姓名：刘杰
职称：教授/博士生导师
联系电话：
电子邮件：liujie56@mail.sysu.edu.cn
主要经历2021.02至今 中山大学生物医学工程学院,教授
2014.06-2021.01，中山大学生物医学工程学院，副教授
2016.08-2017.08，美国耶鲁大学医学院，访问****
2010.10-2014.05，中山大学工学院，生物医学工程，“****”讲师
2007.10-2009.10，美国耶鲁大学工学院，生物医学工程，博士
2007.01-2010.09，华中科技大学生命学院，生物材料与组织工程， 博士
2004.09-2006.12，华中科技大学生命学院，生物医学工程，硕士
2000.09-2004.07，华中科技大学生命学院，生物医学工程，学士
学科方向1.靶向纳米药物/基因载体系统：针对恶性肿瘤治疗，通过功能化生物材料的合成、载体构建以及靶向修饰为手段，开发系列能够用于癌症治疗的纳米药物、基因输送体系，为肿瘤的靶向治疗提供新的方法和策略；
2.多功能纳米诊疗一体化生物材料：结合超声、荧光、光声、磁共振、CT等技术手段，开发能够用于肿瘤及其他重大疾病诊断和治疗一体化的多功能纳米生物材料。
3.器官芯片/体外3D肿瘤模型：结合3D打印、微流控技术以及类器官技术，开发能够用于肿瘤治疗药物或纳米材料评价的体外类组织器官。
科研项目作为项目负责人(PI)主持的科研项目：
[1]国家自然科学基金面上项目，酶催化合成多重刺激响应型聚酯作为索拉非尼/miR-122联合输送载体的研究，2018-2021
[2] 深圳市基础研究专项面上项目，伪装型仿生纳米酶反应器用于肿瘤饥饿/光热/光动力/免疫协同治疗的研究，2020-2023
[3]广东省自然科学基金研究团队项目，多功能输送核酸的纳米体系，2016-2020
[4]广东省自然科学基金自由申请项目，超声触发液气转换型靶向纳米基因载体的研究，2016-2019
[5]广东省科技计划国际合作项目，新型药物输送载体材料的酶催化合成及其应用研究， 2015-2017
[6]广东省科技计划项目，“广东特支计划”科技创新青年拔尖人才，2015-2018
[7]国家自然科学基金青年科学基金项目，酶催化合成新型可降解氨基聚酯作为基因传递系统的研究，2012-2014
[8]广州市珠江科技新星专项，新型双靶向抗肿瘤纳米控释载体的构建及其应用研究，2012- 2015
[9]中山大学中央高校基本科研业务费，结肠生物黏附型靶向纳米载药微粒的研究，2012- 2015
[10]教育部博士点基金，靶向氨基聚酯基因载体的酶促合成及其功能研究，2012-2014
[11]广东省自然科学基金，酶催化合成新型氨基聚酯用于靶向基因传递的研究， 2011-2013
[12]广东高校优秀青年创新人才培养项目，新型靶向氨基聚酯基因载体的酶催化合成及性能研究，2012-2013
论著专利论文[1]Jiangbing Zhou, Jie Liu(共同第一作者), Christopher J. Cheng, Toral R. Patel, Caroline E.Weller, Joseph M. Piepmeier, Zhaozhong Jiang and W. Mark Saltzman*. Biodegradable poly(amine-co-ester) terpolymers for targeted gene delivery. Nature Materials 2012, 11: 82-90 (SCI, IF=36.4)
[2]Man Shu, Junjie Tang, Lili Chen, Qiang Zeng, Chao Li, Shuting Xiao, Zhaozhong Jiang*, Jie Liu*. Tumor microenvironment triple-responsive nanoparticles enable enhanced tumor penetration and synergetic chemo-photodynamic therapy. Biomaterials, 2021, 268, 120574
[3]Xiaoge Zhang, Junjie Tang, Chao Li, Yao Lu, Lili Cheng, Jie Liu*. A targeting black phosphorus nanoparticle based immune cells nano-regulator for photodynamic/photothermal and photo-immunotherapy. Bioactive Materials, 2021, 6(2), 472-489
[4]You Chen, Weilin Li, Chao Zhang, Zhaoying Wu* and Jie Liu*. Recent Developments of Biomaterials for Additive Manufacturing of Bone Scaffolds. Advanced Healthcare Materials, 2020, 9(23), **
[5]Qijun Lv, Lili Cheng, Yao Lu, Xiaoge Zhang, Yizhen Wang, Junfeng Deng, Jiangbing Zhou,* Bo Liu,* and Jie Liu*. Thermosensitive Exosome–Liposome Hybrid Nanoparticle-Mediated Chemoimmunotherapy for Improved Treatment of Metastatic Peritoneal Cancer. Advanced Science, , 1-13
[6]Meifei Su, Jianhua Xie, Qiang Zeng, Man Shu, Jie Liu*, Zhaozhong Jiang*. Enzymatic synthesis of PEGylated lactide-diester-diol copolyesters for highly efficient targeted anticancer drug delivery, MaterialsScience & Engineering C, 2020, 111125
[7] Shuting Xiao, Yao Lu, Miao Feng, Ming Dong, Zhong Cao, Xiaoge Zhang, You Chen, Jie Liu*. Multifunctional FeS₂ theranostic nanoparticles for photothermal-enhanced chemodynamic/photodynamic cancer therapy and photoacoustic imaging. Chemical Engineering Journal, 2020, 396, 125294
[8]Qiang Zeng,Lijuan Qiao,Lili Cheng,Chao Li,Zhong Cao, Zhiyi Chen, Yi Wang andJie Liu*. Perfluorohexane-Loaded Polymeric Nanovesicles with Oxygen Supply for Enhanced Sonodynamic Therapy, ACS Biomater. Sci. Eng. 2020, 6, 2956–2969
[9]Meifei Su, Shuting Xiao, Man Shu, Yao Lu, Qiang Zeng, Jianhua Xie, Zhaozhong Jiang*, Jie Liu*. Enzymatic multifunctional biodegradable polymers for pH- and ROS responsive anticancer drug delivery, Colloids and Surface B: Biointerfaces, 2020, 193, 111067
[10]Qijun Lv, Junfeng Deng, You Chen, Yizhen Wang, Bo Liu* and Jie Liu*. Engineered Human Adipose Stem-Cell-Derived Exosomes Loaded with miR-21-5p to Promote Diabetic Cutaneous Wound Healing, Molecular Pharmaceutics, 2020, 17, 1723-1733
[11]Huanling Guo, Ming Xu, Zhong Cao, Wei Li, Lida Chen, Xiaoyan Xie, Wei Wang*, and Jie Liu*. Ultrasound-Assisted miR-122-Loaded Polymeric Nanodroplets for Hepatocellular Carcinoma Gene Therapy, Molecular Pharmaceutics, 2020, 17, 541-553
[12]Jianhua Xie, Yao Lu, Baiqing Yu, Jun Wu*, Jie Liu*， Galactose-modified enzymatic synthesis of poly(amino-co-ester) micelles for co-delivery miR122 and sorafenib to inhibit hepatocellular carcinoma development, Chinese Chemical Letters, 2020, 31, 1173-1177
[13]Yao Lu, Qijun Lv, Bo Liu and Jie Liu*, Immobilized Candida antarctica lipase B catalyzed synthesis of biodegradable polymers for biomedical applications. Biomaterials Science 2019, 7, 4963 - 4983
[14]Jinbiao Gao, Baiqing Yu, Chao Li, Wei Wang, Ming Xu, Zhong Cao, Xiaoyan Xie, Jie Liu*. Photothermal-Enhanced Phase-Transition Nanodroplets for Ultrasound-Mediated Diagnosis and Gene Transfection, ACS Biomater. Sci. Eng. 2019, 5, 1366-1377
[15]Yi-hong Gong, Man Shu, Jian-hua Xie, Chao Zhang, Zhong Cao, Zhao-zhong Jiang* and Jie Liu*. Enzymatic synthesis of PEG–poly(amine-co-thioether esters) as highly efficient pH and ROS dual-responsive nanocarriers for anticancer drug delivery, Journal of Materials Chemistry B, 2019,7, 651-664
[16]Jinbiao Gao, Baiqing Yu, Chao Li, Ming Xu, Zhong Cao, Xiaoyan Xie, Wei Wang*, Jie Liu*, Ultrasound triggered phase-change nanodroplets for doxorubicin prodrug delivery and ultrasound diagnosis. Colloids and Surfaces B: Biointerfaces, 2019, 174, 416-425
[17]Hui-yan Luo, Zhe Yang, Wei Wei, Ying-qin Li, Hengying Pu, Ya Chen, Hui Sheng, Jie Liu * and Rui-hua Xu*. Enzymatically synthesized poly(amino-co-ester) polyplexes for systemic delivery of pcDNAmiRNA-214 to suppress colorectal cancer liver, metastasis, Journal of Materials Chemistry B, 2018, 6, 6365-6376 (Front Cover)
[18]Zhe Yang, Rui Cheng, Chenyang Zhao, Na Sun, Huiyan Luo, Ya Chen, Zerong Liu, Xian Li, Jie Liu^*, Zhongmin Tian^*, Thermo- and pH-dual responsive polymeric micelles with upper critical solution temperature behavior for photoacoustic imaging-guided synergistic chemo-photothermal therapy against subcutaneous and metastatic breast tumors, Theranostics 2018; 8(15):4097-4115.
[19]Zhe Yang, Na Sun, Rui Cheng, Chenyang Zhao, Zerong Liu, Xian Li, Jie Liu* and Zhongmin Tian*, pH multistage responsive micellar system with charge-switch and PEG layer detachment for co-delivery of paclitaxel and curcumin to synergistically eliminate breast cancer stem cells. Biomaterials, 2017, 147: 53-67
[20]Ya Chen, Meifei Su, Yingqin Li, Jinbiao Gao, Chao Zhang, Zhong Cao, Jiangbing Zhou, Jie Liu,* and Zhaozhong Jiang*. Enzymatic PEG-Poly(amine-co-disulfide ester) Nanoparticles as pH- and Redox-Responsive Drug Nanocarriers for Efficient Antitumor Treatment. ACS Applied Materials & Interfaces, 2017, 9: 30519?30535
[21]Zhe Yang, Na Sun, Rui Cheng, Chenyang Zhao, Jie Liu* and Zhongmin Tian*. Hybrid nanoparticles coated with hyaluronic acid lipoid for targeted co-delivery of paclitaxel and curcumin to synergistically eliminate breast cancer stem cells. Journal of Materials Chemistry B, 2017, 5: 6762--6775
[22]Di Gao, Jinbiao Gao, Ming Xu, Zhong Cao, Luyao Zhou, Yingqin Li, Xiaoyan Xie, Qing Jiang, Wei Wang* and Jie Liu*. Targeted Ultrasound-Triggered Phase Transition Nanodroplets for Her2-Overexpressing Breast Cancer Diagnosis and Gene Transfection. Molecular Pharmaceutics, 2017, 14(4): 984–998
[23]Zhe Yang, Yingqin Li, Jinbiao Gao, Zhong Cao, Qing Jiang, Jie Liu*. pH and redox dual-responsive multifunctional gene delivery with enhanced capability of transporting DNA into the nucleus. Colloids and Surfaces B: Biointerfaces, 2017, 153: 111-122
[24]Yingqin Li, Jinbiao Gao, Chao Zhang, Zhong Cao, Du Cheng, Jie Liu*, and Xintao Shuai*. Stimuli-Responsive Polymeric Nanocarriers for Efficient Gene Delivery. Topic in Current Chemistry, 2017, 375(27): 1-49
[25]Zhe Yang, Huiyan Luo, Zhong Cao, Ya Chen, Jinbiao Gao, Yingqin Li, Qing Jiang, Ruihua Xu* and Jie Liu*，Dual-targeting hybrid nanoparticles for the delivery of SN38 to Her2 and CD44 overexpressed human gastric cancer, Nanoscale, 2016, 8, 11543–11558 (SCI, IF=7.760)
[26]Ya Chen, Yingqin Li, Jinbiao Gao, Zhong Cao, Qing Jiang, Jie Liu*(共同通讯作者), and Zhaozhong Jiang*. Enzymatic PEGylated Poly(lactone-co-β-amino ester) Nanoparticles as Biodegradable, Biocompatible and Stable Vectors for Gene Delivery. ACS Applied Materials & Interfaces, 2016, 8(1): 490-501
[27]Di Gao, Ming Xu, Zhong Cao, Jinbiao Gao, Ya Chen, Yingqin Li, Zhe Yang, Xiaoyan Xie, Qing Jiang, Wei Wang, Jie Liu* (通讯作者). Ultrasound-triggered phase transition cationic nanodroplets for enhanced gene delivery. ACS Applied Materials & Interfaces, 2015, 7(24):13524-37
[28]Bo Liu, Xiaofang Zhang, Ya Chen, Zhicheng Yao, Zhe Yang, Di Gao, Qing Jiang, Jie Liu* (共同通讯作者) and Zhaozhong Jiang*. Enzymatic synthesis of poly(ω-pentadecalactoneco- butylene-co-3,3’-dithiodipropionate) copolyesters and self-assembly of the PEGylated copolymer micelles as redox-responsive nanocarriers for doxorubicin delivery. Polymer Chemistry, 2015, 6: 1997-2010
[29]Zhe Yang, Di Gao, Zhong Cao, Chao Zhang, Du Cheng, Jie Liu* (共同通讯作者) and Xintao Shuai*. Drug and gene co-delivery systems for cancer treatment. Biomaterials Science, 2015, 3, 1035–1049 (SCI, IF=3.614)
[30]Zhe Yang, Zhaozhong Jiang, Zhong Cao, Chao Zhang, Di Gao, Xingen Luo, Xiaofang Zhang, Huiyan Luo, Qing Jiang and Jie Liu (通讯作者). Multifunctional non-viral gene vectors with enhanced stability, improved cellular and nuclear uptake capability, and increased transfection efficiency. Nanoscale, 2014, 6: 10193–10206
[31]Xiaofang Zhang, Wenxin Tang, Zhe Yang, Xingen Luo, Huiyan Luo, Di Gao, Ya Chen, Qing Jiang, Jie Liu* (共同通讯作者) and Zhaozhong Jiang*. PEGylated poly(amine-co-ester) micelles as biodegradable non-viral gene vectors with enhanced stability, reduced toxicity and higher in vivo transfection efficacy. Journal of Materials Chemistry B, 2014, 2: 4034–4044 (SCI)
[32]Xiaofang Zhang, Bo Liu, Zhe Yang, Chao Zhang, Hao Li, Xingen Luo, Huiyan Luo, Di Gao, Qing Jiang, Jie Liu* (共同通讯作者), Zhaozhong Jiang*. Micelles of Enzymatically Synthesized PEG-Poly(amine-co-ester) Block Copolymers as pH-Responsive Nanocarriers for Docetaxel Delivery. Colloids and Surfaces B: Biointerfaces, 2014, 115: 349–358
[33]Zhe Yang, Xiaofang Zhang, Xingen Luo, Qing Jiang, Jie Liu * (共同通讯作者) and Zhaozhong Jiang*. Enzymatic Synthesis of Poly(butylene-co- sebacate-co-glycolate) Copolyesters and Evaluation of the Copolymer Nanoparticles as Biodegradable Carriers for Doxorubicin Delivery. Macromolecules, 2013, 46:1743–1753
[34]Jie Liu, Zhaozhong Jiang, Shengmin Zhang, Chen Liu, Richard A. Gross, Themis R. Kyriakides, W. Mark Saltzman. Biodegradation, biocompatibility, and drug delivery in poly(ω-pentadecalactone-co-p-dioxanone) copolyesters. Biomaterials 2011, 32(27): 6646-6654
[35]Jie. Liu, Z.Z. Jiang, S.M. Zhang, et al. Poly(ω-pentadecalactone-co-butylene-co- succinate) nanoparticles as biodegradable carriers for camptothecin delivery. Biomaterials 2009, 30(29): 5707-5719
专利1. 刘杰、蒋庆、杨哲，一种靶向复合型纳米粒子及其制备方法，国家发明专利，ZL4.1，2013.11.06（已授权）
2. 刘杰、蒋庆，一种10-羟基喜树碱纳米微球及其制备方法，国家发明专利，ZL0.2，2014.08.27（已授权）
3. 蒋庆、刘杰、罗新根、舒雅俊、杨哲，一种多功能微纳样品制备装置，实用新型专利，ZL6.8，2014.02.24（已授权）
4. 刘杰、蒋庆、罗新根、舒雅俊、高迪，一种包载可生物降解纳米粒的口服结肠靶向微囊及其制备方法，国家发明专利，ZL1.5，2015.03.04（已授权）
5. 刘杰、蒋庆、高迪、陈可欣、余柏青，一种阳离子聚氨基酸基因载体材料及其制备方法，国家发明专利，ZL.1，2016.04.20（已授权）
6. 蒋庆、刘杰、罗新根、舒雅俊、杨哲，一种集成式多功能微纳样品制备装置，国家发明专利，8.0，2014.01.22
7. 刘杰、蒋庆、杨哲、甘胜龙、路振平，一种聚乳酸-羟基乙酸共聚物纳米药物载体及其制备方法和应用，国家发明专利，ZL4.2，2017.08.01（已授权）
8. 刘杰、蒋庆、徐瑞华、杨哲、骆卉妍，一种负载7-乙基-10-羟基喜树碱的双靶向复合纳米粒子及其制备方法和应用，国家发明专利，ZL5.2，2017.08.01（已授权）
9. 刘杰、曾强、李超，一种聚氨基酸声敏剂及其制备方法与应用，国家发明专利，5.1，2019.03.13
10. 刘杰、曾强，一种基于酶催化合成聚酯制备立构复合载药胶束的方法，国家发明专利，5.5，2019.04.01
11. 刘杰、李威霖、陈友，一种仿细胞外基质可打印复合生物墨水的制备方法，国家发明专利，2.6，2020.07.05
12. 刘杰、李威霖、陈友，一种用于药物筛选的2D和3D一体化肿瘤器官培养芯片的制备方法，国家发明专利，4.8，2020.07.04
获奖情况广州市珠江科技新星（2012）
广东省科技创新青年拔尖人才（2014）
中山大学优秀青年教师培养计划（2014）
主要兼职中国超声医学工程学会超声分子影像学专委会青年委员
中国生物材料学会会员
广东省生物医学工程学会理事兼副秘书长