吴锦俊 学位：博士
职称：副研究员



教育工作经历
教育经历： 2011/09-2016/06，广州中医药大学，中药学院，博士；导师：林娜、刘中秋
2007/09-2011/06，福建中医药大学，药学院，学士
工作经历： 1.2019/12-至今，广州中医药大学，中药学院，副研究员
2.2018/05-2019/05，美国密苏里大学，医学院，访问****
3.2016/09-2019/12，广州中医药大学，国际中医药转化医学研究所，讲师

研究方向
中药抗肿瘤药理

科研及教学课题
（1）“青年英才培养工程”第四批培养对象，广州中医药大学，QNYC**，2020.4.1-2024.03.31，20万，在研，主持
（2）国家自然科学基金青年科学基金项目，**，Nrf2信号通路介导葡萄糖醛酸化转移酶和外排转运蛋白调控的黄芪个体化用药的分子机制，2018/01-2020/12，20万元，在研，结题
（3）广东省自然科学基金-博士科研启动项目，2017A，中药黄芪调控P糖蛋白的作用及机制，2017/05-2020/05，10万元，在研，结题
（4）广东省普通高校青年创新人才项目，2016KQNCX026，基于P糖蛋白靶点探索中药黄芪抗肿瘤多药耐药作用及机制，2017/01-2019/01，5万元，结题，结题

承担课程
《药物毒理学》和《药理学》

代表性研究论文
[1] Yanmei Lou#, Muyan Kong#, Leyan Li, Yu Hu, Wenjun Zhai, Xiaoxiao Qi, Zhongqiu Liu*, Jinjun Wu*. Inhibition of the Keap1/Nrf2 signaling pathway significantly promotes the progression of type 1 diabetes mellitus, Oxidative Medicine and Cellular Longevity, 2021, 2021: **.
[2] Lin An, Yuefang Lin, Leyan Li, Muyan Kong, Yanmei Lou, Jinjun Wu*, Zhongqiu Liu*, Integrating Network Pharmacology and Experimental Validation to Investigate the Effects and Mechanism of Astragalus Flavonoids Against Hepatic Fibrosis. Frontiers in Pharmacology, 2021, 11: 618262.
[3] Yanmei Lou#, Zhenzhen Guo#, Yuanfeng Zhu#, Muyan Kong, Rongrong Zhang, Linlin Lu, Feichi Wu, Zhongqiu Liu*, Jinjun Wu*, Houttuynia cordata Thunb. and its bioactive compound 2-undecanone significantly suppress benzo(a)pyrene-induced lung tumorigenesis by activating the Nrf2-HO-1/NQO-1 signaling pathway, Journal of Experimental & Clinical Cancer Research, 2019, 38:242
[4] Zhenzhen Guo#, Yanmei Lou#, Muyan Kong, Qing Luo, Zhongqiu Liu*, Jinjun Wu*, A systematic review of phytochemistry, pharmacology and pharmacokinetics on Astragali radix: implications for Astragali radix as a personalized medicine, International Journal of Molecular Sciences, 2019, 20 (6), 1463
[5] Yanmei Lou#, Zhenzhen Guo#, Yuanfeng Zhu, Guiyu Zhang, Ying Wang, Xiaoxiao Qi, Linlin Lu, Zhongqiu Liu*, Jinjun Wu*, Astragali radix and its main bioactive compounds activate the Nrf2-mediated signaling pathway to induce P-glycoprotein and breast cancer resistance protein, Journal of Ethnopharmacology, 2019, 228: 82-91
[6] Jinjun Wu, Zhenzhen Guo, Yuanfeng Zhu, Zhijian Huang, Xia Gong, Yuhuan Li, Wenjie Son, Xiaoyan Li, Yanmei Lou, Lijun Zhu, Linlin Lu, Zhongqiu Liu*, Liang Liu*, A systematic review of pharmacokinetic studies on herbal drug Fuzi: implications for Fuzi as personalized medicine, Phytomedicine, 2018, 44:187-203
[7] Jinjun Wu, Yuanfeng Zhu, Zhenzhen Guo, Yanmei Lou, Shugui He, Yang Guan, Lijun Zhu, Zhongqiu Liu, Linlin Lu*, Liang Liu*, Aconitum alkaloids, the major components of Aconitum species, affect expression of multidrug resistance-associated protein 2 and breast cancer resistance protein by activating the Nrf2-mediated signalling pathway, Phytomedicine, 2018, 44:87-97
[8] Jinjun Wu, Yuanfeng Zhu, Fangyuan Li, Guiyu Zhang, Jian Shi, Rilan Ou, Yunli Tong, Yuting Liu, Liang Liu, Linlin Lu*, Zhongqiu Liu*, Spica prunellae and its marker compound rosmarinic acid induced the expression of efflux transporters through the activation of Nrf2-mediated signaling pathway in HepG2 cells, Journal of Ethnopharmacology, 2016, 193: 1-11
[9] Jinjun Wu, Na Lin, Fangyuan Li, Guiyu Zhang, Shugui He, Yuanfeng Zhu, Rilan Ou, Na Li, Shuqiang Liu, Lizhi Feng, Liang Liu, Zhongqiu Liu, Linlin Lu*, Induction of P-glycoprotein expression and activity of P-glycoprotein by Aconitum alkaloids: implication for clinical drug–drug interactions, Scientific Reports, 2016, 6: 25343