个人简介

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职称：副研究员
学科专业：公共卫生与预防医学
研究方向：药代动力学及药物新剂型
电子邮箱：orangefume@hotmail.com
个人简介：
董栋，女，暨南大学基础医学院副研究员，博士毕业于University of Houston。一直从事药物代谢及药物新剂型的研究，主要研究内容为药物II相代谢——外排转运相互作用机制和微纳米制剂制备、体外表征及其体内药物动力学
。主持国家自然科学基金1项，广东省自然科学基金1项，广东省医学科研基金1项，获广州市人才专项1项，发表SCI论文30余篇，申请发明专利9项。

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学习科研经历

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2015.09-至今，暨南大学，基础医学院，副研究员
2013.08-2015.08，暨南大学， 生物医学工程转业，博士后
2009.08-2012.12，美国休斯敦大学，药剂学专业，博士
2005.09-2008.07，复旦大学，生药学专业，硕士
2001.09-2005.07，苏州大学，药学专业，学士

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主要论文

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第一（含共一）或通讯作者发表A1类SCI论文：
1. Dong D, Wu B, Chow D, Hu M. Substrate selectivity of drug-metabolizing cytochrome P450s predicted from crystal structures and in silico modeling. Drug Metab Rev. 2012;44(2):192-208.
2. Zhang X, Dong D#, Wang H, Ma Z, Wang Y, Wu B. Stable Knock-down of Efflux Transporters Leads to Reduced Glucuronidation in UGT1A1-Overexpressing HeLa Cells: The Evidence for Glucuronidation-Transport Interplay. Mol Pharm. 2015;12(4):1268-78.
3. Dong D, Wang X, Wang H, Zhang X, Wang Y, Wu B. Elucidating the in vivo fate of nanocrystals using a physiologically based pharmacokinetic model: a case study with the anticancer agent SNX-2112. Int J Nanomedicine. 2015;10:2521-35.
4. Dong D, Peng X, Liu J, Qian H, Li J, Wu B. Morbid Obesity Alters Both Pharmacokinetics and Pharmacodynamics of Propofol: Dosing Recommendation for Anesthesia Induction. Drug Metab Dispos. 2016;44(10):1579-83.
5. Zhang T, Dong D#, Lu D, Wang S, Wu B. Cremophor EL-based nanoemulsion enhances transcellular permeation of emodin through glucuronidation reduction in UGT1A1-overexpressing MDCKII cells. Int J Pharm. 2016;501(1-2):190-8.
6. Dong D, Quan E, Yuan X, Xie Q, Li Z, Wu B. Sodium Oleate-Based Nanoemulsion Enhances Oral Absorption of Chrysin through Inhibition of UGT-Mediated Metabolism. Mol Pharm. 2017;14(9):2864-2874.
7. Yuan X, Xie Q, Su K, Li Z, Dong D*, Wu B. Systemic delivery of the anticancer agent arenobufagin using polymeric nanomicelles. Int J Nanomedicine. 2017;12:4981-4989.
8. Lu D, Dong D#, Xie Q, Li Z, Wu B. Disposition of Mianserin and Cyclizine in UGT2B10-Overexpressing Human Embryonic Kidney 293 Cells: Identification of UGT2B10 as a Novel N-Glucosidation Enzyme and Breast Cancer Resistance Protein as an N-Glucoside Transporter. Drug Metab Dispos. 2018;46(7):970-979.
9. Xue Yuan, Dong D#, Zhijie Li, Baojian Wu. Rev-erba activation down-regulates hepatic Pck1 enzyme to lower plasma glucose in mice. Pharmacol Res. 2019;141:310-318.

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获奖及荣誉

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广州市珠江科技新星，2016年

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学术兼职

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1、美国药学科学家协会（AAPS）会员
2、药物缓控释协会（CRS）会员，
3、Xenobiotica、International Journal of Nanomedicine、Journal of Chromatography B、Journal of Pharmaceutical and Biomedical Analysis等SCI杂志审稿人。

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