刘海英

Submitted on 周一, 10/30/2017 - 21:17


性别
女

电子邮件
liuhy5@mail.sysu.edu.cn

职称
副教授

导师类型
硕士生导师

学历
博士

学科方向
0710生物学-09细胞生物学


研究方向
1. 细胞衰老与癌变的机制研究
2. 肿瘤细胞中的端粒DNA损伤修复研究
3. 炎症与衰老的关系研究
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个人经历
博士毕业于清华大学，随后任职于中山大学

讲授课程
本科生必修课《遗传学实验》
全校通识课《衰老与抗衰老》
研究生必修课《实验设计与统计分析》

学术成就
主要从事端粒酶亚基hTERT、hTR的功能研究，以及端粒DNA损伤修复的研究，发现hTERT和hTR在癌症发生以及自己身免疫疾病发生过程中具有重要的作用。曾在Hepatology,? Journal of? Proteome Research, Scientific Reports等国际期刊上发表研究论文十余篇。

承担课题
主持国家自然科学基金面上项目1项，青年科学基金1项，中央高校基本科研业务费1项。

论文专著
Liu H,?Yang Y,?Ge Y,?Liu J,?Zhao Y. TERC promotes cellular inflammatory response independent of telomerase. Nucleic Acids Res.?2019 Sep 5;47(15):8084-8095
Zhang Z,?Zhang T,?Ge Y,?Tang M,?Ma W,?Zhang Q,?Gong S,?Wright WE,?Shay J,?Liu H*,?Zhao Y*.2D gel electrophoresis reveals dynamics of t-loop formation during the cell cycle and t-loop in maintenance regulated by heterochromatin state. J Biol Chem.?2019 Apr 19;294(16):6645-6656.
Liu H, Xie Y, Zhang Z, Mao P, Liu J, Ma W, Zhao Y.Telomeric Recombination Induced by DNA Damage Results in Telomere Extension and Length Heterogeneity. Neoplasia. 2018 Sep;20(9):905-916.
Liu H, Liu Q, Ge Y, Zhao Q, Zheng X, Zhao Y. hTERT promotes cell adhesion and migration independent of telomerase activity. Sci Rep. 2016 Mar 14;6:22886.
Liu H, Yuan Y, Guo H, Mitchelson K, Zhang K, et al. Hepatitis B virus encoded x protein suppresses apoptosis by inhibition of the caspase-independent pathway. J Proteome Res 2012 Oct 5;11(10):4803-13.
Guo H*, Liu H*, Mitchelson K, Rao H, Luo M, et al. MicroRNAs-372/373 promote the expression of hepatitis B virus through the targeting of nuclear factor I/B. Hepatology 2011 Sep 2;54:808-819.
Xu Y*, Liu H*, Li F, Sun N, Ren Y, et al. A polymorphism in the microRNA-30e precursor associated with major depressive disorder risk and P300 waveform. J Affect Disord 2010 Dec;127(1-3):332-6.
Zhang T,?Zhang Z,?Li F,?Hu Q,?Liu H,?Tang M,?Ma W,?Huang J,?Songyang Z,?Rong Y,?Zhang S3,?Chen BP,?Zhao Y. Looping-out Mechanism for Resolution of Replicative Stress at Telomeres. EMBO Rep.?2017 Aug;18(8):1412-1428.
Zheng XH,?Nie X,?Fang Y,?Zhang Z,?Xiao Y,?Mao Z,?Liu H,?Ren J,?Wang F,?Xia L,?Huang J,?Zhao Y. A?Cisplatin?Derivative?Tetra-Pt(bpy) as an?Oncotherapeutic?Agent?for?Targeting?ALT?Cancer. J Natl?Cancer?Inst.?2017 Oct 1;109(10).
Mao P, Liu J, Zhang Z, Zhang H, Liu H, Gao S, Rong YS, Zhao Y. Homologous recombination-dependent repair of telomeric DSBs in proliferating human cells. Nat Commun. 2016 Jul 11;7:12154.
Ge Y, Wu S, Xue Y, Tao J, Li F, Chen Y, Liu H, Ma W, Huang J, Zhao Y. Preferential extension of short telomeres induced by low extracellular pH. Nucleic Acids Res. 2016 Sep 30;44(17):8086-96.
Zheng X, Nie X, Liu H, Fang Y, Zhao Y, Xia L. TMPyP4 promotes cancer cell migration at low doses, but induces cell death at high doses. Sci Rep. 2016 May 25;6:26592.
Chen Y, Deng Zh, Jiang Sh, Hu Q, Liu H, Songyang Zh, Ma W, Chen Sh , Zhao Y. Human Cells Lacking Coilin and Cajal Bodies are Proficient in Telomerase Assembly, Trafficking, and Telomere Maintenance. Nucl Acids Res. 2015 Jan 9;43(1):385-95.
Wu Sh, Ge Y, Huang L, Liu H, Xue Y, Zhao Y. BRG1, the ATPase Subunit of SWI/SNF Chromatin Remodeling Complex, Interacts with HDAC2 to Modulate Telomerase Expression in Human Cancer Cells. Cell Cycle 2014 Sep 15;13(18):2869-78.