傅暘副教授、博士生导师


fuy@sustech.edu.cn
生物楼512
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个人简介傅暘，南方科技大学医学院博士生导师、副教授、正高级研究员。课题组综合利用细菌遗传学、细菌生理生化、免疫学、原位及单颗粒冷冻电镜等技术，从事病原-宿主-共生菌多元互作、抗感染技术和微生物干预疗法研究。于2013年获南开大学生物化学与分子生物学博士学位。自2009年在享誉世界的哈佛大学医学院微生物与免疫生物学系，师从世界著名微生物学家、美国科学院院士John Mekalanos教授进行博士学习并继而从事博士后研究，系统连贯地工作近十年。主要从事病原生物学、肠道病原-宿主-共生微生物组多元互作、抗感染治疗和新型疫苗研究。多年来通过扎实的工作积累了丰富经验，取得了丰硕成果。近年来在Cell Host & Microbe、Science Translational Medicine、P. Natl. Acad. Sci. USA、Clinical Infectious Diseases、Allergy、Journal of Immunology、SCIENCE Bulletin、SCIENCE CHINA Life Sciences和Vaccine等国际权威学术期刊共发表论文16篇，第一作者及通讯作者7篇，均为顶级或1区期刊，高被引文章4篇。累计他引大于2000次，H-index 9。科研成果被国内外多个媒体报道，受邀发表多次重要学术会议报告，获Fogarty Global Health Fellowship奖，担任Bio-Protocol杂志编委，mBio等多家知名科学期刊审稿人。


研究领域主要从事肠道病原菌、共生菌研究，围绕肠道菌致病新机制、细菌分泌系统的体内功能及改造、宿主体内细菌间相互作用的机理、宿主免疫激活等研究。

教育背景1、2001.09-2005.06江南大学，生物工程学专业学士
2、2006.09-2013.06 南开大学，生物化学与分子生物学专业博士
3、2009.09-2013.05 哈佛大学，微生物学与免疫生物学专业联培博士



工作经历1、2005.07-2006.08 南开大学，技术员
2、2008.06-2009.01哈佛大学公共卫生学院，交换生
3、2013.07-2018.06哈佛大学医学院，博士后研究员
4、2018.07-2019.06哈佛大学医学院，助理研究员
5、2019.06-2020.12 南方科技大学，助理教授/博士生导师
6、2021.01-至今 南方科技大学，副教授/博士生导师



获奖情况及荣誉1、国家级人才计划
2、深圳市“孔雀计划”B类人才
3、Fogarty Global Health Fellowship



杂志编委会成员1、Bio-Protocol杂志编辑
2、FrontiersCellular and Infection Microbiology专刊编辑



近年代表文章Cai, Q., D. Huang, P. Ou, H. Yu, Z. Zhu, Z. Xia, Y. Su, Z. Ma, Y. Zhang, Z. Li, Q. He, L. Liu, Y. Fu#and J. Chen#(2020.03.31). COVID-19 in a designated infectious diseases hospital outside Hubei Province, China. Allergy. (IF: 6.771)
# Co-corresponding author
Juanjuan Zhao,Quan Yuan,Haiyan Wang,Wei Liu,Xuejiao Liao, Yingying Su,Xin Wang, Jing Yuan, Tingdong Li,Jinxiu Li,Shen Qian, Congming Hong, Fuxiang Wang, Yingxia Liu, Zhaoqin Wang,Qing He, Zhiyong Li,Bin He, Tianying Zhang,Yang Fu, Shengxiang Ge, Lei Liu, Jun Zhang ,Ningshao Xia, Zheng Zhang(2020.03.28). Antibody responses to SARS-CoV-2 in patients of novel coronavirus disease 2019. Clin Infect Dis. 2020 Mar 28:ciaa344. doi: 10.1093/cid/ciaa344 （IF:9.17）
Juan Xue, Xing Pan, Ting Peng, Meimei Duan , Lijie Du , Xiaohui Zhuang, Xiaobin Cai, Xueying Yi , Yang Fu , Shan Li .（2020.05.05）Auto Arginine-GlcNAcylation Is Crucial for Bacterial Pathogens in Regulating Host Cell Death. Front Cell Infect Microbiol. 2020 May 5;10:197. doi: 10.3389/fcimb.2020.00197
Xuelan Zhou , Fanglin Zhong , Cheng Lin , Xiaohui Hu , Yan Zhang, Bing Xiong , Xiushan Yin , Jinheng Fu , Wei He , Jingjing Duan , Yang Fu, Huan Zhou , Peter J McCormick , Qisheng Wang , Jian Li , Jin Zhang .（2020.9.1）Structure of SARS-CoV-2 main protease in the apo state.Sci China Life Sci.doi: 10.1007/s11427-020-1791-3
Jianghong An, Xuejiao Liao, Tongyang Xiao, Shen Qian, Jing Yuan, Haocheng Ye, Furong Qi, Chengguang Shen, Lifei Wang, Yang Liu, Xiaoya Cheng, Na Li, Qingxian Cai, Fang Wang,Jun Chen, Guojun Li, Qiu’e Cai, Yingxia Liu, Yunfang Wang, Feng Zhang, Yang Fu, Qing He, Xiaohua Tan, Lei Liu, Zheng Zhang.(2020.9.4)Clinical characteristics of the recovered COVID-19 patients with re-detectable positive RNA test.Ann Transl Med 2020;8(17):1084 | http://dx.doi.org/10.21037/atm-20-5602
Jian Li, Xuelan Zhou, Yan Zhang, Fanglin Zhong, Cheng Lin, Peter J.McCormick, Feng Jiang, Jun Luo, Huan Zhou, Qisheng Wang, Yang Fu,Jingjing Duan, Jin Zhang. (2020.9.22) Crystal structure of SARS-CoV-2 main protease in complex with the naturalproduct inhibitor shikonin illuminates a unique binding mode.Science Bulletin https://doi.org/10.1016/j.scib.2020.10.018
Fu Y, Ho BT, & Mekalanos JJ (2018.02.14) Tracking Vibrio cholerae Cell-Cell Interactions during Infection Reveals Bacterial Population Dynamics within Intestinal Microenvironments. Cell host & microbe 23(2):274-281 e272.
(IF: 17.87, Ranked 1st in Microbiology, Cell Press Sub-Publication)
Ho BT*, Fu Y*, Dong TG, & Mekalanos JJ (2017.07.17) Vibrio cholerae type 6 secretion system effector trafficking in target bacterial cells. Proceedings of the National Academy of Sciences of the United States of America 114(35):9427-9432.
(IF: 9.5, Ranked 3rd in Life Science, Health & Medical Sciences) * Co-First Authors
Fu Y, Waldor MK, & Mekalanos JJ (2013.12.11) Tn-Seq analysis of Vibrio cholerae intestinal colonization reveals a role for T6SS-mediated antibacterial activity in the host. Cell host & microbe 14(6):652-663.
(IF: 17.87, Ranked 1st in Microbiology, Cell Press Sub-Publication, Cited By 125)
Fu Y#& Mekalanos JJ# (2014.06.05) Infant Rabbit Colonization Competition Assays. Bio Protoc 4(11). # Co-Corresponding Authors
Altindis E, Fu Y, & Mekalanos JJ (2014.02.28) Proteomic analysis of Vibrio cholerae outer membrane vesicles. Proceedings of the National Academy of Sciences of the United States of America 111(15): E1548-1556. (IF: 9.5, Ranked 3rd in Life Science, Health & Medical Sciences [general], Cited by 74)
Sanchez-Larrayoz AF, Elhosseiny, NM, Chevrette MG, Fu Y, Giunta P, Spallanzani RG, Ravi K, Pier GB, Lory S, and Maira-Litran T (2017.08.30) Complexity of Complement Resistance Factors Expressed by Acinetobacter baumannii Needed for Survival in Human Serum. J Immunol 199, 2803-2814. (IF: 4.54, Ranked 6th in Immunology)
Roux, D, Danilchanka, O, Guillard, T, Cattoir, V, Aschard, H, Fu, Y, Angoulvant, F, Messika, J, Ricard, JD, Mekalanos, JJ, et al. (2015.07.22). Fitness cost of antibiotic susceptibility during bacterial infection. Sci Transl Med 7, 297ra114. (IF: 16.71, Ranked 10th in Health & Medical Sciences [general], Science Sub-Publication, Cited By 63)
Liao Q, Strong A. J, Liu Y, Meng P, Fu Y, Touzjian N, Shao Y, Zhao Z, Lu Y (2012.01.17) HIV vaccine candidates generate in vitro T cell response to putative epitopes in Chinese-origin rhesus macaques. Vaccine. 30(9): 1601-1608. (IF: 3.3, Ranked 3rd in Virology)
Xiangke Duan, Yang Fu, and Liang Yang. Chapter 5Molecular and Systems BiologyApproaches for Analyzing Drug-TolerantBacterial Persister Cells
https://doi.org/10.1007/978-3-030-53024-2_5