田瑞琳助理教授、博士生导师


tianrl@sustech.edu.cn
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个人简介田瑞琳，南方科技大学医学院助理教授、博士生导师。2015年毕业于北京大学生物科学专业，2015年9月至2020年12月在美国加州大学旧金山分校（UCSF）取得博士学位，并进行博士后训练，2020年底加入南方科技大学医学院。
本课题组结合CRISPR基因表达调控系统（CRISPRi和CRISPRa）与人类诱导多能干细胞（iPSC）分化技术，开发出在人类神经元和神经胶质细胞中进行大规模遗传筛选的平台。本课题利用这一平台，并结合各种细胞分子生物学技术和单细胞测序等多组学方法，研究人类神经系统疾病的分子细胞生物学机制。
研究领域1.神经发育疾病和神经退行性疾病的分子细胞生物学机制
2.神经胶质细胞与神经元相互作用
3.基于CRISPR和诱导多能干细胞（iPSC）的遗传筛选方法的开发
4.单细胞组学/系统生物学





教育背景2011.9-2015.6 本科 北京大学 生物科学
2015.9-2020.6 博士 加州大学旧金山分校 生物物理



工作经历2020.6-2020.12 博士后 加州大学旧金山分校
2020.12至今 助理教授 南方科技大学医学院



获奖情况及荣誉2016年 Tau consortium fellowship by the Tau consortium
2015年 北京市优秀毕业生
2015年 北京大学优秀毕业生
2014年 国家奖学金
2013年 北京大学五四奖学金



近年代表文章Tian, R.*,Abarientos, A., Hong, J., Hashemi, S. H., Yan, R., Nalls, M. A., ... & Kampmann, M.* (2020). Genome-wide CRISPRi/a screens in human neurons link lysosomal failure to ferroptosis.bioRxiv. (* corresponding authors)
Semesta, K. M., Tian, R.,Kampmann, M., von Zastrow, M., & Tsvetanova, N. G. (2020). A high-throughput CRISPR interference screen for dissecting functional regulators of GPCR/cAMP signaling.PLoS genetics,16(10), e**.
Ramkumar, P., Abarientos, A. B., Tian, R.,Seyler, M., Leong, J. T., Chen, M., ... & Kampmann, M. (2020). CRISPR-based screens uncover determinants of immunotherapy response in multiple myeloma.Blood advances,4(13), 2899-2911.
Guo, X., Aviles, G., Liu, Y., Tian, R., Unger, B.A., Lin, Y.H.T., Wiita, A.P., Xu, K., Correia, M.A. and Kampmann, M., (2020). Mitochondrial stress is relayed to the cytosol by an OMA1–DELE1–HRI pathway. Nature, 579(7799), pp.427-432.
Tian, R., Gachechiladze, M.A., Ludwig, C.H., Laurie, M.T., Hong, J.Y., …, Ward, M.E. & Kampmann, M., (2019). CRISPR interference-based platform for multimodal genetic screens in human iPSC-derived neurons. Neuron, 10.1016/j.neuron.2019.07.014
-Featured as a cover story in Neuron,
- Featured on the Neuronwebsite with a video abstract
-Featured by a Research Highlight in Nature Reviews Neuroscience.
Ramkumar, P., Tian, R.,Seyler, M., Leong, J. T., Chen, M., Choudhry, P., ... & Kampmann, M., (2019). CRISPR-based screens uncover determinants of immunotherapy response and potential combination therapy strategies. bioRxiv, 833707.
Torres, S.E., Gallagher, C.M., Plate, L., Gupta, M., Liem, C.R., Guo, X., Tian, R., Stroud, R.M., Kampmann, M., Weissman, J.S. and Walter, P., (2019). Ceapins block the unfolded protein response sensor ATF6α by inducing a neomorphic inter-organelle tether. eLife, 8.
Chen, J.J., Nathaniel, D.L., Raghavan, P., Nelson, M., Tian, R., …, and Kampmann, M., (2019). Compromised function of the ESCRT pathway promotes endolysosomal escape of tau seeds and propagation of tau aggregation.Journal of Biological Chemistry, pp.jbc-RA119.
Zhang, Y. J., Guo, L., ... Tian,R., … & Petrucelli, L. (2019). Heterochromatin anomalies and double-stranded RNA accumulation underlie C9orf72 poly (PR) toxicity.Science,363(6428), eaav2606.
Boettcher, M., Tian, R., Blau, J. A., Markegard, E., Wagner, R. T., Wu, D., ... & McManus, M.T., (2018). Dual gene activation and knockout screen reveals directional dependencies in genetic networks.Nature biotechnology,36(2), 170.
-Featured by a News & Views in Nature Biotechnology
Mavor, D., Barlow, K. A., …, Tian, R., … , Kampmann, M. & Fraser, S. J., (2018). Extending chemical perturbations of the ubiquitin fitness landscape in a classroom setting reveals new constraints on sequence tolerance.Biology open,7(7), bio036103.
Pal, S., Lant, B., Yu, B., Tian, R.,Tong, J., Krieger, J. R., ... & Derry, W. B. (2017). CCM-3 promotes C. elegans germline development by regulating vesicle trafficking cytokinesis and polarity. Current Biology, 27(6), 868-876.
Xie, Z., Jay, K.A., Smith, D.L., Zhang, Y., Liu, Z., Zheng, J., Tian, R., Li, H. and Blackburn, E.H. (2015). Early telomerase inactivation accelerates aging independently of telomere length.Cell,160(5), pp.928-939.
He, C., Tsuchiyama, S.K., Nguyen, Q.T., …, Tian, R., …, Kennedy, K.B. & Polymenis, M., (2014). Enhanced longevity by ibuprofen, conserved in multiple species, occurs in yeast through inhibition of tryptophan import.PLoS genetics,10(12), p.e**.