王彩艳 职称/职位：研究员 学位：博士
学院: 中药学院（国际中医药转化医学研究所）
E-mail: wangcaiyan@gzucm.edu.cn
办公电话：
办公室：广州大学城广州中医药大学针灸楼218
个人获得荣誉：广东省青年珠江****、广州中医药大学“杏林青年****”



教育、工作经历
2019年美国加州大学洛杉矶分校访问****。2015年博士毕业于中山大学，随后在中山大学“有害生物控制与资源利用国家重点实验室”从事博士后研究。

研究方向
应用结构生物学等方法研究药理学，从原子水平阐明药物的作用机制，为合理药物设计奠定基础。重大疾病相关蛋白质的结构生物学、基于结构的药物设计与发现、基于蛋白质结构的天然药物作用靶点和机制研究。

科研及教学课题
1)广东省教育厅，2019年广东省高等学校青年珠江****，2019/10-2022/09, 100万，主持，在研。
2)广州中医药大学“青年科研培育项目”，2019/05-2021/05，30 万，主持，在研。
3)国家青年科学基金项目，**，双加氧酶 AlkBH1 调控翻译起始 tRNA(iMet) m1A58 去甲基化的结构及生化性质研究，2018/01-2020/12, 24万, 主持, 结题。
4)广东省基础与应用基础研究专项资金项目，2017A，应激条件下磷酸化激酶 GCN2 激活的结构基础，2017/05-2020/5，10万，主持，结题。
5)中国博士后科学基金特别资助，2017T100654，双加氧酶 AlkBH1 调控翻译起始的结构基础，2017/01-2017/06，15万，主持，结题。

承担的课程
承担《药理学》《药物毒理学》和《结构生物学与现代药学研究》的本科教学。

代表性论文论著
[1]Yuanyuan Cheng#, Liangkai Cheng#, Xiang Gao, Sixuan Chen, Peng Wu, Caiyan Wang*, Zhongqiu Liu*. Pubescenosides A attenuated myocardial ischemia-reperfusion injury by covalently binding to keap1. Theranostics, 2021; 11(2): 861-877.
[2]Hong Li#, Ying Zhang#, Yajuan Guo, Rong Liu, Qi Yu, Lingzhi Gong, Zhongqiu Liu*, Wei Xie*, Caiyan Wang*. ALKBH1 Promotes Lung Cancer by Regulating m6A RNA Demethylation. Biochemical Pharmacology, 2020, 114284.
[3]Structures of capsid and capsid-associated tegument complex inside the Epstein-Barr virus, Wei Liu, Yanxiang Cui, Caiyan Wang, Zihang Li, Danyang Gong, Xinghong Dai, Guo-Qiang Bi, Ren Sun, Z Hong Zhou*, Nature Microbiology, 2020, 5(10):1285-1298.
[4]Qi Yu, Zonglang Liao, Dan Liu, Wei Xie, Zhongqiu Liu, Guochao Liao*, Caiyan Wang*, Small molecule inhibitors of the prostate cancer target KMT2D, Biochemical and Biophysical Research Communications, 2020, 10;533(3):540-547.
[5]Liangkai Cheng#, Hong Zhang#, Fang Wu, Zhongqiu Liu, Yuanyuan Cheng*, Caiyan Wang*. Role of Nrf2 and Its Activators in Cardio-cerebral Vascular Disease. Oxidative Medicine and Cellular Longevity. 2020:**.
[6]Lin Zhang#, Lijun Zhu#, Wei Qu, Fang Wu, Ming Hu, Wei Xei*, Zhongqiu Liu*, Caiyan Wang*, Insight into tartrate inhibition patterns in vitro and in vivo based on cocrystal structure with UDP-glucuronosyltransferase 2B15, Biochemical Pharmacology, 2020, 172:113753.
[7]Dan Liu, Lin Zhang, Lixin Duan, Jinjun Wu, Ming Hu, Zhongqiu Liu*, Caiyan Wang*, Potential of Herb-Drug/Herb Interactions between Substrates and Inhibitors of UGTs Derived from Herbal Medicines, Pharmacological Research, 2019, 150:104510.
[8]Ping He (#), Chunnian Wang (#), Yanlan Wang (#), Caiyan Wang (#) ，Changhua Zhou, Donglin Cao, Jiang Li, David A. Bushnell, Qing Li, Roger D. Kornberg*, Wei Xie*, Zhong Wang*, A novel AKR1C3 specific prodrug TH3424 with potent anti‐tumor activity in liver cancer, Clinical Pharmacology & Therapeutics, 2019, doi: 10.1002/cpt.1708.
[9]Fang Wu, Liangkai Cheng, Qi Yu, Lin Zhang, Hong Li, Caiyan Wang*, Purification and functional characterization of the C-terminal domain of the β-actin-binding protein AIM1 in vitro, Molecules. 2018, 23(12): 3281.
[10]Caiyan Wang#, Qian Jia#, Jianhua Zeng, Ran Chen, Wei Xie*, Structural insight into the methyltransfer mechanism of the bifunctional Trm5, Science Advances, 2017, 3(12):1-9.
[11]Caiyan Wang, Jianhua Zeng, Wei Xie*, A flexible cofactor-binding loop in the novel arginine methyltransferase Sfm1, FEBS Letters, 2017, 591(2):433-441.
[12]Caiyan Wang#, Qian Jia#, Ran Chen, Yuming Wei, Juntao Li, Jie Ma, Wei Xie*, Crystal structures of the bifunctional tRNA methyltransferase Trm5a, Scientific Reports, 2016, 6: 33553.
[13]Caiyan Wang, Yu Guo, Qingnan Tian, Qian Jia, Yuanzhu Gao, Qinfen Zhang, Chun Zhou, Wei Xie*, SerRS-tRNASec complex structures reveal mechanism of the first step in selenocysteine biosynthesis, Nucleic Acids Research, 2015, 43(21): 10534-10545.