朱丽君 学位：博士
职称：副研究员



教育工作经历:
2015/12-至今 广州中医药大学中药学院 副研究员
2014/06-2015/11 广州中医药大学国际中医药转化医学研究所 讲师
2015/05-2015/10 美国休斯顿大学 访问****
2012/07-2014/05 广州医科大学 博士后
2009/9-2012/6 南方医科大学 博士
2005/9-2008/6 中山大学 硕士
2001/9-2005/6 湖南中医药大学 学士

研究方向
1）药物吸收与代谢
2）中药药代动力学及调控机制

科研及教学课题
[1]国家自然科学基金重点国际（地区）合作与交流项目，，经典中药方剂小柴胡汤阻抗伊立替康肠毒性的疗效及药代动力学机制，2020/01-2024/12，300万元，在研，主持
[2]国家自然科学基金面上项目，**，基于“化学-PD/PK”的附子质量标志物发现、确证及其调控毒效的分子机制研究，2019/01-2022/12，57万元，在研，主持
[3]广州市科技计划项目珠江科技新星专题，9，基于UGT代谢酶和外排转运蛋白偶联作用的秦皮香豆素类活性成分及其衍生物体内处置特征及机理研究，2018/04-2021/03，30万元，已结题，主持
[4]国家科技重大专项课题，2017ZX**，组分结构中药新品种奥斯替宝研发及其关键创新技术，2017/01-2020/12，70/319.36万元，已结题，子课题负责人
[6]国家自然科学基金青年项目，**，中药秦皮及其香豆素类活性成分的肝肠处置及调控机制，2017/01-2019/12，17万元，已结题，主持
[5]广东省自然科学基金博士科研启动项目，2014A，外排转运蛋白和CYP酶阻抗附子中乌头生物碱毒性的作用及分子机制，2014/10-2017/10，10万元，已结题，主持
[6]中国博士后科学基金，2013M542166，α1D-AR拮抗剂YM03对映异构体和外消旋体吸收代谢研究，2013/06-2014/06，5万元，已结题，主持

承担的课程
参与《生物药剂学与药物动力学》本科和研究生课程教学。

代表性研究论文
[1]Xiaocui Li#, Xiaowen Ou#, Guangkuo Luo, Xiaojun Ou, Yusha Xie, Mengdi Ying, Wei Qu, Huilin Zuo, Xiaoxiao Qi, Ying Wang, Zhongqiu Liu*, Lijun Zhu*. Mdr1a, Bcrp and Mrp2 regulate the efficacy and toxicity mesaconitine and hypaconitine by altering their tissue accumulation and in vivo residence. Toxicol Appl Pharmacol. 2020, 409：115332
[2]Xiaocui Li, Yushan Xie, Wei Qu, Xiaojun Ou, Xiaowen Ou, Chuang Wang, Xiaoxiao Qi, Ying Wang, Zhongqiu Liu *, Lijun Zhu*. Breast cancer resistance protein and multidrug resistance protein 2 mediate the disposition of leonurine-10-O-β-glucuronide. Curr Drug Metab.2020, 21(13): 1060-1067
[3]Xiaoyan Li, Yiyan Lu, Xiaojun Ou, Sijing Zeng, Ying Wang, Xiaoxiao Qi, Lijun Zhu* and Zhongqiu Liu*. Changes and sex- and age-related differences in the expression of drug metabolizing enzymes in a KRAS-mutant mouse model of lung cancer. PeerJ, 2020, 8: e10182
[4]Rongjin Sun#, Lijun Zhu#, Li Li, Wenjie Song, Xia Gong, Xiaoxiao Qi, Ying Wang, Romi Ghose, Song Gao*, Ming Hu*, Zhongqiu Liu*. Irinotecan-mediated diarrhea is mainly correlated with intestinal exposure to SN-38: Critical role of gut Ugt. Toxicol Appl Pharmacol. 2020, 398: 115032
[5]Lin Zhang#, Lijun Zhu#, Wei Qu, Fang Wu, Ming Hu, Wei Xie, Zhongqiu Liu*, Caiyan Wang*. Insight into Tartrate inhibition patterns in vitro and in vivo based on cocrystal structure with UDP-glucuronosyltransferase 2B15. Biochem Pharmacol, 2020, 172: 113753
[6]Yuhuan Li, Wenjie Song, Xiaojun Ou, Guangkuo Luo, Yushan Xie, Rongjin Sun, Ying Wang, Xiaoxiao Qi, Ming Hu, Zhongqiu Liu*, Lijun Zhu*. Breast cancer resistance protein and multidrug resistance protein 2 determine the disposition of esculetin-7-O-glucuronide and 4-Methylesculetin-7-O-glucuronide. Drug Metab & Dispos. 2019, 47 (3): 203-214
[7]Yuhuan Li, Linlin Lu, Liping Wang, Wei Qu, Wenqin Liu, Yushan Xie, Hongming Zheng, Ying Wang, Xiaoxiao Qi, Ming Hu*, Lijun Zhu*, Zhongqiu Liu*. Interplay of efflux transporters with glucuronidation and its impact on subcellular aglycone and glucuronide disposition: a case study with kaempferol. Mol Pharm. 2018, 15(12): 5602-5614.
[8]Haihui Zheng, Liping Wang, Sijing Zeng, Jiamei Chen, Haojia Wang, Jia Yu, Xia Gong, Huangyu Jiang, Xia Yang, Xiaoxiao Qi, Ying Wang, Linlin Lu, Ming Hu, Lijun Zhu*, Zhongqiu Liu*. Age-related changes in hepatic expression and activity of drug metabolizing enzymes in male wild-type and breast cancer resistance protein knockout mice. Biopharm Drug Dispos.2018, 39(7): 344-353
[9]Jiamei Chen, Qisong Zhang, Xiaoyan Li, Xia Gong, Yanjiao Ruan, Sijing Zeng, Linlin Lu, Xiaoxiao Qi, Ying Wang, Ming Hu, Lijun Zhu*, Zhongqiu Liu*. Tissue distribution and gender-specific protein expression of cytochrome P450 in five mouse genotypes with a background of FVB. Pharm Res. 2018, 35(6): 114
[10]Jiamei Chen, Haihui Zheng, Sijing Zeng, Cong Xie, Xiaoyan Li, Tongmeng Yan, Xia Gong, Linlin Lu, Xiaoxiao Qi, Ying Wang, Ming Hu, Lijun Zhu*, Zhongqiu Liu*. Profiles and gender-specific of UDP-glucuronosyltransferases and sulfotransferases expressions in the major metabolic organs of wild-type and efflux transporter knockout FVB mice. MolPharm. 2017, 9(14): 2967-2976

专著
[1]Zhu LJ, Lu LL, Wang SWJ, Wu JJ, Shi J, Yan TM, Xie C, Li Q, Hu M and Liu ZQ, Chapter 11— Oral Absorption Basics: Pathways and Physicochemical and Biological Factors Affecting Absorption, in “Developing Solid Oral Dosage Forms: Pharmaceutical Theory and Practice” (Edited by Qiu YH, Chen YS, Zhang G, Yu L, and Mantri RV), 2nd Edition, Publisher: Mica Haley, Pages: 297-329, Page Count 1176, eBookISBN: 73, Hard cover ISBN：78, Imprint: Academic Press, 11.28, 2016.http://doi.org/10.1016/B978-0-12-802447-8.00042-X

获奖
[1]Zhu LJ, Lu LL, Wang SWJ, Wu JJ, Shi J, Yan TM, Xie C, Li Q, Hu M and Liu ZQ, Chapter 11— Oral Absorption Basics: Pathways and Physicochemical and Biological Factors Affecting Absorption, in “Developing Solid Oral Dosage Forms: Pharmaceutical Theory and Practice” (Edited by Qiu YH, Chen YS, Zhang G, Yu L, and Mantri RV), 2nd Edition, Publisher: Mica Haley, Pages: 297-329, Page Count 1176, eBookISBN: 73, Hard cover ISBN：78, Imprint: Academic Press, 11.28, 2016.http://doi.org/10.1016/B978-0-12-802447-8.00042-X