职位教授 博士生导师
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? ? ? ?中山大学“****”教授，博士生导师。国家海外高层次引进人才，广东省****基金获得者，广东省珠江人才计划创新团队核心成员兼委托负责人，1997-2004年就读于南开大学并先后获得学士和硕士学位。2010年获得新加坡国立大学博士学位。
? ? ? ? 主要从事病原微生物群体感应、胞内信号传导及致病机理、新型抗菌化合物等研究。以通讯或第一作者在Chem Rev、PNAS、ISME J、?Environ Microbiol、MPP、Mol Microbiol、Appl Environ Microbiol、AAC?等权威期刊发表高水平论文30余篇。申请国际发明专利7项, 授权3项;申请国家发明专利28项, 授权15项。主持包括国家自然科学基金面上项目、973子课题、深圳市基础研究重点项目等科研项目。是多个省部级科研和人才项目评审专家，也是Nat Commun、PNAS、ISME J等30多个期刊审稿人。
电子邮箱dengyle@mail.sysu.edu.cn
个人经历1997.09-2001.06:?南开大学微生物学专业本科毕业，获学士学位
2001.09-2004.06:?南开大学微生物学专业硕士研究生毕业，获硕士学位
2006.01-2010.01:?新加坡国立大学生物科学系博士研究生毕业,?获博士学位
2010.02-2014.03:?新加坡科技研究局分子细胞生物学研究所 研究员/高级研究员
2014.04-2019.03:?华南农业大学 教授、博导
2019.04-至今? ? ? ? 中山大学药学院（深圳）“****”教授、博导
研究方向1.微生物群体感应与胞内信号传导
2.微生物-宿主互作
3.新型抗菌材料研发
科研项目【01】广东省珠江人才计划创新团队,金额:4000万,期限:2013.07-2018.06,团队核心成员与委托负责人。
【02】华南农业大学丁颖人才培养工程(国家级二级),金额:280万,期限:2016.01-2019.12。
【03】2015年国家海外高层次人才计划。
【04】广东省自然科学****基金,金额:100万,期限:2015.01-2018.12，主持。
【05】国家自然科学基金面上项目,金额:75.6万,期限:2016.01-2019.12，主持。
【06】国家重点基础研究发展计划(973课题)子课题,金额:164万,期限:2015.01-2019.12，主持。
【07】广州市珠江科技新星项目,金额:30万,期限:2015.04-2018.03，主持。
【08】国家自然科学基金重点项目,金额:287万,期限:2019.01-2023.12，参与。
【09】深圳市基础研究重点项目,金额:200万,期限:2020.11-2023.11，主持。
代表论著1.?Song#, Yin W#, Sun X, Cui B, Huang L, Li P, Yang L, Zhou J, Deng Y*.?(2020)?Anthranilic acid?from Ralstonia solanacearum?plays dual roles in intraspecies signalling and inter-kingdom communication. The ISME Journal.?14：2248-2260.
2.?Shen F#, Yin W#, Song S#, Zhang Z, Ye P, Zhang Y, He F*, Li P*, and Deng Y*.?(2020) Ralstonia solanacearum?promotes pathogenicity by utilizing L-glutamic acid from host plants. Mol Plant Pathol. 21：1099-1110.
3.?Song S#, Sun X#, Meng L, Wu Q, Wang K, and Deng Y*. (2020) Antifungal activity of hypocrellin compounds and their synergistic effects with antimicrobial agents against Candida albicans.?Microbiol Biotech. DOI: 10.1111/1751-7915.13601.
4.?Meng L#, Sun C#, Zhang C, Song S, Sun X, Ju J,?Deng Y*.?(2019) Efficacy of compounds isolated from?Streptomyces olivaceus?against the morphogenesis and virulence of?Candida albicans.?Mar Drugs?17(8). Pii: E442
5.?Meng L#, Zhao H#, Zhao S#, Sun X, Zhang M*, and?Deng Y*. (2019) Inhibition of yeast-to-hypha transition and virulence of?Candida albicans?by 2-alkylaminoquinoline derivatives.?Antimicrob Agents Chemother?63(4). Pii: e01891-18.
6.?Cui C#, Song S#, Yang C#, Sun X, Huang Y, Li K, Zhao S, Zhang Y,?Deng Y*. (2019)?Disruption of quorum sensing and virulence in?Burkholderia cenocepacia?by a small molecule mimic of the cis-2-dodecenoic acid (BDSF) signal.?Appl Environ Microbiol?85(8). Pii: e00105-19.
7.?Zhong Y, Yan M, Jiang J, Zhang Z, Huang J, Min X, Zhang L,?Deng Y*, Zhou X*, and He F* (2019). Mycophenolic acid inhibited the dimorphic switch of?Sporisorium scitamineum?by targeting ammonium transporter Ssa2.?J Agric Food Chem?67:112-119.
8.?Zhang C, Lv M, Yin W, Dong T, Chang C, Miao Y, Jia Y, and?Deng Y*.?(2019)?Xanthomonas campestris?promotes diffusible signal factor (DSF) biosynthesis and pathogenicity by utilizing glucose and sucrose from host plants.?Mol Plant Microbe Interact?32:157-166.
9.?Zhao S#, Huang JJ#, Sun X#, Huang X, Fu S, Yang L, Liu XW,?He F*, and?Deng Y*.?(2018) (1-aryloxy-2-hydroxypropyl)-phenylpiperazine derivatives suppress?Candida albicans?virulence by interfering with?morphological transition.?Microbiol Biotech. 11(6): 1080-1089.
10.?Cui C#, Yang C#, Song S#, Fu S, Sun X, Yang L, He F, Zhang LH, Zhang Y, and?Deng Y*. (2018) A novel two-component system modulates quorum sensing and pathogenicity in?Burkholderia cenocepacia.?Mol Microbiol. 108:32-44.
11.?Yang C#, Cui C#, Ye Q, Kan J, Fu S, Song S, Huang Y, He F, Zhang LH, Jia Y, Gao Y, Harwood CS*, and?Deng Y*.?(2017)?Burkholderia cenocepacia?integrates cis-2-dodecenoic acid and cyclic dimeric guanosine monophosphate to control virulence.?Proc. Natl. Acad. Sci. U.S.A.?114:13006-13011.
12.?Li P, Yin W, Yan J, Chen Y, Fu S, Song S, Zhou J, Lyu M,?Deng Y*, Zhang LH*. (2017)?Modulation of Inter-kingdom Communication by PhcBSR Quorum Sensing System in?Ralstonia solanacearum?Phylotype I Strain GMI1000.?Front Microbiol.?8:1172. doi: 10.3389.
13.?Deng Y*,?Wu J, Yin W, Li P, Zhou J, Chen S, He F, Cai J, Zhang LH*. (2016).?Diffusible signal factor family signals provide a fitness advantage to?Xanthomonas campestris?pv. campestris in interspecies competition.?Environ Microbiol.?18:1534-45.
14.?Deng Y*,?Liu X, Wu J, Lee J, Chen S, Cheng Y, Zhang C, Zhang LH*. (2015).?The host plant metabolite glucose is the precursor of diffusible signal factor (DSF) family signals in?Xanthomonas campestris.?Appl Environ Microbiol.?81:2861-8.
15.?Lee J#, Wu J#,?Deng Y, Wang J, Wang C, Wang J, Chang C, Dong YH, Williams P, Zhang LH. (2013).?A cell-cell communication signal integrates quorum sensing and stress response.?Nature Chemical Biology?9(5):339-343.?(Cover image, Comment in?Nat.Chem.Biol. 2013 339-343. Exceptional?Faculty of 1000 ).
16.?Deng Y*, Schmid N, Wang C, Wang J, Pessi G, Wu D, Lee J, Aguilar C, Ahrens CH, Chang C, Song H, Eberl L*, Zhang LH* (2012) Cis-2-dodecenoic acid receptor RpfR links quorum-sensing signal perception with regulation of virulence through cyclic dimeric guanosine monophosphate.?Proc. Natl. Acad. Sci. U.S.A.?109:15479-15484.
17.?Deng Y,?Wu J, Tao F and Zhang LH* (2011) Listening to a new language: DSF-based quorum sensing in bacteria.?Chemical Reviews. 111:160-73.
18.?Deng Y,?Wu J, Eberl L, and Zhang LH* (2010) Structural and functional characterization of diffusible signal factor family quorum-sensing signals produced by?Burkholderia cepacia?complex.?Appl Environ Microbiol?76: 4675-4683.
19.?Deng Y,?Boon C, Eberl L, and Zhang LH* (2009) Differential modulation of?Burkholderia cenocepacia?virulence and energy metabolism by quorum sensing signal BDSF and its synthase.?Journal of Bacteriology. 191: 7270-7278.
20.?Boon C#,?Deng Y#, Wang LH, He Y, Yang F, Xu JL, Pan SQ and Zhang LH* (2008) A novel DSF-like signal from?Burkholderia cenocepacia?interferes with?Candida albicans?morphological transition.?The ISME Journal.?2: 27-36.?(#: Co-first authors,?Must Read, Faculty of 1000).
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