个人简介

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职称：教授
学科专业：药理学
研究方向：
1、溶瘤病毒疗法
2、肿瘤靶向治疗
电子邮箱：zhanghp @jnu.edu.cn
个人简介：
张海鹏，暨南大学基础医学院，教授，博士生导师，广东省****，珠江科技新星。主持包括国家自然科学基金面上项目等科研项目7项，授权国际、中国专利8项；研究领域集中在溶瘤病毒疗法和肿瘤靶向治疗等转化医学研究。近年来，以通讯或第一作者发表论文于Science Translational Medicine、Nature Communications、PNAS、Molecular Therapy等国际知名杂志，相关学术成果被《Nature Reviews》专题评述。

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学习经历

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2009.09-2014.06，中山大学/中山医学院，药理学，博士；
2005.09-2009.07，山东大学/药学院，药学，学士。

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工作经历

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2018.04-至今，暨南大学基础医学与公共卫生学院，药理学系，博士生导师，教授；
2014.09-2017.12，中山大学，博士后。

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主要论文

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1. Zhang H, Li K, Lin Y, Xing F, Xiao X, Cai J, Zhu W, Liang J, Tan Y, Fu L, Wang F, Yin W, Lu B, Qiu P, Su X, Gong S, Bai X, Hu J, Yan G. Targeting vcp enhances anticancer activity of oncolytic virus m1 in hepatocellular carcinoma. Science Translational Medicine. 2017;9. (第一作者，IF: 18.559，IF均为五年平均影响因子) Highlighted in Science translational medicine. Comment in Nature reviews| gastroenterology＆hepatology.
2. Xiao X, Liang J, Huang C, Li K, Xing F, Zhu W, Lin Z, Xu W, Wu G, Zhang J, Lin X, Tan Y, Cai J, Hu J, Chen X, Huang Y, Qin Z, Qiu P, Su X, Chen L, Lin Y, Zhang H* (co-corresponding author), Yan G. DNA-PK inhibition synergizes with oncolytic virus M1 by inhibiting antiviral response and potentiating DNA damage. Nature Communications. 2018;9:4342. (共同通讯作者，IF:13.611)
3. Lin Y, Zhang H# (co-first author), Liang J, Li K, Zhu W, Fu L, Wang F, Zheng X, Shi H, Wu S, Xiao X, Chen L, Tang L, Yan M, Yang X, Tan Y, Qiu P, Huang Y, Yin W, Su X, Hu H, Hu J, Yan G. Identification and characterization of alphavirus m1 as a selective oncolytic virus targeting zap-defective human cancers. Proc Natl Acad Sci U S A. 2014;111:E4504-4512. (共同第一作者，IF:10.62)
4. Li K, Zhang H #(co-first author), Qiu J, Lin Y, Liang J, Xiao X, Fu L, Wang F, Cai J, Tan Y, Zhu W, Yin W, Lu B, Xing F, Tang L, Yan M, Mai J, Li Y, Chen W, Qiu P, Su X, Gao G, Tai PW, Hu J, Yan G. Activation of cyclic adenosine monophosphate pathway increases the sensitivity of cancer cells to the oncolytic virus m1. Mol Ther. 2016;24:156-165. (共同第一作者，IF: 7.885)
5. Zhang H, Lin Y, Li K, Liang J, Xiao X, Cai J, Tan Y, Xing F, Mai J, Li Y, Chen W, Sheng L, Gu J, Zhu W, Yin W, Qiu P, Su X, Lu B, Tian X, Liu J, Lu W, Dou Y, Huang Y, Hu B, Kang Z, Gao G, Mao Z, Cheng SY, Lu L, Bai XT, Gong S, Yan G, Hu J. Naturally existing oncolytic virus m1 is nonpathogenic for the nonhuman primates after multiple rounds of repeated intravenous injections. Hum Gene Ther. 2016;27:700-711. (第一作者，IF: 4.22)
6. Zhang H, Zhu W, Su X, Wu S, Lin Y, Li J, Wang Y, Chen J, Zhou Y, Qiu P, Yan G, Zhao S, Hu J, Zhang J. Triptolide inhibits proliferation and invasion of malignant glioma cells. J Neurooncol. 2012;109:53-62. (第一作者，IF: 3.209)
7. Li K, Hu C, Xing F, Gao M, Liang J, Xiao X, Cai J, Tan Y, Hu J, Zhu W, Yin W, Li Y, Chen W, Lu B, Mai J, Qiu P, Su X, Yan G, Zhang H* (co-corresponding author), and Lin Y. Deficiency of the ire1α-autophagy axis enhances the antitumor effects of the oncolytic virus m1. J Virol, 2017. (共同通讯作者，IF: 4.288)
8. Tan Y, Lin Y, Li K, Xiao X, Liang J, Cai J, Guo L, Li C, Zhu W, Xing F, Mai J, Gu J, Tan X, Yin W, Lu B, Qiu P, Su X, Gao M, Hu J, He S, Lu L, Gong S, Yan G, Zhang H* (corresponding author). Selective antagonism of bcl-xl potentiates m1 oncolysis by enhancing mitochondrial apoptosis. Hum Gene Ther. 2017. (通讯作者，IF: 4.22)
9. Li, K., Wu, J. L.; Qin, B., Fan, Z., Tang, Q., Lu, W., Zhang, H., Xing, F., Meng, M., Zou, S., Wei, W., Chen, H., Cai, J.; Wang, H., Zhang, H., Cai, J., Fang, L., Bian, X., Chen, C., Lan, P., Ghesquière,, B., Fang, L. *, Lee, M. *. ILF3 is a substrate of SPOP for regulating serine biosynthesis in colorectal cancer. Cell Research 2020, 30, (2), 163-178. （IF：20.396）
10. Cai J, Lin Y, Zhang H, Liang J, Tan Y, Cavenee WK, Yan G. Selective replication of oncolytic virus m1 results in a bystander killing effect that is potentiated by smac mimetics. Proc Natl Acad Sci U S A. 2017;114:6812-6817. (IF: 10.62)
11. Xing F, Luan Y, Cai J, Wu S, Mai J, Gu J, Zhang H, Li K, Lin Y, Xiao X, Liang J, Li Y, Chen W, Tan Y, Sheng L, Lu B, Lu W, Gao M, Qiu P, Su X, Yin W, Hu J, Chen Z, Sai K, Wang J, Chen F, Chen Y, Zhu S, Liu D, Cheng S, Xie Z, Zhu W, Yan G. The anti-warburg effect elicited by the camp-pgc1alpha pathway drives differentiation of glioblastoma cells into astrocytes. Cell Rep. 2017;18:468-481. (IF: 8.817)
12. Li K, Liang J, Lin Y, Zhang H, Xiao X, Tan Y, Cai J, Zhu W, Xing F, Hu J, Yan G. A classical pka inhibitor increases the oncolytic effect of m1 virus via activation of exchange protein directly activated by camp 1. Oncotarget. 2016;7:48443-48455. (IF: 5.312)
13. Ying L, Cheng H, Xiong XW, Yuan L, Peng ZH, Wen ZW, Ka LJ, Xiao X, Jing C, Qian TY, Liang GZ, Mei YG, Bo ZW, Liang P. Interferon alpha antagonizes the anti-hepatoma activity of the oncolytic virus m1 by stimulating anti-viral immunity. Oncotarget. 2017;8:24694-24705. (IF: 5.312)
14. Shu M, Zhou Y, Zhu W, Zhang H, Wu S, Chen J, Yan G. Microrna 335 is required for differentiation of malignant glioma cells induced by activation of camp/protein kinase a pathway. Mol Pharmacol. 2012;81:292-298. (IF: 3.904)
15. Chen J, Ouyang Y, Cao L, Zhu W, Zhou Y, Zhang H, Yang X, Mao L, Lin S, Lin J, Hu J, Yan G. Diazepam inhibits proliferation of human glioblastoma cells through triggering a g0/g1 cell cycle arrest. J Neurosurg Anesthesiol. 2013;25:285-291. (IF: 2.469)
16. Wang Y, Tang L, Yin W, Chen J, Leng T, Zheng X, Zhu W, Zhang H, Qiu P, Yang X, Yan G, Hu H. Simultaneous determination of seven neuroactive steroids associated with depression in rat plasma and brain by high performance liquid chromatography-tandem mass spectrometry. Anal Sci. 2016;32:981-988. (IF: 1.626)
17. Xiao X, Chen L, Ouyang Y, Zhu W, Qiu P, Su X, Dou Y, Tang L, Yan M, Zhang H, Yang X, Xu D, Yan G. Pregnenolone, a cholesterol metabolite, induces glioma cell apoptosis via activating extrinsic and intrinsic apoptotic pathways. Oncol Lett. 2014;8:645-650. (IF: 2.311)

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获奖及荣誉

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1. 广东省****基金（2021）
2. 珠江科技新星 （2019）

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学术兼职

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1. 中国抗癌协会会员；
2. 中国药理学会会员；
3. 中国病理生理学会会员；
4. 《Cancer management and research》和《Acta Pharmacologica Sinica》期刊审稿人。

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