所系名称
中国科学院南海海洋研究所，中国科学院热带海洋生物资源与生态重点实验室
性别
男
专业名称
海洋生物学
技术职务
责任研究员
行政职务

Mail地址
hmx@scsio.ac.cn
指导博士生总数
6
指导硕士生总数
16
通讯地址
广州市新港西路164号5号楼502A
目前博士生数
2
目前硕士生数
3
邮政编码
510301
研究方向
海水经济贝类的种质资源、遗传育种技术与新品种培育；海洋贝类生长、抗逆、生殖发育等的分子遗传基础和调控机制和贝类新种质发掘，繁育、增殖放流。

研究工作
主要研究方向为海洋经济贝类的种质资源、遗传育种技术与新品种培育；海洋贝类生长、抗逆、生殖发育等的分子遗传基础和调控机制； 海洋贝类新种质发掘，繁育、增殖放流。近年培育出国家水产新品种1个——马氏珠母贝“南科1号”，并进行了大面积的推广应用，开发了2种功能螺类的人工繁育技术。
获奖情况
1. 2001年 中国科学院科技进步一等奖（主要完成人）
2. 2006年 广东省科学技术二等奖 (第一完成人)
3. 2008年 广东省科学技术一等奖（主要完成人）
4. 2016年 马氏珠母贝“南科一号”水产新品种（第一完成人）


指导研究生情况
1. 2001年 中国科学院科技进步一等奖（主要完成人，2001）
2. 2006年 广东省科学技术二等奖 (第一完成人，2006)
3. 2008年 广东省科学技术一等奖（主要完成人，2008）
4. 2016年 马氏珠母贝“南科一号”水产新品种（第一完成人，2016）
5. 国家贝类产业技术体系岗位科学家（2018）


个人简介
学习经历
1990：西南师范大学生物系，理学学士
1993：武汉大学生命科学院，动物学硕士
2000：中国科学院南海海洋研究所，海洋生物学博士

工作经历
1993-至今：中国科学院南海海洋研究所，责任研究员
2001-2003：中国科学院广州分院企业博士后科研工作站，博士后
2007.2-2007.4：美国弗罗里达理工学院 高级访问学者
学术兼职
1. 中国贝类学会理事（2015-至今）

科研成果
论文发表
34. Jing Huang, Meng Xu, Maoxian He*. Discriminant analysis of four cultured populations of the pearl oyster, Pinctada fucata martensii, using morphology and singlenucleotide polymorphism markers. Journal of the World Aquaculture Society. 2019, 1-13
33. Huiru Liu+, Hua Zhang+, Xiaolan Pan, Meng Xu, Jing Huang, Maoxian He*. Ahighdensitygeneticmapbywhole-genomeresequencingforQTLfine-mappinganddissectingcandidategenesforgrowthorsextraitsinthepearloyster(Pinctadafucatamartensii). Aquaculture. DOI: 10.1016/j.aquaculture.2019.734839
32. Meng Xu, Jing Huang, Yu Shi, Hua Zhang, Maoxian He*. Comparative transcriptomic and proteomic analysis of yellow shell and black shell pearl oysters, Pinctada fucata martensii. BMC Genomics. 2019, 20, 469:1-14
31. Huiru Liu+, Hua Zhang+, Xiaolan Pan, Meng Xu, Jing Huang, Maoxian He*. A high density genetic map by whole-genome resequencing for QTL fine-mapping and dissecting candidate genes for growth or sex traits in the pearl oyster (Pinctada fucata martensii)[J]. Aquaculture. 2019, 519: 734839
30. Yu Shi, Meng Xu, Jing Huang, Hua Zhang, Wenguang Liu, Zekui Ou, Maoxian He*. Transcriptome analysis of mantle tissues reveals potential biomineralization-related genes in Tectus pyramis Born. Comparative Biochemistry and Physiology - Part D. 2019,29:131-144
29. Qi Wang, Yu Shi, Maoxian He*. Pf-Dmrt4, a potential factor in sexual development in the pearl oyster Pinctada fucata. Journal of Oceanology and Limnology. 2018,36(6):2337-2350
28. Yu Shi, Wenguang Liu, Maoxian He*. Proteome and Transcriptome Analysis of Ovary, Intersex Gonads, and Testis Reveals Potential Key Sex Reversal/Differentiation Genes and Mechanism in Scallop Chlamys nobilis. Marine Biotechnology. 2018,20(2):220-245
27. Hua Zhang, Zekui Ou, Meng Xu, Xiande Huang, Wenguang Liu, Yu Shi, Maoxian He*. Molecular cloning and characterization of a putative mitogen-activated protein kinase (Erk1/2) gene: Involvement in mantle immunity of Pinctada fucata. Fish and Shellfish Immunology. 2018,80:63-70
26. Hua Zhang, Xiande Huang, Yu Shi, Wenguang Liu, Maoxian He*. Identification and analysis of an MKK4 homologue in response to the nucleus grafting operation and antigens in the pearl oyster, Pinctada fucata. Fish and Shellfish Immunology. 2018,73:279-284
25. Hua Zhang, Mi Zhao, Xuejie Yi, Zekui Ou, Yaoguo Li, Yu Shi*, Maoxian He*. Characterization of the distal-less homologue gene, PfDlx, involved in regulating the expression of Pif in the pearl oyster, Pinctada fucata. Comparative Biochemistry and Physiology, Part B, 2017,212：51-58.
24. Wen G. Liu, Xian D. Huang, Jian S. Lin and Mao X. He*. Effect of ocean acidification on growth, calcification, and gene expression in the pearl oyster, Pinctada fucata. Marine Environmental Research, 2017, 130:174-180.
23. Xian-De Huang, Guo-jian Wei, Mao-xian He*. A PDGF/VEGF homologue provides new insights into the nucleus grafting operation and immune response in the pearl oyster Pinctada fucata. Gene，2017,637:1-8.
22. Hua Zhang, Yu Shi, Maoxian He*. Insulin growth factor binding protein (IGFBP) is involve in endocrine function regulated by insulin-like peptide system of pearl oyster Pinctada fucata. Comparative Biochemistry and Physiology, Part B，2017,214:27-35.
21. 韦国建，李耀国，林坚士，何毛贤*。马氏珠母贝生长性状QTL鉴定及基因型选择效应分析。热带海洋学报，2017,36（2）：19-25
20. Mi Zhao, Maoxian He*, Xiande Huang, Qi Wang, Yu Shi. Functional Characterization and Molecular Mechanism Exploration of Three Granulin Epithelin Precursor Splice Variants in Biomineralization of the Pearl Oyster Pinctada fucata. Molecular Genetics and Genomics.2016,291(1):399-409.
19. Yu Shi, Maoxian He*. PfIRR Can Interact with HrIGF-I and Activate Both MAP kinase and PI3-kinase Signaling Pathways in Pinctada fucata. Scientific Reports, 2016,6:22063
18. Yaoguo Li，Maoxian He*. Analysis of DNA methylation in tissues and development stages of pearl oyster Pinctada fucata. Genes & Genomics, 2015,37:263-270
17. Xian-de Huang, Guo-jian Wei, Hua Zhang, Mao-xian He*. Nuclear factor of activated T cells (NFAT) in pearl oyster Pinctada fucata: Molecular cloning and functional characterization. Fish and Shellfish Immunology,2015,42:108-113.
16. Yaoguo Li, Xiande Huang, Yunyan Guan, Yu Shi, Hua Zhang, Maoxian He*. DNA methylation is associated with expression level changes of galectin gene in mantle wound healing process of pearl oyster, Pinctada fucata. Fish and Shellfish Immunology, 2015,45:912-918
15. Xian-De Huang, Hua Zhang, Mao-xian He*. Comparative and Evolutionary Analysis of the IL17 Gene Family in Invertebrate. PloS One. 2015,10(7):e**
14. Xian-De Huang, Guo-Jian Wei, Mao-Xian He*. Cloning and gene expression of signal transducers and activators of transcription(STAT) homologue provide new insights into the immune response and nucleus graft of the pearl oyster Pinctada fucata. Fish and Shellfish Immunology, 2015，47：847-854.
13. Yu Shi, Qi Wang, Maoxian He*. Molecular identification of dmrt2 and dmrt5 and effect of sex steroids on their expressions in Chlamys nobilis. Aquaculture. 2014,426-427:21-30
12. Yaoguo Li, Maoxian He*. Genetic Mapping and QTL Analysis of Growth-Related Traits in Pinctada fucata Using Restriction-Site Associated DNA Sequencing. PLoS One. 2014,9(11):e111707
11. Mi Zhao, Maoxian He*, Xiande Huang, Qi Wang. A Homeodomain Transcription Factor Gene, PfMSX, Activates Expression of Pif Gene in the Pearl Oyster Pinctada fucata. PLoS One. 2014,9(8):e103830
10. Qi Wang, Maoxian He*. Molecular characterization and analysis of a putative 5-HT receptor involved in reproduction process of the pearl oyster Pinctada fucata.. General and Comparative Endocrinology. 2014,204:71-79
9. Yu Shi, Maoxian He*. Differential gene expression identified by RNA-Seq and qPCR in two sizes of pearl oyster (Pinctada fucata). Gene. 2014,538:313-322
8. Qin Li, Yaoguo Li, Xiande Huang Maoxian He*. Molecular Cloning and Single Nucleotide Polymorphisms (SNPs) Identification of Myostatin cDNA in the Pearl Oyster, Pinctada fucata. Journal of the World Aquaculture Society. 2014,45(6):638-651
7. Wenguang Liu, Xiande Huang, Jianshi Lin, Maoxian He*. Effect of Temperature on Gene Expression in the Pearl Oyster Pinctada fucata. Journal of Ocean University of China. 2014,13(3):509-515
6. WenGuang Liu, XianDe Huang, Qi Wang, Mi Zhao, ShanZeng Wu, YunYan Guan, Yu Shi, MaoXian He*. Gene cloning and function analysis of Cytokine-induced suppressor of cytokine signaling (SOCS) from pearl oyster Pinctada fucata. Fish and Shellfish Immunology 2013,34:849-854
5. ShanZeng Wu, XianDe Huang, Qin Li, MaoXian He*. Interleukin-17 in pearl oyster (Pinctada fucata):Molecular cloning and functional characterization. Fish and Shellfish Immunology 2013,34:1050-1056
4. XianDe Huang, WenGuang Liu, Qi Wang, Mi Zhao, ShanZeng Wu, YunYan Guan, Yu Shi, MaoXian He*. Molecular characterization of interferon regulatory factor 2 (IRF-2) homolog in pearl oyster Pinctada fucata. Fish and Shellfish Immunology 2013,34:1279-1286
3. XianDe Huang, Mi Zhao, Wen-Guang Liu , YunYan Guan, Yu Shi, Qi Wang, Shan-Zeng Wu, Mao-Xian He. Gigabase-Scale Transcriptome Analysis on Four Species of Pearl Oysters. Marine Biotechnology 2013,15:253-264
2. Yu Shi, Yunyan Guan, Maoxian He*. Molecular identification of insulin-related peptide receptor and its potential role in regulating development in Pinctada fucata. Aquaculture 2013,408-409:118-217
1. Shanzeng Wu, Yunyan Guan, Xiande Huang, Maoxian He*. Development of 25 novel microsatellite loci and genetic variation analysis in breeding populations of the pearl oyster Pinctada fucata. Journal Of The World Aquaculture Society 2013,44(4):600-609
授权专利
1. 何毛贤; 韦国建。一种与马氏珠母贝生长性状关联的SNP标记及引物和应用（ZL20**）
2. 何毛贤; 欧泽奎。一种马蹄螺性别的鉴别和标记方法（ZL20**）
3. 何毛贤，管云雁，袁涛。一种红壳色品系马氏珠母贝的制种方法（ZL73）
4. 何毛贤，袁涛，黄良民。一种橙黄色华贵栉孔扇贝的制种方法（ZL7.4）
5. 何毛贤，袁涛，黄良民。一种华贵栉孔扇贝橙黄壳色分子标记及其鉴定方法和试剂盒（ZL4.1）
6. 何毛贤，刘文广。一种华贵栉孔扇贝自交系的建立方法（ZL4.5）
7. 何毛贤，刘文广，林坚士。一种提高海水珍珠质量的细胞小片处理液及制备方法（ZL7.8）
8. 李耀国，何毛贤。一种马氏珠母贝MSAP技术体系的建立方法（ZL2.9）
9. 何毛贤，林坚士，刘文广。一种马氏珠母贝优良育珠贝的培育方法（ZL4.7）
10. 何毛贤，李琴。一种与马氏珠母贝闭壳肌重相关联的SNP标记及鉴别方法（ZL5.3）
11. 何毛贤，赵密。一种能被马氏珠母贝MSX基因激活的Pif启动子及其应用（ZL7.8）
12. 何毛贤，李耀国。一种与马氏珠母贝软体部重和闭壳肌重显著关联的SNP298299标记的检测引物及其应用（ZL1.5）
13. 何毛贤，李耀国。一种与马氏珠母贝壳型与重量大小关联的SNP411871标记的检测引物及其应用（ZL7.2）