中山大学化学学院
邮编：510275
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教育经历
1987.9—1994.6 　　武汉大学化学系高分子化学与物理专业学习, 获理学学士、硕士学位，导师：张俐娜院士；
1994.9—1997.6 　　中山大学高分子研究所高分子化学与物理专业学习, 获理学博士学位，导师：李卓美教授；
2000.3—2004.3 日本国家产业技术综合研究所(National Institute of Advanced Industrial Science and Technology, AIST)，日本学术振兴会(JSPS)博士后和AIST博士后
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工作经历
1997.7—2000.2 广州市轻工研究所，工程师；
2004.4—今 中山大学化学学院高分子研究所，副教授
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讲授课程
研究生课程：《天然高分子与生物高分子》、《高分子结构与性能的现代测试技术》；
本科生课程：《高分子物理》、《功能高分子材料》、《现代化学实验与技术（物理化学实验部分）》、《大学化学实验》。
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科研方向
天然高分子改性及其功能化：
(1)天然多糖的高分子结构及其对生物活性的影响
(2)天然多糖的化学修饰及其生物医用功能化
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科研项目
作为项目负责人承担的项目：
(1) 广东省自然科学基金重点项目（2017B）：茶多糖对血糖调控酶活性的影响及其作用机制研究，2017.05-2021.05
(2) 广东省公益研究与能力建设专项（2016A）：两亲性壳聚糖衍生物复合纳米粒的制备及其智能调控胰岛素释放的研究，2016.1-2018.12
(3) 广州市科技计划项目（9）：小肠靶向高效吸收的多糖载药纳米粒研究，2016.4-2019.3
(4)国家自然科学基金专项基金项目（科学部主任基金）（**）：超支化茶多糖化学改性用作胰岛素基因转染载体的研究，2013.1-2013.12
(5) 国家自然科学基金面上项目（**）：基于“树枝”状两亲性支链淀粉衍生物的单分子反胶束研究，2010.1-2012.12
(6) 国家自然科学基金面上项目（**）：新型两亲性直链淀粉衍生物的合成及其胶束化行为，2006.1-2008.12
(7) 霍英东教育基金第十届高等院校青年教师优选资助课题基金（104036）：茶多糖对预防心脏性猝死的保健功效，2006.3-2009.2
(8) 教育部高校基本科研业务费中山大学青年教师培育项目（09lgpy14）：口服多肽类药物的新型载体材料研究，2010.1-2012.12
(9) 广东省教育部产学研结合项目（2012B)：应用智能靶向型纳米粒包裹中药糖视明缓释新技术的研发，2012.12-2015.12
(10) 广东省教育部产学研结合项目（2012B)：研发高效、安全缓释类风湿关节炎药物的原位水凝胶制剂，2012.06-2015.06
(11) 广东省科技计划项目(2009B)：虾、蟹壳聚糖的化学改性及其生物医学纳米材料的制备与应用，2009.9-2012.8
(12) 广东省教育部产学研结合项目（2009B)：抗菌功能纤维及制品的研发，2009.1-2011.6
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获奖情况
(1) 张俐娜，许小娟，杨立群，丁琼，张玫. 复杂多糖的分子量和链构象及其对功能和性能的影响，2005年12月获得湖北省科技进步一等奖
(2) 张黎明，杨立群，易菊珍，赵三平，王冠海，梁媛媛，马栋，李玮. 生物资源大分子功能化利用的基础研究，2010年11月获得广东省科学技术奖(基础研究类)二等奖
(3) 邓宇斌，万勇，刘少喻 ，陈宁宁，魏富鑫，杨军林，杨立群，张黎明，何志捷，王乐.脊髓损伤修复新疗法的研究及术中电生理检测的应用，2019年3月获得广东省科学技术奖二等奖
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通讯（第一）作者论著
ESI高被引用论文
(1) Liqun Yang*, Li-Ming Zhang. Chemical structural and chain conformational characterization of some bioactive polysaccharides isolated from natural sources. Carbohydrate Polymers, 2009, 76, 349-361. (2017、2018、2019年ESI高被引用论文)
(2) Jingnan Wang, Jiayun Tan, Jiahao Luo, Peilin Huang, Wuyi Zhou, Luming Chen, Lingli Long, Li-Ming Zhang, Banghao Zhu, Liqun Yang*, David YB Deng*. Enhancement of scutellarin oral delivery efficacy by vitamin B12-modified amphiphilic chitosan derivatives to treat type II diabetes induced-retinopathy. Journal of Nanobiotechnology. 2017, 15(18), 1–17. (2019年ESI高被引用论文)
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SCI收录论文
(1) Lin Yin, Shanshan Fu, Roujun Wu, Shuyue Wei, Juzhen Yi, Li-Ming Zhang, Liqun Yang*. Chain conformation of an acidic polysaccharide from green tea and related mechanism of α-amylase inhibitory activity. International Journal of Biological Macromolecules, 2020, 164, 1124-1132.
(2) Lin Yin, Shanshan Fu, Roujun Wu, Shuyue Wei, Juzhen Yi, Li-Ming Zhang, Liqun Yang*. A neutral polysaccharide from green tea: Structure, effect on α-amylase activity and hydrolysis property. Archives of Biochemistry and Biophysics, 2020, 687(108369), 1–10.
(3) Yaqing Huang, Weihong Guo, Junzhao Zhang, Xiao Peng, Guoxin Li*, Li-Ming Zhang*, Liqun Yang*. Thermosensitive hydrogels based on methylcellulose derivatives for prevention of postoperative adhesion. Cellulose, 2020, 27, 1555–1571.
(4) Siyuan Li, Lin Yin, Juzhen Yi, Li-Ming Zhang*, Liqun Yang*. Insight into interaction mechanism between theaflavin-3-gallate and α-glucosidase using spectroscopy and molecular docking analysis. Journal of Food Biochemistry, 2020, e13550, 1-11.
(5) Biyun Lan, Junfeng Wu, Na Li, Chenglin Pan, Li Yan, Chuan Yang, Li-Ming Zhang*, Liqun Yang*, Meng Ren*. Hyperbranched cationic polysaccharide derivatives for ef?cient siRNA delivery and diabetic wound healing enhancement. International Journal of Biological Macromolecules, 2020, 154, 855-865.
(6) Na Li¹, Liqun Yang¹, Chenglin Pan¹, Phei Er Saw, Meng Ren, Biyun Lan, Junfeng Wu, Xiaoyi Wang, Tingting Zeng, Liyan Zhou, Li-Ming Zhang*, Chuan Yang*, Li Yan*. Naturally-occurring bacterial cellulose-hyperbranched cationic polysaccharide derivative/MMP-9 siRNA composite dressing for wound healing enhancement in diabetic rats. Acta Biomaterialia, 2020, 102, 298-314.
(7) Kunhua Lin, Juzhen Yi*, Xuhong Mao, Hao Wu, Li-Ming Zhang, Liqun Yang*. Glucose-sensitive hydrogels from covalently modified carboxylated pullulan and concanavalin A for smart controlled release of insulin. Reactive and Functional Polymers, 2019, 139, 112-119.
(8) Shuyun Wu, Na Li, Chuan Yang, Li Yan, Xuan Liang, Meng Ren*, Liqun Yang*. Synthesis of cationic branched tea polysaccharide derivatives for targeted delivery of siRNA to hepatocytes. International Journal of Biological Macromolecules, 2018, 118, 808-815.
(9) Jiayun Tan, Xiaojuan Wang, Zhong Yu, Jiahao Luo, Biyun Lan, Na Li, Yachuan Xin, Chunlian Zeng, Li Yan, Li-Ming Zhang, Xiaohong Chen, Shanyue Guan, Wei Li*, Liqun Yang*. Spectroscopic investigation of a hyperbranched cationic amylopectin derivative as a multi-guest molecular host for targeted delivery of a photosensitizer to pancreatic cancer cells. Carbohydrate Polymers, 2018, 197, 38-46.
(10) Minghua Lai, Jingnan Wang, Jiayun Tan, Jiahao Luo, Li-Ming Zhang, David Y. B. Deng,* Liqun Yang*. Preparation, complexation mechanism and properties of nano-complexes of Astragalus polysaccharide and amphiphilic chitosan derivatives. Carbohydrate Polymers, 2017, 161, 261–269.
(11) Shuyun Wu, Minghua Lai, Jiahao Luo, Jingwen Pan, Li-Ming Zhang, Liqun Yang*. Interactions between α-amylase and an acidic branched polysaccharide from green tea. International Journal of Biological Macromolecules, 2017, 94, 669–678.
(12) Zhenzhen Liu, Haijun Gong, Rui Zeng, Xuan Liang, Li-Ming Zhang, Liqun Yang*, Yuqing Lan.* Efficient delivery of NF-КB siRNA to human retinal pigment epithelial cells with hyperbranched cationic polysaccharide derivative-based nanoparticles. International Journal of Nanomedicine, 2015, 10, 2735-2749.
(13) Huajie Li, Zhong Yu, Shuangping Wang, Xi Long, Li-Ming Zhang, Zhaohua Zhu, Liqun Yang*. Photosensitizer-encapsulated amphiphilic chitosan derivative micelles: Photoactivity and enhancement of phototoxicity against human pancreatic cancer cells. Journal of Photochemistry and Photobiology B: Biology, 2015, 142, 212-219.
(14) Xuan Liang, Shuyun Wu, Xianyue Ren, Daping Quan, Li-Ming Zhang, Yubing Deng, Liqun Yang.* Complexation behaviors of hyperbranched cationic glycogen derivatives with plasmid DNA revealed by resonance light scattering and circular dichroism spectroscopy. Starch-Starke, 2015, 67, 838–845.
(15) Huajie Li, Zhong Yu, Shuangping Wang, Li-Ming Zhang, Liqun Yang*. Protection of photoactivity of photosensitizers by amphiphilic polysaccharide micelles. Chinese Journal of Polymer Science, 2014, 32, 1413–1418.
(16) Zhong Yu, Huajie Li, Li-Ming Zhang, Zhaohua Zhu, Liqun Yang*. Enhancement of phototoxicity against human pancreatic cancer cells with photosensitizer-encapsulated amphiphilic sodium alginate derivative nanoparticles. International Journal of Pharmaceutics, 2014, 473, 501–509.
(17) Xuan Liang, Xianyue Ren, Zhenzhen Liu, Yingliang Liu, Jue Wang, Jingnan Wang, Li-Ming Zhang, David Y. B. Deng*, Daping Quan, Liqun Yang*. An efficient nonviral gene-delivery vector based on hyperbranched cationic glycogen derivatives. International Journal of Nanomedicine, 2014, 9, 419–435.
(18) Di Zeng, Jizhou Fan, Zhibin Deng, Jiayun Tan, Zheng Deng, Li-Ming Zhang, Liqun Yang*. One-step synthesis of amphiphilic hyperbranched amylopectin derivatives, characterization and use as functional nanovehicles. Carbohydrate Polymers, 2013, 98, 905–913.
(19) Liqun Yang*, Bifang Zhang, Juzhen Yi, Jiabao Liang, Yingliang Liu, Li-Ming Zhang. Preparation, characterization and properties of amylose-ibuprofen inclusion complexes. Starch-Starke, 2013, 65, 593–602.
(20) Yanfang Zhou, Bin Yang, Xianyue Ren, Zhenzhen Liu, Zheng Deng, Luming Chen, Yubin Deng*, Li-Ming Zhang, Liqun Yang*. Hyperbranched cationic amylopectin derivatives for gene delivery. Biomaterials, 2012, 33, 4731-4740.
(21) Huaisheng Zhou, Liqun Yang*, Huajie Li, Haijun Gong, Liangzheng Cheng, Haisheng Zheng, Li-Ming Zhang, Yuqing Lan*. Downregulation of VEGF mRNA expression by triamcinolone acetonide acetate-loaded chitosan derivative nanoparticles in human retinal pigment epithelial cells. International Journal of Nanomedicine, 2012, 7, 4649-4660.
(22) Liqun Yang*, Bin Yang, Di Zeng, Yu Wang, Li-Ming Zhang. Formation and property of a novel complex composed of amylose-grafted chitosan derivative and single-walled carbon nanotubes. Carbohydrate Polymers, 2011, 85, 845-853.
(23) Liqun Yang*, Shanshan Fu, Xiane Zhu, Li-Ming Zhang, Yanrui Yang, Xiaomin Yang, Hui Liu. Hyperbranched acidic polysaccharide from green tea. Biomacromolecules, 2010, 11, 3395-3405.
(24) Liqun Yang*, Yuqing Lan*, Hui Guo, Liangzheng Cheng, Jizhou Fan, Xiang Cai, Li-Ming Zhang, Rufu Chen, Huaisheng Zhou. Ophthalmic drug-loaded N,O-carboxymethyl chitosan hydrogels: Synthesis, in vitro and in vivo evaluation. Acta Pharmacologica Sinica, 2010, 31, 1625-1634.
(25) Xiang Cai, Liqun Yang*, Li-Ming Zhang, Qing Wu. Evaluation of amylose used as a drug delivery carrier. Carbohydrate Research, 2010, 345, 922–928.
(26) Xiang Cai, Liqun Yang*, Li-Ming Zhang, Qing Wu. Synthesis and anaerobic biodegradation of indomethacin-conjugated cellulose ethers used for colon-specific drug delivery. Bioresource Technology, 2009, 100, 4164–4170.
(27) Liqun Yang*, Jianliang Kuang, Jun Wang, Zhiquan Li, Li-Ming Zhang. Loading and in vitro controlled release of indomethacin using amphiphilic cholesteryl-bearing carboxymethylcellulose derivatives, Macromolecular Bioscience, 2008, 8, 279-286.
(28) Liqun Yang*, Bifang Zhang, Yuting Liang, Bin Yang, Tao Kong, Li-Ming Zhang. In situ synthesis of amylose/single-walled carbon nanotubes supramolecular assembly, Carbohydrate Research, 2008, 343, 2463–2467.
(29) Liqun Yang*, Jianliang Kuang, Zhiquan Li, Bifang Zhang, Xiang Cai, Li-Ming Zhang. Amphiphilic cholesteryl-bearing carboxymethylcellulose derivatives: self-assembly and rheological behaviour in aqueous solution, Cellulose, 2008, 15, 659-669.
(30) Liqun Yang*, Bifang Zhang, Liqun Wen, Qiuyi Liang, Li-Ming Zhang. Amphiphilic cholesteryl grafted sodium alginate derivative: Synthesis and self-assembly in aqueous solution, Carbohydrate Polymers, 2007, 68, 218-225.
(31) Liqun Yang*, Li-Ming Zhang, Ryouichi Ito and Youta Matsuo (Ed.). Handbook of Carbohydrate Polymers: Development, Properties and Applications: Chapter 24 – Polysaccharides and Their Derivatives for Biomedical Applications, pp. 693-709. New York: Nova Science Publishers, Inc., 2010, ISBN: 978-1-60876-367-2.
(32) Xiang Cai, Liqun Yang*, Yifu Huang, Ningfu Peng, Li-Ming Zhang, Qing Wu, Rufu Chen. Targeted and controlled release of indomethacin from a prodrug of amylose, International Federation for Medical and Biological Engineering (IFMBE) Proceedings, 2008, 19, 29-31.
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国家发明专利
(1) 吴燕琳，罗嘉浩，白冰，杨立群，张黎明. 一种含多肽靶向因子的多糖衍生物及其制备方法，申请日：2016-11-29 ，专利授权号：ZL 7.7，授权时间：2020-05-20.
(2) 潘成林，张黎明，杨立群.一种含树枝状聚酰胺-胺基团的高度超支化阳离子多糖衍生物及其制备方法，申请日：2017-08-08，专利授权号：ZL 4.3，授权时间：2020-04-28.
(3) 杨立群，赖欣宜，胡亦清，龙茜，罗嘉浩，冯子乐，张黎明. 一种两亲性多糖衍生物/泊洛沙姆温敏型原位水凝胶及其制备方法，专利授权号：ZL 0.0，授权时间：2019-02-01.
(4) 罗嘉浩，杨立群，于钟，黎悦，张黎明. 一种阳离子超支化多糖衍生物及其在增强血卟啉类光敏剂对肿瘤细胞光毒性方面的应用，专利授权号：ZL 3.X，授权时间：2019-03-28.
(5) 杨立群，邓宇斌，谭家运，王竞男，黄玲玉，王双萍，张黎明. 小肠靶向吸收的壳聚糖衍生物、其制备方法及载药纳米粒，专利授权号：ZL3.2，授权时间：2017-04-19.
(6) 杨立群，伍淑韵，梁玄，邹珊珊，潘靖雯，吴燕琳，张黎明. 茶多糖衍生物及其制备方法，专利授权号：ZL 7.5，授权时间：2015-11-18.
(7) 蔡祥，杨立群，张黎明，伍青，一种制备直链淀粉水溶液的方法，专利授权号：ZL 5.4，授权时间：2011-03-30.
(8) 杨立群，孔韬，关文彦，张黎明，麦芽七糖的化学制备方法，专利授权号：ZL 2.8，授权时间：2009-06-24.
(9) 林坤华，易菊珍，杨立群，吴昊. 一种智能调控胰岛素释放的植物凝集素-多糖水凝胶及其制备和应用，申请号：3.2，申请日：2017-07-25，公布号：CNA，公布日：2017-12-01.
(10) 杨立群，严励，潘成林，李娜，杨川，张黎明，吴俊凤，任萌. 一种具有RNA干扰功能的微生物纤维素复合敷料及其制备方法和应用. 申请号：2.6，申请日：2018-05-25，公布号：CNA，公布日：2018-11-23.
(11) 杨立群，尹林，吴柔君，魏书玥，罗嘉浩. 一种高效、快速检测α-葡萄糖苷酶活性的方法. 申请号：4.6，申请日：2019-08-29，公布号：CNA，公布日：2020-02-21.
(12) 李健鹏，杨立群，张黎明. 一种微生物纤维素膜/纳米贵金属复合材料及其制备方法和应用. 申请号：4.3，申请日：2019-08-30，公布号：CNA，公布日：2020-01-10.
(13) 杨立群，毛旭宏，邓宇斌，龙玲俐，林坤华，张黎明. 一种小肠靶向吸收、生物降解的糖原衍生物、其制备方法及其负载茶多糖的纳米粒. 申请号：6.6，申请日：2018-08-30，公布号：CNA，公布日：2018-12-25.
(14) 杨立群*，林坤华，易菊珍*，李春龙，毛旭宏，江桂生. 一种含有胆固醇和植物凝集素基团的两亲性多糖衍生物及其制备方法和应用. 申请号：5.7，申请日：2019-01-30，公布号：CNA，公布日：2019-06-14.
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指导的本科生科研项目
(1) 吴柔君，魏书玥，彭枭，马馨叶，广东省大学生科技创新培育专项资金（“攀登计划”专项资金）（pdjh2019b0020）：酸性茶多糖对α-葡萄糖苷酶活性的影响及其作用机制研究，2019.01-2019.12
(2) 彭枭，马馨叶，中山大学实验室开放基金项目（重点项目）：甲基纤维素/胶原蛋白温敏性大孔水凝胶的制备及性能研究，2019.05-2019.12
(3) 李春龙，吴柔君，吴昊，中山大学大学生创新创业训练计划项目（）（国家级）：两亲性普鲁兰衍生物纳米粒的制备及其智能调控胰岛素释放的研究，2017.03-2017.12
(4) 吴柔君，魏书玥，中山大学大学大学生创新训练计划项目（省级）：茶多糖对α-葡萄糖苷酶活性的影响及其作用机制研究，2019.03-2019.12
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