陈建南 学位：本科
职称：研究员



教育工作经历
1980.09--1984.06 中山大学生物系植物学专业学习,获理学士学位；
1984.07--1993.03 广州中医学院中药系，助教、讲师；
1993.03--1999.11 广州中医学院中药开发研究所(后为广州中医药大学中药与保健开发研究所)，讲师；
1999.11--2006.07 广州中医药大学新药开发研究中心，讲师、副研究员、研究员；
2006.08--2010.10 广州中医药大学高等教育研究所副所长/中医药发展研究中心副主任(主持工作) ，研究员；
2010.11--2018.4 广州中医药大学高等教育研究所所长、中医药发展研究中心主任，研究员；
2018.4—至今 广州中医药大学中医药数理工程研究院/中药学院，研究员，中药学博士生导师。

研究方向
1）中药新产品研究与开发
2）中医药现代化发展战略研究

科研及教学课题
1.广州中医药大学2019年学科研究重大项目，XK**，基于鸦胆子有效部位的中医药防治癌症及炎症性肠病的应用研究，2019.01.01-2021.12.31，50万/年，在研，主持
广州中医药大学“高水平大学建设”面上项目，（无项目号），广藿香有效成分治疗化学性肝损伤作用的物质基础及作用机理研究，2017.05-2018.06，20万，已结题，主持
省重大专项办公室， 2012A，复方野菊花抗感软胶囊的临床前研究，2012.12-2014.12，100万，已结题，主持
4.国家自然科学基金，**，中药药性理论模型化表征方法及药性-功效知识元关联规律研究，2010.01-2012.12，30万，已结题，主持
国家科技重大专项，2009ZX09103-376，复方野菊花抗感滴丸临床前研究，2009.01-2010.12,500万，已结题，主持

承担课程
主要承担《中药现代化引论》、《中药现代化关键技术》等课程。

代表性研究论文
1. Dou Y1, Huang R1, Li Q, Liu Y, Li Y, Chen H, Ai G, Xie J, Zeng H, Chen J, Luo C*, Su Z*. Oxyberberine, an absorbed metabolite of berberine, possess superior hypoglycemic effect via regulating the PI3K/Akt and Nrf2 signaling pathways. Biomed Pharmacother. 2021 Jan 30; 137:111312.
2. Wang Y, Liu J, Huang Z, Li Y, Liang Y, Luo C, Ni C, Xie J, Su Z, Chen J*, Li C*. Coptisine ameliorates DSS-induced ulcerative colitis via improving intestinal barrier dysfunction and suppressing inflammatory response. Eur J Pharmacol. 2021 Apr 5; 896:173912.
3. Xie J1, Lai Z1, Zheng X, Liao H, Xian Y, Li Q, Wu J, Ip S, Xie Y, Chen J, Su Z, Lin Z**, Yang X**. Apoptotic activities of brusatol in human non-small cell lung cancer cells: Involvement of ROS-mediated mitochondrial-dependent pathway and inhibition of Nrf2-mediated antioxidant response. Toxicology. 2021 Mar 15; 451:152680.
4. Wang T1, Dou Y1, Lin G, Li Q, Nie J, Chen B, Xie J, Su Z, Zeng H*, Chen J*, Xie Y*. The anti-hepatocellular carcinoma effect of Brucea javanica oil in ascitic tumor-bearing mice: The detection of brusatol and its role. Biomed Pharmacother. 2021 Feb; 134:111122.
5. Xu N1, Luo H1, Li M, Wu J, Wu X, Chen L, Gan Y, Guan F, Li M, Su Z, Chen J*, Liu Y*. β-patchoulene improves lipid metabolism to alleviate non-alcoholic fatty liver disease via activating AMPK signaling pathway. Biomed Pharmacother. 2021 Feb; 134:111104.
6. Liu Y, Wu J, Chen L, Wu X, Gan Y, Xu N, Li M, Luo H, Guan F, Su Z, Chen J*, Li Y*. β-patchoulene simultaneously ameliorated dextran sulfate sodium-induced colitis and secondary liver injury in mice via suppressing colonic leakage and flora imbalance. Biochem Pharmacol. 2020 Dec; 182:114260.
7. Li C, Ai G, Wang Y, Lu Q, Luo C, Tan L, Lin G, Liu Y, Li Y, Zeng H, Chen J, Lin Z, Xian Y, Huang X, Xie J*, Su Z*. Oxyberberine, a novel gut microbiota-mediated metabolite of berberine, possesses superior anti-colitis effect: Impact on intestinal epithelial barrier, gut microbiota profile and TLR4-MyD88-NF-κB pathway. Pharmacol Res. 2020 Feb; 152:104603.
8. Tan, Lihua#; Wang, Yongfu#; Ai, Gaoxiang; Luo, Chaodan; Chen, Hanbin;Li, Cailan; Zeng, Huifang; Xie, Jianhui; Chen, Jiannan*; Su, Ziren*; Dihydroberberine, a hydrogenated derivative of berberine firstly identified in Phellodendri Chinese Cortex, exerts anti-inflammatory effect via dual modulation of NF-kappa B and MAPK signaling pathways , International Immunopharmacology, 2019, 75: 1-11.
9. Huang, Yan Feng#; Li, Qiao Ping#; Dou, Yao Xing; Wang, Tong Tong; Qu Chang; Liang, Jia Li; Lin, Zhi Xiu; Huang, Xiao Qi; Su, Zi Ren; Chen, Jian Nan*; Xie, You Liang*; Therapeutic effect of Brucea javanica oil emulsion on experimental Crohn's disease in rats: Involvement of TLR4/NF-kappa B signaling pathway, Biomedicine & Pharmacotherapy, 2019, 114: 1-10.
10. Xie JH1, Lai ZQ1, Zheng XH, Xian YF, Li QP, Xie YL, Chen JN, Su ZR, Lin ZX*, Yang XB*. Apoptosis induced by bruceine D in human non?small?cell lung cancer cells involves mitochondrial ROS?mediated death signaling. Int J Mol Med. 2019 Dec;44(6):2015-2026.
11. Huang, Qiong Hui#; Wu, Xue#; Chen, Xiao Hong; Wu, Jia Zhen; Su, Zi Ren;Liang, Jia Li; Li, Yu Cui; Lai, Xiao Ping; Chen, Jian Nan*; Liu, Yu Hong*; Patchouli oil isolated from the leaves of Pogostemon cablin ameliorates ethanol-induced acute liver injury in rats via inhibition of oxidative stress and lipid accumulation , RSC Advances, 2018, 8(43): 24399-24410.
12. Wang L1, Huang QH1, Li YX, Huang YF, Xie JH, Xu LQ, Dou YX, Su ZR, Zeng HF*, Chen JN*. Protective effects of silymarin on triptolide-induced acute hepatotoxicity in rats. Mol Med Rep. 2018 Jan; 17(1):789-800.
13. Liu, Yu Hong#; Huang, Qiong Hui#; Wu, Xue; Wu, Jia Zhen; Liang, Jia Li; Lin, Guo Sheng; Xu, Lie Qiang; Lai, Xiao Ping; Su, Zi Ren*; Chen, Jian Nan*; Polydatin protects against acetaminophen-induced hepatotoxicity in mice via anti-oxidative and anti-apoptotic activities, Food & Function, 2018, 9(11):5891-5902.
14. Zhang, Xiao Jun#; Yuan, Zhong Wen#; Qu, Chang#; Yu, Xiu Ting; Huang,Tao; Chen, Ping Vicky; Su, Zi Ren; Dou, Yao Xing; Wu, Jia Zhen; Zeng, Hui Fang*; Xie, Ying*; Chen, Jian Nan*; Palmatine ameliorated murine colitis by suppressing tryptophan metabolism and regulating gut microbiota , Pharmacological Research, 2018, 137: 34-46.
15. Su ZQ1, Liu YH1, Guo HZ, Sun CY, Xie JH, Li YC, Chen JN, Lai XP, Su ZR*, Chen HM*. Effect-enhancing and toxicity-reducing activity of usnic acid in ascitic tumor-bearing mice treated with bleomycin. Int Immunopharmacol. 2017 May; 46:146-155.
16. Zhan JY, Wang XF, Liu YH, Zhang ZB, Wang L, Chen JN, Huang S, Zeng HF*, Lai XP*. Andrographolide Sodium Bisulfate Prevents UV-Induced Skin Photoaging through Inhibiting Oxidative Stress and Inflammation. Mediators Inflamm. 2016; 2016:**.
17. Wu XL, Feng XX, Li CW, Zhang XJ, Chen ZW, Chen JN, Lai XP, Zhang SX, Li YC*, Su ZR*. The protective effects of the supercritical-carbon dioxide fluid extract of Chrysanthemum indicum against lipopolysaccharide-induced acute lung injury in mice via modulating Toll-like receptor 4 signaling pathway. Mediators Inflamm. 2014; 2014:246407.
13. 高建胜,黄子健,潘碧妍,何国熙,窦耀星,王彤彤,谢友良，陈建南, 苏子仁.鸦胆子药渣抗葡聚糖硫酸钠诱导小鼠肠炎作用研究[J].世界科学技术-中医药现代化,2019,21(10):2128-2134.
14. 唐海明，陈建南, 黎爱,罗宇欣,赖小平,黄松.RP-HPLC法同时测定狭基线纹香茶菜中4个碳苷黄酮[J].中成药,2015,37(01):138-141.
15. 唐海明，陈建南, 张扬,赖小平,黄松.HPLC法同时测定不同来源溪黄草药材中8个水溶性成分的含量[J].药物分析杂志,2015,35(02):228-234.
16. 唐海明，陈建南, 徐香琴,赖小平,黄松.狭基线纹香茶菜水溶性成分及其抗肿瘤活性研究[J].中草药,2014,45(22):3219-3223.
17. 钟燕珠，陈建南, 周福生,许仕杰,郑伟仁,林良诚.丁公藤等5种中药材规范化种植关键技术研究[J].中国中医药现代远程教育,2014,12(15):98-100.
18. 邓丽红，陈建南, 强皎,李润美,汪芳,朱莉,张军.异芹菜脑在隔山香药材中的含量测定及其对心肌细胞缺氧/复氧损伤保护作用[J].中药新药与临床药理,2014,25(04):472-476.