研究领域
招生信息
教育背景
工作经历
教授课程
专利与奖励
出版信息
科研活动
基本信息
鄢德洪男硕导中国科学院深圳先进技术研究院
电子邮件： dh.yan@siat.ac.cn
通信地址： 深圳市南山区西丽深圳大学城学苑大道1068号
邮政编码： 510080
研究领域
从事髓系来源的抑制性细胞（MDSC）在癌症中的基础与转化研究招生信息
招生专业
100102-免疫学071010-生物化学与分子生物学071009-细胞生物学招生方向
鉴定调控MDSC分化和功能的新靶点阐明脂质代谢调控MDSC分化和功能的作用靶向MDSC细胞疗法或/与其他药物联合的抗肿瘤免疫治疗研究教育背景
2010-09--2013-06中山大学中山医学院博士2007-09--2010-07华南农业大学硕士2003-09--2007-07湖北大学本科工作经历
工作简历
2020-01~现在,中国科学院深圳先进技术研究院,副研究员/硕士研究生导师2017-01~2019-12,中国科学院深圳先进技术研究院,助理研究员2014-09~2016-12,中国科学院深圳先进技术研究院,博士后2013-07~2014-08,广州永诺生物科技有限公司,技术副总监社会兼职
2020-08-20-今,Frontiers in Genetics杂志, 审稿人2020-05-29-今,Basic & Clinical Pharmacology & Toxicology杂志, 审稿人
2020-04-11-今,OncoImmunology杂志, 审稿人
2017-01-01-2020-12-31,美国免疫学会, 会员
教授课程
生物技术前沿专利与奖励
奖励信息
（1） AAI Travel Grants for IUIS 2019, 其他, 2019（2） AAI Travel Grants for the 5th European Congress of Immunology, 其他, 2018专利成果
（ 1 ） 多不饱和脂肪酸体外扩增髓系来源的抑制性细胞的方法, 发明, 2016, 第 1 作者, 专利号: 0 .X（ 2 ） 鼠源抗人IgE单克隆抗体的制备方法及其应 用, 发明, 2016, 第 4 作者, 专利号: 0 .8出版信息
发表论文
（1）Adeleye Oluwatosin Adeshakin,Funmilayo O. Adeshakin,Wan Liu,Hua Li,Dehong Yan*,Xiaochun Wan*.Lipidomics data showing the effect of lipofermata on myeloid-derived suppressor cells in the spleens of tumor-bearing mice,Data in Brief,2021,通讯作者（2）Funmilayo Oladunni Adeshakin, Adeleye Oluwatosin Adeshakin, Lukman Olalekan Afolabi, Dehong Yan, Guizhong Zhang* and Xiaochun Wan* .Mechanisms modulating anoikis resistance in cancer and the relevance of metabolic reprogramming,Frontiers in Oncology,2021,第4作者（3）Adeleye Oluwatosin Adeshakin, Wan Liu, Funmilayo O. Adeshakin, Lukman O. Afolabi, Mengqi Zhang, Guizhong Zhang, Lulu Wang, Zhihuan Li, Lilong Lin, Qin Cao, Dehong Yan* , Xiaochun Wan* .Regulation of ROS in myeloid-derived suppressor cells through targetingfatty acid transport protein 2 enhanced anti-PD-L1 tumor immunotherapy,Cellular Immunology,2021,通讯作者（4）Jian Cheng #, Zhao Liu #, Tian Deng , Zhen Lu , Maoxuan Liu , Xiaoxu Lu , Funmilayo Oladunni Adeshakin , Dehong Yan, Guizhong Zhang *, Xiaochun Wan *.CD317 mediates immunocytolysis resistance by RICH2/cytoskeleton-dependent membrane protection,Molecular Immunology,2020,第8作者（5）Oluwamuyiwa A. Ayanshina# , Adeleye O. Adeshakin #, Lukman O. Afolabi , Funmilayo O. Adeshakin, Ganiyu O. Alli-Balogun, Dehong Yan, Samuel Essien-Baidoo*, Xiaochun Wan*. Seasonal variations in Nigeria: understanding COVID-19 transmission dynamics and immune responses.,Journal of Global Health Reports,2020,第6作者（6）Adeleye O Adeshakin#,?Dehong Yan#,?Mengqi Zhang,?Lulu Wang,?Funmilayo O Adeshakin,?Wan Liu,?Xiaochun Wan*. Blockade of myeloid-derived suppressor cell function by valproic acid enhanced anti-PD-L1 tumor immunotherapy.,Biochemical and Biophysical Research Communications,2020,第1作者（7）Qian Chen,?Dehong Yan,?Qingmei Zhang?,?Guizhong Zhang,?Meng Xia,?Junxin Li,?Wugen Zhan?,?Enyun Shen?,?Zhihuan Li?,?Lilong Lin?,?Youhai H Chen*?,?Xiaochun Wan*.Treatment of acetaminophen-induced liver failure by blocking the death checkpoint protein TRAIL.,BBA - Molecular Basis of Disease,2020,第2作者（8）Dehong Yan, Jinghui Wang, Honghong Sun, Ali Zamani, Honglin Zhang, Weihong Chen, Aifa Tang, Qingguo Ruan, Xiaolu Yang, Youhai H. Chen*, Xiaochun Wan*.?TIPE2 specifies the functional polarization of myeloid-derived suppressor cells during tumorigenesis.,Journal of Experimental Medicine,2020,第1作者（9）Dehong Yan#, Adeleye O. Adeshakin#, Meichen Xu, Lukman O. Afolabi, Guizhong Zhang, Youhai H. Chen, Xiaochun Wan*. Lipid Metabolic Pathways Confer the Immunosuppressive Function of Myeloid-Derived Suppressor Cells in Tumor.,Frontiers in Immunology,2019,第1作者（10）鄢德洪#，徐美晨#，王婧惠，万晓春*. 青蒿素类药物靶标及其免疫调节抗肿瘤机制研究进展[J].,免疫学杂志,2018,第1作者（11）Lulu Cui#，Jiacheng Bi#，Dehong Yan，Xiufeng Ye，Mingxing Zheng，Guang Yu*，Xiaochun Wan*. JSI-124 inhibits IgE production in an IgE B cell line.,Biochemical and Biophysical Research Communications,2017,第3作者（12）Dehong Yan, Quan Yang, Maohua Shi, Limei Zhong, Changyou Wu, Tao Meng, Huiyong Yin, Jie Zhou*. Polyunsaturated fatty acids promote the expansion of myeloid-derived suppressor cells by activating JAK2/STAT3 pathway.,European Journal of Immunology,2013,第1作者（13）Weiping Cai#, Aiping Qin#, Pengle Guo, Dehong Yan, Fengyu Hu, Qiong Yang, Min Xu, Yongshui Fu, Jie Zhou*, Xiaoping Tang*. Clinical significance and functional studies of myeloid-derived suppressor cells in chronic hepatitis C patients.,Journal of Clinical Immunology,2013,第4作者（14）Aiping Qin#, Weiping Cai#, Ting Pan#, Kang Wu, Qiong Yang, Yufeng Liu, Nina Wang, Dehong Yan, Fengyu Hu, Pengle Guo, Xiaoping Chen, Ling Chen, Hui Zhang, Xiaoping Tang*, Jie Zhou*. Expansion of Monocytic Myeloid-Derived Suppressor Cells Dampens T Cell Function in HIV-1-Seropositive Individuals.,Journal of Virology,2013,第8作者科研活动
科研项目
（ 1 ） PUFA重编程MDSC脂质代谢的分子机制及其在肿瘤免疫逃逸中的作用研究, 主持,国家级,2016-01--2018-12（ 2 ） PUFA重编程MDSC脂质代谢引起肿瘤免疫逃逸的机制研究, 主持,国家级,2016-01--2017-12（ 3 ） 抑癌基因TIPE2打破肿瘤免疫耐受的分子机制, 主持,省级,2016-06--2018-06（ 4 ） 乳腺癌治疗新靶点研究, 参与,省级,2017-06--2020-06（ 5 ） 双抗原识别型 CAR 回路的设计合成与优化, 参与,国家级,2020-01--2024-12（ 6 ） 青蒿素靶向 MDSCs 逆转肿瘤微环境免疫抑制状态的机制研究, 主持,省级,2020-06--2023-05（ 7 ） TIPE2介导脂质代谢重编程调控MDSC功能极化的分子机制及其在肿瘤免疫抑制中的作用研究, 主持,国家级,2021-01--2024-12参与会议
（1）TIPE2调控肿瘤发生过程中髓系抑制性细胞 (MDSC）功能极化的新机制广东省免疫学会 2020 年学术年会鄢德洪2020-12-05（2）STAT3 induces the expression of fatty acid transport proteins (FATP2 and FATP4) to promote myeloid-derived suppressor cells function in tumorAdeleye Oluwatosin Adeshakin, Dehong Yan, Mengqi Zhang, Lukman Olalekan Afolabi, Funmilayo Oladunni Adeshakin and Xiaochun Wan2020-05-08（3）?Artemisinin improves the efficiency of anti-PD-L1 therapy in T-cell lymphomaDehong Yan, Mengqi Zhang, Adeleye O. Adeshakin and Xiaochun Wan2020-05-08（4）Lipid metabolic pathways confer immunosuppressive function of myeloid-derived suppressor cells in tumorYan D. , Adeleye O.A. , Zhang M. , Xu M. , Chen Y.H. , Wan X2019-10-19（5）TIPE2 Protein Specifies the Functional Polarization of Myeloid-derived Suppressor Cells during Tumorigenesis D. Yan, J. Wang, M. Xu, O. Adeleye, Y. Chen, X. Wan2018-09-02（6）TIPE2, an inflammation transfer switch, regulates the on-and-off immunosuppressive function of MDSCs in tumorsDehong Yan, Jinghui Wang, Adeleye O. Adeshakin, Meichen Xu, Youhai H. Chen and Xiaochun Wan2018-05-04（7）抑癌基因TIPE2打破肿瘤免疫耐受的分子机制中国免疫学会第十二届全国免疫学学术大会鄢德洪，王婧惠，徐美晨，万晓春2017-10-26（8）TIPE2 is a novel direct target of STAT3 in MDSC and inhibition of its expression on MDSC enhanced T cell activation in tumorDe hong Yan, Jing hui Wang and Xiao chun Wan2017-05-122013 © 中国科学院大学，网络信息中心.
