张天鹏 职称： 副研究员
学位： 博士
E-mail: zhangtianpeng@gzucm.edu.cn
个人获得荣誉：广州中医药大学“杏林青年****”




教育、工作经历
2020/10-至今 广州中医药大学 中药学院 副研究员
2018/08-2020/09 暨南大学 中医学院 博士后 导师：王英教授
2013/09-2018/07 暨南大学 中药药理学 博士 导师：吴宝剑教授
2009/09-2013/07 湖北医药学院 药学 学士


研究领域及方向
研究领域：药理学
研究方向：（1）生物钟调控代谢性疾病研究；（2）药物代谢动力学


代表性科研及教学课题
1. 国家自然科学基金青年项目，**，核受体REV-ERB调控药物处置及其作用机制研究，2020/01-2022/12，21万元。（主持）
2. 中国博士后科学基金面上项目，2019M650234，时钟基因REV-ERBa调控药物代谢及其作用机制研究，2019/09-2021/09，12万元。（主持）
3. 国家自然科学基金优秀青年项目，**，中药代谢与转运动力学，2018/01-2020/12，130 万元。（参与）
4. 国家自然科学基金面上项目，**，外排转运蛋白影响葡萄糖醛酸化代谢及其作用机制研究，2016/01-2019/12，64.8万元。（参与）
5. 国家高技术研究发展计划(863计划)，2015AA02091，预测药物葡萄糖醛酸化代谢新技术新方法的探究，2015/01-2018/12，122万元。（参与)




代表性文章

1. Zhang T^#, Yu F^#, Xu H, Chen M, Chen X, Guo L, Zhou C, J Yu*, Wu B*. Dysregulation of REV-ERBα impairs GABAergic function and promotes epileptic seizures in preclinical models. Nat Commun. Accepted. (IF: 12.121)
2. Guo L^#, Zhang T^#, Wang F, Chen X, Xu H, Zhou C, Chen M, Yu F, Wang S, Yang D, Wu B. Targeted inhibition of Rev-erb-α/β limits ferroptosis to ameliorate folic acid-induced acute kidney injury. Br J Pharmacol. 2020. doi: 10.1111/bph.15283. (IF: 7.73)
3. Zhang T, Chen M, Guo L, Yu F, Zhou C, Xu H, Wu B*. REV-ERBα antagonism promotes homocysteine catabolism and ammonia clearance. Hepatology. 2019,70(5):1770-1784. (IF: 14.679)
4. Zhang T^#, Guo L^#, Yu F, Chen M, Wu B*. The nuclear receptor Rev-erbα participates in circadian regulation of Ugt2b enzymes in mice. Biochem Pharmacol. 2019,161:89-97. (IF: 4.96)
5.Yu F^#, Zhang T^#, Zhou C, Xu H, Guo L, Chen M, Wu B*. The Circadian Clock Gene Bmal1 Controls Intestinal Exporter MRP2 and Drug Disposition. Theranostics. 2019, 9(10): 2754-2767. （封面文章）(IF: 8.579)
6. Chen M, Guo L, Dong D, Yu F, Zhang T*, Wu B*. The nuclear receptor Shp regulates morphine withdrawal syndrome via modulation of Ugt2b expression in mice. Biochem Pharmacol. 2019,161:163-172. (IF: 4.96)
7. Chen M^#, Guan B^#, Xu H, Yu F, Zhang T*, Wu B*. The Molecular Mechanism Regulating Diurnal Rhythm of Flavin-Containing Monooxygenase 5 in Mouse Liver. Drug Metab Dispos. 2019, 47(11):1333-1342. (IF: 3.231)
8. Zhang T, Yu F, Guo L, Chen M, Yuan X, Wu B*. Small Heterodimer Partner Regulates Circadian Cytochromes p450 and Drug-Induced Hepatotoxicity. Theranostics. 2018,8(19):5246-5258. (IF: 8.579)
9. Zhang T^#, Zhao M^#, Lu D, Wang S, Yu F, Guo L, Wen S, Wu B*. REV-ERBα Regulates CYP7A1 Through Repression of Liver Receptor Homolog-1. Drug Metab Dispos. 2018,46(3):248-258. (IF: 3.231)
10. Yu F^#, Zhang T^#, Guo L, Wu B*. Liver Receptor Homolog-1 Regulates Organic Anion Transporter 2 and Docetaxel Pharmacokinetics. Drug Metab Dispos. 2018,46(7):980-988. (IF: 3.231)
11. Dong D^#, Zhang T^#, Lu D#, Liu J, Wu B*. In vitro characterization of belinostat glucuronidation: demonstration of both UGT1A1 and UGT2B7 as the main contributing isozymes. Xenobiotica. 2017,47(4):277-283. (IF: 1.902)
12. Zhang T^#, Dong D^#, Lu D, Wang S, Wu B*. Cremophor EL-based nanoemulsion enhances transcellular permeation of emodin through glucuronidation reduction in UGT1A1-overexpressing MDCKII cells. Int J Pharm. 2016,501(1-2):190-8. (IF: 4.845)
13. Chen Z^#, Zhang T^#, Wu B, Zhang X*. Insights into the therapeutic potential of hypoxia-inducible factor-1α small interfering RNA in malignant melanoma delivered via folate-decorated cationic liposomes. Int J Nanomedicine. 2016,11:991-1002. (IF: 4.471)
14. Zhang T^#, Wang H^#, Ye Y, Zhang X*, Wu B*. Micellar emulsions composed of mPEG-PCL/MCT as novel nanocarriers for systemic delivery of genistein: a comparative study with micelles. Int J Nanomedicine. 2015,10:6175-84. (IF: 4.471)
15. Zhang X^#, Zhang T^#, Ye Y, Chen H, Sun H, Zhou X, Ma Z, Wu B*. Phospholipid-stabilized mesoporous carbon nanospheres as versatile carriers for systemic delivery of amphiphobic SNX-2112 (a Hsp90 inhibitor) with enhanced antitumor effect. Eur J Pharm Biopharm. 2015,94:30-41. (IF: 4.604)
16. Zhang X^#, Zhang T^#, Zhou X, Liu H, Sun H, Ma Z, Wu B*. Enhancement of oral bioavailability of tripterine through lipid nanospheres: preparation, characterization, and absorption evaluation. J Pharm Sci. 2014,103(6):1711-9. (IF: 2.997)

专利


1.吴宝剑，张天鹏，邢会杰，赵梦静. BJ16的新应用. CN 7.1
2.吴宝剑，张天鹏，邢会杰，赵梦静. 黄秋葵水提取物在保护消化道功能中的应用.
CN 8.6
3. 吴宝剑，周晓伟，张天鹏，王帅. 一种用于急性脑血管疾病后遗症的中药组方.