姓名：吴钧
职称：教授/博士生导师
联系方式：
电子邮箱：wujun29@mail.sysu.edu.cn
一、主要经历
2017.07-现在, 中山大学, 生物医学工程学院, 教授
2015.12-2017.6, 中山大学, 工学院, 教授
2015.8至2015.12, 美国哈佛大学, 医学院, 讲师
2010.9至2015.8, 美国哈佛大学，美国麻省理工学院, 博士后，合作导师：Professor Robert Langer, Professor Omid Farokhzad
2005.8至2011.1, 康奈尔大学, 生物医学工程, 博士,导师; Professor C.C. Chu
2002.8至2005.8, 纽约州立大学石溪分校, 化学, 硕士，导师：Professor Ben Hsiao, Professor Ben Chu
1996.9至2000.7, 南京大学, 化学, 学士, 导师：沈健教授，孟庆金教授
二、学科方向
1.药物递送：开发新型生物可降解，生物无毒的治疗型高分子功能聚合物，构建多功能高载药缓控释药物输送体系，在肿瘤治疗，糖尿病，免疫疗法及口服给药中的应用。
2. 再生医学：利用新型功能高分子材料，结合纳米技术、药物缓控释技术与干细胞技术，构建新型组织工程支架材料，用于组织再生，骨修复，创伤修复及干细胞修复的应用。
3. 医学影像：利用新型功能高分子材料及医学成像材料，结合纳米技术，构建新型高效安全无毒的医学影像试剂用于诊疗一体化。
三、科研项目
主持国家自然科学基金面上项目、国家卫计委科技重大专项（课题负责人）、广东省省级科技计划项目、广州市科技计划项目、深圳市科技计划项目以及高校基本业务费重点项目等科研项目。作为核心成员参加国家自然科学基金重点国际(地区)合作研究项目、广东省“珠江人才计划”创新创业团队等科研项目。
四、论著发明
以第一作者或通讯作者在国际高水平期刊上发表100余篇高水平论文，其中超过20篇发表于影响因子大于10的领域主流顶级期刊Angew. Chem. Int. Ed.、Adv. Funct. Mater.、PNAS、Adv. Sci、Nano. Lett.、ACS Nano、Small；全部160余篇高水平论文总引用超过10500次；申请超过30项国际国国内发明专利（已经获批美国专利1项，中国专利10项）。
近年代表性高水平论文：
(1) Hongxia Zhang, Xinru You, Xiaojuan Wang, Lei Cuia, Zining Wang, Feifei Xu, Mengyun Li, Zhenggang Yang, Jinyun Liu, Peng Huang, Yang Kang, Jun Wu* (corresponding author), and Xiaojun Xia*, Delivery of mRNA vaccine with a lipid-like material potentiates antitumor efficacy through Toll-like receptor 4 signaling, Proceedings of the National Academy of Sciences of the United States of America, 2021, 118 (6), e.
(2) Xinyu Zhang, Xiao Duan, Yueying Hu, Zhongmin Tang, Congxiu Miao*, Wei Tao*, Jun Wu* (corresponding author), One-step and facile synthesis of peptide-like poly(melphalan) nanodrug for cancer therapy, Nano Today, 2021,37,101098.
(3) ChenSong Huang, Xinru You, Chunlei Dai, QiongCong Xu, Fuxi Li, Li Wang, XiTai Huang, JieQin Wang, ShiJin Li, Zhuoxing Gao, Jun Wu* (corresponding author), XiaoYu Yin*, Wei Zhao*, Targeting Super-Enhancers via Nanoparticle-Facilitated BRD4 and CDK7 Inhibitors Synergistically Suppresses Pancreatic Ductal Adenocarcinoma, Advanced Science, 2020, **.
(4) Phei Er Saw, Xiaoding Xu, Meng Zhang, Shuwen Cao, Omid Farokhzad*, Jun Wu* (corresponding author), Engineering of novel nanostructures by simple tuning of lipid combinations, Angewandte Chemie International Edition, 2020, 59, 6249.
(5) Kunyong Ou, Xiaojun Xu, Shuyu Guan, Ruhe Zhang, Xinyu Zhang, Yang Kang*, and Jun Wu*(corresponding author), Nanodrug Carrier Based on Poly(Ursolic Acid) with Self-Anticancer Activity against Colorectal Cancer, Advanced Functional Materials, 2020, 30, **.
(6) Shaohan Zhang, Jingyi Hou, Qijuan Yuan, Peikun Xin, Huitong Cheng, Zhipeng Gu, Jun Wu* (corresponding author), Arginine derivatives assist dopamine-hyaluronic acid hybrid hydrogels to have enhanced antioxidant activity for wound healing, Chemical Engineering Journal, 2019, 123775.
(7) Fei Xiong, Xiang Ling, Xing Chen, Jing Chen, Jiaxing Tan, Wuji Cao, Liang Ge*, Minglin Ma*, Jun Wu*(corresponding author), Pursuing Specific Chemotherapy of Orthotopic Breast Cancer with Lung Metastasis from Docking Nanoparticles Driven by Bioinspired Exosomes, Nano Letters, 2019, 19, 3256?3266.
(8) Yinghao Zheng, Xinru You, Shuyu Guan, Jun Huang, Liying Wang, Jiayuan Zhang, Jun Wu*(corresponding author). Poly(Ferulic Acid) with an Anticancer Effect as a Drug Nanocarrier for Enhanced Colon Cancer Therapy. Advanced Functional Materials, 2019, **.
（9）Xiaoding Xu, Jun Wu(co-first), Shuaishuai Liu, Phei Er Saw, Wei Tao, Yujing Li, Lisa Krygsman, Srinivasan Yegnasubramanian, Angelo M De Marzo, Jinjun Shi, Charles J Bieberich, Omid C Farokhzad. Redox-Responsive Nanoparticle-Mediated Systemic RNAi for Effective Cancer Therapy. Small, 2018, **.
（10）Ling X, Chen X, Riddell IA, Tao W, Wang J, Hollett G, Wu J*(corresponding author ), et al. Glutathione-Scavenging Poly(disulfide amide) Nanoparticles for the Effective Delivery of Pt(IV) Prodrugs and Reversal of Cisplatin Resistance. Nano Letters, 2018, 18, 4618-25.
（11）Li Ding, Zhu Xianbing, Wang Yiling, Shi Bingyang, Ling Xiang, Chen Houjie, Nan Wenhao, Barrent Austin, Guo Zilei, Tao Wei*, Wu Jun*(corresponding author ), Shi Xiaojun*. Intracellular Fate of Nanoparticles with Polydopamine Surface Engineering and a Novel Strategy for Exocytosis-Inhibiting, Lysosome Impairment-Based Cancer Therapy. Nano Letter, 17(11): 6790-6801.
(12) Xu Xiaoding,Wu Jun (co-first),Liu Yanlan,Saw Phei Er,Tao Wei,Yu Mikyung,Zope Harshal,Si Michelle,Victorious Amanda, RasmussenJonathan,Ayyash Dana,Farokhzad Omid C. *, andShi Jinjun *, Multifunctional Envelope-Type siRNA Delivery Nanoparticle Platform for Prostate Cancer Therapy. ACS Nano, 11(3)：2618-2627.
(13)Zhu, Xi，Wu, Jun(co-first)，Shan, Wei，Zhou, Zhou，Liu, Min，Huang, Yuan^*，Sub-50 nm Nanoparticles with Biomimetic Surfaces to Sequentially Overcome the Mucosal Diffusion Barrier and the Epithelial Absorption Barrier，Advanced Functional Materials，2016，26（16）：2728~2738.
(14)Xu, Xiaoding，Wu, Jun(co-first)，Liu, Yanlan，Yu, Mikyung，Zhao, Lili，Zhu, Xi，Bhasin, Sushant，Li, Qing，Ha, Emily，Shi, Jinjun^*，Farokhzad, Omid C.^*，Ultra‐pH‐Responsive and Tumor‐Penetrating Nanoplatform for Targeted siRNA Delivery with Robust Anti‐Cancer Efficacy，Angewandte Chemie International Edition，2016，（55）：7091~7094.
(15)Zhu, Xi，Wu, Jun(co-first)，Shan, Wei，Tao, Wei，Zhao, Lili，Lim, Jong-Min，D'Ortenzio, Mathew，Karnik, Rohit，Huang, Yuan^*，Shi, Jinjun^*，Farokhzad, Omid C^*，Polymeric Nanoparticles Amenable to Simultaneous Installation of Exterior Targeting and Interior Therapeutic Proteins.，Angew Chem Int Ed Engl，2016，55（10）：3309~3312.
(16)Wu, Jun，Zhao, Lili，Xu, Xiaoding，Bertrand, Nicolas，Choi, Won I. I.，Yameen, Basit，Shi, Jinjun，Shah, Vishva，Mulvale, Matthew，MacLean, James L.，Farokhzad, Omid C.^*，Hydrophobic Cysteine Poly(disulfide)-based Redox-Hypersensitive Nanoparticle Platform for Cancer Theranostics，Angewandte Chemie International Edition，2015，54（32）：9218~9223.
(17)Wu, Jun，Kamaly, Nazila，Shi, Jinjun，Zhao, Lili，Xiao, Zeyu，Hollett, Geoffrey，John, Rohit，Ray, Shaunak，Xu, Xiaoyang，Zhang, Xueqing，Kantoff, Philip W.，Farokhzad, Omid C.^*，Development of Multinuclear Polymeric Nanoparticles as Robust Protein Nanocarriers，Angewandte Chemie-International Edition，2014，53（34）：8975~8979.
(18)Bertrand, Nicolas，Wu, Jun(co-first)，Xu, Xiaoyang，Kamaly, Nazila，Farokhzad, Omid C.^*，Cancer nanotechnology: The impact of passive and active targeting in the era of modern cancer biology，Advanced Drug Delivery Reviews，2014，66：2~25.
(19)Wu, Jun，Wu, Dequn，Mutschler, Martha A.，Chu, Chih-Chang^*，Cationic Hybrid Hydrogels from Amino-Acid-Based Poly(ester amide): Fabrication, Characterization, and Biological Properties，Advanced Functional Materials，2012，22（18）：3815~3823.
五、荣誉获奖情况及主要兼职
国家青年特聘专家
卫健委辅助循环重点实验室学术委员会成员
Materials Express副主编
Biomedical Horizons 副主编
Journal of Biomedical Nanotechnology编委
Engineered Regeneration编委
中国化学快报青年编委（第二届及第三届）
中国医药生物技术协会纳米生物技术分会第二届常务委员
广东省自然医学研究会第二届常务理事
广东省生物医学工程学会第十届常务理事
广东省自然医学研究会-干细胞与中医再生医学专业委员会第一届副主任委员
广东省生物医学工程学会-生物材料及临床应用专委会副主任委员
广东省辅助循环创新工程技术研究中心学术委员
广东省“珠江人才计划”第六批引进创新创业团队核心成员
广东省海外青年协会常务理事