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中国科学院广州生物医药与健康研究院研究生导师介绍王金勇

广州生物医药与健康研究院 免费考研网/2012-11-04

姓名:
王金勇性别:

职务:
职称:
研究员
学历:
博士通讯地址:
广州市科学城开源大道190号
电话:
邮政编码:
510530
传真:
电子邮件:
wang_jinyong@gibh.ac.cn


简历:
学习及工作简历

2012-,中国科学院广州生物医药与健康研究院,研究员

2007-2012,美国威斯康星医学院、威斯康星大学,博士后、助理科学家

2001-2006,浙江大学,博士





研究领域:

1.造血干细胞的体外获得、扩繁培养、定向分化与治疗性移植

2.血液肿瘤的发病与恶化机制、耐药性机制及靶向治疗

3.正常与疾病状态下造血干细胞与微环境相互作用的信号调控网络,造血干细胞自我更新与分化的调控机制

4.血液疾病与自身免疫疾病的非人类灵长类模型、小鼠模型




社会任职:


获奖及荣誉:

代表论著:
1.JinyongWang1*,GuangyaoKong1,YangangLiu,JuanDu,XinminZhang,AlisaDamnernsawad,ErikA.Ranheim,Myung-JeomRyu,JingZhang*.EndogenousNrasG12D/+andG12D/G12Ddistinctlyregulatetheproliferationanddifferentiationofhaematopoieticstemcells.2012;(1,equalcontribution,*,correspondingauthor)(submitted)

2.JuanDu,YangangLiu,BenjaminMeline,GuangyaoKong,LiXuanTan,JuinnCherngLo,JinyongWang,ErikRanheim,LiZhang,Yuan-IChang,Myung-JeomRyu1,JingfangZhang,JingZhang.LossofCD44attenuatesaberrantGM-CSFsignalinginKrasG12Dhematopoieticprogenitor/precursorcellsandprolongsthesurvivalofdiseasedanimals.Leukemia,2012;(Accepted)

3.KirbyD.Johnson,Myung-JeomRyu,AmyP.Hsu,JinyongWang,XinGao,MeghanE.Boyer,SunduzKeles,YoungsookLee,KatherineR.Calvo,JingZhang,StevenM.Holland,andEmeryH.Bresnick.Cis-ElementMutatedinaGATA2-DependentImmunodeficiencySyndromeGovernsHematopoiesisandVascularIntegrity.JournalofClinicalInvestigation,2012;(Inpress)

4.JuanDu1,JinyongWang1*,GuangyaoKong,JingJiang,JingfangZhang,YangangLiu,WeiTong,JingZhang*.Signalingprofilingatthesingle-celllevelidentifiesadistinctsignalingsignatureinmurinehematopoieticstemcells.StemCells,2012;30(7):1447-1454.(1,equalcontribution,*correspondingauthor)

5.Myung-JeomRyu,YangangLiu,XiaofenZhong,JuanDu,NicholasPeterson,GuangyaoKong,HongdaLi,JinyongWang,ShahriarSalamat,QiangChang,andJingZhang.OncogenicKrasExpressioninPostmitoticNeuronsLeadstoS100A8-S100A9ProteinOverexpressionandGliosis.JournalofBiologicalChemistry,2012;287(27):22948-22958.

6.JinyongWang,YangangLiu,LiXuanTan,JuinnCherngLo,JuanDu,Myung-JeomRyu,ErikA.Ranheim,JingZhang.DistinctrequirementsofhematopoieticstemcellactivityandNrasG12Dsignalingindifferentcelltypesduringleukemogenesis.Cellcycle,2011;10(17),1-4.

7.JinyongWang,YangangLiu,ZeyangLi,ZhongdeWang,LiXuanTan,Myung-JeomRyu,BenjaminMeline,JuanDu,KenHYoung,ErikRanheim,QiangChang,andJingZhang.EndogenousoncogenicNrasmutationinitiateshematopoieticmalignanciesinadose-andcelltype-dependentmanner.Blood,2011;118(2)368-379.

8.JinyongWang,YangangLiu,JuanDu,Myung-JeomRyu,ErikRanheim,JingZhang.EndogenousoncogenicNrassignalingpromotesproliferativeexhaustionofhematopoieticstemcellsthroughadose-dependenthyperactivationofERK.Blood,2011;118(21):1710-1711.

9.JinyongWang,YangangLiu,ZeyangLi,JuanDu,Myung-JeomRyu,PhilipTaylor,MarkD.Fleming,KenH.Young,HenryPitot,JingZhang.EndogenousoncogenicNrasmutationpromotesaberrantGM-CSFsignalingingranulocytic/monocyticprecursorsinamurinemodelofchronicmyelomonocyticleukemia.Blood,2010;116(26):5991-6002.



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