胡文浩，中山大学教授、药学院院长。国家****基金获得者、教育部“****”****。胡文浩教授先后在四川大学获得学士学位（1987）、中科院成都有机所获得硕士学位（1990）和香港理工大学获得博士学位（1998，导师：陈新滋院士），随后在美国亚利桑那大学从事博士后研究（1998-2002）。胡文浩教授先后在美国Genesoft 和Bristol-Myers Squibb 公司担任高级研究员，之后于2006年回国加入华东师范大学任华东师范大学化学系教授、上海市高校“****” ****（2009-2016）和上海分子治疗与新药创制工程技术研究中心主任（2011-2016），2016年8月全职加入中山大学任教授、药学院院长，广东省“珠江人才计划”创新创业团队带头人，广东省手性分子与药物发现重点实验室主任（2019起）。目前担任国务院学位委员会第八届药学学科评议组成员，教育部高校药学类教学指导委员会委员，广东省药学会副理事长等学术任职。曾获上海市自然科学一等奖（2016）、教育部自然科学二等奖（2010）、享受国务院特殊津贴专家（2016）和国家百千****才工程人选、有突出贡献中青年专家等国内外二十余项奖。研究方向主要集中在有机合成方法学、多组分反应、新药研发和药物合成工艺等，至今已在Nature Chemistry, Nature Communications, Science Advances, Journal of the American Chemical Society, Angewandte Chemie?International?Edition和Journal of Medicinal Chemistry等期刊上发表论文220余篇，引用5000余次，申请专利100余项（授权40余项）。
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学术任职：
《有机化学》编委
《化学学报》编委
《化学快报》编委
《中国医药工业杂志》副主编
《Molecular Diversity》副主编
中国药学会制药工程专委会委员
中国药学会药物化学专委会委员
国务院学位委员会第八届药学学科评议组成员
教育部高校药学类教学指导委员会委员
中国化学会手性化学专业委员会委员，中国化学会有机化学学科委员
广东省药学会副理事长
广东省化学会化学制药专业委员会主任委员
广东省药学会药物化学专业委员会副主任委员
广东省药学会制药工程专业委员会副主任委员
荣誉与获奖情况：
2016年? 上海市自然科学一等奖
2016年? 享受国务院特殊津贴专家
2015年? 国家百千****才工程人选，有突出贡献中青年专家
2015年? 教育部“****” ****
2012年? 国家****基金获得者
2010年? 教育部自然科学二等奖
2010年? Asian Core Program Lectureship Award
2009年? 上海市高校“****”****
2009年? “上海市优秀学科带头人”
2008年? Thieme Chemistry Journal Award
2007年? 上海市“浦江计划”
2006年? 上海市“曙光****”
2005年? “四川省学术和技术带头人”
2002年? 四川省科学技术进步一等奖
2000年? 中国科学院“****”入选者
1994年? 四川省科学技术进步二等奖
代表性论文：
Liu Hu, Xing Cai, Suzhen Dong, Yongjia Zhen, Jidi Hu, Shenjun Wang, Jingwen Jiang, Jiawu Huang, Yuqiao Han, Yu Qian, Yanqiu Yuan, Wenhao Hu, Synthesis and Anticancer Activity of Novel Actinonin Derivatives as HsPDF Inhibitors. Journal of Medicinal Chemistry, 2020, 63, 6959-6978. (IF 6.205)
Jiuling Li; Dan Zhang; Jianghui Chen; Chaoqun Ma; Wenhao Hu, Enantioselective Synthesis of Fluoroalkyl-Substituted syn-Diamines by the Asymmetric gem-Difunctionalization of 2,2,2-Trifluorodiazoethane. ACS Catalysis, 2020, 10, 4559-4565. (IF 135)
Jiuwei Che,Li Niu,Shikun Jia,Dong Xing,Wenhao Hu, Enantioselective three-component aminomethylation of α-diazo ketones with alcohols and 1,3,5-triazines. Nature Communications. 2020, 11, 1511. (IF 12.121)
Guizhi Dong; Ming Bao; Xiongda Xie; Shikun Jia; Wenhao Hu; Xinfang Xu; Asymmetric Allylation by Chiral Organocatalyst Promoted Formal Hetero-Ene Reactions of Alkylgold Intermediates. Angew Chem Int Edit,?2020, doi.org/10.1002/anie. (IF 12.959)
Dan Zhang, Xin Wang, Mengchu Zhang, Zhenghui Kang, Guolan Xiao, Xinfang Xu, and Wenhao Hu， Highly Enantioselective Trapping of Carboxylic Oxonium Ylides with Imines for Direct Assembly of Enantioenriched γ-Butenolides, CCS Chem. 2020, 2, 432–439.
Xinxin Lv, Shuhao Liu, Su Zhou, Guizhi Dong, Dong Xing, Xinfang Xu, and Wenhao Hu, Asymmetric Three-Component Propargyloxylation for Direct Assembly of Polyfunctionalized Chiral Succinate Derivatives, CCS Chem. 2020, 2, 1903–1912.
Zhenghui Kang, Yongheng Wang, Dan Zhang, Ruibo Wu, Xinfang Xu, Wenhao Hu, Asymmetric Counter-Anion-Directed Aminomethylation: Synthesis of Chiral β-Amino Acids via Trapping of an Enol Intermediate. Journal of the American Chemical Society 2019, 141, 1473-1478. (IF 14.612)
Deyu Kong,Tao Xue,Bin Guo,Jianjun Cheng,Shunyin Liu,Jianhai Wei,Zhengyu Lu,Haoran Liu,Guoqing Gong,Tian Lan,Wenhao Hu, Yushe Yang, Optimization of P2Y12 Antagonist Ethyl 6-(4-((Benzylsulfonyl)carbamoyl)piperidin-1-yl)-5-cyano-2-methylnicotinate (AZD1283) Led to the Discovery of an Oral Antiplatelet Agent with Improved Druglike Properties. Journal of Medicinal Chemistry, 2019, 62, 3088-3106. (IF 6.205)
Dan Zhang, Zhenghui Kang, Junwen Liu, Wenhao Hu, Metal-Dependent Umpolung Reactivity of Carbenes Derived from Cyclopropenes. iScience 2019, 14, 292-300. (IF 4.447)
Yuanxiang Wang,*?Wenhao Hu, and?Yanqiu Yuan.* Protein Arginine Methyltransferase 5 (PRMT5) as an Anticancer Target and Its Inhibitor Discovery. J. Med. Chem. 2018, DOI:?1021/acs.jmedchem.8b00598.
Shunying Liu, Wenfeng Yao, Yuan Liu, Qinghua Wei, Jianghui Chen, Xiang Wu, Fei Xia,* Wenhao Hu*. A Rh(II)-catalyzed multicomponent reaction by trapping an a-amino enol intermediate in a traditional two-component reaction pathway. Sci. Adv. 2017, 3: e**. DOI: 10.1126/sciadv.**.
Shunying Liu, Jun Jiang, Jianghui Chen, Qinghua Wei, Wenfeng Yao, Fei Xia* and Wenhao Hu*, A DFT calculation-inspired Rh(I)-catalyzed reaction via suppression of a-H shift in a alkyldiazoacetates. Chem. Sci. 2017, 8, 4312–4317.
Liqin Jiang, Weifeng Jin, and Wenhao Hu*, Double C?H Functionalization of Indoles via Three-Component Reactions/CuCl₂-Catalyzed Aerobic Dehydrogenative Coupling for the Synthesis of Polyfunctional Cyclopenta[b]indoles, ACS Catal. 2016, 6, 6146-6150.
Dan Zhang, Jun Zhou, Fei Xia, Zhenghui Kang, and Wenhao Hu*, Bond cleavage, fragment modification and reassembly in enantioselective three-component reactions, Nat Commun. 2015, 6, 5801.
Xiaochu Ma, Jun Jiang, Siying Lv, Wenfeng Yao, Yang Yang, Shunying Liu,* Fei Xia, and Wenhao Hu*, An Ylide Transformation of Rhodium(I) Carbene: Enantioselective Three-Component Reaction through Trapping of Rhodium(I)-Associated Ammonium Ylides by β-Nitroacrylates, Angew. Chem. Int. Ed. 2014, 53, 13136-13139.
Shikun Jia, Dong Xing, Dan Zhang, and Wenhao Hu*, Catalytic Asymmetric Functionalization of Aromatic C-H Bonds by Electrophilic Trapping of Metal-Carbene-Induced Zwitterionic Intermediates, Angew. Chem. Int. Ed. 2014, 53, 13098-13101.
Xufeng Cao, Zhaoshuan Sun, Yongbing Cao, Ruilian Wang, Tongkai Cai, Wenjing Chu, Wenhao Hu,* and Yushe Yang*, Design, Synthesis, and Structure-Activity Relationship Studies of Novel Fused Heterocycles-Linked Triazoles with Good Activity and Water Solubility, J. Med. Chem. 2014, 57, 3687-3706.
Brendan Frett, Robert V. Brown, Mingliang Ma, Wenhao Hu, Haiyong Han, and Hong-yu Li*, Therapeutic Melting Pot of Never in Mitosis Gene A Related Kinase2 (Nek2): A Perspective on Nek2 as an Oncology Target and Recent Advancements in Nek2 Small Molecule Inhibition, J. Med. Chem. 2014, 57, 5835-5844.
Dan Zhang, Huang Qiu, Liqin Jiang,* Fengping Lv, Chaoqun Ma, and Wenhao Hu*,. Enantioselective Palladium(II) Phosphate Catalyzed Three-Component Reactions of Pyrrole, Diazoesters, and Imines. Angew. Chem. Int. Ed. 2013, 125, 13598-13602.
Changcheng Jing, Dong Xing, Yu Qian, Taoda Shi, Yun Zhao, and Wenhao Hu*, Diversity-Oriented Three-Component Reactions of Diazo Compounds with Anilines and 4-Oxo-Enoates. Angew. Chem. Int. Ed. 2013, 52, 9289-9292.
Xin Guo, and Wenhao Hu*, Novel Multicomponent Reactions via Trapping of Protic Onium Ylides with Electrophiles, Acc. Chem. Res. 2013, 46, 2427-2440.
Jun Jiang, Xiaoyu Guan, Shunying Liu, Baiyan Ren, Xiaochu Ma, Xin Guo, Fengping Lv, Xiang Wu, and Wenhao Hu*, Highly Diastereoselective Multicomponent Cascade Reactions: Efficient Synthesis of Functionalized 1-Indanols, Angew. Chem. Int. Ed. 2013, 52, 1539-1542.
Huang Qiu, Ming Li, Li-Qin Jiang, Feng-Ping Lv, Li Zan, Chang-Wei Zhai, Michael P. Doyle, and Wen-Hao Hu*, Highly enantioselective trapping of zwitterionic intermediates by imines, Nat. Chem. 2012, 4, 733-739.
Jun Jiang, Hua-Dong Xu, Jian-Bei Xi, Bai-Yan Ren, Feng-Ping Lv, Xin Guo, Li-Qin Jiang, Zhi-Yong Zhang, and Wenhao Hu*, Diastereoselectively Switchable Enantioselective Trapping of Carbamate Ammonium Ylides with Imines, J. Am. Chem. Soc. 2011, 133, 8428-8431.
Xiaoyu Guan, Liping Yang, and Wenhao Hu*, Cooperative Catalysis in Multicomponent Reactions: Highly Enantioselective Synthesis of γ-Hydroxyketones with a Quaternary Carbon Stereocenter, Angew. Chem. Int. Ed. 2010, 49, 2190-2192.
Xu Zhang, Haoxi Huang, Xin Guo, Xiaoyu Guan, Liping Yang, and Wenhao Hu*, Catalytic enantioselective trapping of an alcoholic oxonium ylide with aldehydes: Rh-II/Zr-IV-co-catalyzed three-component reactions of aryl diazoacetates, benzyl alcohol, and aldehydes, Angew. Chem. Int. Ed. 2008, 47, 6647–6649.
Wenhao Hu*, Xinfang Xu, Jing Zhou, Wei-Jun Liu, Haoxi Huang, Juan Hu, Liping Yang, and Liu-Zhu Gong*, Cooperative Catalysis with Chiral Br?nsted Acid-Rh₂(OAc)₄: Highly Enantioselective Three-Component Reactions of Diazo Compounds with Alcohols and Imines, J. Am. Chem. Soc. 2008, 130, 7782-7783.
Haoxi Huang, Xin Guo, and Wenhao Hu*, Efficient Trapping of Oxonium Ylides with Imines: A Highly Diastereoselective Three-Component Reaction for the Synthesis of β-Amino-α-hydroxyesters with Quaternary Stereocenters, Angew. Chem. Int. Ed. 2007, 46, 1337-1339.
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参与撰写的专著：
《Multicomponent Reactions in Organic Synthesis》
《实用有机合成工艺研发手册》
《现代药物合成》
《有机化学学科前沿与展望》
《高速发展的中国化学》
《不对称催化反应进展》
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代表性专利：
胡文浩，江俊，管晓渝，郭鑫，马晓初，刘顺英；一种多取代茚醇衍生物的制备方法；专利号：ZL1。
胡文浩，昝力，厉铭，黄海峰，周静，张霞，杨琍苹；一种3，3'-二取代-3-羟基双吲哚酮衍生物及其制备方法和应用；专利号：ZL7.0。
胡文浩，石炜，段月娇，钱宇，厉铭，杨琍苹；含2,5-二氢吡咯的肽脱甲酰基酶抑制剂及合成方法；专利号：ZL6.9。正在申请国际专利?PCT/CN2010/000268，已授权。
胡文浩，徐新芳，郭新，邱林，周静，杨琍苹；一种合成多芳基取代噁唑烷的方法；专利号：ZL2.0。
胡文浩，史滔达，郭震球，杨琍苹；一种制备α-羟基-β-氨基丙酸乙酯衍生物的方法；专利号：ZL 7.X。
胡文浩，朱映光，翟昌伟，岳永力，杨琍苹；一种二氢吡咯衍生物的制备方法；专利号：ZL2.X。
胡文浩，翟昌伟，马超群，荆常诚，邢栋；一种螺[吡咯啉基-3,2’-氧化吲哚]衍生物及其合成方法和应用；申请号：8.3。
胡文浩，马明亮，席间备，吕思莹，王文科，章雄文，方艳芬；一种咪唑并吡啶骨架结构的新化合物的合成及应用；申请号：5.2。
胡文浩，周俊，张丹，邢栋，刘顺英； 硫酸化岩藻-半乳四糖及其制备方法和应用；申请号：3.4。