刘永强
学位： 博士
职称： 副研究员



教育工作经历
2020/8-至今，副研究员，广州中医药大学 中药学院 中药资源科学与工程研究中心
2017/7-2020/7，副研究员，广州中医药大学 科技创新中心
2014/11-2017/6，博士后，美国福克斯蔡司癌症研究中心
2009/10-2013/12，博士，中国科学院 动物研究所膜生物学国家重点实验室
2007/7-2009/9, 硕士，中国科学院 广州生物医药与健康研究院

研究方向
1）中药抗肿瘤分子机制研究
2）肿瘤分子靶向治疗。

科研及教学课题
1.广东省医学科研基金面上项目，B**，F-box蛋白NIPA促进肺癌细胞增殖以及介导化疗耐药的分子机理研究，2020/07-2022/06，1.5万元，在研，主持。
2.国家自然科学基金青年项目，小胶质细胞通过分泌IL-1β招募星形胶质细胞进而促进髓母细胞瘤发生的分子机理研究，**，2019.1-2021.12，21万元，在研，主持。
3.高水平大学建设杏林人才科研配套经费，2017.7-2020.7，40万，主持。

承担课程
主要承担《生物学》等课程。

代表性研究论文
1.Yong-Qiang Liu*, Xiao-Lu Wang, Dan-Hua He, Yong-Xian Cheng*. Protection against chemotherapy- and radiotherapy-induced side effects: mechanisms and therapeutic opportunities of phytochemicals. Phytomedicine. 2021, 80: 153402.
2.Yi-le Zhou, Yong-ming Yan, Si-yi Li, Dan-hua He, Sha Xiong, Su-fen Wei, Wei Liu, Ling Hu, Qi Wang, Hua-feng Pan*, Yong-xian Cheng*, Yong-Qiang Liu*. 6-O-angeloylplenolin exerts neuroprotection against lipopolysaccharide-induced neuroinflammation in vitro and in vivo. Acta Pharmacologica Sinica, 2020, 41: 10–21.
3.Si-Yi Li, Yi-Le Zhou, Dan-Hua He, Wei Liu, Xiang-Zhen Fan, Qi Wang, Hua-Feng Pan*, Yong-Xian Cheng*, Yong-Qiang Liu*. Centipeda minima extract exerts antineuroinflammatory effects via the inhibition of NF-κB signaling pathway. Phytomedicine, 2020, 67: 153164.
4.Yi-Jie Wang, Xin-Yue Wang, Xu-Yi Hao, Yong-Ming Yan, Ming Hong, Su-Fen Wei, Yi-Le Zhou, Qi Wang*, Yong-Xian Cheng*, Yong-Qiang Liu*. Ethanol Extract of Centipeda minima Exerts Antioxidant and Neuroprotective Effects via Activation of the Nrf2 Signaling Pathway. Oxidative Medicine and Cellular Longevity, 2019, **.
5.Yongqiang Liu#, Larra Yuelling#, Yuan Wan, Fang Du, Renata E. Gordon, Jenny A. O'Brien, Jessica M.Y. Ng, Shannon Robins, Eric H. Lee, Hailong Liu, Tom Curran, Zeng-Jie Yang. Astrocytes promote medulloblastoma progression through hedgehog secretion. Cancer Research, 2017, 77(23): 6692-6703.
6.Wenfeng Lu#, Yongqiang Liu#, Haikuo Ma, Jiyue Zheng, Sheng Tian, Zhijian Sun, Lusong Luo, Jiajun Li, Hongjian Zhang, Zeng-Jie Yang, Xiaohu Zhang. Design, Synthesis, and Structure-Activity-Relationship of Tetrahydropyrido[4,3-d]pyrimidine Derivatives as Potent Smoothened Antagonists with in Vivo Activity. ACS Chemical Neuroscience, 2017, 8(9):1980-1994. (co-first author)
7.Yong-Qiang Liu, Xiao-Lu Wang, Xin Cheng, Yong-Zhi Lu, Gui-Zhen Wang, Xin-Chun Li, Jian Zhang, Zhe-Sheng Wen, Zhi-Liang Huang, Qin-Lei Gao, Li-Na Yang, Yong-Xian Cheng, Sheng-Ce Tao, Jinsong Liu, Guang-Biao Zhou. Skp1 in lung cancer: clinical significance and therapeutic efficacy of its small molecule inhibitors. Oncotarget, 2015, 6(33): 34953-67.
8.Gui-Zhen Wang#, Yong-Qiang Liu#, Xin Cheng, Guang-Biao Zhou. Celastrol induces proteasomal degradation of FANCD2 to sensitize lung cancer cells to DNA crosslinking agents. Cancer Science, 2015, 106(7): 902–908. (co-first author).