更新日期：2018年9月3日
姓 名 杨小蓉 性 别 女
出生年月 1974年2月 籍贯
民 族 汉族 政治面貌
最后学历 博士研究生 最后学位 理学博士
技术职称 副教授 导师类别 硕导
行政职务Email birxyang@scut.edu.cn
工作单位 生物科学与工程学院 邮政编码
通讯地址 华南理工大学南校区
单位电话


工作经历
2014.10—目前 副教授，华南理工大学 生物科学与工程学院
2010.9—2014.9 Research Scientist，美国宾州州立大学（Penn State University) 化学部
2008.8—2010.8 Post-doctoral Scholar，美国宾州州立大学（Penn State University) 化学部
2006.5—2007.2 教学助理，德国斯图加特大学 (Stuttgart University) 物理化学研究所
1996.7—2000.5 技术员，中国重庆三峡油漆股份有限公司
教育经历
2003.5—2007.2 德国斯图加特大学 (Stuttgart University) 物理化学所 物理化学 博士
2000.9—2003.3 中国科学院北京化学所 分析化学 硕士
1992.9—1996.6 重庆大学 化工学院 精细化工 本科
研究领域
生物大分子与小分子化合物相互作用；酶学与酶工程
科研项目
主持国家自然科学基金面上项目、广州市科学研究一般专项等
发表论文
[1] Huiping Liu, Yanyun Zhu, Xiaorong Yang*, Ying Lin*, Four second-sphere residues of Thermus thermophilus SG0.5JP17-16 laccase tune the catalysis by hydrogen-bonding networks, Appl Microbiol Biotechnol, 2018, 102(9), 4049-4061.
[2] Xiaorong Yang*, Conformational dynamics play important roles upon the function of N-acetyl glutamate kinase, Appl Microbiol Biotechnol, 2017, 101(9), 3485-3492.
[3] Xiaorong Yang, Xinran Liu, Derek M. Musser, Ibrahim M Moustafa, Jamie J. Arnold, Craig E. Cameron and David D. Boehr, Triphosphate Reorientation of the Incoming Nucleotide as a Fidelity Checkpoint in Viral RNA-dependent RNA Polymerases, J Biol Chem. 2017, 292(9), 3810-3826.
[4] Yuanyuan Huang, Cheng Li, Hao Zhang, Shuli Liang, Shuangyan Han, Ying Lin, Xiaorong Yang*, Suiping Zheng*, Monomeric Corynebacterium glutamicum N-acetyl glutamate kinase maintains sensitivity to L-arginine but has a lower intrinsic catalytic activity, Appl Microbiol Biotechnol, 2016, 100(4), 1789-1798.
[5] Xinran Liu, Derek M. Musser, Cheri A. Lee, Xiaorong Yang, Jamie J. Arnold, Craig E. Cameron and David D. Boehr, Nucleobase but not Sugar Fidelity is Maintained in the Sabin I RNA-Dependent RNA Polymerase, Viruses, 2015, 7, 5571-5586.
[6] Ibrahim M Moustafa, Victoria S Korneeva, Jamie J Arnold, Eric D Smidansky, Laura L Marcotte, David W Gohara, Xiaorong Yang, Maria A Sánchez-Farrán, David Filman, Janna K Maranas, David D Boehr, James M Hogle, Coray M Colina, Craig E Cameron, Structural Dynamics as a Contributor to Error-prone Replication by a RNA-dependent RNA Polymerase, J Biol Chem. 2014, 289, 36229-36248.
[7] David D Boehr, Xinran Liu, Xiaorong Yang, Targeting structural dynamics of the RNA-dependent RNA polymerase for anti-viral strategies. Curr Opin Virol. 2014, 9, 194-200.
[8] Xinran Liu, Xiaorong Yang (共同第一作), Cheri A. Lee, Ibrahim M. Moustafa, Eric D. Smidansky, David Lum, Jamie J. Arnold, Craig E. Cameron, David D. Boehr, Vaccine-derived mutation in motif D of poliovirus RNA-dependent RNA polymerase lowers nucleotide incorporation fidelity, J Biol. Chem. 2013, 288, 32753-65.
[9] Yan M Chan, Xiaorong Yang, David D Boehr, The Role of Phosphatidylinositol Phosphates (PIPs) in Poliovirus Replication Complexes Trafficking to Viral Replication Organelles, BIOPHYSICAL JOURNAL, 2013, 104(2), Supplement:1, Pages:98A-98A.
[10] Ibrahim M Moustafa, Victoria S Korneeva, Jamie J Arnold, Eric D Smidansky, Laura L Marcotte, Xiaorong Yang, Janna K Maranas, David D Boehr, James M Hogle, Coray M Colina, Craig E Cameron, Nanosecond-Timescale Dynamics of the Viral RNA-Dependent RNA Polymerase as a Determinant of Incorporation Fidelity, BIOPHYSICAL JOURNAL, 2013, 104(2), Supplement:1, Pages:213A-213A.
[11] Xiaorong Yang, Eric D. Smidansky, Kenneth R. Maksimchuk, David Lum, Jesse L. Welch, Jamie J. Arnold, Craig E. Cameron, David D. Boehr, Motif D of viral RNA-dependent RNA polymerases determines efficiency and fidelity of nucleotide addition, Structure, 2012, 20, 1519-1527.
[12] Xiaorong Yang*, Klaus Müller, The guest ordering and dynamics in urea inclusion compounds studied by solid state 1H and 13C MAS NMR spectroscopy, J. Mol. Struct. 2011, 1006, 113-120.
[13] Xiaorong Yang*, Klaus Müller, The structural and dynamic properties of 1-bromodecane in urea inclusion compounds investigated by solid state 1H, 13C and 2H NMR spectroscopy, Magn. Reson. Chem. 2011, 49, 514-522.
[14] Xiaorong Yang, Jesse L. Welch, Jamie J. Arnold, David D. Boehr, Long-range interaction networks in the function and fidelity of poliovirus RNA-dependent RNA polymerase studied by nuclear magnetic resonance, Biochemistry, 2010, 49, 9361-9371.
[15] Xiaorong Yang, Klaus Müller, Solid state NMR investigations on urea inclusion compounds: Order and dynamics of 1, 6-dibromohexane, J. Mol. Struct. 2007, 831, 75- 89.
[16] Xiaorong Yang, Klaus Müller, Solid state NMR studies of the guest ordering and dynamics in α, ?-dibromoalkane/urea inclusion compounds, Appl. Magn. Reson. 2007, Vol. 32, No. 3, 407-431.
[17] Junfeng Xiang, Xiaorong Yang, Ciping Chen, Yalin. Tang, Wenpeng Yan, Guangzhi Xu, Effects of NaCl on the J-aggregation of Two Thiacarbocyanine Dyes in the Aqueous Solutions, J. Colloid Interface Sci. 2003, Vol. 258, 198-205.
[18] Xiaorong Yang, Tongxin Wang, Deqing Zhang, Yalin Tang, Lipu Li, Keyue Hou, NMR Relaxation Times of Alkanethiol Monolayer Self-assembling on Nano-scale Gold Particles, Acta Chimica Sinica. 2002, Vol. 60, No. 9, 1575-1580.
（* 代表通讯作者）
科研创新
1. 一种提高染料脱色效率的漆酶突变体及其制备方法与应用，杨小蓉，祝艳云，林影，刘慧平，申请号：**5.X.
教学活动
主讲本科生专业课《生物药剂学》，本科生基础课《大学化学》、《有机化学》，参与讲授研究生课程《酶学与酶工程》；