暨南大学基础医学与公共卫生学院导师教师师资介绍简介-陈果

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本站小编 Free考研考试/2021-05-22

个人简介

职称：教授
学科专业：医学生物化学与分子生物学
研究方向：肿瘤药理与治疗
电子邮箱：gchen84@jnu.edu.cn

学习科研经历

2019.04-至今，暨南大学基础医学院生化系，教授
2018.05-2019.04，美国埃默里大学放射肿瘤系，副研究员
2013.05-2018.05，美国埃默里大学放射肿瘤系，博士后
2012.05-2017.05，美国明尼苏达大学细胞生物学系，博士后

主要论文

1. Chen G, Luo Y, Warncke K, Yu DS, Fu H, Behera M, Ramalingam SS, Lammers M, Doetsch PW, Curran WJ, Deng X. Acetylation regulates ribonucleotide reductase activity and cancer cell growth. Nat Commun. 2019 Jul 19;10(1):3213.
2. Chen G#, Park D#, Magis AT, Behera M, Ramalingam SS, Owonikoko TK, Sica GL, Ye K, Zhang C, Chen Z, Curran WJ, Deng X. Mcl-1 Interacts with Akt to Promote Lung Cancer Progression. Cancer Res. 2019 Dec 15;79(24):6126-6138.
3. Chen G, Magis AT, Xu K, Park D, Yu DS, Owonikoko TK, Sica GL, Satola SW, Ramalingam SS, Curran WJ, Doetsch PW, Deng X. Targeting Mcl-1 enhances DNA replication stress sensitivity to cancer therapy. J Clin Invest. 2018 Jan 2;128(1):500-516.
4. Chen G*#, Chen JX#, Qiao YT, Shi YR, Liu W, Zeng Q, Xie H, Shi XR, Sun YW, Liu X, Li TY, Zhou LQ, Wan JQ, Xie T, Wang HX*, Wang Fu*. ZNF830 mediates cancer chemoresistance through promoting homologous-recombination repair. Nucleic Acids Research, 2018 Feb 16;46(3):1266-1279.
5. Chen G*#, Zhang B#, Xu H, Sun Y, Shi Y, Luo Y, Jia H, Wang F*. Suppression of Sirt1 sensitizes lung cancer cells to WEE1 inhibitor MK-1775-induced DNA damage and apoptosis. Oncogene. 2017 Dec 14;36(50):6863-6872.
6. Chen G, Deng X. Targeting Bcl2 in cancer. Oncoscience. 2015 Sep 2;2(10):813-4.
7. Chen G, Tang B, Yang BY, Chen JX, Zhou JH, Hua ZC. Tumor-targeting Salmonella typhimurium, a natural tool for activation of prodrug 6-methylpurine 2'-deoxyriboside and their combination therapy in murine melanoma model. Appl Microbiol Biotechnol. 2013 May;97(10):4393-401.
8. Chen G, Dai Y, Chen JX, Wang XT, Tang B, Zhu YC, Hua ZC. Oral delivery of the Sj23LHD-GST antigen by Salmonella typhimurium type III secretion system protects against Schistosoma japonicum infection in mice. Plos Neglect. Trop. Dis. 2011 Sep;5(9):e1313.
9. Chen G, Wang K, Yang BY, Tang B, Chen JX, Hua ZC. Synergistic antitumor activity of oridonin and arsenic trioxide on hepatocellular carcinoma cells. Int J Oncol. 2011;40:139-147.
10. Chen G, Wei DP, Jia LJ, Tang B, Shu L, Zhang K, Xu Y, Gao J, Huang XF, Jiang WH, Hu QG, Huang Y, Wu Q, Sun ZH, Zhang JF, Hua ZC. Oral delivery of tumor-targeting Salmonella exhibits promising therapeutic efficacy and low toxicity. Cancer Sci. 2009;100(12):2437-43.
11. Chen G, Deng X. Cell Synchronization by Double Thymidine Block. Bio Protoc. 2018 Sep. 05;8(17).
12. Liu W#, Zhang B#, Chen G#, Wu W, Zhou L, Shi Y, Zeng Q, Li Y, Sun Y, Deng X, Wang F. Targeting miR-21 with Sophocarpine inhibits tumor progression and reverses epithelial-mesenchymal transition in head and neck cancer. Mol Ther. 2017 2017 Sep 6;25(9):2129-2139.
13. Xu K#, Chen G#, Li X, Wu X, Chang Z, Xu J, Zhu Y, Yin P, Liang X, Dong L. MFN2 suppresses cancer progression through inhibition of mTORC2/Akt signaling. Sci Rep. 2017 Feb 8;7:41718.
14. Xu K#, Chen G#, Qiu YY, Yuan ZT, Li HC, Yuan X, Sun J, Xu JH, Liang X, Yin PH. miR-503-5p confers drug resistance by targeting PUMA in colorectal carcinoma. Oncotarget. 2017; 8:21719-21732.
15. Luo Y, Zhou Y, Song Y, Chen G, Wang YX, Tian Y, Fan WW, Yang YS, Cheng T, Zhu HL. Optimization of substituted cinnamic acyl sulfonamide derivatives as tubulin polymerization inhibitors with anticancer activity. Bioorg Med Chem Lett. 2018 15;28(23-24):3634-3638.
16. Chen J, Qiao Y, Tang B, Chen G, Liu X, Yang B, Wei J, Zhang X, Cheng X, Du P, Jiang W, Hu Q, Hua ZC. Modulation of Salmonella Tumor-Colonization and Intratumoral Anti-angiogenesis by Triptolide and Its Mechanism. Theranostics. 2017 Jun 1;7(8):2250-2260.
17. Li R, Ding C, Zhang J, Xie M, Park D, Ding Y, Chen G, Zhang G, Gilbert-Ross M, Zhou W, Marcus A, Sun SY, Chen ZG, Sica GL, Ramalingam SS, Magis A, Fu H, Khuri F, Curran WJ, Owonikoko TK, Shin DM, Zhou J, Deng X. Modulation of Bax and mTOR for cancer therapeutics. Cancer Res. 2017 Jun 1;77(11):3001-3012.
18. Wang X, Beitler JJ, Huang W, Chen G, Qian G, Magliocca KR, Patel MR, Chen AY, Zhang J, Nannapaneni S, Kim S, Chen Z, Deng X, Saba NF, Chen ZG, Arbiser J, Shin DM. Honokiol Radiosensitizes Squamous Cell Carcinoma of the Head and Neck by Downregulation of Survivin. Clin Cancer Res. 2017 Nov 27. pii: clincanres.0345.2017.
19. Park D, Wang D, Chen G, Deng X.Establishment of Patient-derived Xenografts in Mice. Bio Protoc. 2016 Nov 20;6(22).
20. Chen J, Wei D, Zhuang H, Qiao Y, Tang B, Zhang X, Wei J, Fang S, Chen G, Du P, Huang X, Jiang W, Hu Q, Hua ZC. Proteomic screening of anaerobically regulated promoters from Salmonella and its antitumor applications. Mol Cell Proteomics. 2011 Jun;10(6):M111.009399.
21. Chen JX, Yang BY, Cheng XW, Qiao YT, Tang B, Chen G, Wei J, Liu XF, Cheng W, Du P, Huang XF, Jiang WH, Hu QG, Hu YQ, Li JH, Hua ZC. Salmonella-mediated tumor-targeting TRAIL gene therapy displays better tumor suppression on melanoma mice model. Cancer Sci. 2012 Feb;103(2):325-33.
22. Lu, X, Zhang H, Li X, Chen G, Li QS, Luo Y, Ruan BF, Chen XW, Zhu HL. Design, synthesis and biological evaluation of pyridine acyl sulfonamide derivatives as novel COX-2 inhibitors. Bioorg Med Chem. 2011 Nov 15;19(22):6827-32.
23. Luo Y, Liu ZJ, Chen G, Shi J, Li JR, Zhu HL. 1,3,4-Oxadiazole derivatives as potential antitumor agents: discovery, optimization and biological activity valuation. Med. Chem. Commun., 2016,7, 263-271.
24. Fu J, Chen G, Yang Y, Zhang ZM, Zeng QF, An SQ and Zhu HL. Ultraviolet irradiation combined with manganese ore catalyzed ozonation of 4-chlorophenol in aqueous solution. Water Science & Technology: Water Supply—WSTWS Vol 10 No 1 pp 97–104. 2010.
25. Pan F, Xu A, Xia D, Yu Y, Chen G, Meyer M, Zhao D, Huang CH, Wu Q, Fu J. Effects of octahedral molecular sieve on treatment performance, microbial metabolism, and microbial community in expanded granular sludge bed reactor. Water Res. 2015 Dec 15;87:127-36.

获奖及荣誉

1、中国生物化学与分子学会“青年科学家论坛奖”，2019年